iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000156374.14	ENST00000337211.8	ENSP00000338845.4
ENSG00000156374.14	ENST00000369847.3	ENSP00000358862.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM	SZDB
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UDP/UFD/RAWUL	RAWUL	17320162; 18588675

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.00071	21.7	134	173
ULD/UDP/UFD/RAWUL	1.90e-20	74.8	253	340

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC+  + d + ++ C H+f+++C+ +        + + rCP C+
   Q: 134  CSICKGYLIDATTITECLHTFCKSCIVRH------FYYSNRCPKCN 173
           ********99999*************555......689999**996 PP

ULD/UDP/UFD/RAWUL

   S: 1    islsLeplesnkakddsk.lkkkylrcsarltVkhlkkflaeklklsssyevdllcedevLednetLeeikyifiwk..kegpLvLqY 85
           +sl Le++ +n+ ++++k l+kk++r+s+++t++h++kfl++k+ l+++++vd++c d++Le+++tL+ei++++ +   ++g LvL+Y
   Q: 253  MSLLLEFIGANEGTGHFKpLEKKFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLEQYQTLREIRRAIGDAamQDGLLVLHY 340
           799*******************************************************************9999988899******** PP

Organism

Homo sapiens

Functional Description
(View)

Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Protein Sequence
(Fasta)

MEGVAVVTAG SVGAAKTEGA AALPPPPPVS PPALTPAPAA GEEGPAPLSE TGAPGCSGSR 60
PPELEPERSL GRFRGRFEDE DEELEEEEEL EEEEEEEEED MSHFSLRLEG GRQDSEDEEE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGTCCGAG GCCGGCCGAA CTCCCGCGCT CTCCCGCCGC CTCGCCTCGC CTGGTGTCTC 60
TCCCGACCAT GGAGGGGGTC GCGGTGGTGA CGGCGGGCAG CGTAGGCGCT GCCAAAACCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR029071--Ubiquitin-rel_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0035102--C:PRC1 complex
GO:0003677--F:DNA binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0001227--F:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:84108

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001804	Ailuropoda melanoleuca	98.30	6.00e-155	540.00
IUUC-Apl-003651	Anas platyrhynchos	89.52	2.00e-120	424.00
IUUC-Aca-005303	Anolis carolinensis	83.24	9.00e-86	309.00
IUUC-Ath-007327	Arabidopsis thaliana	49.25	8.00e-12	65.10
IUUC-Ame-011707	Astyanax mexicanus	62.93	1.00e-85	309.00
IUUC-Bta-012998	Bos taurus	97.30	7.00e-154	536.00
IUUC-Cja-018814	Callithrix jacchus	99.67	6.00e-151	526.00
IUUC-Cfa-020385	Canis familiaris	98.31	3.00e-156	544.00
IUUC-Cpo-021535	Cavia porcellus	91.53	9.00e-145	506.00
IUUC-Csa-023795	Chlorocebus sabaeus	99.67	6.00e-162	563.00
IUUC-Cho-024728	Choloepus hoffmanni	62.57	4.00e-80	291.00
IUUC-Dre-028499	Danio rerio	60.76	3.00e-82	298.00
IUUC-Dno-029702	Dasypus novemcinctus	98.80	2.00e-142	497.00
IUUC-Ete-032808	Echinops telfairi	92.20	2.00e-132	464.00
IUUC-Eca-033860	Equus caballus	95.95	2.00e-149	521.00
IUUC-Eeu-035280	Erinaceus europaeus	88.86	4.00e-146	510.00
IUUC-Fca-036544	Felis catus	99.60	4.00e-147	513.00
IUUC-Fal-037301	Ficedula albicollis	91.67	3.00e-116	411.00
IUUC-Gmo-038862	Gadus morhua	54.55	2.00e-58	218.00
IUUC-Gga-040130	Gallus gallus	91.30	7.00e-117	413.00
IUUC-Gac-041439	Gasterosteus aculeatus	56.57	8.00e-62	229.00
IUUC-Ggo-045646	Gorilla gorilla	88.31	8.00e-137	479.00
IUUC-Itr-048489	Ictidomys tridecemlineatus	96.61	5.00e-154	536.00
IUUC-Lch-049961	Latimeria chalumnae	79.86	7.00e-59	220.00
IUUC-Loc-052192	Lepisosteus oculatus	66.22	3.00e-84	305.00
IUUC-Laf-053828	Loxodonta africana	98.40	2.00e-142	498.00
IUUC-Mcc-055235	Macaca mulatta	100.00	5.00e-161	560.00
IUUC-Meu-056696	Macropus eugenii	94.51	2.00e-79	288.00
IUUC-Mmr-060686	Microcebus murinus	97.01	9.00e-147	512.00
IUUC-Mdo-062342	Monodelphis domestica	88.85	2.00e-134	472.00
IUUC-Mmu-063449	Mus musculus	94.02	3.00e-152	531.00
IUUC-Mpu-065971	Mustela putorius furo	98.31	2.00e-156	545.00
IUUC-Mlu-068172	Myotis lucifugus	96.27	3.00e-152	531.00
IUUC-Nle-070080	Nomascus leucogenys	81.61	2.00e-135	474.00
IUUC-Oan-073170	Ornithorhynchus anatinus	92.75	1.00e-63	234.00
IUUC-Ocu-074478	Oryctolagus cuniculus	95.29	5.00e-153	533.00
IUUC-Opu-083660	Oryza punctata	46.38	2.00e-11	63.50
IUUC-Ola-086801	Oryzias latipes	63.68	3.00e-85	308.00
IUUC-Oga-088951	Otolemur garnettii	96.18	5.00e-137	480.00
IUUC-Oar-089539	Ovis aries	96.28	1.00e-151	529.00
IUUC-Ptr-090745	Pan troglodytes	100.00	2.00e-162	564.00
IUUC-Pan-091899	Papio anubis	100.00	5.00e-161	560.00
IUUC-Psi-092970	Pelodiscus sinensis	85.78	8.00e-104	369.00
IUUC-Pma-094764	Petromyzon marinus	54.26	8.00e-69	253.00
IUUC-Pfo-096092	Poecilia formosa	60.78	5.00e-82	297.00
IUUC-Pab-098230	Pongo abelii	99.67	3.00e-161	561.00
IUUC-Pca-101116	Procavia capensis	81.71	4.00e-122	431.00
IUUC-Pva-102607	Pteropus vampyrus	86.82	1.00e-116	412.00
IUUC-Rno-106016	Rattus norvegicus	93.69	3.00e-145	508.00
IUUC-Smo-109158	Selaginella moellendorffii	42.31	1.00e-11	64.70
IUUC-Sbi-114041	Sorghum bicolor	44.87	7.00e-13	66.60
IUUC-Tgu-116601	Taeniopygia guttata	91.23	9.00e-116	409.00
IUUC-Tru-117540	Takifugu rubripes	55.47	2.00e-41	160.00
IUUC-Tni-120638	Tetraodon nigroviridis	56.20	2.00e-42	164.00
IUUC-Tbe-127300	Tupaia belangeri	71.98	8.00e-89	319.00
IUUC-Ttr-129281	Tursiops truncatus	92.43	5.00e-148	516.00
IUUC-Vpa-130504	Vicugna pacos	98.70	3.00e-130	457.00
IUUC-Xtr-132184	Xenopus tropicalis	77.43	3.00e-104	370.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence