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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-136747
Ensembl Protein ID ENSP00000277632.3
UniProt Accession Q9H8M7; Q5SZ68; Q5SZ69; Q5SZ70; Q6IA40; Q6P7P0; Q7Z2S1; Q8WUF1; Q9H3I4; MINY3_HUMAN
Genbank Protein ID AB014761; AK023459; AL833873; CR457315; AF176916; AL590439; AL590439; AL590439; AL590439; CH471072; CH471072; BC020605; BC061585; BC067799; AF063600
Protein Name Ubiquitin carboxyl-terminal hydrolase MINDY-3;Dermal papilla-derived protein 5;Deubiquitinating enzyme MINDY-3;Protein CARP
Genbank Nucleotide ID BAB87802.1; BAB14582.1; CAD38730.1; CAG33596.1; AAQ13660.1; CAI13817.1; CAI13818.1; CAI13819.1; CAI13820.1; EAW86233.1; EAW86234.1; AAH20605.1; AAH61585.1; AAH67799.1; AAG43159.1
Gene Name MINDY3;C10orf97;CARP;DERP5;FAM188A;MSTP126;My042
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000148481.13 ENST00000277632.7 ENSP00000277632.3
ENSG00000148481.13 ENST00000436829.1 ENSP00000389883.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
AREsitecircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPM
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/MINDY MINDY 27292798; 27392144
UBD/Alpha-Helix/MIU MIU 27292798; 27392144
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.
 Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.
Protein Sequence
(Fasta)
MSELTKELME LVWGTKSSPG LSDTIFCRWT QGFVFSESEG SALEQFEGGP CAVIAPVQAF 60
LLKKLLFSSE KSSWRDCSEE EQKELLCHTL CDILESACCD HSGSYCLVSW LRGKTTEETA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-136747|DUB,MINDY;UBD,MIU|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAGTGGCACC AGCACTTCCG GTACGGAAAA CTCGCTGCTG CCCCAACCTG GCTTGACAGG 60
CTTGGTCTCT GCAAGTGGCT CTCAGCCCCT TCTTCTTTCC TGCCTCACCT TCCAATTCGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-136747|DUB,MINDY;UBD,MIU|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR025257--DUF4205
IPR011992--EF-hand-dom_pair
Pfam

PF13898--DUF4205
SMART

SM01174--DUF4205
Gene Ontology

GO:0031965--C:nuclear membrane
GO:0005654--C:nucleoplasm
GO:0016807--F:cysteine-type carboxypeptidase activity
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0006915--P:apoptotic process
KEGG hsa:80013
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-136377 Aegilops tauschii 30.56 7.00e-46 178.00
IUUC-Aml-136379 Ailuropoda melanoleuca 97.98 0.00e+00 866.00
IUUC-Atr-136383 Amborella trichopoda 30.00 1.00e-41 164.00
IUUC-Apl-136385 Anas platyrhynchos 87.70 0.00e+00 666.00
IUUC-Aca-136389 Anolis carolinensis 84.53 0.00e+00 784.00
IUUC-Aly-136394 Arabidopsis lyrata 29.94 3.00e-46 179.00
IUUC-Ath-136396 Arabidopsis thaliana 30.77 8.00e-47 181.00
IUUC-Ame-136407 Astyanax mexicanus 74.72 0.00e+00 711.00
IUUC-Bta-136411 Bos taurus 97.53 0.00e+00 867.00
IUUC-Bdi-136416 Brachypodium distachyon 29.82 7.00e-47 182.00
IUUC-Bol-136419 Brassica oleracea 31.53 8.00e-45 175.00
IUUC-Bra-136421 Brassica rapa 31.13 1.00e-44 174.00
IUUC-Cja-136424 Callithrix jacchus 99.10 0.00e+00 879.00
IUUC-Cfa-136428 Canis familiaris 94.44 0.00e+00 777.00
IUUC-Cpo-136432 Cavia porcellus 96.63 0.00e+00 861.00
IUUC-Csa-136438 Chlorocebus sabaeus 100.00 0.00e+00 887.00
IUUC-Cho-136444 Choloepus hoffmanni 91.56 3.00e-165 575.00
IUUC-Cin-136447 Ciona intestinalis 42.42 1.00e-96 347.00
IUUC-Csv-136448 Ciona savignyi 42.48 1.00e-95 343.00
IUUC-Dre-136452 Danio rerio 74.22 0.00e+00 664.00
IUUC-Dno-136456 Dasypus novemcinctus 96.18 0.00e+00 855.00
IUUC-Dor-136461 Dipodomys ordii 92.86 0.00e+00 665.00
IUUC-Dme-136466 Drosophila melanogaster 42.80 3.00e-110 392.00
IUUC-Ete-136467 Echinops telfairi 74.83 0.00e+00 650.00
IUUC-Eca-136471 Equus caballus 98.88 0.00e+00 877.00
IUUC-Eeu-136476 Erinaceus europaeus 90.56 0.00e+00 767.00
IUUC-Fca-136477 Felis catus 97.53 0.00e+00 867.00
IUUC-Fal-136481 Ficedula albicollis 86.71 0.00e+00 774.00
IUUC-Gmo-136486 Gadus morhua 70.02 0.00e+00 627.00
IUUC-Gga-136491 Gallus gallus 86.77 0.00e+00 805.00
IUUC-Gac-136495 Gasterosteus aculeatus 69.96 0.00e+00 643.00
IUUC-Gma-136499 Glycine max 30.11 1.00e-43 171.00
IUUC-Ggo-136502 Gorilla gorilla 90.38 0.00e+00 782.00
IUUC-Hvu-136508 Hordeum vulgare 33.70 1.00e-38 153.00
IUUC-Itr-136510 Ictidomys tridecemlineatus 97.64 2.00e-111 394.00
IUUC-Lch-136515 Latimeria chalumnae 78.40 0.00e+00 716.00
IUUC-Lpe-136518 Leersia perrieri 28.21 3.00e-41 163.00
IUUC-Loc-136521 Lepisosteus oculatus 77.51 0.00e+00 718.00
IUUC-Laf-136527 Loxodonta africana 97.30 0.00e+00 860.00
IUUC-Mcc-136530 Macaca mulatta 100.00 0.00e+00 887.00
IUUC-Meu-136534 Macropus eugenii 59.45 5.00e-91 328.00
IUUC-Mga-136543 Meleagris gallopavo 86.63 0.00e+00 751.00
IUUC-Mmr-136547 Microcebus murinus 98.88 0.00e+00 877.00
IUUC-Mdo-136551 Monodelphis domestica 91.01 0.00e+00 853.00
IUUC-Mmu-136555 Mus musculus 95.73 0.00e+00 847.00
IUUC-Mpu-136561 Mustela putorius furo 97.66 0.00e+00 654.00
IUUC-Mlu-136565 Myotis lucifugus 95.96 0.00e+00 854.00
IUUC-Nle-136572 Nomascus leucogenys 100.00 0.00e+00 887.00
IUUC-Opr-136576 Ochotona princeps 68.18 3.00e-139 488.00
IUUC-Ont-136579 Oreochromis niloticus 69.13 0.00e+00 634.00
IUUC-Oan-136582 Ornithorhynchus anatinus 88.09 0.00e+00 759.00
IUUC-Ocu-136585 Oryctolagus cuniculus 98.65 0.00e+00 872.00
IUUC-Oba-136589 Oryza barthii 27.45 4.00e-48 186.00
IUUC-Obr-136592 Oryza brachyantha 27.57 3.00e-47 182.00
IUUC-Ogl-136593 Oryza glaberrima 27.45 3.00e-48 186.00
IUUC-Ogu-136595 Oryza glumaepatula 27.45 4.00e-48 186.00
IUUC-Oin-136597 Oryza indica 27.92 2.00e-46 179.00
IUUC-Olo-136599 Oryza longistaminata 27.69 2.00e-48 186.00
IUUC-Oni-136602 Oryza nivara 27.45 3.00e-48 186.00
IUUC-Opu-136604 Oryza punctata 27.50 8.00e-48 185.00
IUUC-Oru-136606 Oryza rufipogon 27.45 3.00e-48 186.00
IUUC-Osa-136608 Oryza sativa 31.21 3.00e-33 135.00
IUUC-Ola-136610 Oryzias latipes 70.18 0.00e+00 656.00
IUUC-Oga-136614 Otolemur garnettii 97.54 0.00e+00 863.00
IUUC-Oar-136619 Ovis aries 97.30 0.00e+00 865.00
IUUC-Ptr-136623 Pan troglodytes 99.78 0.00e+00 885.00
IUUC-Pan-136627 Papio anubis 100.00 0.00e+00 887.00
IUUC-Psi-136631 Pelodiscus sinensis 87.97 0.00e+00 645.00
IUUC-Pma-136635 Petromyzon marinus 71.13 3.00e-47 181.00
IUUC-Pfo-136641 Poecilia formosa 66.89 0.00e+00 643.00
IUUC-Pab-136645 Pongo abelii 99.78 0.00e+00 884.00
IUUC-Pop-136650 Populus trichocarpa 30.21 4.00e-37 149.00
IUUC-Pca-136652 Procavia capensis 91.67 6.00e-122 430.00
IUUC-Ppe-136656 Prunus persica 29.40 9.00e-46 178.00
IUUC-Pva-136658 Pteropus vampyrus 88.31 0.00e+00 748.00
IUUC-Rno-136665 Rattus norvegicus 95.06 0.00e+00 847.00
IUUC-Sha-136671 Sarcophilus harrisii 91.01 0.00e+00 853.00
IUUC-Sit-136680 Setaria italica 29.41 1.00e-36 147.00
IUUC-Sly-136683 Solanum lycopersicum 29.45 2.00e-43 170.00
IUUC-Sar-136685 Sorex araneus 87.63 0.00e+00 648.00
IUUC-Sbi-136688 Sorghum bicolor 31.21 3.00e-46 179.00
IUUC-Ssc-136691 Sus scrofa 98.20 0.00e+00 873.00
IUUC-Tgu-136694 Taeniopygia guttata 88.89 0.00e+00 765.00
IUUC-Tru-136698 Takifugu rubripes 68.40 0.00e+00 652.00
IUUC-Tsy-136703 Tarsius syrichta 93.03 0.00e+00 800.00
IUUC-Tni-136706 Tetraodon nigroviridis 71.14 0.00e+00 665.00
IUUC-Tca-136711 Theobroma cacao 30.08 5.00e-44 172.00
IUUC-Tae-136714 Triticum aestivum 30.30 2.00e-48 187.00
IUUC-Tur-136716 Triticum urartu 26.30 7.00e-30 125.00
IUUC-Tbe-136719 Tupaia belangeri 97.34 0.00e+00 794.00
IUUC-Ttr-136722 Tursiops truncatus 93.03 0.00e+00 825.00
IUUC-Vda-136727 Verticillium dahliae 24.36 4.80e-02 32.00
IUUC-Vpa-136729 Vicugna pacos 97.34 0.00e+00 800.00
IUUC-Vvi-136732 Vitis vinifera 29.57 2.00e-45 177.00
IUUC-Xtr-136734 Xenopus tropicalis 72.75 0.00e+00 627.00
IUUC-Xma-136738 Xiphophorus maculatus 68.90 0.00e+00 651.00
Created Date 25-Jun-2017

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