iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000040990.17	ENSMUST00000112456.8	ENSMUSP00000108075.2
ENSMUSG00000040990.17	ENSMUST00000080394.12	ENSMUSP00000079257.6
ENSMUSG00000040990.17	ENSMUST00000141354.7	ENSMUSP00000114262.1
ENSMUSG00000040990.17	ENSMUST00000073094.9	ENSMUSP00000072840.3
ENSMUSG00000040990.17	ENSMUST00000112451.7	ENSMUSP00000108070.1
ENSMUSG00000040990.17	ENSMUST00000112453.8	ENSMUSP00000108072.2
ENSMUSG00000040990.17	ENSMUST00000152426.1	ENSMUSP00000117618.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	Phospho.ELM
UniProt	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	5.70e-67	222.7	312	370

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
            k++++v+++yeaqnddeLt+k+Gd+v++i+k++ d gW++g  el+g+rG+fP+nFv+ l
   Q: 312  TKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEG--ELNGRRGVFPDNFVKLL 370
           6899**************************************..9*************976 PP

Organism

Mus musculus

Functional Description
(View)

Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit. May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration (By similarity).

Protein Sequence
(Fasta)

MVEAIVEFDY QAQHDDELTI SVGEVITNIR KEDGGWWEGQ INGRRGLFPD NFVREIKKDM 60
KKDLLSNKAP EKPMHDVSSG NALLSSETIL RTNKRGERRR RRCQVAFSYL PQNDDELELK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGGGGAGA GCAGGCTCCG AGGCGGCTGC AGGGCACTGG GCTGGGCGGT GCTTTTTTTC 60
TTTTCTTTTC TTTTCTTTCT TTCTTTTTTT TTCTTCTTCT TCTTCTTTTT TTTTTTTTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0965--Cell junction
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0254--Endocytosis
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0729--SH3-binding
KW-0770--Synapse
KW-0771--Synaptosome
KW-0832--Ubl conjugation

Interpro

IPR001452--SH3_domain

PROSITE

PS50002--SH3

Pfam

PF14604--SH3_9

PRINTS

PR00452--SH3DOMAIN

SMART

SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005737--C:cytoplasm
GO:0030659--C:cytoplasmic vesicle membrane
GO:0005856--C:cytoskeleton
GO:0030139--C:endocytic vesicle
GO:0005925--C:focal adhesion
GO:0043005--C:neuron projection
GO:0045202--C:synapse
GO:0006915--P:apoptotic process
GO:0016477--P:cell migration
GO:0007010--P:cytoskeleton organization
GO:0006897--P:endocytosis
GO:0008360--P:regulation of cell shape

KEGG

mmu:58194

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001438	Ailuropoda melanoleuca	86.46	0.00e+00	923.00
IUUC-Aca-004302	Anolis carolinensis	68.05	0.00e+00	775.00
IUUC-Bta-013116	Bos taurus	86.20	0.00e+00	813.00
IUUC-Cel-018134	Caenorhabditis elegans	53.57	2.00e-14	74.30
IUUC-Cja-019960	Callithrix jacchus	88.42	0.00e+00	786.00
IUUC-Cfa-020798	Canis familiaris	87.75	0.00e+00	942.00
IUUC-Cpo-021383	Cavia porcellus	89.99	0.00e+00	969.00
IUUC-Csa-023514	Chlorocebus sabaeus	91.54	0.00e+00	1006.00
IUUC-Cho-024892	Choloepus hoffmanni	56.36	3.00e-92	332.00
IUUC-Cin-025203	Ciona intestinalis	60.34	8.00e-15	75.10
IUUC-Dre-028767	Danio rerio	48.55	6.00e-105	375.00
IUUC-Dno-029821	Dasypus novemcinctus	92.61	0.00e+00	898.00
IUUC-Dor-030415	Dipodomys ordii	76.87	0.00e+00	775.00
IUUC-Dse-031523	Dothistroma septosporum	53.70	4.00e-10	58.50
IUUC-Dme-032184	Drosophila melanogaster	39.74	6.00e-30	126.00
IUUC-Ete-032658	Echinops telfairi	78.48	1.00e-76	280.00
IUUC-Eca-033923	Equus caballus	91.02	0.00e+00	907.00
IUUC-Eeu-034514	Erinaceus europaeus	77.98	0.00e+00	769.00
IUUC-Fca-036452	Felis catus	89.21	0.00e+00	835.00
IUUC-Fal-036800	Ficedula albicollis	75.00	0.00e+00	851.00
IUUC-Gmo-039271	Gadus morhua	44.98	1.00e-53	204.00
IUUC-Gga-041020	Gallus gallus	75.42	9.00e-161	560.00
IUUC-Gac-041864	Gasterosteus aculeatus	48.01	5.00e-101	362.00
IUUC-Ggo-045320	Gorilla gorilla	88.01	0.00e+00	933.00
IUUC-Hsa-046500	Homo sapiens	88.29	0.00e+00	935.00
IUUC-Itr-048261	Ictidomys tridecemlineatus	97.25	4.00e-111	393.00
IUUC-Lch-049490	Latimeria chalumnae	53.72	8.00e-74	271.00
IUUC-Laf-053962	Loxodonta africana	91.67	0.00e+00	1023.00
IUUC-Mcc-055767	Macaca mulatta	93.94	0.00e+00	1053.00
IUUC-Meu-056289	Macropus eugenii	68.82	0.00e+00	714.00
IUUC-Mga-060121	Meleagris gallopavo	75.21	0.00e+00	668.00
IUUC-Mmr-061156	Microcebus murinus	94.69	0.00e+00	1023.00
IUUC-Mdo-062586	Monodelphis domestica	79.75	0.00e+00	833.00
IUUC-Mpu-065723	Mustela putorius furo	89.86	0.00e+00	961.00
IUUC-Mlu-068066	Myotis lucifugus	90.58	0.00e+00	813.00
IUUC-Nle-069669	Nomascus leucogenys	84.63	0.00e+00	857.00
IUUC-Oan-073557	Ornithorhynchus anatinus	80.36	0.00e+00	839.00
IUUC-Ocu-073825	Oryctolagus cuniculus	87.43	0.00e+00	921.00
IUUC-Oga-088075	Otolemur garnettii	93.71	0.00e+00	891.00
IUUC-Oar-090245	Ovis aries	89.55	0.00e+00	855.00
IUUC-Pan-092138	Papio anubis	84.59	0.00e+00	816.00
IUUC-Psi-093515	Pelodiscus sinensis	72.47	0.00e+00	659.00
IUUC-Pma-094757	Petromyzon marinus	40.50	2.00e-30	125.00
IUUC-Pab-097832	Pongo abelii	88.01	0.00e+00	929.00
IUUC-Pca-100541	Procavia capensis	72.84	0.00e+00	737.00
IUUC-Pva-102718	Pteropus vampyrus	82.68	0.00e+00	832.00
IUUC-Rno-105482	Rattus norvegicus	94.64	0.00e+00	1033.00
IUUC-Sha-106922	Sarcophilus harrisii	83.77	0.00e+00	748.00
IUUC-Sar-113614	Sorex araneus	75.55	2.00e-141	496.00
IUUC-Ssc-115772	Sus scrofa	92.39	0.00e+00	1033.00
IUUC-Tgu-116556	Taeniopygia guttata	73.00	0.00e+00	783.00
IUUC-Tsy-118989	Tarsius syrichta	95.38	3.00e-146	511.00
IUUC-Tni-120756	Tetraodon nigroviridis	49.47	2.00e-82	300.00
IUUC-Tbe-128043	Tupaia belangeri	84.38	0.00e+00	856.00
IUUC-Ttr-128634	Tursiops truncatus	87.31	0.00e+00	947.00
IUUC-Vpa-130612	Vicugna pacos	73.05	7.00e-125	441.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence