iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000153558.13	ENST00000484457.5	ENSP00000417601.1
ENSG00000153558.13	ENST00000435207.5	ENSP00000411484.1
ENSG00000153558.13	ENST00000432809.5	ENSP00000411273.1
ENSG00000153558.13	ENST00000451636.5	ENSP00000416332.1
ENSG00000153558.13	ENST00000425973.5	ENSP00000405084.1
ENSG00000153558.13	ENST00000507198.5	ENSP00000426163.1
ENSG00000153558.13	ENST00000422741.5	ENSP00000406737.1
ENSG00000153558.13	ENST00000421391.5	ENSP00000408895.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
AREsite	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	21343341; 26037928

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	0.00076	21.2	11	55

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 102  lldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
           + ++lp+e+l++i+++ld  +l+r+a++++ w+ la + + w+++
   Q: 11   INKKLPKELLLRIFSFLDIVTLCRCAQISKAWNILALDGSNWQRI 55
           5689*****************************888778888875 PP

Organism

Homo sapiens

Functional Description
(View)

Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0) (PubMed:22020328, PubMed:22323446). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy (PubMed:23604317). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant (By similarity).

Protein Sequence
(Fasta)

MVFSNNDEGL INKKLPKELL LRIFSFLDIV TLCRCAQISK AWNILALDGS NWQRIDLFNF 60
QTDVEGRVVE NISKRCGGFL RKLSLRGCIG VGDSSLKTFA QNCRNIEHLN LNGCTKITDS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TATTATAACA ACTCATTGGA AGCTTGAAGC AGATAGAATG GAATCTGAGC AGTAGCTACT 60
TCAGGTGCTG GGGTGAGTGT CGTTTTATCC TTTTAAATTC TTGTTATTGG TAATTTAAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0106--Calcium
KW-0112--Calmodulin-binding
KW-0181--Complete proteome
KW-0945--Host-virus interaction
KW-0433--Leucine-rich repeat
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0621--Polymorphism
KW-0636--Prenylation
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR006553--Leu-rich_rpt_Cys-con_subtyp

PROSITE

PS50181--FBOX

Pfam

PF12937--F-box-like
PF13516--LRR_6

SMART

SM00256--FBOX
SM00367--LRR_CC

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016020--C:membrane
GO:0019005--C:SCF ubiquitin ligase complex
GO:0036312--F:phosphatidylinositol 3-kinase regulatory subunit binding
GO:0019903--F:protein phosphatase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006464--P:cellular protein modification process
GO:0006513--P:protein monoubiquitination
GO:0016567--P:protein ubiquitination
GO:0006508--P:proteolysis
GO:0010506--P:regulation of autophagy
GO:0014066--P:regulation of phosphatidylinositol 3-kinase signaling
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0016032--P:viral process

KEGG

hsa:25827

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000558	Aegilops tauschii	29.30	1.00e-24	107.00
IUUC-Aml-001591	Ailuropoda melanoleuca	98.58	0.00e+00	840.00
IUUC-Atr-002443	Amborella trichopoda	31.48	5.00e-37	148.00
IUUC-Apl-004140	Anas platyrhynchos	91.04	0.00e+00	765.00
IUUC-Aly-006077	Arabidopsis lyrata	28.45	1.00e-36	148.00
IUUC-Ath-007544	Arabidopsis thaliana	28.45	1.00e-36	148.00
IUUC-Acl-008241	Aspergillus clavatus	29.09	8.00e-41	162.00
IUUC-Afl-008737	Aspergillus flavus	30.37	2.00e-39	157.00
IUUC-Ani-009150	Aspergillus nidulans	27.65	2.00e-34	141.00
IUUC-Ang-009576	Aspergillus niger	30.22	1.00e-41	164.00
IUUC-Aor-010026	Aspergillus oryzae	30.37	2.00e-39	157.00
IUUC-Ate-010557	Aspergillus terreus	29.03	1.00e-42	168.00
IUUC-Ame-011331	Astyanax mexicanus	81.28	0.00e+00	723.00
IUUC-Bgr-012170	Blumeria graminis	30.05	1.00e-36	147.00
IUUC-Bta-013330	Bos taurus	95.27	0.00e+00	725.00
IUUC-Bol-016123	Brassica oleracea	31.60	2.00e-38	153.00
IUUC-Bra-017999	Brassica rapa	30.46	3.00e-38	152.00
IUUC-Cja-019372	Callithrix jacchus	95.31	0.00e+00	773.00
IUUC-Cfa-020668	Canis familiaris	99.05	0.00e+00	842.00
IUUC-Cpo-022092	Cavia porcellus	95.26	0.00e+00	806.00
IUUC-Cre-022929	Chlamydomonas reinhardtii	27.31	3.00e-07	49.70
IUUC-Csa-023598	Chlorocebus sabaeus	99.76	0.00e+00	849.00
IUUC-Cho-024787	Choloepus hoffmanni	92.89	0.00e+00	772.00
IUUC-Cgl-026536	Colletotrichum gloeosporioides	29.85	8.00e-40	158.00
IUUC-Dre-028795	Danio rerio	80.81	0.00e+00	723.00
IUUC-Dno-030049	Dasypus novemcinctus	93.84	0.00e+00	800.00
IUUC-Dor-030749	Dipodomys ordii	73.56	6.00e-115	407.00
IUUC-Dse-031311	Dothistroma septosporum	28.16	2.00e-34	141.00
IUUC-Ete-033027	Echinops telfairi	85.54	0.00e+00	678.00
IUUC-Eca-033723	Equus caballus	99.29	0.00e+00	842.00
IUUC-Eeu-034930	Erinaceus europaeus	84.36	0.00e+00	697.00
IUUC-Fca-035670	Felis catus	98.34	0.00e+00	838.00
IUUC-Fal-037377	Ficedula albicollis	91.94	0.00e+00	773.00
IUUC-Fox-037979	Fusarium oxysporum	28.70	6.00e-40	159.00
IUUC-Fso-038098	Fusarium solani	28.83	1.00e-40	161.00
IUUC-Gmo-038722	Gadus morhua	80.09	0.00e+00	714.00
IUUC-Gga-040836	Gallus gallus	90.52	0.00e+00	759.00
IUUC-Gac-041367	Gasterosteus aculeatus	80.57	0.00e+00	716.00
IUUC-Ggo-044534	Gorilla gorilla	100.00	0.00e+00	849.00
IUUC-Hvu-047491	Hordeum vulgare	29.70	1.00e-31	130.00
IUUC-Kpa-049356	Komagataella pastoris	29.88	1.00e-32	134.00
IUUC-Lch-050194	Latimeria chalumnae	83.41	0.00e+00	712.00
IUUC-Loc-052267	Lepisosteus oculatus	83.65	0.00e+00	744.00
IUUC-Lma-052999	Leptosphaeria maculans	27.43	2.00e-37	151.00
IUUC-Laf-053965	Loxodonta africana	92.96	0.00e+00	791.00
IUUC-Mcc-055012	Macaca mulatta	99.76	0.00e+00	849.00
IUUC-Mor-057009	Magnaporthe oryzae	28.61	2.00e-32	134.00
IUUC-Mtr-057762	Medicago truncatula	31.58	7.00e-39	154.00
IUUC-Mga-059494	Meleagris gallopavo	90.09	0.00e+00	753.00
IUUC-Mmr-061409	Microcebus murinus	99.76	0.00e+00	848.00
IUUC-Mmu-063281	Mus musculus	95.98	0.00e+00	828.00
IUUC-Mac-064776	Musa acuminata	31.37	1.00e-35	144.00
IUUC-Mpu-065900	Mustela putorius furo	99.05	0.00e+00	844.00
IUUC-Mlu-067809	Myotis lucifugus	97.16	0.00e+00	825.00
IUUC-Ncr-068681	Neurospora crassa	28.99	1.00e-29	125.00
IUUC-Nle-069953	Nomascus leucogenys	100.00	0.00e+00	849.00
IUUC-Opr-070495	Ochotona princeps	85.31	0.00e+00	715.00
IUUC-Oan-072994	Ornithorhynchus anatinus	90.28	0.00e+00	757.00
IUUC-Osa-085630	Oryza sativa	31.76	3.00e-32	134.00
IUUC-Oga-088914	Otolemur garnettii	99.50	0.00e+00	801.00
IUUC-Oar-089424	Ovis aries	90.64	0.00e+00	691.00
IUUC-Ptr-090892	Pan troglodytes	100.00	0.00e+00	849.00
IUUC-Pan-092497	Papio anubis	99.76	0.00e+00	849.00
IUUC-Pno-095080	Phaeosphaeria nodorum	29.13	1.00e-38	155.00
IUUC-Ppa-095706	Physcomitrella patens	30.11	3.00e-35	143.00
IUUC-Pab-097772	Pongo abelii	100.00	0.00e+00	849.00
IUUC-Pop-100090	Populus trichocarpa	32.43	8.00e-31	129.00
IUUC-Pca-100518	Procavia capensis	80.09	0.00e+00	644.00
IUUC-Pva-102623	Pteropus vampyrus	97.87	0.00e+00	834.00
IUUC-Pte-104289	Pyrenophora teres	28.40	2.00e-40	160.00
IUUC-Pyt-104761	Pyrenophora triticirepentis	28.40	9.00e-40	158.00
IUUC-Rno-105398	Rattus norvegicus	95.74	0.00e+00	825.00
IUUC-Smo-109364	Selaginella moellendorffii	31.56	1.00e-36	147.00
IUUC-Sit-110254	Setaria italica	30.53	2.00e-36	147.00
IUUC-Tgu-117483	Taeniopygia guttata	91.23	0.00e+00	769.00
IUUC-Tsy-119215	Tarsius syrichta	89.10	0.00e+00	745.00
IUUC-Tre-122101	Trichoderma reesei	29.98	2.00e-37	150.00
IUUC-Tvi-122616	Trichoderma virens	30.41	8.00e-41	162.00
IUUC-Tur-126305	Triticum urartu	30.30	4.00e-33	136.00
IUUC-Tme-127127	Tuber melanosporum	29.78	1.00e-40	161.00
IUUC-Tbe-128062	Tupaia belangeri	95.01	0.00e+00	798.00
IUUC-Ttr-129221	Tursiops truncatus	90.28	0.00e+00	719.00
IUUC-Vda-129798	Verticillium dahliae	29.10	2.00e-37	151.00
IUUC-Vpa-130791	Vicugna pacos	89.34	0.00e+00	740.00
IUUC-Xma-133224	Xiphophorus maculatus	81.04	0.00e+00	716.00
IUUC-Yli-134644	Yarrowia lipolytica	28.27	2.00e-29	124.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence