iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000143569.18	ENST00000343815.10	ENSP00000345308.6
ENSG00000143569.18	ENST00000361546.6	ENSP00000355343.2
ENSG00000143569.18	ENST00000433615.5	ENSP00000407672.1
ENSG00000143569.18	ENST00000428595.1	ENSP00000398609.1
ENSG00000143569.18	ENST00000613315.4	ENSP00000478447.1
ENSG00000143569.18	ENST00000271877.11	ENSP00000271877.8

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	25185265; 26310274

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	7.20e-07	30.8	50	89

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlve.MGFdreealqaLraannnleaAveyLldg 41
           +e+k+ ql++ +G +++e++ aL ++n+++++A++ Ll+g
   Q: 50   FEEKVKQLIDiTGKNQDECVIALHDCNGDVNRAINVLLEG 89
           79***********************************986 PP

Organism

Homo sapiens

Functional Description
(View)

Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs).

Protein Sequence
(Fasta)

MMTSVGTNRA RGNWEQPQNQ NQTQHKQRPQ ATAEQIRLAQ MISDHNDADF EEKVKQLIDI 60
TGKNQDECVI ALHDCNGDVN RAINVLLEGN PDTHSWEMVG KKKGVSGQKD GGQTESNEEG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCGACTAAG TGACTTAAAC TCCCACCTAC TCCTGGAATA AGGAGTCAAA GCCCGGATAG 60
GCGCAGGTGA GTGGGTGGAG AATGCAGACG GGGTACAGCT CAAAAGGAGG GTCTCTACTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0488--Methylation
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome

Interpro

IPR022166--DUF3697_Uba2
IPR015940--UBA
IPR009060--UBA-like

PROSITE

PS50030--UBA

Pfam

PF12478--DUF3697

SMART

SM00165--UBA

Gene Ontology

GO:0005737--C:cytoplasm
GO:0031519--C:PcG protein complex
GO:0003723--F:RNA binding
GO:0007339--P:binding of sperm to zona pellucida
GO:0061484--P:hematopoietic stem cell homeostasis
GO:0010628--P:positive regulation of gene expression

KEGG

hsa:9898

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002224	Ailuropoda melanoleuca	95.93	0.00e+00	1279.00
IUUC-Apl-003891	Anas platyrhynchos	87.59	0.00e+00	773.00
IUUC-Aca-004775	Anolis carolinensis	71.21	2.00e-120	426.00
IUUC-Ani-009287	Aspergillus nidulans	40.54	3.20e-02	34.30
IUUC-Ang-009672	Aspergillus niger	43.24	1.80e-02	33.50
IUUC-Ame-011168	Astyanax mexicanus	56.63	8.00e-139	488.00
IUUC-Bta-012828	Bos taurus	98.66	0.00e+00	1145.00
IUUC-Cja-019745	Callithrix jacchus	96.34	0.00e+00	1296.00
IUUC-Cfa-021052	Canis familiaris	97.79	0.00e+00	1285.00
IUUC-Cpo-021884	Cavia porcellus	96.57	0.00e+00	1285.00
IUUC-Cho-024952	Choloepus hoffmanni	92.87	0.00e+00	796.00
IUUC-Cin-025284	Ciona intestinalis	41.05	2.00e-14	74.70
IUUC-Dre-027917	Danio rerio	57.93	3.00e-137	483.00
IUUC-Dno-028928	Dasypus novemcinctus	95.19	0.00e+00	809.00
IUUC-Dor-031085	Dipodomys ordii	100.00	7.00e-124	438.00
IUUC-Eca-033794	Equus caballus	96.39	0.00e+00	1303.00
IUUC-Eeu-035149	Erinaceus europaeus	89.90	0.00e+00	1117.00
IUUC-Fca-036151	Felis catus	96.79	0.00e+00	845.00
IUUC-Fal-037010	Ficedula albicollis	83.82	0.00e+00	763.00
IUUC-Gmo-038568	Gadus morhua	64.04	4.00e-97	350.00
IUUC-Gga-040927	Gallus gallus	85.46	0.00e+00	775.00
IUUC-Gac-042377	Gasterosteus aculeatus	67.11	1.00e-110	394.00
IUUC-Ggo-045228	Gorilla gorilla	99.71	0.00e+00	897.00
IUUC-Itr-048492	Ictidomys tridecemlineatus	97.00	0.00e+00	890.00
IUUC-Lch-050547	Latimeria chalumnae	78.88	0.00e+00	708.00
IUUC-Loc-051792	Lepisosteus oculatus	72.20	3.00e-131	463.00
IUUC-Laf-054557	Loxodonta africana	94.80	0.00e+00	868.00
IUUC-Mcc-055019	Macaca mulatta	99.85	0.00e+00	898.00
IUUC-Meu-056728	Macropus eugenii	98.95	7.00e-117	415.00
IUUC-Mga-059865	Meleagris gallopavo	78.30	0.00e+00	675.00
IUUC-Mmr-061272	Microcebus murinus	99.27	0.00e+00	901.00
IUUC-Mdo-062882	Monodelphis domestica	93.02	0.00e+00	837.00
IUUC-Mmu-064078	Mus musculus	94.53	0.00e+00	862.00
IUUC-Mpu-066636	Mustela putorius furo	95.87	0.00e+00	917.00
IUUC-Mlu-067554	Myotis lucifugus	97.98	0.00e+00	1305.00
IUUC-Nle-069820	Nomascus leucogenys	99.71	0.00e+00	897.00
IUUC-Opr-070427	Ochotona princeps	85.37	3.00e-173	603.00
IUUC-Ont-071731	Oreochromis niloticus	63.03	2.00e-123	437.00
IUUC-Ocu-073849	Oryctolagus cuniculus	93.43	0.00e+00	1251.00
IUUC-Ola-087073	Oryzias latipes	57.06	2.00e-139	489.00
IUUC-Oga-088352	Otolemur garnettii	93.64	0.00e+00	1135.00
IUUC-Oar-089189	Ovis aries	98.25	0.00e+00	929.00
IUUC-Ptr-090471	Pan troglodytes	99.85	0.00e+00	899.00
IUUC-Pan-091960	Papio anubis	89.58	0.00e+00	811.00
IUUC-Psi-093123	Pelodiscus sinensis	83.50	0.00e+00	758.00
IUUC-Pfo-096779	Poecilia formosa	64.53	1.00e-114	408.00
IUUC-Pab-097725	Pongo abelii	99.42	0.00e+00	897.00
IUUC-Pca-100364	Procavia capensis	89.46	4.00e-164	572.00
IUUC-Pva-103206	Pteropus vampyrus	97.21	0.00e+00	837.00
IUUC-Rno-104849	Rattus norvegicus	94.53	0.00e+00	879.00
IUUC-Sha-107007	Sarcophilus harrisii	92.09	0.00e+00	820.00
IUUC-Sar-113554	Sorex araneus	95.87	0.00e+00	1255.00
IUUC-Ssc-116394	Sus scrofa	98.11	0.00e+00	891.00
IUUC-Tgu-116920	Taeniopygia guttata	83.82	0.00e+00	771.00
IUUC-Tru-117891	Takifugu rubripes	56.31	3.00e-159	556.00
IUUC-Tsy-119473	Tarsius syrichta	95.55	0.00e+00	669.00
IUUC-Tni-120870	Tetraodon nigroviridis	48.30	2.00e-121	430.00
IUUC-Tbe-127249	Tupaia belangeri	86.12	1.00e-140	494.00
IUUC-Ttr-128196	Tursiops truncatus	89.31	0.00e+00	682.00
IUUC-Vpa-130530	Vicugna pacos	96.66	0.00e+00	857.00
IUUC-Xtr-132315	Xenopus tropicalis	70.46	0.00e+00	717.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence