iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000145743.15	ENST00000496714.1	ENSP00000418111.1
ENSG00000145743.15	ENST00000542267.5	ENSP00000437464.1
ENSG00000145743.15	ENST00000619412.4	ENSP00000481439.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	24035498

Organism

Homo sapiens

Functional Description
(View)

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Protein Sequence
(Fasta)

MGHLLSKEPR NRPSQKRPRC CSWCRRRRPL LRLPRRTPAK VPPQPAAPRS RDCFFRGPCM 60
LCFIVHSPGA PAPAGPEEEP PLSPPPRDGA YAAASSSQHL ARRYAALAAE DCAAAARRFL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAGTCGCGG GTGCGCGCGC CGGCGGCGGA TCCGCAGTTA AAATGGTCCG AGCGGGACCC 60
GGCCTTTCCC CGGCCGCTCC GCTGACTGAC TGAGCCGGCT GGCCGGGCCC GGACTGGTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR006553--Leu-rich_rpt_Cys-con_subtyp

PROSITE

PS50181--FBOX

Pfam

PF12937--F-box-like
PF13516--LRR_6

SMART

SM00256--FBOX
SM00367--LRR_CC

KEGG

hsa:64839

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002032	Ailuropoda melanoleuca	99.46	0.00e+00	729.00
IUUC-Apl-003766	Anas platyrhynchos	92.75	8.00e-176	609.00
IUUC-Aca-005107	Anolis carolinensis	89.96	7.00e-147	513.00
IUUC-Acl-008301	Aspergillus clavatus	28.80	6.00e-38	152.00
IUUC-Afl-008738	Aspergillus flavus	29.21	3.00e-35	143.00
IUUC-Ani-009369	Aspergillus nidulans	30.05	2.00e-38	154.00
IUUC-Ang-009719	Aspergillus niger	28.02	6.00e-36	145.00
IUUC-Aor-009957	Aspergillus oryzae	28.65	4.00e-35	142.00
IUUC-Ame-011514	Astyanax mexicanus	75.27	5.00e-82	298.00
IUUC-Bta-013098	Bos taurus	97.86	2.00e-78	283.00
IUUC-Cja-019467	Callithrix jacchus	95.60	0.00e+00	1023.00
IUUC-Cfa-020024	Canis familiaris	96.17	0.00e+00	741.00
IUUC-Cpo-021473	Cavia porcellus	97.92	3.00e-139	487.00
IUUC-Csa-023932	Chlorocebus sabaeus	96.48	0.00e+00	806.00
IUUC-Cho-024827	Choloepus hoffmanni	98.78	0.00e+00	630.00
IUUC-Dre-028302	Danio rerio	41.81	1.00e-62	233.00
IUUC-Dor-030648	Dipodomys ordii	85.37	2.00e-148	518.00
IUUC-Ete-032460	Echinops telfairi	85.21	3.00e-119	421.00
IUUC-Eca-034004	Equus caballus	99.67	1.00e-170	592.00
IUUC-Eeu-034554	Erinaceus europaeus	81.16	5.00e-130	457.00
IUUC-Fca-035592	Felis catus	99.67	1.00e-170	592.00
IUUC-Fal-036750	Ficedula albicollis	92.19	0.00e+00	732.00
IUUC-Gmo-038685	Gadus morhua	70.33	8.00e-74	269.00
IUUC-Gga-040203	Gallus gallus	90.86	0.00e+00	709.00
IUUC-Lch-049535	Latimeria chalumnae	80.08	4.00e-123	434.00
IUUC-Loc-052238	Lepisosteus oculatus	75.00	2.00e-82	298.00
IUUC-Mcc-054939	Macaca mulatta	97.16	0.00e+00	1051.00
IUUC-Meu-056168	Macropus eugenii	74.38	6.00e-83	300.00
IUUC-Mor-057058	Magnaporthe oryzae	25.33	2.00e-30	127.00
IUUC-Mpo-057320	Magnaporthe poae	27.89	6.00e-34	139.00
IUUC-Mmr-061483	Microcebus murinus	99.67	1.00e-170	592.00
IUUC-Mdo-062006	Monodelphis domestica	95.54	0.00e+00	755.00
IUUC-Mpu-065771	Mustela putorius furo	99.73	0.00e+00	729.00
IUUC-Mlu-067338	Myotis lucifugus	99.15	1.00e-138	485.00
IUUC-Nfi-068473	Neosartorya fischeri	28.37	1.00e-34	141.00
IUUC-Opr-070744	Ochotona princeps	88.12	1.00e-145	509.00
IUUC-Ola-086864	Oryzias latipes	70.93	6.00e-72	263.00
IUUC-Oga-088756	Otolemur garnettii	98.13	0.00e+00	833.00
IUUC-Oar-089491	Ovis aries	98.35	3.00e-167	580.00
IUUC-Ptr-091120	Pan troglodytes	99.43	0.00e+00	1051.00
IUUC-Pan-092746	Papio anubis	98.06	0.00e+00	810.00
IUUC-Psi-093402	Pelodiscus sinensis	93.99	2.00e-177	614.00
IUUC-Pma-094211	Petromyzon marinus	50.00	4.00e-43	167.00
IUUC-Pca-100179	Procavia capensis	88.62	5.00e-149	520.00
IUUC-Pva-102200	Pteropus vampyrus	85.23	2.00e-158	552.00
IUUC-Rno-105491	Rattus norvegicus	97.36	1.00e-166	578.00
IUUC-Sha-107408	Sarcophilus harrisii	95.38	5.00e-97	346.00
IUUC-Sar-113484	Sorex araneus	73.17	6.00e-127	447.00
IUUC-Ssc-116229	Sus scrofa	91.88	2.00e-174	605.00
IUUC-Tgu-116754	Taeniopygia guttata	90.48	9.00e-162	562.00
IUUC-Tsy-119390	Tarsius syrichta	99.09	0.00e+00	633.00
IUUC-Tni-120505	Tetraodon nigroviridis	71.68	1.00e-73	268.00
IUUC-Ttr-129011	Tursiops truncatus	82.46	3.00e-157	547.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence