iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000146054.17	ENST00000274773.11	ENSP00000274773.7
ENSG00000146054.17	ENST00000393319.7	ENSP00000376994.3
ENSG00000146054.17	ENST00000334421.5	ENSP00000334666.5

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	miRTarBase	microRNA
TRANSFAC	TargetScan	RepTar	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	1.10e-06	30.2	27	96
E3 activity/RING/RING	4.40e-06	28.8	29	82

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 6    flCpIslelMrdPvvlpsGitydrssIekwlasggk..............tcPvtrqplteedlvPnltl 61
             C+I lel+r+Pv +++G+++ r++I ++ ++ g                cP +r+p ++++l Pn  l
   Q: 27   ATCSICLELFREPVSVECGHSFCRACIGRCWERPGAgsvgaatrappfplPCPQCREPARPSQLRPNRQL 96
           67*****************************88877889999*************************987 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkw..pglknssskefr........CPlCr 46
           C+iCle f++ p+++ CgH f++ C+  +w  p     s ++++        CP Cr
   Q: 29   CSICLELFRE-PVSVECGHSFCRACIgRCWerP--GAGSVGAATrappfplpCPQCR 82
           ********88.***************9999552..2223333335566667799997 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MAAVGPRTGP GTGAEALALA AELQGEATCS ICLELFREPV SVECGHSFCR ACIGRCWERP 60
GAGSVGAATR APPFPLPCPQ CREPARPSQL RPNRQLAAVA TLLRRFSLPA AAPGEHGSQA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGTAGTCAA CGTGCGCCTC CCCTCCCGGC TCCCAGCCGG GCGCGCCCCG GGCTCGAGTC 60
TCTGCCTGCC CAGTGGCAGC CCCGCCCTTC CTCTCCCAGT GGGCCCTCGG CGCCCAGCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR020457--Znf_B-box_chordata
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01406--BBOXZNFINGER
PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0008270--F:zinc ion binding

KEGG

hsa:81786

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002208	Ailuropoda melanoleuca	77.65	1.00e-164	573.00
IUUC-Aca-004600	Anolis carolinensis	51.95	2.00e-127	449.00
IUUC-Bta-013412	Bos taurus	89.04	0.00e+00	786.00
IUUC-Cja-018837	Callithrix jacchus	80.51	0.00e+00	672.00
IUUC-Cfa-021142	Canis familiaris	85.14	0.00e+00	699.00
IUUC-Csa-023833	Chlorocebus sabaeus	96.29	0.00e+00	831.00
IUUC-Dno-029233	Dasypus novemcinctus	90.22	0.00e+00	763.00
IUUC-Dor-030639	Dipodomys ordii	75.63	2.00e-116	412.00
IUUC-Ete-032949	Echinops telfairi	75.82	9.00e-178	616.00
IUUC-Fca-035623	Felis catus	90.22	0.00e+00	801.00
IUUC-Fal-037164	Ficedula albicollis	53.88	4.00e-143	501.00
IUUC-Gga-040382	Gallus gallus	52.16	1.00e-144	506.00
IUUC-Gac-041608	Gasterosteus aculeatus	31.81	4.00e-62	232.00
IUUC-Ggo-044993	Gorilla gorilla	98.96	0.00e+00	866.00
IUUC-Itr-048378	Ictidomys tridecemlineatus	91.39	0.00e+00	808.00
IUUC-Mcc-054752	Macaca mulatta	97.26	0.00e+00	859.00
IUUC-Mga-059412	Meleagris gallopavo	48.89	2.00e-132	466.00
IUUC-Mvi-060296	Microbotryum violaceum	51.61	2.00e-05	44.70
IUUC-Mdo-062980	Monodelphis domestica	75.14	0.00e+00	725.00
IUUC-Mmu-063677	Mus musculus	89.43	0.00e+00	776.00
IUUC-Mpu-066023	Mustela putorius furo	88.85	0.00e+00	791.00
IUUC-Nle-069798	Nomascus leucogenys	93.74	0.00e+00	874.00
IUUC-Opr-071019	Ochotona princeps	83.56	0.00e+00	717.00
IUUC-Ocu-074797	Oryctolagus cuniculus	91.00	0.00e+00	841.00
IUUC-Oar-090169	Ovis aries	88.85	0.00e+00	782.00
IUUC-Ptr-091172	Pan troglodytes	97.85	0.00e+00	855.00
IUUC-Pan-092631	Papio anubis	97.65	0.00e+00	868.00
IUUC-Pab-098704	Pongo abelii	99.10	1.00e-152	532.00
IUUC-Pca-100337	Procavia capensis	93.18	3.00e-101	362.00
IUUC-Rno-105413	Rattus norvegicus	87.87	0.00e+00	787.00
IUUC-Sha-107360	Sarcophilus harrisii	65.71	1.00e-163	569.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence