iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000143514.16	ENST00000343537.11	ENSP00000341957.7
ENSG00000143514.16	ENST00000483398.5	ENSP00000417174.1
ENSG00000143514.16	ENST00000494100.1	ENSP00000420225.1
ENSG00000143514.16	ENST00000465119.1	ENSP00000418252.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRecords	RepTar	miRNAMap	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB	SCOP
Disease-associated Variation
GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.50e-12	47.4	1066	1118

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlvi.ekeeqdegWlkgvkelegkrGlfPen 57
            ++ +l+dye+qnddeL +k+Gd +++i  ++e + +W+ +   l+ k+G +P n
   Q: 1066 GVIYALWDYEPQNDDELPMKEGDCMTIIhREDEDEIEWWWA--RLNDKEGYVPRN 1118
           56789***********************87888888***99..9*********99 PP

Organism

Homo sapiens

Functional Description
(View)

Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.

Protein Sequence
(Fasta)

MRFGSKMMPM FLTVYLSNNE QHFTEVPVTP ETICRDVVDL CKEPGESDCH LAEVWCGSER 60
PVADNERMFD VLQRFGSQRN EVRFFLRHER PPGRDIVSGP RSQDPSLKRN GVKVPGEYRR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTGGGGCCC GACCCGGGAT TAGTTGGTTT CGGAGCGGAG GAGGGAGCCC CGACCGTCAC 60
GAGCGTCGAA GAGACAAAGC CGCGTCAGGG GGCCCGGCCG GGGCGGGGGA GCCCGGGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-0053--Apoptosis
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0729--SH3-binding

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001452--SH3_domain
IPR013315--Spectrin_alpha_SH3
IPR029071--Ubiquitin-rel_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50002--SH3

Pfam

PF12796--Ank_2
PF00018--SH3_1

PRINTS

PR01887--SPECTRNALPHA

SMART

SM00248--ANK
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0042802--F:identical protein binding
GO:0051059--F:NF-kappaB binding
GO:0002039--F:p53 binding
GO:0005070--F:SH3/SH2 adaptor activity
GO:0007049--P:cell cycle
GO:0072332--P:intrinsic apoptotic signaling pathway by p53 class mediator
GO:0045786--P:negative regulation of cell cycle
GO:1900119--P:positive regulation of execution phase of apoptosis
GO:1901216--P:positive regulation of neuron death
GO:1900740--P:positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0042981--P:regulation of apoptotic process
GO:1901796--P:regulation of signal transduction by p53 class mediator
GO:0007165--P:signal transduction

KEGG

hsa:7159

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001474	Ailuropoda melanoleuca	87.91	0.00e+00	1801.00
IUUC-Apl-003477	Anas platyrhynchos	78.95	0.00e+00	1522.00
IUUC-Aca-005300	Anolis carolinensis	76.97	0.00e+00	1566.00
IUUC-Bta-013530	Bos taurus	91.65	0.00e+00	1830.00
IUUC-Cja-019881	Callithrix jacchus	97.82	0.00e+00	660.00
IUUC-Cfa-021199	Canis familiaris	88.44	0.00e+00	1802.00
IUUC-Cpo-021960	Cavia porcellus	81.01	0.00e+00	1608.00
IUUC-Csa-023763	Chlorocebus sabaeus	98.41	0.00e+00	2092.00
IUUC-Cho-025060	Choloepus hoffmanni	83.82	0.00e+00	982.00
IUUC-Csv-025927	Ciona savignyi	65.17	1.00e-87	318.00
IUUC-Dno-029432	Dasypus novemcinctus	86.45	0.00e+00	1691.00
IUUC-Dor-030603	Dipodomys ordii	90.08	0.00e+00	1177.00
IUUC-Ete-032395	Echinops telfairi	71.79	0.00e+00	809.00
IUUC-Eca-034204	Equus caballus	91.64	0.00e+00	1887.00
IUUC-Eeu-035021	Erinaceus europaeus	76.65	0.00e+00	636.00
IUUC-Fca-035718	Felis catus	80.28	0.00e+00	1598.00
IUUC-Fal-037272	Ficedula albicollis	76.73	0.00e+00	1470.00
IUUC-Gga-040793	Gallus gallus	78.79	0.00e+00	1397.00
IUUC-Ggo-045018	Gorilla gorilla	98.76	0.00e+00	2122.00
IUUC-Itr-048708	Ictidomys tridecemlineatus	93.06	0.00e+00	1948.00
IUUC-Lch-050430	Latimeria chalumnae	69.22	0.00e+00	1362.00
IUUC-Loc-052603	Lepisosteus oculatus	56.10	0.00e+00	645.00
IUUC-Laf-054080	Loxodonta africana	90.15	0.00e+00	1897.00
IUUC-Mcc-055676	Macaca mulatta	98.50	0.00e+00	2089.00
IUUC-Meu-056686	Macropus eugenii	79.11	0.00e+00	931.00
IUUC-Mga-059342	Meleagris gallopavo	79.91	0.00e+00	1614.00
IUUC-Mmr-061245	Microcebus murinus	93.23	0.00e+00	1919.00
IUUC-Mdo-063015	Monodelphis domestica	85.15	0.00e+00	1779.00
IUUC-Mmu-063141	Mus musculus	91.01	0.00e+00	1882.00
IUUC-Mpu-065986	Mustela putorius furo	86.67	0.00e+00	1686.00
IUUC-Mlu-067869	Myotis lucifugus	86.76	0.00e+00	1765.00
IUUC-Nle-069765	Nomascus leucogenys	99.03	0.00e+00	2051.00
IUUC-Opr-070648	Ochotona princeps	87.40	0.00e+00	1761.00
IUUC-Oan-073404	Ornithorhynchus anatinus	84.04	0.00e+00	1709.00
IUUC-Ocu-074540	Oryctolagus cuniculus	89.87	0.00e+00	1811.00
IUUC-Ola-086986	Oryzias latipes	48.05	3.00e-143	503.00
IUUC-Oga-088550	Otolemur garnettii	91.61	0.00e+00	1880.00
IUUC-Oar-090212	Ovis aries	89.87	0.00e+00	1788.00
IUUC-Ptr-091623	Pan troglodytes	98.94	0.00e+00	2041.00
IUUC-Psi-093092	Pelodiscus sinensis	79.22	0.00e+00	1611.00
IUUC-Pab-098154	Pongo abelii	99.21	0.00e+00	2050.00
IUUC-Pca-100620	Procavia capensis	94.85	3.00e-162	566.00
IUUC-Pva-103003	Pteropus vampyrus	86.62	0.00e+00	1266.00
IUUC-Rno-105035	Rattus norvegicus	89.16	0.00e+00	1833.00
IUUC-Sha-106806	Sarcophilus harrisii	84.49	0.00e+00	1723.00
IUUC-Sar-113225	Sorex araneus	85.80	0.00e+00	1796.00
IUUC-Ssc-115981	Sus scrofa	91.12	0.00e+00	1801.00
IUUC-Tgu-116747	Taeniopygia guttata	73.86	0.00e+00	1014.00
IUUC-Tru-118643	Takifugu rubripes	45.76	0.00e+00	744.00
IUUC-Tsy-119114	Tarsius syrichta	90.64	0.00e+00	1912.00
IUUC-Tni-120786	Tetraodon nigroviridis	80.36	6.00e-116	412.00
IUUC-Ttr-128278	Tursiops truncatus	89.25	0.00e+00	1805.00
IUUC-Vpa-130152	Vicugna pacos	89.63	0.00e+00	810.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence