iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028092

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase NOSIP; RING-type E3 ubiquitin transferase NOSIP

Genbank Nucleotide ID

BC085409

Gene Name

nosip; zgc:101669

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000037958.7	ENSDART00000055312.7	ENSDARP00000055311.6

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	1.10e-14	55.2	40	95

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggk.......tcPvtrqpl 50
           + ++ +C++sl++ rdPv +++G+ y++++I +++ ++++          + +q l
   Q: 40   IKDFDCCSLSLQPCRDPVLTEDGYLYEKEAILQYILHQKTeiakkmkAYEKQKQAL 95
           567889*****************************888874444443444455555 PP

Organism

Danio rerio

Functional Description
(View)

E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face (By similarity). Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity (By similarity).

Protein Sequence
(Fasta)

MTRHGKNCTA GAVYTYHEKR KDTAASGYGT QSVRLGKDAI KDFDCCSLSL QPCRDPVLTE 60
DGYLYEKEAI LQYILHQKTE IAKKMKAYEK QKQALKSEGQ LESKSEERER AEKFKQRENN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACGAGAATG TCAACTTTTA TTTTGAAGTT TTTTTATGAC GAACCAGGAA AAGGAGCAAA 60
GGATCTTTTC CGGTTTACGA CCATAGGAGG TAAACAGAAA CATCTGTGCT TATTACTGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR016818--Nitric_oxide_synth-interacting
IPR031790--Znf-NOSIP
IPR013083--Znf_RING/FYVE/PHD

Pfam

PF15906--zf-NOSIP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0007275--P:multicellular organism development
GO:0016567--P:protein ubiquitination
GO:0050999--P:regulation of nitric-oxide synthase activity

KEGG

dre:492793

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000769	Aegilops tauschii	46.51	1.00e-14	75.10
IUUC-Aml-002069	Ailuropoda melanoleuca	62.10	3.00e-114	404.00
IUUC-Atr-002661	Amborella trichopoda	31.10	1.00e-27	117.00
IUUC-Aca-004630	Anolis carolinensis	66.12	4.00e-116	410.00
IUUC-Aly-006316	Arabidopsis lyrata	31.58	5.00e-32	131.00
IUUC-Ath-007000	Arabidopsis thaliana	31.25	1.00e-31	130.00
IUUC-Acl-008175	Aspergillus clavatus	31.15	1.00e-05	44.30
IUUC-Afl-008440	Aspergillus flavus	26.05	1.00e-10	60.80
IUUC-Afu-009012	Aspergillus fumigatus	28.80	2.00e-06	46.60
IUUC-Ani-009153	Aspergillus nidulans	32.09	5.00e-04	39.30
IUUC-Ang-009556	Aspergillus niger	24.61	2.00e-11	63.50
IUUC-Aor-009892	Aspergillus oryzae	32.74	7.00e-07	48.50
IUUC-Ate-010473	Aspergillus terreus	29.36	9.00e-05	42.70
IUUC-Ame-011874	Astyanax mexicanus	83.12	2.00e-133	468.00
IUUC-Bgr-012090	Blumeria graminis	24.38	1.00e-04	40.80
IUUC-Bta-012956	Bos taurus	65.46	1.00e-118	419.00
IUUC-Bci-013897	Botrytis cinerea	38.75	2.00e-09	56.60
IUUC-Bdi-014968	Brachypodium distachyon	32.66	1.00e-34	140.00
IUUC-Bol-015578	Brassica oleracea	31.58	6.00e-35	141.00
IUUC-Bra-017234	Brassica rapa	31.58	6.00e-35	141.00
IUUC-Cel-018637	Caenorhabditis elegans	40.49	4.00e-56	211.00
IUUC-Cja-019632	Callithrix jacchus	65.26	2.00e-118	418.00
IUUC-Cfa-020192	Canis familiaris	64.47	3.00e-117	414.00
IUUC-Cpo-021939	Cavia porcellus	65.46	9.00e-117	412.00
IUUC-Cre-023005	Chlamydomonas reinhardtii	33.33	5.00e-36	144.00
IUUC-Csa-023802	Chlorocebus sabaeus	64.29	5.00e-118	417.00
IUUC-Cho-024637	Choloepus hoffmanni	54.09	7.00e-42	163.00
IUUC-Cin-025180	Ciona intestinalis	51.15	8.00e-84	303.00
IUUC-Csv-026206	Ciona savignyi	57.64	3.00e-46	177.00
IUUC-Cgl-026696	Colletotrichum gloeosporioides	24.25	1.00e-13	70.90
IUUC-Cne-026827	Cryptococcus neoformans	27.07	7.00e-09	55.10
IUUC-Dno-029501	Dasypus novemcinctus	60.33	5.00e-102	364.00
IUUC-Dor-030542	Dipodomys ordii	65.46	3.00e-119	421.00
IUUC-Dse-031188	Dothistroma septosporum	23.82	2.00e-12	67.00
IUUC-Dme-031734	Drosophila melanogaster	49.68	7.00e-84	303.00
IUUC-Eca-033577	Equus caballus	65.13	1.00e-118	419.00
IUUC-Fca-035761	Felis catus	65.46	1.00e-118	419.00
IUUC-Fox-037703	Fusarium oxysporum	35.80	7.00e-08	51.60
IUUC-Fso-038208	Fusarium solani	25.35	1.00e-11	63.90
IUUC-Gmo-038523	Gadus morhua	70.83	4.00e-70	257.00
IUUC-Ggr-040087	Gaeumannomyces graminis	37.18	3.00e-08	52.80
IUUC-Gac-042621	Gasterosteus aculeatus	75.16	3.00e-126	444.00
IUUC-Gma-042698	Glycine max	33.78	1.00e-34	140.00
IUUC-Ggo-045357	Gorilla gorilla	65.26	4.00e-118	417.00
IUUC-Hsa-046195	Homo sapiens	65.26	4.00e-118	417.00
IUUC-Hvu-047174	Hordeum vulgare	32.66	3.00e-33	135.00
IUUC-Itr-048487	Ictidomys tridecemlineatus	65.79	4.00e-118	417.00
IUUC-Lch-050569	Latimeria chalumnae	68.49	1.00e-111	396.00
IUUC-Lpe-050992	Leersia perrieri	35.78	6.00e-21	95.10
IUUC-Loc-052522	Lepisosteus oculatus	74.92	1.00e-120	425.00
IUUC-Lma-053254	Leptosphaeria maculans	25.42	2.00e-08	53.90
IUUC-Laf-053397	Loxodonta africana	64.80	5.00e-117	413.00
IUUC-Mcc-054681	Macaca mulatta	64.61	4.00e-118	418.00
IUUC-Meu-056723	Macropus eugenii	64.82	1.00e-116	412.00
IUUC-Mor-056961	Magnaporthe oryzae	35.40	1.00e-09	57.40
IUUC-Mtr-058063	Medicago truncatula	33.11	6.00e-36	144.00
IUUC-Mla-059004	Melampsora laricipopulina	26.75	5.00e-20	92.00
IUUC-Mvi-060460	Microbotryum violaceum	28.40	3.00e-23	102.00
IUUC-Mmr-060847	Microcebus murinus	65.46	7.00e-119	419.00
IUUC-Mdo-062480	Monodelphis domestica	66.23	6.00e-117	413.00
IUUC-Mmu-063809	Mus musculus	64.50	5.00e-117	414.00
IUUC-Mac-064870	Musa acuminata	32.78	2.00e-35	143.00
IUUC-Mpu-066322	Mustela putorius furo	65.58	2.00e-118	418.00
IUUC-Mlu-067556	Myotis lucifugus	64.47	6.00e-118	416.00
IUUC-Nfi-068440	Neosartorya fischeri	28.80	3.00e-06	46.60
IUUC-Ncr-068898	Neurospora crassa	35.90	4.00e-07	49.30
IUUC-Nle-070049	Nomascus leucogenys	65.26	2.00e-118	418.00
IUUC-Opr-070972	Ochotona princeps	64.47	9.00e-118	416.00
IUUC-Ont-071682	Oreochromis niloticus	80.46	7.00e-136	476.00
IUUC-Oan-073296	Ornithorhynchus anatinus	86.44	3.00e-28	117.00
IUUC-Ocu-074218	Oryctolagus cuniculus	63.60	7.00e-103	366.00
IUUC-Oba-075284	Oryza barthii	33.00	2.00e-32	132.00
IUUC-Obr-076651	Oryza brachyantha	31.99	1.00e-34	140.00
IUUC-Ogl-077899	Oryza glaberrima	33.00	2.00e-32	132.00
IUUC-Ogu-078477	Oryza glumaepatula	33.00	2.00e-32	132.00
IUUC-Oin-080011	Oryza indica	33.00	2.00e-32	132.00
IUUC-Olo-080545	Oryza longistaminata	33.33	3.00e-24	106.00
IUUC-Ome-081543	Oryza meridionalis	33.00	2.00e-32	132.00
IUUC-Oni-082955	Oryza nivara	33.00	2.00e-32	132.00
IUUC-Opu-083565	Oryza punctata	32.66	2.00e-32	132.00
IUUC-Oru-084474	Oryza rufipogon	33.00	2.00e-32	132.00
IUUC-Osa-085913	Oryza sativa	33.00	2.00e-32	132.00
IUUC-Ola-086851	Oryzias latipes	76.64	6.00e-136	476.00
IUUC-Olu-087724	Ostreococcus lucimarinus	31.07	3.00e-11	62.80
IUUC-Oga-087970	Otolemur garnettii	65.25	4.00e-117	414.00
IUUC-Oar-089756	Ovis aries	63.49	2.00e-111	395.00
IUUC-Ptr-091485	Pan troglodytes	64.61	5.00e-115	407.00
IUUC-Pan-091832	Papio anubis	64.61	2.00e-118	419.00
IUUC-Pma-094551	Petromyzon marinus	60.91	1.00e-102	365.00
IUUC-Pno-094830	Phaeosphaeria nodorum	30.39	5.00e-06	45.10
IUUC-Ppa-095255	Physcomitrella patens	31.10	7.00e-29	120.00
IUUC-Pfo-096373	Poecilia formosa	80.07	2.00e-140	491.00
IUUC-Pab-098247	Pongo abelii	65.26	4.00e-118	417.00
IUUC-Pop-099186	Populus trichocarpa	33.33	6.00e-34	137.00
IUUC-Pca-100677	Procavia capensis	59.71	1.00e-91	329.00
IUUC-Ppe-101403	Prunus persica	30.43	3.00e-31	129.00
IUUC-Pva-103000	Pteropus vampyrus	65.46	3.00e-119	421.00
IUUC-Pgr-103663	Puccinia graminis	29.72	2.00e-27	117.00
IUUC-Ptt-103712	Puccinia triticina	33.85	7.00e-08	51.20
IUUC-Pte-104287	Pyrenophora teres	31.63	6.00e-07	48.50
IUUC-Pyt-104579	Pyrenophora triticirepentis	31.25	5.00e-07	48.90
IUUC-Rno-106069	Rattus norvegicus	64.50	3.00e-117	414.00
IUUC-Sha-106553	Sarcophilus harrisii	64.80	4.00e-116	410.00
IUUC-Smo-108874	Selaginella moellendorffii	34.22	3.00e-38	152.00
IUUC-Sit-110307	Setaria italica	33.00	1.00e-30	127.00
IUUC-Sly-111094	Solanum lycopersicum	32.78	6.00e-35	141.00
IUUC-Stu-112363	Solanum tuberosum	32.78	5.00e-35	141.00
IUUC-Sar-113480	Sorex araneus	63.82	5.00e-113	400.00
IUUC-Sbi-113939	Sorghum bicolor	33.33	4.00e-33	135.00
IUUC-Ssc-115644	Sus scrofa	64.61	2.00e-118	418.00
IUUC-Tru-118781	Takifugu rubripes	76.22	1.00e-134	472.00
IUUC-Tni-119672	Tetraodon nigroviridis	75.86	3.00e-36	142.00
IUUC-Tca-121795	Theobroma cacao	32.11	7.00e-35	140.00
IUUC-Tre-122037	Trichoderma reesei	32.47	1.00e-06	47.80
IUUC-Tvi-122524	Trichoderma virens	25.00	1.00e-13	70.90
IUUC-Tae-122828	Triticum aestivum	33.00	2.00e-33	136.00
IUUC-Tur-126387	Triticum urartu	32.82	8.00e-26	111.00
IUUC-Tme-127111	Tuber melanosporum	36.90	8.00e-08	51.20
IUUC-Ttr-128227	Tursiops truncatus	65.26	6.00e-118	417.00
IUUC-Vda-129924	Verticillium dahliae	24.65	1.00e-15	77.40
IUUC-Vpa-130802	Vicugna pacos	69.66	3.00e-34	138.00
IUUC-Vvi-131105	Vitis vinifera	33.00	6.00e-34	137.00
IUUC-Xtr-132830	Xenopus tropicalis	64.89	2.00e-117	415.00
IUUC-Xma-133618	Xiphophorus maculatus	80.26	6.00e-134	469.00
IUUC-Zma-135389	Zea mays	33.33	1.00e-32	133.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence