iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000142230.11	ENST00000413379.7	ENSP00000416557.2
ENSG00000142230.11	ENST00000600706.5	ENSP00000468931.1
ENSG00000142230.11	ENST00000598840.5	ENSP00000470741.1
ENSG00000142230.11	ENST00000414294.6	ENSP00000398818.1
ENSG00000142230.11	ENST00000270225.11	ENSP00000270225.6
ENSG00000142230.11	ENST00000596995.1	ENSP00000473037.1
ENSG00000142230.11	ENST00000392776.3	ENSP00000440818.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	miRWalk
RepTar	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB	SCOP
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E1	E1_ThiF	9920803; 20682785

Classification

Family	E-value	Score	Start	End
E1	2.30e-90	305.5	19	335

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnvea 92
           YDRQirlwG eaq++l+ ++vllvG++glG+E++KnL+laGv+ +t++D+++v+ +++++qFL+r  +vg+++Ae+++e++++lnp+v+v++
   Q: 19   YDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKV 110
           ******************************************************************************************** PP
   S: 93   heesiteleeeivFfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfctlketpnaae 184
           ++e+i+++ e+  Ff++fd V+l++++r+   kv+++c+++++++++++++G++G++                       f +l+e++ ++e
   Q: 111  DTEDIEKKPES--FFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYT-----------------------FANLGEHEFVEE 177
           ***********..********************************************.......................************ PP
   S: 185  htiewavlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttinsikqllksfecdivtkskspfwvsf 276
           +t +        ++ e+g++++++klds+e++++k+kv                                                     f
   Q: 178  KTKVAK----VSQGVEDGPDTKRAKLDSSETTMVKKKV----------------------------------------------------VF 213
           ***955....89999**********************9....................................................8* PP
   S: 277  csnaealqvpekvekdeevvkasaplylllralerfekkkgrkpgelsfekdddsavdlvtaaanlraeslgiepkldddlikeiagniipa 368
           c+++eal+v+++ ek ++++k++ + y+ll++l +f+++kgr+p++ ++e+d++ ++++ ++++     slgi+p   d l + ++++++++
   Q: 214  CPVKEALEVDWSSEKAKAALKRTTSDYFLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVL----DSLGISP---DLLPEDFVRYCFSE 298
           ****************************************************************....*******...555555666899** PP
   S: 369  iattnavvgGlaaqEviKvvsgkfeplknfflfdaee 405
           +a+++avvgG++aqE++K++s++  p++nff+fd+++
   Q: 299  MAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMK 335
           **********************************985 PP

Organism

Homo sapiens

Functional Description
(View)

The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.

Protein Sequence
(Fasta)

MVEKEEAGGG ISEEEAAQYD RQIRLWGLEA QKRLRASRVL LVGLKGLGAE IAKNLILAGV 60
KGLTMLDHEQ VTPEDPGAQF LIRTGSVGRN RAEASLERAQ NLNPMVDVKV DTEDIEKKPE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCCGAGGGG AGGCGGAAAT AGCCGAAAGG AGCTGAGCAG GAGCGAGGAG GCGACGGGGG 60
AGAGCCAGAA AGAGCTGAAG GTGGTGATAT GGGTGGGGCT AGAGAGAGCA TGAGAAACCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0436--Ligase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR000011--UBQ/SUMO-activ_enz_E1-like

Pfam

PF00899--ThiF

PRINTS

PR01849--UBIQUITINACT

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0031510--C:SUMO activating enzyme complex
GO:0043008--F:ATP-dependent protein binding
GO:0008047--F:enzyme activator activity
GO:0008022--F:protein C-terminus binding
GO:0046982--F:protein heterodimerization activity
GO:0004839--F:ubiquitin activating enzyme activity
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0016925--P:protein sumoylation
GO:0016567--P:protein ubiquitination

KEGG

hsa:10055

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000695	Aegilops tauschii	30.81	1.00e-39	157.00
IUUC-Aml-001477	Ailuropoda melanoleuca	96.35	0.00e+00	656.00
IUUC-Atr-002536	Amborella trichopoda	31.86	2.00e-41	162.00
IUUC-Apl-003982	Anas platyrhynchos	72.90	2.00e-104	372.00
IUUC-Aca-004868	Anolis carolinensis	80.30	3.00e-154	537.00
IUUC-Aly-005588	Arabidopsis lyrata	32.28	1.00e-44	173.00
IUUC-Ath-006677	Arabidopsis thaliana	33.33	2.00e-45	176.00
IUUC-Ago-007891	Ashbya gossypii	33.04	3.00e-44	172.00
IUUC-Acl-008197	Aspergillus clavatus	35.39	4.00e-53	202.00
IUUC-Afl-008520	Aspergillus flavus	33.33	3.00e-52	199.00
IUUC-Afu-009107	Aspergillus fumigatus	32.04	2.00e-45	176.00
IUUC-Ani-009143	Aspergillus nidulans	32.37	1.00e-42	167.00
IUUC-Ang-009804	Aspergillus niger	34.73	9.00e-54	204.00
IUUC-Aor-010190	Aspergillus oryzae	33.33	3.00e-52	199.00
IUUC-Ame-011043	Astyanax mexicanus	69.28	1.00e-127	449.00
IUUC-Bgr-012084	Blumeria graminis	32.09	3.00e-46	179.00
IUUC-Bta-012723	Bos taurus	96.34	0.00e+00	657.00
IUUC-Bci-013809	Botrytis cinerea	33.62	3.00e-50	192.00
IUUC-Bdi-014800	Brachypodium distachyon	33.33	5.00e-45	174.00
IUUC-Bol-015744	Brassica oleracea	30.99	8.00e-41	160.00
IUUC-Bra-016683	Brassica rapa	31.58	5.00e-42	164.00
IUUC-Cel-018434	Caenorhabditis elegans	30.92	5.00e-39	154.00
IUUC-Cja-019815	Callithrix jacchus	98.27	0.00e+00	703.00
IUUC-Cfa-020329	Canis familiaris	96.05	0.00e+00	657.00
IUUC-Cpo-022208	Cavia porcellus	94.22	0.00e+00	668.00
IUUC-Csa-023592	Chlorocebus sabaeus	98.56	1.00e-162	565.00
IUUC-Cho-024345	Choloepus hoffmanni	86.59	4.00e-127	447.00
IUUC-Cin-025351	Ciona intestinalis	44.94	7.00e-85	307.00
IUUC-Cgl-026491	Colletotrichum gloeosporioides	32.49	7.00e-43	168.00
IUUC-Cne-026970	Cryptococcus neoformans	28.88	1.00e-24	107.00
IUUC-Dre-028263	Danio rerio	69.36	6.00e-132	463.00
IUUC-Dno-030055	Dasypus novemcinctus	94.53	0.00e+00	652.00
IUUC-Dor-030864	Dipodomys ordii	92.01	1.00e-173	601.00
IUUC-Dse-031565	Dothistroma septosporum	33.91	2.00e-49	189.00
IUUC-Dme-032011	Drosophila melanogaster	39.42	5.00e-59	221.00
IUUC-Ete-032982	Echinops telfairi	83.14	3.00e-165	574.00
IUUC-Eca-034164	Equus caballus	95.54	2.00e-180	624.00
IUUC-Eeu-035135	Erinaceus europaeus	79.82	1.00e-100	359.00
IUUC-Fca-035564	Felis catus	96.96	0.00e+00	660.00
IUUC-Fox-037928	Fusarium oxysporum	32.77	4.00e-47	182.00
IUUC-Fso-038404	Fusarium solani	32.87	2.00e-46	180.00
IUUC-Gmo-038867	Gadus morhua	67.54	4.00e-127	447.00
IUUC-Ggr-040068	Gaeumannomyces graminis	35.80	4.00e-51	195.00
IUUC-Gga-041197	Gallus gallus	74.47	5.00e-128	450.00
IUUC-Gac-042609	Gasterosteus aculeatus	67.34	4.00e-129	454.00
IUUC-Gma-044135	Glycine max	30.55	3.00e-44	172.00
IUUC-Ggo-044600	Gorilla gorilla	100.00	0.00e+00	679.00
IUUC-Itr-049038	Ictidomys tridecemlineatus	97.87	0.00e+00	668.00
IUUC-Kpa-049371	Komagataella pastoris	28.81	7.00e-34	137.00
IUUC-Lch-050045	Latimeria chalumnae	77.68	2.00e-155	541.00
IUUC-Lpe-051103	Leersia perrieri	32.08	3.00e-42	166.00
IUUC-Loc-051749	Lepisosteus oculatus	64.97	4.00e-125	441.00
IUUC-Lma-053150	Leptosphaeria maculans	36.24	1.00e-50	193.00
IUUC-Laf-053875	Loxodonta africana	95.74	0.00e+00	657.00
IUUC-Mcc-055107	Macaca mulatta	98.68	2.00e-179	621.00
IUUC-Meu-056076	Macropus eugenii	64.16	4.00e-123	434.00
IUUC-Mor-057029	Magnaporthe oryzae	35.26	3.00e-48	186.00
IUUC-Mtr-058633	Medicago truncatula	32.65	5.00e-43	168.00
IUUC-Mvi-060367	Microbotryum violaceum	33.71	4.00e-52	198.00
IUUC-Mmr-061294	Microcebus murinus	95.05	2.00e-173	601.00
IUUC-Mdo-062827	Monodelphis domestica	87.32	0.00e+00	632.00
IUUC-Mmu-063568	Mus musculus	93.01	6.00e-177	613.00
IUUC-Mac-064495	Musa acuminata	29.74	3.00e-41	162.00
IUUC-Mpu-065826	Mustela putorius furo	95.44	0.00e+00	653.00
IUUC-Mlu-067751	Myotis lucifugus	94.27	5.00e-178	616.00
IUUC-Nfi-068597	Neosartorya fischeri	34.84	4.00e-55	208.00
IUUC-Ncr-068768	Neurospora crassa	32.80	4.00e-46	179.00
IUUC-Nle-069882	Nomascus leucogenys	100.00	4.00e-93	333.00
IUUC-Opr-071077	Ochotona princeps	66.87	7.00e-122	430.00
IUUC-Ont-072576	Oreochromis niloticus	69.65	2.00e-123	435.00
IUUC-Oan-073560	Ornithorhynchus anatinus	84.82	7.00e-158	549.00
IUUC-Ocu-074732	Oryctolagus cuniculus	87.43	2.00e-170	591.00
IUUC-Oba-075956	Oryza barthii	31.85	3.00e-44	172.00
IUUC-Obr-076004	Oryza brachyantha	31.25	8.00e-42	164.00
IUUC-Ogu-078335	Oryza glumaepatula	31.85	5.00e-44	171.00
IUUC-Oin-079177	Oryza indica	31.85	9.00e-45	174.00
IUUC-Olo-080537	Oryza longistaminata	29.64	9.00e-37	147.00
IUUC-Ome-081880	Oryza meridionalis	31.85	9.00e-45	174.00
IUUC-Oni-082688	Oryza nivara	32.14	1.00e-45	176.00
IUUC-Opu-083231	Oryza punctata	32.67	3.00e-48	185.00
IUUC-Oru-084759	Oryza rufipogon	31.85	9.00e-45	174.00
IUUC-Osa-085601	Oryza sativa	31.55	2.00e-44	172.00
IUUC-Ola-086496	Oryzias latipes	69.16	8.00e-124	436.00
IUUC-Oga-089005	Otolemur garnettii	88.82	4.00e-175	607.00
IUUC-Oar-089611	Ovis aries	96.34	0.00e+00	657.00
IUUC-Ptr-091337	Pan troglodytes	100.00	0.00e+00	679.00
IUUC-Pan-092401	Papio anubis	92.40	0.00e+00	625.00
IUUC-Pma-094210	Petromyzon marinus	59.88	7.00e-120	423.00
IUUC-Pno-094975	Phaeosphaeria nodorum	34.86	5.00e-49	188.00
IUUC-Ppa-095925	Physcomitrella patens	35.65	2.00e-53	202.00
IUUC-Pfo-096890	Poecilia formosa	68.21	1.00e-128	452.00
IUUC-Pab-098173	Pongo abelii	100.00	0.00e+00	680.00
IUUC-Pop-099145	Populus trichocarpa	33.14	2.00e-46	179.00
IUUC-Pca-100899	Procavia capensis	78.42	5.00e-140	490.00
IUUC-Ppe-101274	Prunus persica	30.22	7.00e-32	130.00
IUUC-Pva-102625	Pteropus vampyrus	93.92	0.00e+00	646.00
IUUC-Pgr-103426	Puccinia graminis	36.63	6.00e-55	208.00
IUUC-Pte-104082	Pyrenophora teres	35.90	2.00e-48	186.00
IUUC-Pyt-104818	Pyrenophora triticirepentis	35.51	1.00e-47	183.00
IUUC-Rno-106129	Rattus norvegicus	92.15	0.00e+00	644.00
IUUC-Sce-106370	Saccharomyces cerevisiae	34.02	6.00e-44	171.00
IUUC-Sha-107120	Sarcophilus harrisii	85.40	2.00e-157	548.00
IUUC-Sja-107996	Schizosaccharomyces japonicus	31.29	4.00e-39	155.00
IUUC-Spo-108321	Schizosaccharomyces pombe	29.22	2.00e-31	129.00
IUUC-Ssl-108608	Sclerotinia sclerotiorum	34.21	3.00e-49	188.00
IUUC-Smo-109539	Selaginella moellendorffii	29.91	6.00e-35	141.00
IUUC-Sit-110166	Setaria italica	32.86	3.00e-47	182.00
IUUC-Sly-111116	Solanum lycopersicum	31.83	2.00e-42	166.00
IUUC-Stu-112397	Solanum tuberosum	32.13	3.00e-42	165.00
IUUC-Sar-113506	Sorex araneus	84.10	8.00e-172	596.00
IUUC-Sbi-114548	Sorghum bicolor	33.72	2.00e-47	182.00
IUUC-Ssc-115891	Sus scrofa	96.66	0.00e+00	661.00
IUUC-Tru-118469	Takifugu rubripes	64.74	8.00e-123	433.00
IUUC-Tsy-119304	Tarsius syrichta	86.58	9.00e-158	549.00
IUUC-Tni-119803	Tetraodon nigroviridis	59.83	5.00e-118	417.00
IUUC-Tca-121747	Theobroma cacao	33.04	6.00e-46	178.00
IUUC-Tre-122060	Trichoderma reesei	33.33	2.00e-45	176.00
IUUC-Tvi-122324	Trichoderma virens	33.62	6.00e-47	181.00
IUUC-Tae-123512	Triticum aestivum	32.14	1.00e-44	173.00
IUUC-Tur-126224	Triticum urartu	32.46	2.00e-43	169.00
IUUC-Tme-126939	Tuber melanosporum	34.84	2.00e-52	199.00
IUUC-Tbe-127982	Tupaia belangeri	85.71	1.00e-168	585.00
IUUC-Ttr-128758	Tursiops truncatus	96.05	0.00e+00	660.00
IUUC-Vda-129664	Verticillium dahliae	32.30	7.00e-43	168.00
IUUC-Vpa-130778	Vicugna pacos	80.60	3.00e-136	477.00
IUUC-Vvi-131399	Vitis vinifera	32.36	1.00e-44	173.00
IUUC-Xtr-131919	Xenopus tropicalis	73.49	6.00e-144	503.00
IUUC-Xma-133482	Xiphophorus maculatus	69.36	4.00e-126	444.00
IUUC-Yli-134596	Yarrowia lipolytica	28.92	1.00e-34	140.00
IUUC-Zma-135688	Zea mays	33.14	6.00e-47	181.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence