iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000155428.12	ENST00000395244.5	ENSP00000378665.1
ENSG00000155428.12	ENST00000285805.3	ENSP00000285805.3

Annotation

Cancer Mutation
ICGC	COSMIC	CGAP	IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
HPM
DNA & RNA Element
UTRdb	miRTarBase	microRNA	TRANSFAC
RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
OMIM
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18398435

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	1.30e-06	30.4	16	56

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           C+iCle fk+  l l+CgH +++ Cl   + l++   ++ rCP C
   Q: 16   CPICLEVFKE-SLMLQCGHSYCKGCL---VSLSYHLDTKVRCPMC 56
           ********99.899************...5668889********* PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MAWQVSLLEL EDWLQCPICL EVFKESLMLQ CGHSYCKGCL VSLSYHLDTK VRCPMCWQVV 60
DGSSSLPNVS LAWVIEALRL PGDPEPKVCV HHRNPLSLFC EKDQELICGL CGLLGSHQHH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGCATGATG GGGCATGTGC GGGAGCGCCA GGCGGGGCAT GTAACCAGAG CGTGCGGGGC 60
ATGATGGGGC ACGGACATGG GGGGTTAGGT GGGGCACGTA ATTGGAGCTC GCGGGGCAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00643--zf-B_box
PF13445--zf-RING_UBOX

SMART

SM00336--BBOX
SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0008270--F:zinc ion binding

KEGG

hsa:378108

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence