iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000144451.18	ENST00000331683.9	ENSP00000332592.5
ENSG00000144451.18	ENST00000406979.6	ENSP00000385496.2
ENSG00000144451.18	ENST00000432529.6	ENSP00000415079.2
ENSG00000144451.18	ENST00000413312.5	ENSP00000390494.1
ENSG00000144451.18	ENST00000420497.6	ENSP00000411077.1
ENSG00000144451.18	ENST00000440779.5	ENSP00000404949.1
ENSG00000144451.18	ENST00000452556.5	ENSP00000398926.1
ENSG00000144451.18	ENST00000447990.1	ENSP00000400847.1
ENSG00000144451.18	ENST00000451561.1	ENSP00000416600.1
ENSG00000144451.18	ENST00000272898.11	ENSP00000272898.8

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Variation
ClinVar	GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.10e-34	116.8	476	515
UBD/Beta-Prp	4.50e-90	303.5	393	630

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sdtllvsGsdDgtikvWDlrtgvllks 38
           gHtdsv++++f   s ++l+++s D+t+ +WD rtg +++s
   Q: 476  GHTDSVNSIEFfpfS-NTLLTSSADKTLSIWDARTGICEQS 515
           8*********99865.899*******************996 PP

UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlsl 100
           h++ +++ +f+p+++ lat+s d t+k+wd+ +g+++ +++gh+ +v+++++++ g++ +++s D+t k+wd+++  c  tl gh+dsv s+
   Q: 393  HTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSI 484
           67889999************************************************************************************ PP
   S: 101  sfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsng 192
           +f+p +++l++ s+d+t+ +wd +tg c +  l gh++++n + ++p g +++s+ + ++ +lWd +    +        ++ + ++fds+g
   Q: 485  EFFPFSNTLLTSSADKTLSIWDARTGICEQ-SLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDI-GPSPGNEVNFDSSG 574
           ****99************************.***********************************88888888865.899*********** PP
   S: 193  kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           + l+ +s +g + l dl++ge +++l gh++    v fs ++e+l sg+sDg++r W
   Q: 575  RVLAQASGNGVIHLLDLKSGE-IHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
           ********************9.*********************************** PP

Organism

Homo sapiens

Functional Description
(View)

Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia (By similarity).

Protein Sequence
(Fasta)

MAAQRGMPSS AVRVLEEALG MGLTAAGDAR DTADAVAAEG AYYLEQVTIT EASEDDYEYE 60
EIPDDNFSIP EGEEDLAKAI QMAQEQATDT EILERKTVLP SKHAVPEVIE DFLCNFLIKM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCGGAATCT CGCGAGAGCT CCCGGGGGCC GTTGGGTAGC GTCTTCGCTG TTGCCCTTAG 60
GGACGGCTGT GGGCCTGCTG GGGGTGGGGG CCCGAAGCGC CAGAGATGGC TGCTCAGCGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0966--Cell projection
KW-0969--Cilium
KW-0970--Cilium biogenesis/degradation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0282--Flagellum
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:1990716--C:axonemal central apparatus
GO:0005930--C:axoneme
GO:0005737--C:cytoplasm
GO:0031514--C:motile cilium
GO:0005634--C:nucleus
GO:0035082--P:axoneme assembly
GO:0097231--P:cell motility in response to calcium ion
GO:0060271--P:cilium assembly
GO:0060294--P:cilium movement involved in cell motility
GO:0051012--P:microtubule sliding
GO:0007288--P:sperm axoneme assembly

KEGG

hsa:79582

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003836	Anas platyrhynchos	69.51	2.00e-68	250.00
IUUC-Aca-004890	Anolis carolinensis	50.16	1.00e-174	606.00
IUUC-Ame-011811	Astyanax mexicanus	49.72	3.00e-154	538.00
IUUC-Cfa-020939	Canis familiaris	90.00	3.00e-79	286.00
IUUC-Cpo-022422	Cavia porcellus	80.73	4.00e-137	480.00
IUUC-Cre-022910	Chlamydomonas reinhardtii	44.65	3.00e-44	172.00
IUUC-Cho-024331	Choloepus hoffmanni	82.34	0.00e+00	926.00
IUUC-Cin-025207	Ciona intestinalis	47.93	4.00e-172	598.00
IUUC-Csv-026299	Ciona savignyi	43.49	6.00e-128	451.00
IUUC-Dre-028682	Danio rerio	48.03	5.00e-171	594.00
IUUC-Dor-030289	Dipodomys ordii	79.52	0.00e+00	634.00
IUUC-Ete-032579	Echinops telfairi	73.53	0.00e+00	943.00
IUUC-Eca-033907	Equus caballus	81.08	0.00e+00	926.00
IUUC-Eeu-034723	Erinaceus europaeus	70.14	0.00e+00	814.00
IUUC-Fca-036062	Felis catus	83.68	0.00e+00	899.00
IUUC-Fal-036929	Ficedula albicollis	56.70	1.00e-102	366.00
IUUC-Gmo-039703	Gadus morhua	40.92	3.00e-81	295.00
IUUC-Gga-040394	Gallus gallus	55.88	0.00e+00	652.00
IUUC-Gac-041652	Gasterosteus aculeatus	40.78	6.00e-115	407.00
IUUC-Lch-049436	Latimeria chalumnae	54.31	0.00e+00	694.00
IUUC-Loc-052062	Lepisosteus oculatus	58.44	1.00e-114	405.00
IUUC-Mcc-054825	Macaca mulatta	96.20	0.00e+00	1157.00
IUUC-Meu-056457	Macropus eugenii	51.69	6.00e-136	477.00
IUUC-Mmu-063303	Mus musculus	74.07	0.00e+00	945.00
IUUC-Mpu-066714	Mustela putorius furo	89.45	4.00e-118	416.00
IUUC-Nle-069920	Nomascus leucogenys	96.79	1.00e-128	451.00
IUUC-Opr-070273	Ochotona princeps	70.63	0.00e+00	901.00
IUUC-Ont-072313	Oreochromis niloticus	41.15	2.00e-121	429.00
IUUC-Ptr-091332	Pan troglodytes	99.05	0.00e+00	1201.00
IUUC-Psi-093988	Pelodiscus sinensis	62.27	2.00e-106	378.00
IUUC-Pma-094595	Petromyzon marinus	47.96	4.00e-171	594.00
IUUC-Ppa-095608	Physcomitrella patens	39.15	2.00e-107	382.00
IUUC-Pfo-097048	Poecilia formosa	43.19	4.00e-73	268.00
IUUC-Pab-097856	Pongo abelii	90.49	0.00e+00	1063.00
IUUC-Pca-100171	Procavia capensis	74.06	0.00e+00	697.00
IUUC-Pva-103088	Pteropus vampyrus	78.61	0.00e+00	926.00
IUUC-Rno-105955	Rattus norvegicus	78.02	6.00e-133	466.00
IUUC-Smo-108997	Selaginella moellendorffii	38.64	1.00e-104	373.00
IUUC-Sar-113008	Sorex araneus	66.49	0.00e+00	773.00
IUUC-Tgu-116809	Taeniopygia guttata	66.46	4.00e-65	240.00
IUUC-Tsy-119183	Tarsius syrichta	89.05	3.00e-147	515.00
IUUC-Tbe-127666	Tupaia belangeri	65.13	0.00e+00	761.00
IUUC-Ttr-128610	Tursiops truncatus	74.26	8.00e-146	510.00
IUUC-Vpa-130702	Vicugna pacos	80.85	0.00e+00	884.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence