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Tag Content
iUUCD ID IUUC-Ncr-068750
Ensembl Protein ID EAA28720
UniProt Accession Q7S083; ATG12_NEUCR
Genbank Protein ID EAA28720.3
Protein Name Ubiquitin-like protein atg12; Autophagy-related protein 12
Genbank Nucleotide ID CM002241
Gene Name atg12; NCU10049
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
NCU10049 EAA28720 EAA28720
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UBL/ATG12 29.46 2.00e-10 62.40 IUUC-Hsa-046903
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Neurospora crassa
Functional Description
(View)

Functional Description


     Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with apg-4/atg5 through a ubiquitin-like conjugating system involving also apg-5/atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-apg-4/atg5 conjugate functions as an E3-like enzyme which is required for lipidation of apg-6/atg8 and apg-6/atg8 association to the vesicle membranes (By similarity).
 Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with apg-4/atg5 through a ubiquitin-like conjugating system involving also apg-5/atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-apg-4/atg5 conjugate functions as an E3-like enzyme which is required for lipidation of apg-6/atg8 and apg-6/atg8 association to the vesicle membranes (By similarity).
Protein Sequence
(Fasta)
MASSQPLHGT ASPSLVHDDN NPNSSTASPV LEGRDSPNLP LTMTASTVLM TLPRDATAAL 60
AEAGTFDQEK VVIRFKPVGS APALRREQVK VLSTHSFETV VAYLRKTLKV QETDSVFLYV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Ncr-068750|ULD,ATG12|Neurospora crassa
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Nucleotide Sequence
(Fasta)
GTCGTCAACA TCATCAGCCT CACTCGATAG CCGACCGGTG CGGCCTACAA GCAGAGTCAC 60
CTGAATATAG CCGTTGGATC TCAGGCTGCT CAAGAAAGCT ACCAAAGGAA CACCACGATC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ncr-068750|ULD,ATG12|Neurospora crassa
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway
Interpro

IPR007242--Atg12
IPR029071--Ubiquitin-rel_dom
Pfam

PF04110--APG12
Gene Ontology

GO:0034274--C:Atg12-Atg5-Atg16 complex
GO:0034045--C:pre-autophagosomal structure membrane
GO:0019776--F:Atg8 ligase activity
GO:0000045--P:autophagosome assembly
GO:0006501--P:C-terminal protein lipidation
GO:0000422--P:mitophagy
GO:0044804--P:nucleophagy
GO:0015031--P:protein transport
KEGG ncr:NCU10049
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001177 Aegilops tauschii 32.22 8.00e-12 59.70
IUUC-Aml-002116 Ailuropoda melanoleuca 30.00 9.00e-12 60.80
IUUC-Atr-002615 Amborella trichopoda 33.71 9.00e-11 56.20
IUUC-Apl-003753 Anas platyrhynchos 43.90 2.00e-05 38.10
IUUC-Aca-005231 Anolis carolinensis 30.00 4.00e-08 48.50
IUUC-Aly-006172 Arabidopsis lyrata 35.96 1.00e-11 59.30
IUUC-Ath-006953 Arabidopsis thaliana 34.83 1.00e-11 58.90
IUUC-Ago-007970 Ashbya gossypii 37.50 3.00e-09 53.10
IUUC-Acl-008072 Aspergillus clavatus 60.00 2.00e-35 139.00
IUUC-Afl-008725 Aspergillus flavus 55.80 4.00e-40 155.00
IUUC-Afu-008967 Aspergillus fumigatus 55.73 9.00e-39 150.00
IUUC-Ani-009248 Aspergillus nidulans 52.90 6.00e-39 151.00
IUUC-Ang-009684 Aspergillus niger 50.34 2.00e-35 139.00
IUUC-Aor-009947 Aspergillus oryzae 55.80 4.00e-40 155.00
IUUC-Ame-011656 Astyanax mexicanus 27.47 8.00e-10 53.90
IUUC-Bgr-012174 Blumeria graminis 56.56 5.00e-33 131.00
IUUC-Bta-012483 Bos taurus 31.11 4.00e-12 61.60
IUUC-Bci-013755 Botrytis cinerea 60.66 6.00e-38 147.00
IUUC-Bdi-014156 Brachypodium distachyon 33.00 2.00e-11 58.20
IUUC-Bol-015683 Brassica oleracea 35.96 2.00e-12 61.60
IUUC-Bra-016802 Brassica rapa 33.71 1.00e-10 55.80
IUUC-Cel-018242 Caenorhabditis elegans 32.61 1.00e-12 63.20
IUUC-Cja-019514 Callithrix jacchus 31.11 1.00e-11 60.80
IUUC-Cfa-020748 Canis familiaris 30.00 1.00e-11 60.80
IUUC-Cpo-021965 Cavia porcellus 30.00 1.00e-11 61.20
IUUC-Cre-023009 Chlamydomonas reinhardtii 40.66 1.00e-14 68.60
IUUC-Csa-023494 Chlorocebus sabaeus 31.11 3.00e-12 62.00
IUUC-Cho-024631 Choloepus hoffmanni 31.11 8.00e-12 61.60
IUUC-Cin-025609 Ciona intestinalis 42.05 9.00e-18 79.70
IUUC-Cgl-026722 Colletotrichum gloeosporioides 53.57 8.00e-41 157.00
IUUC-Dre-027479 Danio rerio 27.47 1.00e-10 56.20
IUUC-Dno-029693 Dasypus novemcinctus 27.78 2.00e-05 39.70
IUUC-Dse-031440 Dothistroma septosporum 50.00 1.00e-31 126.00
IUUC-Dme-031892 Drosophila melanogaster 27.47 2.00e-10 55.50
IUUC-Ete-032550 Echinops telfairi 31.76 4.00e-11 58.20
IUUC-Eca-033553 Equus caballus 31.11 3.00e-12 62.00
IUUC-Fca-036524 Felis catus 30.00 4.00e-10 55.50
IUUC-Fal-036942 Ficedula albicollis 34.48 2.00e-12 61.20
IUUC-Fox-037753 Fusarium oxysporum 61.43 4.00e-46 175.00
IUUC-Gmo-039498 Gadus morhua 26.67 2.00e-09 52.00
IUUC-Ggr-039852 Gaeumannomyces graminis 67.77 6.00e-37 144.00
IUUC-Gga-041263 Gallus gallus 28.47 1.00e-12 63.90
IUUC-Gac-042346 Gasterosteus aculeatus 29.41 3.00e-09 51.60
IUUC-Gma-042896 Glycine max 33.71 1.00e-10 56.20
IUUC-Ggo-045601 Gorilla gorilla 31.11 8.00e-12 61.60
IUUC-Hsa-046903 Homo sapiens 31.11 4.00e-12 62.00
IUUC-Hvu-047239 Hordeum vulgare 33.68 2.00e-12 62.00
IUUC-Itr-048445 Ictidomys tridecemlineatus 31.11 5.00e-12 62.00
IUUC-Kpa-049355 Komagataella pastoris 30.71 3.00e-09 52.40
IUUC-Lch-050619 Latimeria chalumnae 31.11 5.00e-12 61.60
IUUC-Loc-052102 Lepisosteus oculatus 41.67 8.00e-05 36.20
IUUC-Lma-053299 Leptosphaeria maculans 52.53 4.00e-25 104.00
IUUC-Laf-054205 Loxodonta africana 30.17 2.00e-12 62.80
IUUC-Meu-056804 Macropus eugenii 30.00 8.00e-12 60.80
IUUC-Mor-057052 Magnaporthe oryzae 70.09 5.00e-43 164.00
IUUC-Mtr-057961 Medicago truncatula 34.83 3.00e-11 58.20
IUUC-Mla-059045 Melampsora laricipopulina 44.66 5.00e-22 94.00
IUUC-Mvi-060360 Microbotryum violaceum 43.96 8.00e-20 87.00
IUUC-Mmr-061654 Microcebus murinus 31.11 3.00e-12 62.00
IUUC-Mdo-062649 Monodelphis domestica 31.11 3.00e-12 62.40
IUUC-Mmu-064105 Mus musculus 31.11 4.00e-12 61.60
IUUC-Mac-065532 Musa acuminata 32.22 4.00e-11 57.40
IUUC-Mpu-066269 Mustela putorius furo 30.00 5.00e-12 61.60
IUUC-Mlu-067631 Myotis lucifugus 31.11 4.00e-12 62.40
IUUC-Nfi-068468 Neosartorya fischeri 60.00 8.00e-36 140.00
IUUC-Nle-069483 Nomascus leucogenys 31.11 3.00e-12 62.80
IUUC-Opr-070936 Ochotona princeps 31.11 4.00e-12 62.80
IUUC-Obr-076322 Oryza brachyantha 35.16 2.00e-13 64.70
IUUC-Ogl-077226 Oryza glaberrima 33.33 2.00e-10 55.50
IUUC-Oin-079220 Oryza indica 32.35 5.00e-06 40.80
IUUC-Olo-080688 Oryza longistaminata 33.33 2.00e-10 55.50
IUUC-Ome-081265 Oryza meridionalis 33.33 2.00e-10 55.50
IUUC-Oru-084342 Oryza rufipogon 35.16 1.00e-12 64.70
IUUC-Osa-086212 Oryza sativa 33.33 2.00e-10 55.50
IUUC-Ola-087277 Oryzias latipes 28.57 1.00e-10 56.20
IUUC-Olu-087780 Ostreococcus lucimarinus 38.04 3.00e-12 61.20
IUUC-Oga-088175 Otolemur garnettii 31.11 4.00e-12 61.60
IUUC-Oar-089477 Ovis aries 31.11 9.00e-12 60.80
IUUC-Ptr-091129 Pan troglodytes 31.11 8.00e-12 61.60
IUUC-Psi-093351 Pelodiscus sinensis 30.00 2.00e-11 60.10
IUUC-Pno-094948 Phaeosphaeria nodorum 53.33 1.00e-26 110.00
IUUC-Ppa-095788 Physcomitrella patens 32.97 2.00e-11 58.50
IUUC-Pfo-096993 Poecilia formosa 26.37 3.00e-09 51.60
IUUC-Pab-098502 Pongo abelii 31.11 8.00e-12 61.60
IUUC-Pop-098819 Populus trichocarpa 34.09 3.00e-11 57.80
IUUC-Ppe-101560 Prunus persica 34.88 3.00e-11 57.40
IUUC-Pva-102810 Pteropus vampyrus 31.88 3.00e-09 52.40
IUUC-Pgr-103531 Puccinia graminis 47.57 3.00e-23 98.60
IUUC-Ptt-103753 Puccinia triticina 47.57 7.00e-23 97.10
IUUC-Pyt-104733 Pyrenophora triticirepentis 46.58 6.00e-32 127.00
IUUC-Rno-106072 Rattus norvegicus 31.11 4.00e-12 62.00
IUUC-Sce-106275 Saccharomyces cerevisiae 35.96 2.00e-13 67.00
IUUC-Sha-107554 Sarcophilus harrisii 30.00 4.00e-12 62.00
IUUC-Sja-107682 Schizosaccharomyces japonicus 33.33 2.00e-18 82.80
IUUC-Spo-108275 Schizosaccharomyces pombe 37.36 4.00e-14 68.20
IUUC-Smo-109151 Selaginella moellendorffii 33.33 6.00e-10 53.10
IUUC-Sit-110270 Setaria italica 32.58 4.00e-11 57.40
IUUC-Sly-111862 Solanum lycopersicum 32.97 3.00e-11 57.80
IUUC-Sbi-114148 Sorghum bicolor 32.58 4.00e-11 57.40
IUUC-Sre-115216 Sporisorium reilianum 42.42 6.00e-21 90.90
IUUC-Ssc-116051 Sus scrofa 31.11 3.00e-12 62.00
IUUC-Tru-118466 Takifugu rubripes 28.74 8.00e-09 49.70
IUUC-Tni-119792 Tetraodon nigroviridis 28.74 3.00e-09 50.80
IUUC-Tca-121861 Theobroma cacao 33.33 4.00e-11 58.20
IUUC-Tvi-122499 Trichoderma virens 61.11 3.00e-41 158.00
IUUC-Tae-123431 Triticum aestivum 32.22 8.00e-12 59.70
IUUC-Tme-126934 Tuber melanosporum 48.08 2.00e-23 100.00
IUUC-Ttr-129001 Tursiops truncatus 28.89 4.00e-07 45.80
IUUC-Uma-129324 Ustilago maydis 41.41 1.00e-20 90.10
IUUC-Vda-129846 Verticillium dahliae 63.11 4.00e-43 164.00
IUUC-Vpa-130202 Vicugna pacos 41.46 5.00e-05 38.90
IUUC-Vvi-131474 Vitis vinifera 38.03 2.00e-10 55.80
IUUC-Xtr-132782 Xenopus tropicalis 30.00 5.00e-12 61.60
IUUC-Xma-134140 Xiphophorus maculatus 26.37 8.00e-09 50.80
IUUC-Yli-134517 Yarrowia lipolytica 39.09 3.00e-15 73.20
IUUC-Zma-134764 Zea mays 32.58 3.00e-11 57.40
Created Date 25-Jun-2017

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