iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000053153.14	ENSMUST00000065425.11	ENSMUSP00000069821.5
ENSMUSG00000053153.14	ENSMUST00000113940.3	ENSMUSP00000109573.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.10e-36	123.4	484	523
UBD/Beta-Prp	9.60e-97	324.9	401	638

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sdtllvsGsdDgtikvWDlrtgvllks 38
           gHtdsv++++f   s ++l+++s D+t+ vWD rtg++++s
   Q: 484  GHTDSVNSIEFfpfS-NILLTASADKTLSVWDARTGKCEQS 523
           8*********99854.9*********************996 PP

UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
           h++ ++  +f+p++s lat+s d+tik+wd+ +g +  +l+gh+ +v+++++++ g++ +++s D+t k+wd+++  c +tl gh+dsv
   Q: 401  HTDWLSGCCFHPSGSKLATSSGDSTIKLWDLNKGECTLTLEGHNHAVWSCTWHSCGDFVASASLDMTSKIWDVNSERCRYTLYGHTDSV 489
           67888999********************************************************************************* PP
   S: 98   lslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysl 186
            s++f+p ++ l+++s+d+t+ vwd +tg+c +  l gh+++vn +++ p g +++s+ + ++ +lWd +    +        +s + +
   Q: 490  NSIEFFPFSNILLTASADKTLSVWDARTGKCEQ-SLYGHMHSVNDATFTPRGHIIASCDARGVTKLWDFRKLIPIVSIDV-GPSSGNEV 576
           *******99************************.*********************************9976666666665.78999*** PP
   S: 187  sfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           +fd++g+ l+ +s +g + l dl++g+ +++l gh++ v sv fs  +e l+sg+sDg+ir+W
   Q: 577  NFDQSGRVLAQASANGIIHLLDLKSGQ-IHKLVGHESEVHSVVFSHLGENLYSGGSDGTIRLW 638
           **************************8.*********************************** PP

Organism

Mus musculus

Functional Description
(View)

Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia.

Protein Sequence
(Fasta)

MAAPSGVPPL RVLEELGIGL SPTGEVTEAV TSEGAYYLEQ VTITETSEDE CEYEEIPDDN 60
FSIPEGEEDL EKAIHIIGEQ ARDIHILEQQ TILPARNVMQ EAIEDFLCNF LIKMGMTRTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTCGGAGGG GCACCGAGGG GCGCAGTTGC AAGCATGGCT GCTCCGTCTG GGGTCCCGCC 60
GCTGCGGGTG CTGGAGGAGC TGGGCATTGG CTTGTCACCC ACCGGCGAGG TGACAGAGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0966--Cell projection
KW-0969--Cilium
KW-0970--Cilium biogenesis/degradation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0282--Flagellum
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:1990716--C:axonemal central apparatus
GO:0005930--C:axoneme
GO:0005737--C:cytoplasm
GO:0031514--C:motile cilium
GO:0005634--C:nucleus
GO:0019901--F:protein kinase binding
GO:0035082--P:axoneme assembly
GO:0097231--P:cell motility in response to calcium ion
GO:0060271--P:cilium assembly
GO:0060294--P:cilium movement involved in cell motility
GO:0051012--P:microtubule sliding
GO:0007288--P:sperm axoneme assembly

KEGG

mmu:66722

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003836	Anas platyrhynchos	72.84	5.00e-72	263.00
IUUC-Aca-004890	Anolis carolinensis	48.97	5.00e-170	590.00
IUUC-Ame-011811	Astyanax mexicanus	46.93	6.00e-146	511.00
IUUC-Cfa-020939	Canis familiaris	82.00	8.00e-74	268.00
IUUC-Cpo-022422	Cavia porcellus	73.58	4.00e-130	457.00
IUUC-Cre-022910	Chlamydomonas reinhardtii	50.98	1.00e-39	157.00
IUUC-Cho-024331	Choloepus hoffmanni	73.68	0.00e+00	853.00
IUUC-Cin-025207	Ciona intestinalis	46.18	9.00e-165	573.00
IUUC-Csv-026299	Ciona savignyi	41.77	5.00e-115	407.00
IUUC-Dre-028682	Danio rerio	45.31	3.00e-158	552.00
IUUC-Dor-030289	Dipodomys ordii	75.19	9.00e-179	620.00
IUUC-Ete-032579	Echinops telfairi	68.38	0.00e+00	882.00
IUUC-Eca-033907	Equus caballus	71.77	0.00e+00	836.00
IUUC-Eeu-034723	Erinaceus europaeus	64.42	0.00e+00	760.00
IUUC-Fca-036062	Felis catus	72.57	0.00e+00	809.00
IUUC-Fal-036929	Ficedula albicollis	55.28	4.00e-102	364.00
IUUC-Gmo-039703	Gadus morhua	38.85	1.00e-81	296.00
IUUC-Gga-040394	Gallus gallus	53.33	0.00e+00	632.00
IUUC-Gac-041652	Gasterosteus aculeatus	41.30	9.00e-118	417.00
IUUC-Hsa-046165	Homo sapiens	73.45	0.00e+00	920.00
IUUC-Lch-049436	Latimeria chalumnae	52.31	0.00e+00	669.00
IUUC-Loc-052062	Lepisosteus oculatus	57.37	3.00e-112	397.00
IUUC-Mcc-054825	Macaca mulatta	74.22	0.00e+00	936.00
IUUC-Meu-056457	Macropus eugenii	46.94	1.00e-126	446.00
IUUC-Mpu-066714	Mustela putorius furo	84.40	1.00e-114	405.00
IUUC-Nle-069920	Nomascus leucogenys	83.03	8.00e-112	395.00
IUUC-Opr-070273	Ochotona princeps	65.16	0.00e+00	828.00
IUUC-Ont-072313	Oreochromis niloticus	40.00	4.00e-121	428.00
IUUC-Ptr-091332	Pan troglodytes	73.45	0.00e+00	921.00
IUUC-Psi-093988	Pelodiscus sinensis	64.10	5.00e-112	397.00
IUUC-Pma-094595	Petromyzon marinus	47.96	6.00e-174	603.00
IUUC-Ppa-095608	Physcomitrella patens	37.68	2.00e-104	373.00
IUUC-Pfo-097048	Poecilia formosa	44.90	2.00e-78	285.00
IUUC-Pab-097856	Pongo abelii	67.70	0.00e+00	816.00
IUUC-Pca-100171	Procavia capensis	73.22	3.00e-118	419.00
IUUC-Pva-103088	Pteropus vampyrus	68.64	0.00e+00	839.00
IUUC-Rno-105955	Rattus norvegicus	88.69	3.00e-149	520.00
IUUC-Smo-108997	Selaginella moellendorffii	42.96	2.00e-73	270.00
IUUC-Sar-113008	Sorex araneus	59.93	0.00e+00	724.00
IUUC-Tgu-116809	Taeniopygia guttata	67.28	4.00e-66	243.00
IUUC-Tsy-119183	Tarsius syrichta	84.25	2.00e-141	495.00
IUUC-Tbe-127666	Tupaia belangeri	58.16	0.00e+00	696.00
IUUC-Ttr-128610	Tursiops truncatus	62.89	4.00e-121	428.00
IUUC-Vpa-130702	Vicugna pacos	70.95	0.00e+00	801.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence