iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pno-094948

Ensembl Protein ID

SNOT_06553

UniProt Accession

Q0UNW1; ATG12_PHANO

Genbank Protein ID

EAT86384.2

Protein Name

Ubiquitin-like protein ATG12; Autophagy-related protein 12

Genbank Nucleotide ID

CH445333

Gene Name

ATG12; SNOG_06553

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SNOG_06553	SNOT_06553	SNOT_06553

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UBL/ATG12	28.12	1.00e-03	39.70	IUUC-Hsa-046903

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Phaeosphaeria nodorum

Functional Description
(View)

Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate functions as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity).

Protein Sequence
(Fasta)

MSAQEERIPE DDDTTEAPLT MAASVVLTNL PRDASKALET AGSLNVQKIR LHPIGSAPAL 60
TQRVFKLSTN QRFDTIVRFL RKRLGVKEHE SVFCYVGSVF APGLDEGVGG LWSVSCDFYF 120

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Nucleotide Sequence
(Fasta)

ATGTCAGCCC AAGAAGAACG AATACCAGAA GACGACGACA CGACCGAAGC GCCACTCACC 60
ATGGCCGCAT CCGTCGTCCT GACAAATCTC CCGCGCGACG CATCCAAAGC CCTCGAAACA 120

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Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway

Interpro

IPR007242--Atg12
IPR029071--Ubiquitin-rel_dom

Pfam

PF04110--APG12

Gene Ontology

GO:0034274--C:Atg12-Atg5-Atg16 complex
GO:0034045--C:pre-autophagosomal structure membrane
GO:0019776--F:Atg8 ligase activity
GO:0000045--P:autophagosome assembly
GO:0006501--P:C-terminal protein lipidation
GO:0000422--P:mitophagy
GO:0044804--P:nucleophagy
GO:0015031--P:protein transport

KEGG

pno:SNOG_06553

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001177	Aegilops tauschii	33.73	3.00e-08	47.80
IUUC-Aml-002116	Ailuropoda melanoleuca	26.56	7.00e-05	38.10
IUUC-Atr-002615	Amborella trichopoda	37.50	3.00e-08	47.80
IUUC-Aca-005231	Anolis carolinensis	26.56	1.40e-01	26.90
IUUC-Aly-006172	Arabidopsis lyrata	35.44	3.00e-09	51.20
IUUC-Ath-006953	Arabidopsis thaliana	38.46	6.00e-10	53.50
IUUC-Ago-007970	Ashbya gossypii	32.81	3.00e-05	39.70
IUUC-Acl-008072	Aspergillus clavatus	60.64	2.00e-30	122.00
IUUC-Afl-008725	Aspergillus flavus	59.81	1.00e-34	137.00
IUUC-Afu-008967	Aspergillus fumigatus	57.94	1.00e-33	134.00
IUUC-Ani-009248	Aspergillus nidulans	56.64	8.00e-34	134.00
IUUC-Ang-009684	Aspergillus niger	55.56	7.00e-33	131.00
IUUC-Aor-009947	Aspergillus oryzae	59.81	1.00e-34	137.00
IUUC-Ame-011656	Astyanax mexicanus	25.40	2.00e-04	35.80
IUUC-Bgr-012174	Blumeria graminis	40.43	6.00e-14	67.80
IUUC-Bta-012483	Bos taurus	28.12	2.00e-05	39.30
IUUC-Bci-013755	Botrytis cinerea	53.00	9.00e-22	93.60
IUUC-Bdi-014156	Brachypodium distachyon	34.38	3.00e-09	51.20
IUUC-Bol-015683	Brassica oleracea	36.84	3.00e-09	51.20
IUUC-Bra-016802	Brassica rapa	38.57	3.00e-08	47.80
IUUC-Cel-018242	Caenorhabditis elegans	34.72	2.00e-05	39.30
IUUC-Cja-019514	Callithrix jacchus	28.57	7.00e-05	38.50
IUUC-Cfa-020748	Canis familiaris	26.56	1.00e-04	37.70
IUUC-Cpo-021965	Cavia porcellus	26.56	7.00e-05	38.10
IUUC-Cre-023009	Chlamydomonas reinhardtii	40.35	3.00e-06	40.80
IUUC-Csa-023494	Chlorocebus sabaeus	28.12	2.00e-05	39.30
IUUC-Cho-024631	Choloepus hoffmanni	28.12	7.00e-05	38.50
IUUC-Cin-025609	Ciona intestinalis	34.38	4.00e-09	51.20
IUUC-Cgl-026722	Colletotrichum gloeosporioides	47.17	2.00e-25	105.00
IUUC-Dre-027479	Danio rerio	25.00	6.00e-05	37.70
IUUC-Dse-031440	Dothistroma septosporum	60.95	2.00e-34	135.00
IUUC-Dme-031892	Drosophila melanogaster	27.91	2.00e-06	42.70
IUUC-Ete-032550	Echinops telfairi	28.12	4.00e-05	38.10
IUUC-Eca-033553	Equus caballus	28.12	2.00e-05	39.70
IUUC-Fca-036524	Felis catus	26.56	4.00e-03	32.30
IUUC-Fal-036942	Ficedula albicollis	28.12	2.00e-05	38.90
IUUC-Fox-037753	Fusarium oxysporum	59.38	1.00e-27	114.00
IUUC-Gmo-039498	Gadus morhua	25.00	9.00e-05	37.00
IUUC-Ggr-039852	Gaeumannomyces graminis	55.56	6.00e-20	88.60
IUUC-Gga-041263	Gallus gallus	26.36	1.00e-04	37.40
IUUC-Gac-042346	Gasterosteus aculeatus	26.98	7.00e-05	37.40
IUUC-Gma-042896	Glycine max	36.62	3.00e-08	47.80
IUUC-Ggo-045601	Gorilla gorilla	28.12	5.00e-05	38.90
IUUC-Hsa-046903	Homo sapiens	28.12	2.00e-05	39.30
IUUC-Hvu-047239	Hordeum vulgare	35.96	4.00e-09	50.80
IUUC-Itr-048445	Ictidomys tridecemlineatus	28.12	4.00e-05	38.90
IUUC-Kpa-049355	Komagataella pastoris	34.71	5.00e-11	58.20
IUUC-Lch-050619	Latimeria chalumnae	31.25	5.00e-07	45.10
IUUC-Loc-052102	Lepisosteus oculatus	38.64	7.00e-05	36.60
IUUC-Lma-053299	Leptosphaeria maculans	74.77	9.00e-44	166.00
IUUC-Laf-054205	Loxodonta africana	28.12	2.00e-05	39.70
IUUC-Meu-056804	Macropus eugenii	26.56	3.00e-05	38.90
IUUC-Mor-057052	Magnaporthe oryzae	51.58	7.00e-21	91.30
IUUC-Mtr-057961	Medicago truncatula	36.36	4.00e-09	50.80
IUUC-Mla-059045	Melampsora laricipopulina	34.31	3.00e-14	68.20
IUUC-Mvi-060360	Microbotryum violaceum	41.27	8.00e-13	63.90
IUUC-Mmr-061654	Microcebus murinus	26.32	5.00e-06	41.20
IUUC-Mdo-062649	Monodelphis domestica	26.47	3.00e-06	42.40
IUUC-Mmu-064105	Mus musculus	28.12	3.00e-05	39.30
IUUC-Mac-065532	Musa acuminata	35.38	1.00e-08	49.30
IUUC-Mpu-066269	Mustela putorius furo	26.56	3.00e-05	39.30
IUUC-Mlu-067631	Myotis lucifugus	28.12	6.00e-05	38.10
IUUC-Nfi-068468	Neosartorya fischeri	60.64	2.00e-30	122.00
IUUC-Ncr-068750	Neurospora crassa	53.33	1.00e-26	110.00
IUUC-Nle-069483	Nomascus leucogenys	28.12	5.00e-05	38.90
IUUC-Opr-070936	Ochotona princeps	26.83	5.00e-05	38.90
IUUC-Obr-076322	Oryza brachyantha	35.38	9.00e-09	49.30
IUUC-Ogl-077226	Oryza glaberrima	38.98	2.00e-08	48.50
IUUC-Oin-079220	Oryza indica	33.33	3.00e-04	35.00
IUUC-Olo-080688	Oryza longistaminata	38.98	2.00e-08	48.50
IUUC-Ome-081265	Oryza meridionalis	38.98	2.00e-08	48.50
IUUC-Oru-084342	Oryza rufipogon	35.38	1.00e-07	48.10
IUUC-Osa-086212	Oryza sativa	38.98	2.00e-08	48.50
IUUC-Ola-087277	Oryzias latipes	24.71	5.00e-05	37.70
IUUC-Olu-087780	Ostreococcus lucimarinus	35.38	5.00e-06	40.40
IUUC-Oga-088175	Otolemur garnettii	28.12	2.00e-05	39.30
IUUC-Oar-089477	Ovis aries	28.12	6.00e-05	38.50
IUUC-Ptr-091129	Pan troglodytes	28.12	6.00e-05	38.50
IUUC-Psi-093351	Pelodiscus sinensis	27.63	3.00e-05	38.90
IUUC-Ppa-095788	Physcomitrella patens	36.84	9.00e-08	46.60
IUUC-Pfo-096993	Poecilia formosa	25.00	1.00e-04	37.00
IUUC-Pab-098502	Pongo abelii	28.12	6.00e-05	38.50
IUUC-Pop-098819	Populus trichocarpa	32.89	3.00e-08	47.80
IUUC-Ppe-101560	Prunus persica	35.38	1.00e-07	45.80
IUUC-Pva-102810	Pteropus vampyrus	28.12	4.00e-05	38.90
IUUC-Pgr-103531	Puccinia graminis	36.27	1.00e-14	69.70
IUUC-Ptt-103753	Puccinia triticina	35.71	8.00e-13	63.50
IUUC-Pyt-104733	Pyrenophora triticirepentis	76.86	7.00e-48	180.00
IUUC-Rno-106072	Rattus norvegicus	26.80	2.00e-06	42.70
IUUC-Sce-106275	Saccharomyces cerevisiae	38.57	9.00e-11	58.20
IUUC-Sha-107554	Sarcophilus harrisii	26.56	3.00e-05	39.30
IUUC-Sja-107682	Schizosaccharomyces japonicus	33.04	3.00e-18	82.00
IUUC-Spo-108275	Schizosaccharomyces pombe	43.08	2.00e-12	62.80
IUUC-Smo-109151	Selaginella moellendorffii	31.82	2.00e-08	48.10
IUUC-Sit-110270	Setaria italica	36.23	2.00e-08	48.50
IUUC-Sly-111862	Solanum lycopersicum	36.92	3.00e-08	47.80
IUUC-Sbi-114148	Sorghum bicolor	36.23	2.00e-08	48.50
IUUC-Sre-115216	Sporisorium reilianum	33.33	2.00e-10	56.20
IUUC-Ssc-116051	Sus scrofa	28.12	2.00e-05	39.70
IUUC-Tru-118466	Takifugu rubripes	27.87	5.00e-05	37.00
IUUC-Tni-119792	Tetraodon nigroviridis	27.87	1.00e-05	38.90
IUUC-Tca-121861	Theobroma cacao	31.87	6.00e-09	50.80
IUUC-Tvi-122499	Trichoderma virens	48.51	1.00e-22	96.70
IUUC-Tae-123431	Triticum aestivum	33.73	3.00e-08	47.80
IUUC-Tme-126934	Tuber melanosporum	51.19	1.00e-19	87.00
IUUC-Uma-129324	Ustilago maydis	33.33	9.00e-11	57.40
IUUC-Vda-129846	Verticillium dahliae	53.06	3.00e-25	105.00
IUUC-Vpa-130202	Vicugna pacos	50.00	4.70e-01	25.80
IUUC-Vvi-131474	Vitis vinifera	31.11	4.00e-08	48.50
IUUC-Xtr-132782	Xenopus tropicalis	26.56	2.00e-05	39.70
IUUC-Xma-134140	Xiphophorus maculatus	25.00	2.00e-04	36.20
IUUC-Yli-134517	Yarrowia lipolytica	47.83	6.00e-15	72.00
IUUC-Zma-134764	Zea mays	36.23	2.00e-08	48.50

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence