iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045735

UUCD1 version

UUC-HoS-00447

Ensembl Protein ID

ENSP00000270279.3

UniProt Accession

Q9ULV8; Q8N1E5; Q9Y5Z2; Q9Y5Z3; CBLC_HUMAN

Genbank Protein ID

BAA86298.1; AAD34341.1; AAD34342.1; AAH28915.1

Protein Name

E3 ubiquitin-protein ligase CBL-C; RING finger protein 57; RING-type E3 ubiquitin transferase CBL-C; SH3-binding protein CBL-3; SH3-binding protein CBL-C; Signal transduction protein CBL-C

Genbank Nucleotide ID

AB028645; AF117646; AF117647; BC028915

Gene Name

CBLC; CBL3; RNF57

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000142273.10	ENST00000270279.7	ENSP00000270279.3
ENSG00000142273.10	ENST00000341505.4	ENSP00000340250.4

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	miRWalk
TargetScan	RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18239087; 24425877

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.00028	23.0	351	390

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e+ kd +++ pCgH+ +  Cl +w     + s +++CP Cr
   Q: 351  CKICAESNKD-VKIEPCGHLLCSCCLAAW-----QHSDSQTCPFCR 390
           99********.******************.....6889999****8 PP

Organism

Homo sapiens

Functional Description
(View)

Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.

Protein Sequence
(Fasta)

MALAVAPWGR QWEEARALGR AVRMLQRLEE QCVDPRLSVS PPSLRDLLPR TAQLLREVAH 60
SRRAAGGGGP GGPGGSGDFL LIYLANLEAK SRQVAALLPP RGRRSANDEL FRAGSRLRRQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTCTGGGCG AGGCCGCCCC TATCCCAGCC GCACCGGTCC TTCCCGGCAC ACGCGAGGCT 60
CCCATGGCTC TGGCGGTGGC CCCGTGGGGG CGACAGTGGG AAGAGGCCCG CGCCCTGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0106--Calcium
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0729--SH3-binding
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3

SMART

SM00184--RING

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005509--F:calcium ion binding
GO:0005154--F:epidermal growth factor receptor binding
GO:0001784--F:phosphotyrosine binding
GO:0030971--F:receptor tyrosine kinase binding
GO:0017124--F:SH3 domain binding
GO:0004871--F:signal transducer activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007166--P:cell surface receptor signaling pathway
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0043407--P:negative regulation of MAP kinase activity
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

hsa:23624

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002286	Ailuropoda melanoleuca	83.98	0.00e+00	649.00
IUUC-Bta-012705	Bos taurus	84.52	0.00e+00	669.00
IUUC-Cja-019179	Callithrix jacchus	89.87	0.00e+00	808.00
IUUC-Cfa-020593	Canis familiaris	79.95	0.00e+00	633.00
IUUC-Cpo-021289	Cavia porcellus	76.36	2.00e-176	612.00
IUUC-Csa-023966	Chlorocebus sabaeus	93.38	0.00e+00	770.00
IUUC-Dor-030246	Dipodomys ordii	78.03	3.00e-129	454.00
IUUC-Eca-033921	Equus caballus	71.89	1.00e-152	532.00
IUUC-Fca-035747	Felis catus	67.50	4.00e-159	554.00
IUUC-Ggo-044622	Gorilla gorilla	98.60	0.00e+00	691.00
IUUC-Itr-049001	Ictidomys tridecemlineatus	83.48	5.00e-170	590.00
IUUC-Laf-053983	Loxodonta africana	82.27	0.00e+00	680.00
IUUC-Mmr-061310	Microcebus murinus	81.97	0.00e+00	669.00
IUUC-Mmu-064155	Mus musculus	74.66	0.00e+00	650.00
IUUC-Mpu-066655	Mustela putorius furo	82.93	0.00e+00	662.00
IUUC-Mlu-067929	Myotis lucifugus	83.44	3.00e-151	527.00
IUUC-Nle-070065	Nomascus leucogenys	82.70	0.00e+00	700.00
IUUC-Ocu-074049	Oryctolagus cuniculus	77.03	5.00e-134	470.00
IUUC-Oga-087952	Otolemur garnettii	83.47	0.00e+00	741.00
IUUC-Oar-089382	Ovis aries	80.93	0.00e+00	650.00
IUUC-Ptr-090579	Pan troglodytes	83.33	1.00e-163	569.00
IUUC-Pan-092075	Papio anubis	93.67	0.00e+00	810.00
IUUC-Pab-098100	Pongo abelii	88.40	0.00e+00	770.00
IUUC-Pca-100830	Procavia capensis	79.84	7.00e-111	394.00
IUUC-Pva-102714	Pteropus vampyrus	78.04	5.00e-166	577.00
IUUC-Rno-105348	Rattus norvegicus	76.03	0.00e+00	653.00
IUUC-Sha-107138	Sarcophilus harrisii	64.69	3.00e-122	431.00
IUUC-Ssc-116424	Sus scrofa	81.88	0.00e+00	674.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence