iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Yli-134517

Ensembl Protein ID

CAG78834

UniProt Accession

Q6BZZ1; ATG12_YARLI

Genbank Protein ID

CAG78834.1

Protein Name

Ubiquitin-like protein ATG12; Autophagy-related protein 12

Genbank Nucleotide ID

CR382132

Gene Name

ATG12; YALI0F29689g

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YALI0_F29689g	CAG78834	CAG78834

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UBL/ATG12	36.25	5.00e-09	58.50	IUUC-Hsa-046903

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Yarrowia lipolytica

Functional Description
(View)

Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate functions as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity).

Protein Sequence
(Fasta)

MIESDSDTSD DAPQEYVSAS ANIPAQFELA TAHMKATPEP QPTQQPDAEA LHDDDPLTTT 60
QDHPTGPSAT ASDTIDSTPQ PMAPATLSAS AVLPSLPSDT AALLETFSQQ LQQSNVKCQL 120

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Nucleotide Sequence
(Fasta)

ATGATCGAAA GTGACTCAGA CACCAGCGAC GACGCTCCCC AGGAGTACGT CTCGGCGTCT 60
GCTAACATTC CTGCGCAATT TGAACTCGCC ACAGCACATA TGAAGGCTAC TCCAGAGCCC 120

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Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway

Interpro

IPR007242--Atg12
IPR029071--Ubiquitin-rel_dom

Pfam

PF04110--APG12

Gene Ontology

GO:0034274--C:Atg12-Atg5-Atg16 complex
GO:0034045--C:pre-autophagosomal structure membrane
GO:0019776--F:Atg8 ligase activity
GO:0000045--P:autophagosome assembly
GO:0006501--P:C-terminal protein lipidation
GO:0000422--P:mitophagy
GO:0044804--P:nucleophagy
GO:0015031--P:protein transport

KEGG

yli:YALI0F29689g

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001177	Aegilops tauschii	41.25	3.00e-13	64.30
IUUC-Aml-002116	Ailuropoda melanoleuca	36.25	5.00e-11	58.20
IUUC-Atr-002615	Amborella trichopoda	37.50	4.00e-12	60.50
IUUC-Apl-003753	Anas platyrhynchos	45.00	2.00e-05	37.70
IUUC-Aca-005231	Anolis carolinensis	45.45	4.00e-07	45.10
IUUC-Aly-006172	Arabidopsis lyrata	41.11	3.00e-14	67.40
IUUC-Ath-006953	Arabidopsis thaliana	38.89	6.00e-14	66.60
IUUC-Ago-007970	Ashbya gossypii	37.78	6.00e-09	51.60
IUUC-Acl-008072	Aspergillus clavatus	43.33	1.00e-20	89.40
IUUC-Afl-008725	Aspergillus flavus	43.90	2.00e-22	96.70
IUUC-Afu-008967	Aspergillus fumigatus	43.90	5.00e-22	94.70
IUUC-Ani-009248	Aspergillus nidulans	39.84	2.00e-19	86.30
IUUC-Ang-009684	Aspergillus niger	42.86	5.00e-21	91.70
IUUC-Aor-009947	Aspergillus oryzae	43.90	2.00e-22	96.70
IUUC-Ame-011656	Astyanax mexicanus	31.25	5.00e-08	47.80
IUUC-Bgr-012174	Blumeria graminis	41.76	2.00e-13	65.90
IUUC-Bta-012483	Bos taurus	36.25	8.00e-11	57.00
IUUC-Bci-013755	Botrytis cinerea	34.13	2.00e-14	68.90
IUUC-Bdi-014156	Brachypodium distachyon	42.50	7.00e-14	66.20
IUUC-Bol-015683	Brassica oleracea	40.00	2.00e-14	68.20
IUUC-Bra-016802	Brassica rapa	40.00	1.00e-13	65.10
IUUC-Cja-019514	Callithrix jacchus	36.25	1.00e-10	57.40
IUUC-Cfa-020748	Canis familiaris	36.25	6.00e-11	58.20
IUUC-Cpo-021965	Cavia porcellus	36.25	9.00e-11	57.80
IUUC-Cre-023009	Chlamydomonas reinhardtii	40.00	2.00e-11	57.80
IUUC-Csa-023494	Chlorocebus sabaeus	36.25	8.00e-11	57.40
IUUC-Cho-024631	Choloepus hoffmanni	36.25	1.00e-10	57.00
IUUC-Cin-025609	Ciona intestinalis	36.67	2.00e-10	55.10
IUUC-Cgl-026722	Colletotrichum gloeosporioides	40.91	2.00e-25	105.00
IUUC-Dre-027479	Danio rerio	32.50	2.00e-09	52.00
IUUC-Dno-029693	Dasypus novemcinctus	45.00	1.00e-05	40.40
IUUC-Dse-031440	Dothistroma septosporum	40.65	1.00e-22	96.30
IUUC-Dme-031892	Drosophila melanogaster	33.75	1.00e-10	55.80
IUUC-Ete-032550	Echinops telfairi	36.25	7.00e-11	57.00
IUUC-Eca-033553	Equus caballus	36.25	6.00e-11	57.80
IUUC-Fca-036524	Felis catus	33.75	2.00e-09	53.10
IUUC-Fal-036942	Ficedula albicollis	36.25	1.00e-10	55.50
IUUC-Fox-037753	Fusarium oxysporum	43.31	1.00e-20	90.10
IUUC-Gmo-039498	Gadus morhua	31.25	4.00e-08	47.80
IUUC-Ggr-039852	Gaeumannomyces graminis	37.10	2.00e-18	83.60
IUUC-Gga-041263	Gallus gallus	36.25	6.00e-11	57.80
IUUC-Gac-042346	Gasterosteus aculeatus	31.25	3.00e-08	48.50
IUUC-Gma-042896	Glycine max	38.38	4.00e-13	63.90
IUUC-Ggo-045601	Gorilla gorilla	36.25	1.00e-10	57.40
IUUC-Hsa-046903	Homo sapiens	36.25	8.00e-11	57.40
IUUC-Hvu-047239	Hordeum vulgare	41.11	2.00e-13	64.30
IUUC-Itr-048445	Ictidomys tridecemlineatus	36.25	8.00e-11	57.80
IUUC-Kpa-049355	Komagataella pastoris	36.62	2.00e-18	82.40
IUUC-Lch-050619	Latimeria chalumnae	32.22	2.00e-10	55.80
IUUC-Lma-053299	Leptosphaeria maculans	39.45	2.00e-16	75.50
IUUC-Laf-054205	Loxodonta africana	36.25	3.00e-11	58.90
IUUC-Meu-056804	Macropus eugenii	30.91	6.00e-11	57.80
IUUC-Mor-057052	Magnaporthe oryzae	40.50	4.00e-20	88.60
IUUC-Mtr-057961	Medicago truncatula	40.00	3.00e-13	64.30
IUUC-Mla-059045	Melampsora laricipopulina	40.00	2.00e-13	65.50
IUUC-Mga-060198	Meleagris gallopavo	30.77	5.00e-03	35.00
IUUC-Mvi-060360	Microbotryum violaceum	38.89	7.00e-13	63.90
IUUC-Mmr-061654	Microcebus murinus	36.25	5.00e-11	57.40
IUUC-Mdo-062649	Monodelphis domestica	36.25	3.00e-11	58.50
IUUC-Mmu-064105	Mus musculus	36.25	7.00e-11	57.40
IUUC-Mac-065532	Musa acuminata	37.78	2.00e-12	61.60
IUUC-Mpu-066269	Mustela putorius furo	36.25	1.00e-11	59.70
IUUC-Mlu-067631	Myotis lucifugus	36.25	2.00e-11	59.30
IUUC-Nfi-068468	Neosartorya fischeri	43.33	4.00e-20	87.80
IUUC-Ncr-068750	Neurospora crassa	38.12	5.00e-21	91.30
IUUC-Nle-069483	Nomascus leucogenys	36.25	7.00e-11	58.20
IUUC-Opr-070936	Ochotona princeps	36.25	1.00e-10	57.40
IUUC-Obr-076322	Oryza brachyantha	36.67	5.00e-13	63.20
IUUC-Ogl-077226	Oryza glaberrima	37.65	3.00e-12	61.20
IUUC-Oin-079220	Oryza indica	31.88	1.00e-07	46.20
IUUC-Olo-080688	Oryza longistaminata	37.65	3.00e-12	61.20
IUUC-Ome-081265	Oryza meridionalis	37.65	3.00e-12	61.20
IUUC-Oni-082451	Oryza nivara	32.31	1.20e+00	27.70
IUUC-Oru-084342	Oryza rufipogon	36.67	3.00e-12	63.20
IUUC-Osa-086212	Oryza sativa	37.65	3.00e-12	61.20
IUUC-Ola-087277	Oryzias latipes	32.50	2.00e-09	52.40
IUUC-Oga-088175	Otolemur garnettii	36.25	9.00e-11	57.00
IUUC-Oar-089477	Ovis aries	36.25	1.00e-10	57.00
IUUC-Ptr-091129	Pan troglodytes	36.25	1.00e-10	57.40
IUUC-Psi-093351	Pelodiscus sinensis	36.25	8.00e-11	57.40
IUUC-Pno-094948	Phaeosphaeria nodorum	45.71	3.00e-20	88.20
IUUC-Ppa-095788	Physcomitrella patens	38.89	4.00e-13	63.90
IUUC-Pfo-096993	Poecilia formosa	31.25	1.00e-08	49.70
IUUC-Pab-098502	Pongo abelii	36.25	9.00e-11	57.80
IUUC-Pop-098819	Populus trichocarpa	36.36	8.00e-11	56.20
IUUC-Ppe-101560	Prunus persica	38.75	3.00e-12	60.50
IUUC-Pva-102810	Pteropus vampyrus	36.07	1.00e-06	43.50
IUUC-Pgr-103531	Puccinia graminis	36.89	6.00e-13	63.90
IUUC-Ptt-103753	Puccinia triticina	36.94	3.00e-13	64.70
IUUC-Pyt-104733	Pyrenophora triticirepentis	40.16	1.00e-21	93.60
IUUC-Rno-106072	Rattus norvegicus	36.25	2.00e-11	59.70
IUUC-Sce-106275	Saccharomyces cerevisiae	41.11	4.00e-15	72.40
IUUC-Sha-107554	Sarcophilus harrisii	36.25	2.00e-11	59.30
IUUC-Sja-107682	Schizosaccharomyces japonicus	39.83	2.00e-20	89.40
IUUC-Spo-108275	Schizosaccharomyces pombe	42.11	1.00e-17	79.30
IUUC-Smo-109151	Selaginella moellendorffii	38.20	4.00e-12	60.50
IUUC-Sit-110270	Setaria italica	42.50	3.00e-13	64.30
IUUC-Sly-111862	Solanum lycopersicum	40.00	2.00e-12	61.20
IUUC-Stu-112663	Solanum tuberosum	30.91	3.00e-05	38.10
IUUC-Sbi-114148	Sorghum bicolor	42.50	3.00e-13	64.30
IUUC-Sre-115216	Sporisorium reilianum	33.98	2.00e-12	62.80
IUUC-Ssc-116051	Sus scrofa	36.25	5.00e-11	57.80
IUUC-Tgu-117008	Taeniopygia guttata	27.78	1.60e+00	22.30
IUUC-Tru-118466	Takifugu rubripes	32.50	1.00e-08	48.50
IUUC-Tsy-119334	Tarsius syrichta	33.75	4.00e-07	45.40
IUUC-Tni-119792	Tetraodon nigroviridis	33.75	2.00e-09	51.20
IUUC-Tca-121861	Theobroma cacao	37.78	5.00e-12	60.80
IUUC-Tvi-122499	Trichoderma virens	39.10	1.00e-17	79.30
IUUC-Tae-123431	Triticum aestivum	41.25	3.00e-13	64.30
IUUC-Tme-126934	Tuber melanosporum	46.67	2.00e-19	86.30
IUUC-Ttr-129001	Tursiops truncatus	34.18	2.00e-08	49.70
IUUC-Uma-129324	Ustilago maydis	35.92	2.00e-13	65.50
IUUC-Vda-129846	Verticillium dahliae	43.08	7.00e-21	90.90
IUUC-Vpa-130202	Vicugna pacos	45.00	6.00e-06	42.00
IUUC-Vvi-131474	Vitis vinifera	41.27	6.00e-08	47.80
IUUC-Xtr-132782	Xenopus tropicalis	37.50	2.00e-11	59.30
IUUC-Xma-134140	Xiphophorus maculatus	31.25	3.00e-08	48.50
IUUC-Zma-134764	Zea mays	42.50	2.00e-13	64.30

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence