iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000148331.11	ENST00000277459.8	ENSP00000277459.4
ENSG00000148331.11	ENST00000277458.4	ENSP00000277458.4
ENSG00000148331.11	ENST00000450050.6	ENSP00000416172.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	SOCS	16325183

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	6.30e-16	59.6	363	413

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 2    sklwllrseprSLqhLCRlaIrrclgsqrl.kaidkLPLPksLkdYLlyed 51
            +l++l+s p++L+hLCR+aIr +l+ + +  ++++LPLP++Lk+YLl+e+
   Q: 363  FSLRQLESYPPPLKHLCRVAIRLYLQPWPVdVKVKALPLPDRLKWYLLSEH 413
           57899********************************************98 PP

Organism

Homo sapiens

Functional Description
(View)

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MPFLHGFRRI IFEYQPLVDA ILGSLGIQDP ERQESLDRPS YVASEESRIL VLTELLERKA 60
HSPFYQEGVS NALLKMAELG LTRAADVLLR HGANLNFEDP VTYYTALHIA VLRNQPDMVE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCACTTCCG GCGGGGGCGC GGCTTGGACT GAGGAGCGGA CCCGGCCGGG CGCAGGGGCT 60
GGACTGGCGG AGCAGGTGGG GTCCGCGGCC GCCGGAGCGT TCCGGTCGGC GTCTGGGCAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001496--SOCS_box

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50225--SOCS

Pfam

PF12796--Ank_2
PF07525--SOCS_box

SMART

SM00248--ANK
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination

KEGG

hsa:140459

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002347	Ailuropoda melanoleuca	95.25	0.00e+00	824.00
IUUC-Apl-004040	Anas platyrhynchos	69.10	5.00e-172	597.00
IUUC-Aca-005115	Anolis carolinensis	62.11	2.00e-112	399.00
IUUC-Bta-013038	Bos taurus	94.54	0.00e+00	817.00
IUUC-Cja-019234	Callithrix jacchus	97.67	0.00e+00	776.00
IUUC-Cfa-021244	Canis familiaris	95.96	0.00e+00	827.00
IUUC-Cpo-021929	Cavia porcellus	91.90	0.00e+00	796.00
IUUC-Csa-023836	Chlorocebus sabaeus	98.57	0.00e+00	854.00
IUUC-Cho-024476	Choloepus hoffmanni	71.13	4.00e-89	320.00
IUUC-Dre-028690	Danio rerio	49.88	2.00e-92	333.00
IUUC-Dno-029283	Dasypus novemcinctus	85.21	0.00e+00	716.00
IUUC-Dor-030485	Dipodomys ordii	87.96	0.00e+00	635.00
IUUC-Ete-032418	Echinops telfairi	85.09	4.00e-163	566.00
IUUC-Eca-033988	Equus caballus	95.31	0.00e+00	745.00
IUUC-Eeu-034941	Erinaceus europaeus	92.40	0.00e+00	798.00
IUUC-Fca-036496	Felis catus	95.49	0.00e+00	826.00
IUUC-Fal-036984	Ficedula albicollis	68.24	2.00e-158	551.00
IUUC-Gmo-039150	Gadus morhua	63.13	7.00e-66	244.00
IUUC-Gga-041266	Gallus gallus	65.89	6.00e-157	547.00
IUUC-Gac-042080	Gasterosteus aculeatus	53.32	4.00e-108	384.00
IUUC-Ggo-044937	Gorilla gorilla	99.76	0.00e+00	858.00
IUUC-Itr-048455	Ictidomys tridecemlineatus	94.52	0.00e+00	744.00
IUUC-Lch-050601	Latimeria chalumnae	68.27	5.00e-153	533.00
IUUC-Loc-052854	Lepisosteus oculatus	54.04	5.00e-109	387.00
IUUC-Laf-054179	Loxodonta africana	95.96	0.00e+00	828.00
IUUC-Mcc-054853	Macaca mulatta	98.81	0.00e+00	855.00
IUUC-Meu-056311	Macropus eugenii	89.62	9.00e-166	575.00
IUUC-Mga-059491	Meleagris gallopavo	62.85	6.00e-144	504.00
IUUC-Mmr-060741	Microcebus murinus	96.20	0.00e+00	834.00
IUUC-Mdo-061962	Monodelphis domestica	85.27	0.00e+00	706.00
IUUC-Mmu-063538	Mus musculus	90.14	0.00e+00	761.00
IUUC-Mpu-066576	Mustela putorius furo	94.30	0.00e+00	817.00
IUUC-Mlu-067582	Myotis lucifugus	92.49	0.00e+00	731.00
IUUC-Nle-069380	Nomascus leucogenys	98.19	0.00e+00	772.00
IUUC-Opr-070468	Ochotona princeps	84.29	0.00e+00	719.00
IUUC-Ont-071911	Oreochromis niloticus	53.18	5.00e-105	374.00
IUUC-Ola-087028	Oryzias latipes	53.08	2.00e-112	399.00
IUUC-Oga-088844	Otolemur garnettii	95.49	0.00e+00	832.00
IUUC-Oar-089960	Ovis aries	86.85	0.00e+00	734.00
IUUC-Ptr-091084	Pan troglodytes	100.00	0.00e+00	861.00
IUUC-Pan-092635	Papio anubis	98.44	0.00e+00	781.00
IUUC-Psi-093269	Pelodiscus sinensis	78.30	0.00e+00	658.00
IUUC-Pfo-096198	Poecilia formosa	53.90	2.00e-101	363.00
IUUC-Pab-098489	Pongo abelii	95.74	0.00e+00	680.00
IUUC-Pca-100298	Procavia capensis	89.82	0.00e+00	683.00
IUUC-Pva-102166	Pteropus vampyrus	96.30	0.00e+00	693.00
IUUC-Rno-105914	Rattus norvegicus	91.28	0.00e+00	639.00
IUUC-Sha-106776	Sarcophilus harrisii	85.27	0.00e+00	726.00
IUUC-Ssc-116376	Sus scrofa	96.91	0.00e+00	835.00
IUUC-Tgu-116627	Taeniopygia guttata	68.81	1.00e-154	539.00
IUUC-Tru-118229	Takifugu rubripes	52.59	6.00e-108	384.00
IUUC-Tni-120261	Tetraodon nigroviridis	52.87	4.00e-109	388.00
IUUC-Tbe-127507	Tupaia belangeri	95.29	4.00e-89	322.00
IUUC-Ttr-128163	Tursiops truncatus	96.67	0.00e+00	834.00
IUUC-Xtr-132889	Xenopus tropicalis	72.77	1.00e-180	625.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence