iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046080

Ensembl Protein ID

ENSP00000313983.7

UniProt Accession

Q9BZ95; B7ZL11; D3DSX1; Q1RMD3; Q3B796; Q6ZSA5; Q9BYU8; Q9BYU9; Q9H2M8; Q9H9W9; Q9NXA6; NSD3_HUMAN

Genbank Protein ID

AAK00354.1; AAK00355.1; CAC28350.1; CAC28351.1; CAC28352.1; AAG44637.1; BAA91110.1; BAB14099.1; EAW63320.1; EAW63321.1; AAH12059.1; AAH62631.1; AAI01718.1; AAI07735.1; AAI13470.1; AAI15007.1; AAI43511.1; ENSP00000313410

Protein Name

Histone-lysine N-methyltransferase NSD3; Nuclear SET domain-containing protein 3; Protein whistle; WHSC1-like 1 isoform 9 with methyltransferase activity to lysine; Wolf-Hirschhorn syndrome candidate 1-like protein 1

Genbank Nucleotide ID

AF332468; AF332469; AJ295990; AJ295991; AJ295992; AF255649; AK000360; AK022560; AK127594; CH471080; BC012059; BC062631; BC101717; BC107734; BC113469; BC115006; BC143510; AC087362

Gene Name

WHSC1L1; NSD3; DC28

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000147548.16	ENST00000317025.12	ENSP00000313983.7
ENSG00000147548.16	ENST00000433384.6	ENSP00000393284.2
ENSG00000147548.16	ENST00000527502.5	ENSP00000434730.1
ENSG00000147548.16	ENST00000316985.7	ENSP00000313410.3
ENSG00000147548.16	ENST00000528627.1	ENSP00000435073.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM	SZDB
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	6.30e-10	40.7	702	746

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCek.CrewfHpaClklsveeelpnsekwiCpkCr 52
           +vC +C+++g+   sl+ Ce  C++ fH +Cl+l+   +lp+s+ +iC +C+
   Q: 702  TVCQICESSGD---SLIPCEGeCCKHFHLECLGLA---SLPDSK-FICMECK 746
           79********9...5********************...*****7.******7 PP

Organism

Homo sapiens

Functional Description
(View)

Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.

Protein Sequence
(Fasta)

MDFSFSFMQG IMGNTIQQPP QLIDSANIRQ EDAFDNNSDI AEDGGQTPYE ATLQQGFQYP 60
ATTEDLPPLT NGYPSSISVY ETQTKYQSYN QYPNGSANGF GAVRNFSPTD YYHSEIPNTR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGGCTTTG TGCGCGGCGG CGGCGGGAGA GGCGGCGGCG GCGGCCAGCA CGGAGGCGGA 60
GGCCGAGGGG GCTGTGCACA GGTCGCCGCG GAGAGGCGTG CGAATTCCGA GCCGAGCGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0160--Chromosomal rearrangement
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0677--Repeat
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006560--AWS_dom
IPR003616--Post-SET_dom
IPR000313--PWWP_dom
IPR001214--SET_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51215--AWS
PS50868--POST_SET
PS50812--PWWP
PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF00855--PWWP
PF00856--SET

SMART

SM00570--AWS
SM00249--PHD
SM00508--PostSET
SM00293--PWWP
SM00317--SET

Gene Ontology

GO:0005694--C:chromosome
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0008270--F:zinc ion binding
GO:0016571--P:histone methylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:54904

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000310	Aegilops tauschii	29.41	5.00e-12	66.60
IUUC-Aml-001809	Ailuropoda melanoleuca	95.75	0.00e+00	1769.00
IUUC-Apl-004027	Anas platyrhynchos	78.51	0.00e+00	2107.00
IUUC-Aca-005380	Anolis carolinensis	83.02	0.00e+00	2241.00
IUUC-Ame-011234	Astyanax mexicanus	67.96	0.00e+00	1269.00
IUUC-Bta-013575	Bos taurus	92.57	0.00e+00	2647.00
IUUC-Bdi-014781	Brachypodium distachyon	31.61	6.00e-13	69.70
IUUC-Cja-020013	Callithrix jacchus	98.19	0.00e+00	2851.00
IUUC-Cfa-021060	Canis familiaris	96.32	0.00e+00	2694.00
IUUC-Cpo-021834	Cavia porcellus	94.65	0.00e+00	2610.00
IUUC-Csa-023370	Chlorocebus sabaeus	98.40	0.00e+00	2856.00
IUUC-Cho-025058	Choloepus hoffmanni	87.55	0.00e+00	1123.00
IUUC-Dre-027664	Danio rerio	61.82	0.00e+00	1512.00
IUUC-Dno-029302	Dasypus novemcinctus	94.17	0.00e+00	2634.00
IUUC-Eca-033626	Equus caballus	93.76	0.00e+00	2665.00
IUUC-Fca-035556	Felis catus	95.76	0.00e+00	2722.00
IUUC-Fal-037101	Ficedula albicollis	82.98	0.00e+00	2248.00
IUUC-Gmo-038901	Gadus morhua	57.71	0.00e+00	1568.00
IUUC-Gga-040366	Gallus gallus	83.85	0.00e+00	2225.00
IUUC-Gac-042047	Gasterosteus aculeatus	62.60	0.00e+00	1383.00
IUUC-Ggo-044695	Gorilla gorilla	96.32	0.00e+00	2740.00
IUUC-Itr-048622	Ictidomys tridecemlineatus	95.76	0.00e+00	2732.00
IUUC-Lch-050544	Latimeria chalumnae	70.67	0.00e+00	1670.00
IUUC-Loc-052656	Lepisosteus oculatus	66.07	0.00e+00	1631.00
IUUC-Laf-054112	Loxodonta africana	95.22	0.00e+00	2688.00
IUUC-Mcc-054956	Macaca mulatta	99.03	0.00e+00	2868.00
IUUC-Meu-056051	Macropus eugenii	86.61	0.00e+00	2258.00
IUUC-Mga-060139	Meleagris gallopavo	86.06	0.00e+00	2304.00
IUUC-Mmr-060789	Microcebus murinus	96.11	0.00e+00	2794.00
IUUC-Mdo-062908	Monodelphis domestica	90.50	0.00e+00	2534.00
IUUC-Mmu-063165	Mus musculus	87.35	0.00e+00	2443.00
IUUC-Mpu-066002	Mustela putorius furo	96.31	0.00e+00	2718.00
IUUC-Nle-069417	Nomascus leucogenys	97.87	0.00e+00	2666.00
IUUC-Ont-071900	Oreochromis niloticus	59.51	0.00e+00	1658.00
IUUC-Oan-072857	Ornithorhynchus anatinus	90.49	0.00e+00	2541.00
IUUC-Ocu-073809	Oryctolagus cuniculus	95.35	0.00e+00	2679.00
IUUC-Obr-076122	Oryza brachyantha	30.36	8.00e-09	54.30
IUUC-Ola-087085	Oryzias latipes	59.50	0.00e+00	1625.00
IUUC-Oga-088289	Otolemur garnettii	95.20	0.00e+00	2681.00
IUUC-Oar-089398	Ovis aries	93.26	0.00e+00	2644.00
IUUC-Ptr-090510	Pan troglodytes	99.65	0.00e+00	2863.00
IUUC-Pan-092291	Papio anubis	98.54	0.00e+00	2860.00
IUUC-Psi-093547	Pelodiscus sinensis	87.66	0.00e+00	2386.00
IUUC-Pma-094747	Petromyzon marinus	48.72	0.00e+00	1098.00
IUUC-Pfo-096669	Poecilia formosa	60.07	0.00e+00	1628.00
IUUC-Pab-097727	Pongo abelii	98.75	0.00e+00	2843.00
IUUC-Pca-100474	Procavia capensis	87.04	0.00e+00	2343.00
IUUC-Pva-102539	Pteropus vampyrus	94.40	0.00e+00	2419.00
IUUC-Rno-105685	Rattus norvegicus	90.24	0.00e+00	2490.00
IUUC-Sha-107287	Sarcophilus harrisii	91.60	0.00e+00	2529.00
IUUC-Sar-113547	Sorex araneus	88.76	0.00e+00	2538.00
IUUC-Ssc-116208	Sus scrofa	96.24	0.00e+00	2783.00
IUUC-Tgu-117006	Taeniopygia guttata	85.63	0.00e+00	2343.00
IUUC-Tru-118375	Takifugu rubripes	59.09	0.00e+00	1655.00
IUUC-Tsy-119323	Tarsius syrichta	96.18	0.00e+00	2729.00
IUUC-Tni-120509	Tetraodon nigroviridis	59.61	0.00e+00	1667.00
IUUC-Tae-124687	Triticum aestivum	29.41	5.00e-12	66.60
IUUC-Ttr-128240	Tursiops truncatus	93.60	0.00e+00	2611.00
IUUC-Vpa-130666	Vicugna pacos	94.85	0.00e+00	2654.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence