iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000142784.15	ENST00000361771.7	ENSP00000355317.3
ENSG00000142784.15	ENST00000447062.2	ENSP00000434578.1
ENSG00000142784.15	ENST00000319394.7	ENSP00000317971.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWAS Central
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	17588513

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.30e-27	95.5	45	76

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDl 30
           gH++ v+cl++   ++ll+sGsdD    vWD+
   Q: 45   GHSGCVNCLEWneKGDLLASGSDDQHTIVWDP 76
           8**********65339***************6 PP

Organism

Homo sapiens

Functional Description
(View)

May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Protein Sequence
(Fasta)

MAKVNITRDL IRRQIKERGA LSFERRYHVT DPFIRRLGLE AELQGHSGCV NCLEWNEKGD 60
LLASGSDDQH TIVWDPLHHK KLLSMHTGHT ANIFSVKFLP HAGDRILITG AADSKVHVHD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGTGGGGGG GCCCGGCTAG CCATTCTGGA AGCGGCCGGG CGCAGTCTTC GTAGCGTACC 60
CGCCGGCTGC GAGGCGCAGG GCGGAGGCGG AGACTGCGTG GCGCAGGCGC GTTGCTGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50293--TPR_REGION
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00028--TPR
SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0004857--F:enzyme inhibitor activity
GO:0055082--P:cellular chemical homeostasis
GO:0032869--P:cellular response to insulin stimulus
GO:0006006--P:glucose metabolic process
GO:0001701--P:in utero embryonic development
GO:0035264--P:multicellular organism growth
GO:0045717--P:negative regulation of fatty acid biosynthetic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0016567--P:protein ubiquitination
GO:0008361--P:regulation of cell size

KEGG

hsa:23038

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000083	Aegilops tauschii	29.02	1.00e-57	218.00
IUUC-Aml-001699	Ailuropoda melanoleuca	98.67	0.00e+00	1356.00
IUUC-Atr-002509	Amborella trichopoda	31.31	1.00e-50	194.00
IUUC-Apl-003379	Anas platyrhynchos	93.35	0.00e+00	1289.00
IUUC-Aca-005202	Anolis carolinensis	90.56	0.00e+00	1259.00
IUUC-Aly-006475	Arabidopsis lyrata	31.49	8.00e-54	205.00
IUUC-Ath-007666	Arabidopsis thaliana	30.95	4.00e-53	203.00
IUUC-Afl-008592	Aspergillus flavus	27.97	7.00e-26	113.00
IUUC-Ani-009263	Aspergillus nidulans	27.35	3.00e-25	110.00
IUUC-Ang-009671	Aspergillus niger	27.32	3.00e-26	115.00
IUUC-Aor-010229	Aspergillus oryzae	27.68	6.00e-26	113.00
IUUC-Ame-010988	Astyanax mexicanus	81.68	0.00e+00	1006.00
IUUC-Bdi-014100	Brachypodium distachyon	29.67	8.00e-50	192.00
IUUC-Bol-016409	Brassica oleracea	31.75	5.00e-52	199.00
IUUC-Bra-016979	Brassica rapa	31.32	2.00e-51	197.00
IUUC-Cel-018561	Caenorhabditis elegans	32.73	2.00e-34	140.00
IUUC-Cja-019212	Callithrix jacchus	97.19	0.00e+00	1310.00
IUUC-Cfa-020200	Canis familiaris	98.53	0.00e+00	1354.00
IUUC-Cpo-021739	Cavia porcellus	98.67	0.00e+00	1353.00
IUUC-Cre-022659	Chlamydomonas reinhardtii	33.85	2.00e-34	140.00
IUUC-Csa-023648	Chlorocebus sabaeus	100.00	0.00e+00	1358.00
IUUC-Cin-025155	Ciona intestinalis	44.56	2.00e-63	236.00
IUUC-Csv-026289	Ciona savignyi	46.25	9.00e-149	520.00
IUUC-Cme-027316	Cyanidioschyzon merolae	27.99	5.00e-26	113.00
IUUC-Dre-028745	Danio rerio	80.80	0.00e+00	1115.00
IUUC-Dno-029403	Dasypus novemcinctus	93.21	0.00e+00	1265.00
IUUC-Dor-030332	Dipodomys ordii	88.22	0.00e+00	1221.00
IUUC-Dme-031811	Drosophila melanogaster	37.56	2.00e-109	389.00
IUUC-Ete-032331	Echinops telfairi	82.24	0.00e+00	723.00
IUUC-Eca-033783	Equus caballus	98.38	0.00e+00	1355.00
IUUC-Eeu-034732	Erinaceus europaeus	95.43	0.00e+00	1300.00
IUUC-Fca-036543	Felis catus	98.67	0.00e+00	1356.00
IUUC-Fal-037245	Ficedula albicollis	92.71	0.00e+00	1300.00
IUUC-Gmo-039346	Gadus morhua	78.47	0.00e+00	1121.00
IUUC-Gga-041034	Gallus gallus	93.21	0.00e+00	1285.00
IUUC-Gac-041297	Gasterosteus aculeatus	79.65	0.00e+00	1113.00
IUUC-Gma-042727	Glycine max	31.62	9.00e-50	192.00
IUUC-Ggo-045309	Gorilla gorilla	100.00	0.00e+00	1358.00
IUUC-Itr-049052	Ictidomys tridecemlineatus	97.99	0.00e+00	1173.00
IUUC-Lch-049810	Latimeria chalumnae	85.67	0.00e+00	1162.00
IUUC-Lpe-051600	Leersia perrieri	27.31	6.00e-67	249.00
IUUC-Loc-052088	Lepisosteus oculatus	85.67	0.00e+00	1188.00
IUUC-Laf-054097	Loxodonta africana	98.82	0.00e+00	1354.00
IUUC-Mcc-054848	Macaca mulatta	100.00	0.00e+00	1358.00
IUUC-Meu-056022	Macropus eugenii	73.47	0.00e+00	812.00
IUUC-Mtr-057735	Medicago truncatula	30.64	6.00e-47	182.00
IUUC-Mga-059622	Meleagris gallopavo	93.21	0.00e+00	1285.00
IUUC-Mmr-060709	Microcebus murinus	99.26	0.00e+00	1357.00
IUUC-Mdo-062401	Monodelphis domestica	95.86	0.00e+00	1310.00
IUUC-Mmu-063899	Mus musculus	96.46	0.00e+00	1324.00
IUUC-Mac-064840	Musa acuminata	31.50	5.00e-49	189.00
IUUC-Mpu-066268	Mustela putorius furo	98.53	0.00e+00	1353.00
IUUC-Mlu-067211	Myotis lucifugus	99.03	0.00e+00	855.00
IUUC-Nle-070019	Nomascus leucogenys	99.85	0.00e+00	1335.00
IUUC-Opr-071008	Ochotona princeps	98.52	0.00e+00	1352.00
IUUC-Ont-072123	Oreochromis niloticus	80.97	0.00e+00	1140.00
IUUC-Ocu-074166	Oryctolagus cuniculus	98.52	0.00e+00	1353.00
IUUC-Oba-075298	Oryza barthii	29.05	8.00e-43	169.00
IUUC-Obr-076849	Oryza brachyantha	33.77	4.00e-37	149.00
IUUC-Ogl-077515	Oryza glaberrima	29.05	1.00e-42	168.00
IUUC-Ogu-077968	Oryza glumaepatula	29.05	1.00e-38	154.00
IUUC-Oin-079231	Oryza indica	28.96	1.00e-37	151.00
IUUC-Olo-081045	Oryza longistaminata	34.40	1.00e-31	133.00
IUUC-Ome-081395	Oryza meridionalis	29.17	3.00e-37	150.00
IUUC-Oni-082801	Oryza nivara	29.05	2.00e-42	167.00
IUUC-Opu-083585	Oryza punctata	29.12	1.00e-42	168.00
IUUC-Oru-085163	Oryza rufipogon	33.77	2.00e-36	147.00
IUUC-Osa-085550	Oryza sativa	33.60	8.00e-29	120.00
IUUC-Ola-086925	Oryzias latipes	78.61	0.00e+00	1101.00
IUUC-Oga-088095	Otolemur garnettii	97.20	0.00e+00	1349.00
IUUC-Oar-090285	Ovis aries	96.76	0.00e+00	1315.00
IUUC-Ptr-091221	Pan troglodytes	100.00	0.00e+00	1358.00
IUUC-Pan-091771	Papio anubis	100.00	0.00e+00	1358.00
IUUC-Psi-093977	Pelodiscus sinensis	92.17	0.00e+00	1274.00
IUUC-Ppa-095373	Physcomitrella patens	30.67	1.00e-48	187.00
IUUC-Pfo-096640	Poecilia formosa	80.35	0.00e+00	1122.00
IUUC-Pab-098513	Pongo abelii	100.00	0.00e+00	1358.00
IUUC-Pop-098837	Populus trichocarpa	31.25	3.00e-45	177.00
IUUC-Pca-101095	Procavia capensis	90.10	0.00e+00	1202.00
IUUC-Ppe-101507	Prunus persica	29.94	1.00e-47	185.00
IUUC-Pva-102444	Pteropus vampyrus	98.67	0.00e+00	1354.00
IUUC-Rno-105952	Rattus norvegicus	97.49	0.00e+00	1332.00
IUUC-Sha-106614	Sarcophilus harrisii	96.16	0.00e+00	1318.00
IUUC-Smo-108844	Selaginella moellendorffii	32.34	1.00e-45	177.00
IUUC-Sit-110154	Setaria italica	28.57	2.00e-66	247.00
IUUC-Sly-111707	Solanum lycopersicum	31.96	3.00e-49	190.00
IUUC-Sar-113129	Sorex araneus	82.30	0.00e+00	1090.00
IUUC-Sbi-113858	Sorghum bicolor	28.16	5.00e-61	229.00
IUUC-Ssc-116275	Sus scrofa	98.97	0.00e+00	1356.00
IUUC-Tgu-117507	Taeniopygia guttata	93.21	0.00e+00	1288.00
IUUC-Tru-117969	Takifugu rubripes	78.47	0.00e+00	1123.00
IUUC-Tsy-119374	Tarsius syrichta	87.20	0.00e+00	865.00
IUUC-Tni-119887	Tetraodon nigroviridis	77.08	0.00e+00	1070.00
IUUC-Tca-121722	Theobroma cacao	32.90	2.00e-49	191.00
IUUC-Tae-124583	Triticum aestivum	30.20	1.00e-42	168.00
IUUC-Tur-125968	Triticum urartu	35.34	2.00e-33	139.00
IUUC-Tme-126910	Tuber melanosporum	34.26	3.00e-24	107.00
IUUC-Tbe-127511	Tupaia belangeri	92.31	1.00e-90	326.00
IUUC-Ttr-128390	Tursiops truncatus	95.63	0.00e+00	1282.00
IUUC-Uma-129509	Ustilago maydis	27.85	2.00e-13	71.60
IUUC-Vpa-130124	Vicugna pacos	59.11	2.00e-147	516.00
IUUC-Vvi-131565	Vitis vinifera	29.08	2.00e-34	141.00
IUUC-Xtr-132290	Xenopus tropicalis	77.53	0.00e+00	1063.00
IUUC-Xma-134025	Xiphophorus maculatus	79.91	0.00e+00	1117.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence