iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000146021.14	ENST00000309755.8	ENSP00000312397.4
ENSG00000146021.14	ENST00000504208.5	ENSP00000423585.1
ENSG00000146021.14	ENST00000505853.1	ENSP00000426173.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box	BTB_3-box	23387299; 23665031; 23962426

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	1.90e-21	77.9	50	116
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	1.30e-11	43.5	149	180

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           +Dv++v +++e++ah++vLaa+S++F a+f+++++esk  +++eikdv+ + ++ l++++Yt +++ +
   Q: 50   CDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESK-AKKIEIKDVDGQTLSKLIDYIYTAEIEVT 116
           8*************************************.************************99876 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           + Nclgi++fAd ++c+dL ++a+ ++++hF+
   Q: 149  PTNCLGIRAFADVHTCTDLLQQANAYAEQHFP 180
           78*****************************6 PP

Organism

Homo sapiens

Functional Description
(View)

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation.

Protein Sequence
(Fasta)

MEGESVKLSS QTLIQAGDDE KNQRTITVNP AHMGKAFKVM NELRSKQLLC DVMIVAEDVE 60
IEAHRVVLAA CSPYFCAMFT GDMSESKAKK IEIKDVDGQT LSKLIDYIYT AEIEVTEENV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATTCTTTGC AGCCTAGACA GAGGAGGCAG GAGCCCCAGG GGCGGGCTAA TCGCCTGGGC 60
TGGGGATGCC TGGGCAGATG CAGAGGAAGC TGGAAAGGTG GCAGTGCACC TGGGTCGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0009--Actin-binding
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0225--Disease mutation
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005198--F:structural molecule activity
GO:0072156--P:distal tubule morphogenesis
GO:0050801--P:ion homeostasis
GO:0070936--P:protein K48-linked ubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0070294--P:renal sodium ion absorption

KEGG

hsa:26249

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001632	Ailuropoda melanoleuca	97.95	0.00e+00	1168.00
IUUC-Apl-003965	Anas platyrhynchos	94.68	0.00e+00	1110.00
IUUC-Aca-004912	Anolis carolinensis	93.53	0.00e+00	1096.00
IUUC-Ame-010670	Astyanax mexicanus	79.73	0.00e+00	947.00
IUUC-Bta-013354	Bos taurus	98.63	0.00e+00	1176.00
IUUC-Bra-017771	Brassica rapa	29.82	5.00e-13	70.10
IUUC-Cel-018136	Caenorhabditis elegans	42.62	2.00e-132	466.00
IUUC-Cja-019183	Callithrix jacchus	94.31	0.00e+00	1032.00
IUUC-Cfa-020465	Canis familiaris	97.09	0.00e+00	1160.00
IUUC-Cpo-022115	Cavia porcellus	98.97	0.00e+00	1182.00
IUUC-Csa-024219	Chlorocebus sabaeus	99.49	0.00e+00	1198.00
IUUC-Csv-026032	Ciona savignyi	60.61	0.00e+00	704.00
IUUC-Cgl-026620	Colletotrichum gloeosporioides	30.42	3.00e-24	105.00
IUUC-Dre-028524	Danio rerio	75.32	0.00e+00	950.00
IUUC-Dno-029075	Dasypus novemcinctus	99.29	0.00e+00	1144.00
IUUC-Dor-030156	Dipodomys ordii	81.23	0.00e+00	948.00
IUUC-Ete-033064	Echinops telfairi	83.02	0.00e+00	861.00
IUUC-Eca-033887	Equus caballus	98.45	0.00e+00	1169.00
IUUC-Eeu-035244	Erinaceus europaeus	78.88	0.00e+00	930.00
IUUC-Fca-035375	Felis catus	97.61	0.00e+00	1162.00
IUUC-Fal-037119	Ficedula albicollis	96.22	0.00e+00	1070.00
IUUC-Fso-038219	Fusarium solani	39.06	2.00e-10	57.00
IUUC-Gga-041094	Gallus gallus	95.80	0.00e+00	1106.00
IUUC-Gac-042585	Gasterosteus aculeatus	78.18	0.00e+00	910.00
IUUC-Ggo-045485	Gorilla gorilla	99.49	0.00e+00	1192.00
IUUC-Itr-048605	Ictidomys tridecemlineatus	98.63	0.00e+00	1176.00
IUUC-Lch-050246	Latimeria chalumnae	86.99	0.00e+00	1008.00
IUUC-Laf-053700	Loxodonta africana	96.93	0.00e+00	1157.00
IUUC-Mcc-054732	Macaca mulatta	99.60	0.00e+00	1028.00
IUUC-Mga-059994	Meleagris gallopavo	94.88	0.00e+00	999.00
IUUC-Mdo-062923	Monodelphis domestica	97.27	0.00e+00	1171.00
IUUC-Mmu-063842	Mus musculus	97.27	0.00e+00	1164.00
IUUC-Mpu-066380	Mustela putorius furo	97.79	0.00e+00	1178.00
IUUC-Mlu-067922	Myotis lucifugus	98.27	0.00e+00	1158.00
IUUC-Nle-069761	Nomascus leucogenys	99.66	0.00e+00	1199.00
IUUC-Opr-070287	Ochotona princeps	89.44	0.00e+00	1050.00
IUUC-Ont-071654	Oreochromis niloticus	80.70	0.00e+00	959.00
IUUC-Ocu-074957	Oryctolagus cuniculus	98.29	0.00e+00	1165.00
IUUC-Ola-086853	Oryzias latipes	79.30	0.00e+00	908.00
IUUC-Oga-088559	Otolemur garnettii	98.30	0.00e+00	1181.00
IUUC-Oar-089925	Ovis aries	98.30	0.00e+00	1182.00
IUUC-Ptr-091487	Pan troglodytes	100.00	0.00e+00	1202.00
IUUC-Pan-091705	Papio anubis	99.49	0.00e+00	1198.00
IUUC-Psi-093478	Pelodiscus sinensis	91.67	0.00e+00	1056.00
IUUC-Pfo-097450	Poecilia formosa	80.70	0.00e+00	900.00
IUUC-Pab-097618	Pongo abelii	99.83	0.00e+00	1199.00
IUUC-Pca-100739	Procavia capensis	88.80	0.00e+00	659.00
IUUC-Sha-106935	Sarcophilus harrisii	98.93	0.00e+00	756.00
IUUC-Ssc-115599	Sus scrofa	98.45	0.00e+00	1171.00
IUUC-Tgu-117001	Taeniopygia guttata	95.58	0.00e+00	1090.00
IUUC-Tru-118078	Takifugu rubripes	79.55	0.00e+00	950.00
IUUC-Tsy-119161	Tarsius syrichta	86.79	0.00e+00	914.00
IUUC-Tni-120888	Tetraodon nigroviridis	77.14	0.00e+00	889.00
IUUC-Tbe-127285	Tupaia belangeri	83.90	0.00e+00	682.00
IUUC-Ttr-128884	Tursiops truncatus	83.24	2.00e-154	539.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence