iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000143669.13	ENST00000389793.6	ENSP00000374443.2
ENSG00000143669.13	ENST00000487530.2	ENSP00000417168.1
ENSG00000143669.13	ENST00000389794.7	ENSP00000374444.4

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	SomamiR	miRcode	RAID2
LncRNADisease
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
ClinVar	GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.00e-06	29.6	3614	3646

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sdtllvsGsdDgtikvWDlr 31
           gHt+++t+l f   +  +l+s s+Dgt+ +WDl 
   Q: 3614 GHTEEITSL-FvckPYSILISVSRDGTCIIWDLN 3646
           8********.99875578**************85 PP

Organism

Homo sapiens

Functional Description
(View)

Interacts with CENPJ, LIP8 and ZNF521.

Protein Sequence
(Fasta)

MSTDSNSLAR EFLTDVNRLC NAVVQRVEAR EEEEEETHMA TLGQYLVHGR GFLLLTKLNS 60
IIDQALTCRE ELLTLLLSLL PLVWKIPVQE EKATDFNLPL SADIILTKEK NSSSQRSTQE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCAAGGGCT TCTAAGAAGC CATCCCAATG ACCTTTTGGC TTTGAGAAGA GCAGTCCTCA 60
TACCAGAGTG TTTGGGGTTT TGGCCTCTTT CAGTGTTTAT TCATTCTTAC GTGGGAAAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR016024--ARM-type_fold
IPR000409--BEACH_dom
IPR030464--LYST
IPR023362--PH-BEACH_dom
IPR011993--PH_dom-like
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50197--BEACH
PS51783--PH_BEACH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF02138--Beach
PF14844--PH_BEACH
PF00400--WD40

SMART

SM01026--Beach
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0015630--C:microtubule cytoskeleton
GO:0042742--P:defense response to bacterium
GO:0042832--P:defense response to protozoan
GO:0051607--P:defense response to virus
GO:0032510--P:endosome to lysosome transport via multivesicular body sorting pathway
GO:0030595--P:leukocyte chemotaxis
GO:0007040--P:lysosome organization
GO:0033364--P:mast cell secretory granule organization
GO:0032438--P:melanosome organization
GO:0042267--P:natural killer cell mediated cytotoxicity
GO:0043473--P:pigmentation
GO:0015031--P:protein transport

KEGG

hsa:1130

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002188	Ailuropoda melanoleuca	90.62	0.00e+00	6982.00
IUUC-Apl-003779	Anas platyrhynchos	73.01	0.00e+00	5449.00
IUUC-Ame-010834	Astyanax mexicanus	61.57	0.00e+00	4505.00
IUUC-Bta-013274	Bos taurus	90.48	0.00e+00	6895.00
IUUC-Cja-019682	Callithrix jacchus	96.42	0.00e+00	7347.00
IUUC-Cfa-020625	Canis familiaris	90.32	0.00e+00	6822.00
IUUC-Cpo-022515	Cavia porcellus	86.20	0.00e+00	6500.00
IUUC-Csa-023804	Chlorocebus sabaeus	97.14	0.00e+00	7383.00
IUUC-Cin-025176	Ciona intestinalis	44.92	2.00e-85	309.00
IUUC-Csv-026108	Ciona savignyi	53.42	0.00e+00	711.00
IUUC-Dre-027544	Danio rerio	63.10	0.00e+00	3352.00
IUUC-Dno-029030	Dasypus novemcinctus	88.20	0.00e+00	6721.00
IUUC-Dor-031065	Dipodomys ordii	81.93	0.00e+00	2908.00
IUUC-Eca-034391	Equus caballus	90.64	0.00e+00	6918.00
IUUC-Fal-037194	Ficedula albicollis	71.95	0.00e+00	5399.00
IUUC-Gmo-039256	Gadus morhua	74.48	0.00e+00	2305.00
IUUC-Gga-040318	Gallus gallus	72.72	0.00e+00	5412.00
IUUC-Gac-042425	Gasterosteus aculeatus	64.51	0.00e+00	3500.00
IUUC-Ggo-045550	Gorilla gorilla	98.74	0.00e+00	7491.00
IUUC-Laf-054133	Loxodonta africana	89.52	0.00e+00	6744.00
IUUC-Mcc-055373	Macaca mulatta	97.45	0.00e+00	7443.00
IUUC-Mga-059475	Meleagris gallopavo	70.90	0.00e+00	5247.00
IUUC-Mmr-061795	Microcebus murinus	93.58	0.00e+00	7066.00
IUUC-Mlu-067930	Myotis lucifugus	85.29	0.00e+00	3768.00
IUUC-Nle-069205	Nomascus leucogenys	97.06	0.00e+00	7324.00
IUUC-Ont-071764	Oreochromis niloticus	61.88	0.00e+00	4388.00
IUUC-Ocu-074479	Oryctolagus cuniculus	90.26	0.00e+00	6865.00
IUUC-Ptr-091393	Pan troglodytes	99.08	0.00e+00	7536.00
IUUC-Pan-092369	Papio anubis	97.37	0.00e+00	7406.00
IUUC-Pfo-096100	Poecilia formosa	61.05	0.00e+00	4394.00
IUUC-Pab-098733	Pongo abelii	97.19	0.00e+00	7344.00
IUUC-Pca-100429	Procavia capensis	77.83	0.00e+00	2531.00
IUUC-Sha-106595	Sarcophilus harrisii	73.85	0.00e+00	5392.00
IUUC-Sar-113059	Sorex araneus	77.93	0.00e+00	1851.00
IUUC-Ssc-115879	Sus scrofa	84.19	0.00e+00	6187.00
IUUC-Tru-118616	Takifugu rubripes	60.43	0.00e+00	4362.00
IUUC-Tsy-119568	Tarsius syrichta	86.58	0.00e+00	5617.00
IUUC-Tni-120782	Tetraodon nigroviridis	60.22	0.00e+00	4347.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence