iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tgu-117478

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16

Genbank Nucleotide ID

ABQF01042678

Gene Name

USP16

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTGUG00000013588.1	ENSTGUT00000014150.1	ENSTGUP00000013991.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.00e-82	277.9	195	817

Active Site

Position(s)	Description	Evidence
204	Nucleophile	ECO:0000256\|HAMAP-Rule:MF_03062}
754	Proton acceptor	ECO:0000256\|HAMAP-Rule:MF_03062}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle..........kkkeklneenp...kepkgellkslqklfeelwkskkkavsprellka 76
           +Gl+NlgNtC++N+v+Q Ls++p lrell+e          + +e +  e +    ++ g+l+ +++++++e++++kk++v+p+el+++
   Q: 195  KGLSNLGNTCFFNAVMQNLSQTPVLRELLKEakmpgttikiESPELCMSEPQlikLDQPGPLTLAMHQFVTEMQETKKGVVTPKELFAQ 283
           5******************************87666666654444444433377788899***************************** PP
   S: 77   lkkeaeefsgyeqqDaqEflaflldqleeelkk.....eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecd 160
           ++k+a +f+gy+qqD++E+l++lld+++ e  +       +   ++ ++++++ +++++e++kkk  +s+++++F+g+l+s+i+c+ec+
   Q: 284  VCKKAIRFKGYQQQDSHELLRYLLDGMRAEEIQqisigILKALSDSNKQNEEELKKKIKEYEKKKGIQSFVDRIFGGELTSTIMCEECR 372
           ***************************988866455543333333333333344445599999************************** PP
   S: 161  nvssreepfldlslpvpgkeetkke................................................................ 185
           +vs  +e+fldlslp+ + ++ k++                                                                
   Q: 373  TVSLVHESFLDLSLPILDVQKGKNTkrenikknkekesedeedkindhylkqkyephgtskhlqkktkkqakkkaksqrhqeklkgkml 461
           *****************99998888999************************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 462  hltdlctteqpeidvdcnresetemssetldkkpeeessddckdrcltqkdlsiqgnsteiqsrdenagkteqeceenelrfsyevcqw 550
           ***************************************************************************************** PP
   S: 186  ...............................................................................slqdcLesft 195
                                                                                          s+++cL +ft
   Q: 551  piffsldnlslkeeddneeeeelatdfsklhlgasdtsdtstldglqpvpnktcevstddpetafctlanreelnpeedSIHHCLYQFT 639
           ***************************************************************************************** PP
   S: 196  keeelegenkyycekckkkqe...............aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspe 269
           ++e+l++ nk+ c+ c+++                 a+k++ ++  P++L+lhLkRf  ++++ + +k+n++++fp+ +dl+pfct ++
   Q: 640  RNETLTETNKLLCDVCTQRHCgpknnisekkyvytnAKKQMLISLAPPILTLHLKRF--QQAGFNLQKVNRHIKFPEVIDLAPFCTAKC 726
           *****************7777888888888888888*********************..9999************************99 PP
   S: 270  ekqke...kkkYeLiavvvHsGslssGHYvayvkn.......................ekgkWllfdDskVtevkeeevleetgstaYv 332
           ++++e   k+ Y+L++vv HsG+++sGHY+ayvk                         kg+W++++D++V++v+ ++vl+   s+aY+
   Q: 727  KNVAEgntKVLYSLYGVVEHSGTMRSGHYTAYVKMramnnhlsdlvlrgksqasetepVKGQWFHISDTHVQPVSVSKVLS---SQAYL 812
           999888889**************************999999999998888888877777999*******************...***** PP
   S: 333  lfYkr 337
           lfY+r
   Q: 813  LFYER 817
           ***98 PP

Organism

Taeniopygia guttata

Functional Description
(View)

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.

Protein Sequence
(Fasta)

MGKKRIKGRT AQSDESPDRL KPVCNHIRKG LDQGHVRKAL QNVEWHVCQD CKADSKTQEK 60
AEEEETDEGT SIWLCLKCGH RGCDRNSPDQ HALKHFKTPR SDPHCLVLNL DSWSVWCYLC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGCAAGA AACGTATCAA AGGCAGAACT GCACAGTCCG ATGAGTCTCC GGATAGACTG 60
AGTATGTTTC CTTGGAGAAG TTTGTGGACC TAATGTTTCT TTTAACCTCA GAGAAGGCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0016578--P:histone deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000997	Aegilops tauschii	29.63	4.00e-28	120.00
IUUC-Aml-001931	Ailuropoda melanoleuca	59.38	0.00e+00	857.00
IUUC-Atr-003015	Amborella trichopoda	30.70	8.00e-34	139.00
IUUC-Apl-004145	Anas platyrhynchos	76.48	0.00e+00	1089.00
IUUC-Aca-004314	Anolis carolinensis	59.91	0.00e+00	847.00
IUUC-Ame-011659	Astyanax mexicanus	46.62	1.00e-97	350.00
IUUC-Bta-013362	Bos taurus	59.83	0.00e+00	850.00
IUUC-Bdi-014624	Brachypodium distachyon	30.77	1.00e-28	121.00
IUUC-Bol-015941	Brassica oleracea	30.08	5.00e-31	129.00
IUUC-Cja-019177	Callithrix jacchus	61.10	0.00e+00	860.00
IUUC-Cfa-020051	Canis familiaris	59.21	0.00e+00	854.00
IUUC-Cpo-021886	Cavia porcellus	58.06	0.00e+00	839.00
IUUC-Csa-024103	Chlorocebus sabaeus	60.79	0.00e+00	855.00
IUUC-Cho-024315	Choloepus hoffmanni	56.05	1.00e-70	260.00
IUUC-Cin-025775	Ciona intestinalis	48.23	2.00e-38	150.00
IUUC-Csv-026075	Ciona savignyi	49.75	5.00e-53	202.00
IUUC-Dre-028388	Danio rerio	51.56	4.00e-103	369.00
IUUC-Dno-029409	Dasypus novemcinctus	59.23	0.00e+00	862.00
IUUC-Dor-030443	Dipodomys ordii	57.34	2.00e-105	376.00
IUUC-Dse-031252	Dothistroma septosporum	29.19	7.00e-12	65.50
IUUC-Ete-032807	Echinops telfairi	59.67	2.00e-127	449.00
IUUC-Eca-033479	Equus caballus	60.00	0.00e+00	862.00
IUUC-Eeu-034835	Erinaceus europaeus	51.40	6.00e-95	341.00
IUUC-Fca-036320	Felis catus	59.50	0.00e+00	865.00
IUUC-Fal-037029	Ficedula albicollis	89.96	0.00e+00	1308.00
IUUC-Gmo-039480	Gadus morhua	47.32	2.00e-99	356.00
IUUC-Gga-040527	Gallus gallus	75.49	0.00e+00	1080.00
IUUC-Gac-042343	Gasterosteus aculeatus	47.07	8.00e-102	364.00
IUUC-Gma-043919	Glycine max	29.24	6.00e-35	142.00
IUUC-Ggo-045598	Gorilla gorilla	60.98	0.00e+00	855.00
IUUC-Hsa-046598	Homo sapiens	60.94	0.00e+00	855.00
IUUC-Hvu-047146	Hordeum vulgare	31.78	5.00e-29	122.00
IUUC-Itr-047951	Ictidomys tridecemlineatus	59.45	0.00e+00	851.00
IUUC-Lch-050536	Latimeria chalumnae	54.15	6.00e-112	398.00
IUUC-Lpe-050703	Leersia perrieri	29.94	9.00e-30	125.00
IUUC-Loc-051814	Lepisosteus oculatus	53.40	2.00e-110	392.00
IUUC-Laf-053732	Loxodonta africana	58.60	0.00e+00	837.00
IUUC-Mcc-054661	Macaca mulatta	60.91	0.00e+00	857.00
IUUC-Meu-055967	Macropus eugenii	59.60	1.00e-120	427.00
IUUC-Mtr-057945	Medicago truncatula	31.02	2.00e-36	147.00
IUUC-Mga-059551	Meleagris gallopavo	74.97	0.00e+00	1106.00
IUUC-Mvi-060391	Microbotryum violaceum	31.38	2.00e-17	84.70
IUUC-Mmr-061747	Microcebus murinus	59.51	0.00e+00	826.00
IUUC-Mdo-062220	Monodelphis domestica	58.37	0.00e+00	825.00
IUUC-Mmu-063582	Mus musculus	58.40	0.00e+00	826.00
IUUC-Mac-064941	Musa acuminata	34.77	1.00e-37	150.00
IUUC-Mpu-066339	Mustela putorius furo	59.06	0.00e+00	857.00
IUUC-Mlu-067511	Myotis lucifugus	59.52	0.00e+00	833.00
IUUC-Nle-069252	Nomascus leucogenys	61.15	0.00e+00	857.00
IUUC-Opr-070969	Ochotona princeps	56.76	0.00e+00	787.00
IUUC-Ont-071786	Oreochromis niloticus	48.15	3.00e-103	369.00
IUUC-Ocu-074704	Oryctolagus cuniculus	60.17	0.00e+00	826.00
IUUC-Oba-075094	Oryza barthii	30.56	2.00e-30	127.00
IUUC-Obr-076743	Oryza brachyantha	29.94	2.00e-29	124.00
IUUC-Ogl-077739	Oryza glaberrima	30.56	9.00e-31	128.00
IUUC-Ogu-078851	Oryza glumaepatula	30.56	2.00e-30	128.00
IUUC-Oin-079402	Oryza indica	30.56	1.00e-30	128.00
IUUC-Olo-080431	Oryza longistaminata	30.56	1.00e-30	128.00
IUUC-Ome-081580	Oryza meridionalis	30.25	2.00e-30	127.00
IUUC-Oni-082644	Oryza nivara	30.56	1.00e-30	128.00
IUUC-Opu-083452	Oryza punctata	30.12	9.00e-31	128.00
IUUC-Oru-084546	Oryza rufipogon	30.56	2.00e-30	127.00
IUUC-Osa-085858	Oryza sativa	30.56	2.00e-30	128.00
IUUC-Ola-086795	Oryzias latipes	45.15	8.00e-98	351.00
IUUC-Oga-088713	Otolemur garnettii	60.48	0.00e+00	843.00
IUUC-Oar-089887	Ovis aries	59.88	0.00e+00	852.00
IUUC-Ptr-091670	Pan troglodytes	61.22	0.00e+00	856.00
IUUC-Pan-092293	Papio anubis	60.91	0.00e+00	857.00
IUUC-Psi-093101	Pelodiscus sinensis	63.90	0.00e+00	914.00
IUUC-Pab-098773	Pongo abelii	61.28	0.00e+00	655.00
IUUC-Pop-099136	Populus trichocarpa	30.73	6.00e-40	159.00
IUUC-Pca-101069	Procavia capensis	51.70	2.00e-95	343.00
IUUC-Ppe-101794	Prunus persica	31.40	6.00e-36	145.00
IUUC-Pva-103092	Pteropus vampyrus	54.71	4.00e-102	365.00
IUUC-Rno-105237	Rattus norvegicus	56.87	0.00e+00	816.00
IUUC-Sha-106889	Sarcophilus harrisii	60.48	0.00e+00	857.00
IUUC-Sit-110283	Setaria italica	31.21	4.00e-30	126.00
IUUC-Sly-111491	Solanum lycopersicum	29.85	6.00e-36	145.00
IUUC-Stu-112820	Solanum tuberosum	31.88	7.00e-38	152.00
IUUC-Sar-113530	Sorex araneus	58.74	0.00e+00	833.00
IUUC-Sbi-113785	Sorghum bicolor	37.16	8.00e-24	105.00
IUUC-Ssc-116091	Sus scrofa	59.67	0.00e+00	850.00
IUUC-Tru-118640	Takifugu rubripes	48.57	3.00e-103	369.00
IUUC-Tsy-119042	Tarsius syrichta	51.58	2.00e-149	522.00
IUUC-Tni-120015	Tetraodon nigroviridis	47.71	1.00e-100	360.00
IUUC-Tca-121701	Theobroma cacao	31.21	2.00e-35	144.00
IUUC-Tae-125785	Triticum aestivum	30.12	5.00e-28	119.00
IUUC-Tur-126788	Triticum urartu	29.81	8.00e-28	119.00
IUUC-Tbe-127309	Tupaia belangeri	60.06	2.00e-93	336.00
IUUC-Ttr-128271	Tursiops truncatus	60.19	0.00e+00	835.00
IUUC-Vpa-130674	Vicugna pacos	58.29	0.00e+00	759.00
IUUC-Xtr-131869	Xenopus tropicalis	54.62	4.00e-120	425.00
IUUC-Xma-134195	Xiphophorus maculatus	48.71	6.00e-107	381.00
IUUC-Zma-135157	Zea mays	30.22	2.00e-26	114.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence