• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Details
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP
  • Cancer Mutation
    • TCGA
    • ICGC
    • COSMIC
    • CGAP
    • IntOGen
  • SNP
    • dbSNP
  • mRNA Expression
    • GEO
    • ArrayExpress
    • TCGA
    • ICGC
    • COSMIC
    • HPM
  • DNA & RNA Element
    • UTRdb
    • AREsite
    • circBase
    • circRNADb
    • CircNet
    • miRTarBase
    • microRNA
    • TRANSFAC
    • TargetScan
    • RepTar
    • SomamiR
    • miRcode
    • RAID2
  • PPI
    • IID
    • iRefIndex
    • HINT
    • Mentha
    • InWeb_IM
  • Disease
    • GWASdb
    • OMIM
  • PTM
    • dbPAF
    • PhosphositePlus
  • DNA Methylation
    • MethyCancer
    • TCGA
    • ICGC
    • COSMIC
  • Proteomics
    • THPA
    • HPM
    • GPMDB

Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Hsa-046810
UUCD1 version UUC-HoS-00384
Ensembl Protein ID ENSP00000282369.3
UniProt Accession Q9NQ86; A1L3Z1; A6NDD0; B7Z3V4; B7ZAV7; E9PFI8; Q0P5Z9; TRI36_HUMAN
Genbank Protein ID CAB94831.1; BAH14793.1; BAH12340.1; EAW48972.1; AAH45164.1; AAH46096.1; AAI30335.1
Protein Name E3 ubiquitin-protein ligase TRIM36; RING finger protein 98; RING-type E3 ubiquitin transferase TRIM36; Tripartite motif-containing protein 36; Zinc-binding protein Rbcc728
Genbank Nucleotide ID AJ272269; BX460627; AK296389; AC008494; BC045164; BC046096; BC130334
Gene Name TRIM36; RBCC728; RNF98
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000152503.9 ENST00000282369.7 ENSP00000282369.3
ENSG00000152503.9 ENST00000513154.5 ENSP00000423934.1
ENSG00000152503.9 ENST00000508894.1 ENSP00000424743.1
ENSG00000152503.9 ENST00000379618.6 ENSP00000368938.2
ENSG00000152503.9 ENST00000379617.2 ENSP00000368937.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 19232519; 19675128
Classification
Family E-value Score Start End
E3 activity/RING/RING 1.80e-05 26.8 33 118
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw............pglknssskefr................................CPlC 45
    C+ C+e f + pl+lpC+H ++++C++ + + +n+ss+ r CP C
   Q: 33 CPACKELFTH-PLILPCQHSICHKCVKELlltlddsfndvgSDNSNQSSP--RlrlpspsmdkidrinrpgwkrnsltprttvfpCPGC 118
    ********99.**************9888888899998854333334444..3448888888888888888888888888888888888 PP
   

Organism Homo sapiens
Functional Description
(View)

Functional Description



     E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome reaction and fertilization.
E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome reaction and fertilization.
Protein Sequence
(Fasta)
MSESGEMSEF GYIMELIAKG KVTIKNIERE LICPACKELF THPLILPCQH SICHKCVKEL 60
LLTLDDSFND VGSDNSNQSS PRLRLPSPSM DKIDRINRPG WKRNSLTPRT TVFPCPGCEH 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Hsa-046810|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GATGGGGCTT TTTTCCAGAT CTTCGCGCCG AGAGCCGGGG ACGGCCAACC TGCCGGCATG 60
CGATAAAGGC CGGGGAATGT CTAGCTGGGG CCGCGCTGAG CCGAGTGCGG ACCCGCTTTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Hsa-046810|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR017903--COS_domain
IPR003961--FN3_dom
IPR013783--Ig-like_fold
IPR027726--Trim36
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS51262--COS
PS50853--FN3
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00041--fn3
PF00643--zf-B_box
PF13445--zf-RING_UBOX

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00184--RING

Gene Ontology

GO:0001669--C:acrosomal vesicle
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007340--P:acrosome reaction
GO:0000209--P:protein polyubiquitination
GO:0051726--P:regulation of cell cycle

KEGG hsa:55521
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002038 Ailuropoda melanoleuca 94.79 0.00e+00 1428.00
IUUC-Apl-003863 Anas platyrhynchos 76.12 0.00e+00 1080.00
IUUC-Aca-005003 Anolis carolinensis 78.01 0.00e+00 1182.00
IUUC-Ame-011283 Astyanax mexicanus 64.75 0.00e+00 926.00
IUUC-Bta-013517 Bos taurus 94.79 0.00e+00 1430.00
IUUC-Cja-019181 Callithrix jacchus 97.94 0.00e+00 1470.00
IUUC-Cfa-020375 Canis familiaris 95.34 0.00e+00 1434.00
IUUC-Cpo-021827 Cavia porcellus 92.45 0.00e+00 1404.00
IUUC-Csa-023819 Chlorocebus sabaeus 98.73 0.00e+00 1440.00
IUUC-Cho-024602 Choloepus hoffmanni 94.29 0.00e+00 1246.00
IUUC-Dre-028570 Danio rerio 62.53 0.00e+00 918.00
IUUC-Dno-029385 Dasypus novemcinctus 94.80 0.00e+00 1375.00
IUUC-Ete-032498 Echinops telfairi 93.19 0.00e+00 1376.00
IUUC-Eca-034142 Equus caballus 94.65 0.00e+00 1431.00
IUUC-Eeu-034756 Erinaceus europaeus 86.11 7.00e-144 504.00
IUUC-Fca-035508 Felis catus 95.34 0.00e+00 1394.00
IUUC-Fal-037617 Ficedula albicollis 73.76 0.00e+00 1144.00
IUUC-Gmo-038943 Gadus morhua 62.46 0.00e+00 783.00
IUUC-Gac-041330 Gasterosteus aculeatus 61.83 0.00e+00 796.00
IUUC-Ggo-045308 Gorilla gorilla 99.04 0.00e+00 1484.00
IUUC-Lch-050382 Latimeria chalumnae 68.71 0.00e+00 1012.00
IUUC-Loc-051809 Lepisosteus oculatus 62.69 0.00e+00 884.00
IUUC-Laf-054251 Loxodonta africana 93.97 0.00e+00 1376.00
IUUC-Mcc-054735 Macaca mulatta 98.90 0.00e+00 1483.00
IUUC-Meu-056861 Macropus eugenii 83.45 0.00e+00 1041.00
IUUC-Mmr-061266 Microcebus murinus 94.79 0.00e+00 1430.00
IUUC-Mdo-061996 Monodelphis domestica 87.03 0.00e+00 1318.00
IUUC-Mmu-063846 Mus musculus 92.46 0.00e+00 1431.00
IUUC-Mpu-065916 Mustela putorius furo 94.51 0.00e+00 1427.00
IUUC-Mlu-067753 Myotis lucifugus 91.52 0.00e+00 1366.00
IUUC-Nle-068991 Nomascus leucogenys 98.35 0.00e+00 1471.00
IUUC-Opr-070512 Ochotona princeps 89.22 0.00e+00 1126.00
IUUC-Ont-072641 Oreochromis niloticus 62.52 0.00e+00 927.00
IUUC-Oan-072998 Ornithorhynchus anatinus 73.10 0.00e+00 1092.00
IUUC-Ocu-074891 Oryctolagus cuniculus 90.36 0.00e+00 1244.00
IUUC-Ola-086318 Oryzias latipes 63.58 0.00e+00 785.00
IUUC-Oga-088089 Otolemur garnettii 94.63 0.00e+00 1386.00
IUUC-Oar-089836 Ovis aries 94.79 0.00e+00 1430.00
IUUC-Ptr-091083 Pan troglodytes 99.18 0.00e+00 1486.00
IUUC-Pan-092310 Papio anubis 97.65 0.00e+00 1447.00
IUUC-Psi-093663 Pelodiscus sinensis 80.70 0.00e+00 1227.00
IUUC-Pfo-096697 Poecilia formosa 63.98 0.00e+00 914.00
IUUC-Pab-098766 Pongo abelii 96.44 0.00e+00 732.00
IUUC-Pca-100938 Procavia capensis 86.59 0.00e+00 743.00
IUUC-Pva-102799 Pteropus vampyrus 94.92 0.00e+00 1025.00
IUUC-Rno-105823 Rattus norvegicus 92.73 0.00e+00 1432.00
IUUC-Sha-106921 Sarcophilus harrisii 87.00 0.00e+00 1343.00
IUUC-Sar-113002 Sorex araneus 77.72 0.00e+00 883.00
IUUC-Ssc-115356 Sus scrofa 95.20 0.00e+00 1461.00
IUUC-Tgu-117350 Taeniopygia guttata 71.95 0.00e+00 1067.00
IUUC-Tru-117786 Takifugu rubripes 62.85 0.00e+00 921.00
IUUC-Tsy-119009 Tarsius syrichta 93.69 0.00e+00 1395.00
IUUC-Tni-119753 Tetraodon nigroviridis 62.15 0.00e+00 919.00
IUUC-Ttr-128842 Tursiops truncatus 95.06 0.00e+00 1431.00
IUUC-Vpa-130330 Vicugna pacos 95.62 0.00e+00 1427.00
IUUC-Xtr-132760 Xenopus tropicalis 68.46 0.00e+00 1053.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved