iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000157911.9	ENST00000288774.7	ENSP00000288774.3
ENSG00000157911.9	ENST00000447513.6	ENSP00000407922.2
ENSG00000157911.9	ENST00000507596.5	ENSP00000424291.1
ENSG00000157911.9	ENST00000510434.1	ENSP00000423051.1
ENSG00000157911.9	ENST00000514502.1	ENSP00000425924.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Information
ClinVar	GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19687296; 18644345

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	8.10e-07	31.1	273	311

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C +Cle+ ++ p  +pCgH+f+ +C+ +w       s ++ CPlCr
   Q: 273  CTLCLEERRH-PTATPCGHLFCWECITAW------CSSKAECPLCR 311
           9*******88.999***************......999999****8 PP

Organism

Homo sapiens

Functional Description
(View)

Interacts with PEX19.

Protein Sequence
(Fasta)

MAPAAASPPE VIRAAQKDEY YRGGLRSAAG GALHSLAGAR KWLEWRKEVE LLSDVAYFGL 60
TTLAGYQTLG EEYVSIIQVD PSRIHVPSSL RRGVLVTLHA VLPYLLDKAL LPLEQELQAD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCACAGCTG AGCTCCTGTA GATGGAACCA GAGGTGAGGC AAGGAACTGG AGGCCCTCCC 60
CACTGAGGTC AGCGGGGCGC AGACGCCCCC TTGTCGTGCC CTGCCTTCCT CCTGCAATCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0472--Membrane
KW-0479--Metal-binding
KW-0576--Peroxisome
KW-0962--Peroxisome biogenesis
KW-0958--Peroxisome biogenesis disorder
KW-1185--Reference proteome
KW-0861--Zellweger syndrome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR025654--PEX10
IPR006845--Pex_N
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF04757--Pex2_Pex12

SMART

SM00184--RING

Gene Ontology

GO:0005779--C:integral component of peroxisomal membrane
GO:0005622--C:intracellular
GO:0005778--C:peroxisomal membrane
GO:0005777--C:peroxisome
GO:0008022--F:protein C-terminus binding
GO:0008270--F:zinc ion binding
GO:0007031--P:peroxisome organization
GO:0016558--P:protein import into peroxisome matrix

KEGG

hsa:5192

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002056	Ailuropoda melanoleuca	80.31	4.00e-112	397.00
IUUC-Atr-003000	Amborella trichopoda	39.81	4.00e-16	79.30
IUUC-Apl-003238	Anas platyrhynchos	58.42	8.00e-98	350.00
IUUC-Aly-006189	Arabidopsis lyrata	31.42	1.00e-38	154.00
IUUC-Ath-007024	Arabidopsis thaliana	32.12	8.00e-40	157.00
IUUC-Ago-007728	Ashbya gossypii	25.57	2.00e-18	86.70
IUUC-Acl-008372	Aspergillus clavatus	26.91	1.00e-30	127.00
IUUC-Afl-008450	Aspergillus flavus	28.00	5.00e-35	141.00
IUUC-Afu-009049	Aspergillus fumigatus	27.97	2.00e-31	129.00
IUUC-Ani-009256	Aspergillus nidulans	27.20	9.00e-33	134.00
IUUC-Ang-009867	Aspergillus niger	25.77	6.00e-30	125.00
IUUC-Aor-010008	Aspergillus oryzae	28.00	5.00e-35	141.00
IUUC-Ate-010548	Aspergillus terreus	28.61	3.00e-34	139.00
IUUC-Ame-011719	Astyanax mexicanus	52.92	2.00e-92	332.00
IUUC-Bgr-012234	Blumeria graminis	28.26	9.00e-20	91.30
IUUC-Bci-013613	Botrytis cinerea	27.40	3.00e-24	105.00
IUUC-Bdi-015068	Brachypodium distachyon	28.65	1.00e-35	144.00
IUUC-Bol-016320	Brassica oleracea	33.52	1.00e-41	164.00
IUUC-Bra-018029	Brassica rapa	29.91	8.00e-27	114.00
IUUC-Cja-019237	Callithrix jacchus	90.18	6.00e-141	493.00
IUUC-Cfa-020353	Canis familiaris	74.35	4.00e-58	218.00
IUUC-Cpo-022370	Cavia porcellus	81.06	1.00e-120	426.00
IUUC-Cre-022661	Chlamydomonas reinhardtii	55.77	5.00e-15	74.30
IUUC-Csa-023279	Chlorocebus sabaeus	95.09	5.00e-140	490.00
IUUC-Cgl-026468	Colletotrichum gloeosporioides	56.86	8.00e-14	70.10
IUUC-Cne-026965	Cryptococcus neoformans	29.28	1.00e-15	77.00
IUUC-Cme-027215	Cyanidioschyzon merolae	48.78	2.00e-09	57.00
IUUC-Dre-027835	Danio rerio	52.29	2.00e-91	328.00
IUUC-Dno-029561	Dasypus novemcinctus	76.07	3.00e-100	358.00
IUUC-Dor-030772	Dipodomys ordii	73.98	2.00e-114	405.00
IUUC-Dse-031244	Dothistroma septosporum	31.03	3.00e-23	102.00
IUUC-Dme-031760	Drosophila melanogaster	30.86	5.00e-40	157.00
IUUC-Ete-032976	Echinops telfairi	65.97	8.00e-54	204.00
IUUC-Eca-034245	Equus caballus	80.41	4.00e-127	447.00
IUUC-Eeu-034911	Erinaceus europaeus	63.91	2.00e-98	352.00
IUUC-Fca-035785	Felis catus	69.14	4.00e-112	397.00
IUUC-Fal-036609	Ficedula albicollis	61.71	4.00e-101	361.00
IUUC-Fso-038131	Fusarium solani	27.67	2.00e-24	106.00
IUUC-Gmo-039623	Gadus morhua	54.15	2.00e-95	342.00
IUUC-Ggr-040036	Gaeumannomyces graminis	56.86	1.00e-13	71.20
IUUC-Gga-040589	Gallus gallus	58.28	5.00e-117	414.00
IUUC-Gac-041474	Gasterosteus aculeatus	54.32	7.00e-91	327.00
IUUC-Gma-043204	Glycine max	28.77	2.00e-35	143.00
IUUC-Ggo-044851	Gorilla gorilla	92.49	7.00e-151	526.00
IUUC-Hvu-047776	Hordeum vulgare	55.56	5.00e-12	63.50
IUUC-Itr-048857	Ictidomys tridecemlineatus	85.09	1.00e-112	399.00
IUUC-Kpa-049246	Komagataella pastoris	48.65	5.00e-06	47.00
IUUC-Lch-049916	Latimeria chalumnae	55.45	5.00e-96	344.00
IUUC-Lpe-051012	Leersia perrieri	30.12	3.00e-38	152.00
IUUC-Loc-051752	Lepisosteus oculatus	56.19	2.00e-92	332.00
IUUC-Lma-053179	Leptosphaeria maculans	32.24	9.00e-19	87.80
IUUC-Laf-053371	Loxodonta africana	71.08	1.00e-128	452.00
IUUC-Mcc-055582	Macaca mulatta	89.60	3.00e-136	477.00
IUUC-Meu-056560	Macropus eugenii	70.43	5.00e-121	427.00
IUUC-Mor-056982	Magnaporthe oryzae	58.82	5.00e-14	72.40
IUUC-Mpo-057519	Magnaporthe poae	56.86	1.00e-13	69.30
IUUC-Mtr-058245	Medicago truncatula	29.54	2.00e-35	143.00
IUUC-Mga-059233	Meleagris gallopavo	58.05	2.00e-107	382.00
IUUC-Mvi-060286	Microbotryum violaceum	33.95	3.00e-31	129.00
IUUC-Mmr-060841	Microcebus murinus	83.78	1.00e-113	402.00
IUUC-Mdo-061896	Monodelphis domestica	66.19	1.00e-115	409.00
IUUC-Mmu-063986	Mus musculus	82.97	1.00e-112	399.00
IUUC-Mac-064785	Musa acuminata	28.73	1.00e-34	140.00
IUUC-Mpu-065978	Mustela putorius furo	77.35	2.00e-103	369.00
IUUC-Mlu-067613	Myotis lucifugus	63.00	5.00e-83	300.00
IUUC-Nfi-068271	Neosartorya fischeri	28.25	1.00e-32	133.00
IUUC-Ncr-068697	Neurospora crassa	55.77	4.00e-14	72.40
IUUC-Nle-069662	Nomascus leucogenys	92.20	3.00e-150	524.00
IUUC-Opr-070595	Ochotona princeps	75.23	3.00e-99	354.00
IUUC-Ont-072321	Oreochromis niloticus	57.93	2.00e-99	355.00
IUUC-Oan-072739	Ornithorhynchus anatinus	70.85	1.00e-105	375.00
IUUC-Oba-075983	Oryza barthii	28.90	5.00e-31	129.00
IUUC-Obr-076297	Oryza brachyantha	28.57	3.00e-31	129.00
IUUC-Ogl-077266	Oryza glaberrima	28.85	3.00e-34	139.00
IUUC-Oin-079246	Oryza indica	28.85	3.00e-34	139.00
IUUC-Oni-082408	Oryza nivara	28.86	7.00e-31	129.00
IUUC-Oru-084691	Oryza rufipogon	28.86	2.00e-30	128.00
IUUC-Osa-085301	Oryza sativa	28.85	3.00e-34	139.00
IUUC-Ola-087206	Oryzias latipes	54.51	2.00e-71	262.00
IUUC-Olu-087804	Ostreococcus lucimarinus	28.25	8.00e-23	101.00
IUUC-Oga-088763	Otolemur garnettii	84.66	3.00e-122	431.00
IUUC-Oar-090235	Ovis aries	72.87	1.00e-100	359.00
IUUC-Ptr-091507	Pan troglodytes	98.47	3.00e-134	471.00
IUUC-Pan-091920	Papio anubis	95.09	2.00e-139	488.00
IUUC-Pno-095101	Phaeosphaeria nodorum	28.46	3.00e-29	122.00
IUUC-Ppa-095462	Physcomitrella patens	32.02	9.00e-29	121.00
IUUC-Pfo-097220	Poecilia formosa	52.28	3.00e-81	295.00
IUUC-Pab-098149	Pongo abelii	96.01	2.00e-144	505.00
IUUC-Pop-098873	Populus trichocarpa	29.08	3.00e-36	145.00
IUUC-Pca-100244	Procavia capensis	78.95	2.00e-38	152.00
IUUC-Ppe-101364	Prunus persica	31.58	4.00e-40	159.00
IUUC-Pgr-103455	Puccinia graminis	33.04	4.00e-19	89.40
IUUC-Ptt-103786	Puccinia triticina	41.03	4.00e-06	42.70
IUUC-Pte-104170	Pyrenophora teres	31.16	7.00e-15	75.10
IUUC-Pyt-104531	Pyrenophora triticirepentis	31.34	1.00e-14	73.90
IUUC-Rno-105929	Rattus norvegicus	84.83	3.00e-110	391.00
IUUC-Sce-106361	Saccharomyces cerevisiae	23.71	6.00e-24	104.00
IUUC-Sha-106867	Sarcophilus harrisii	62.80	2.00e-102	364.00
IUUC-Sja-107981	Schizosaccharomyces japonicus	27.88	3.00e-16	79.00
IUUC-Spo-108312	Schizosaccharomyces pombe	55.56	4.00e-14	72.00
IUUC-Ssl-108393	Sclerotinia sclerotiorum	27.95	6.00e-29	121.00
IUUC-Sit-109899	Setaria italica	28.33	1.00e-31	130.00
IUUC-Sly-111809	Solanum lycopersicum	29.97	7.00e-38	151.00
IUUC-Stu-112440	Solanum tuberosum	28.77	7.00e-38	151.00
IUUC-Sbi-114846	Sorghum bicolor	28.37	6.00e-34	138.00
IUUC-Sre-115184	Sporisorium reilianum	26.26	3.00e-15	76.60
IUUC-Ssc-115730	Sus scrofa	76.69	7.00e-136	476.00
IUUC-Tgu-116534	Taeniopygia guttata	61.92	2.00e-103	369.00
IUUC-Tru-118341	Takifugu rubripes	46.77	1.00e-76	279.00
IUUC-Tni-120642	Tetraodon nigroviridis	49.85	2.00e-87	315.00
IUUC-Tca-121102	Theobroma cacao	29.86	1.00e-40	160.00
IUUC-Tre-121931	Trichoderma reesei	29.56	6.00e-18	85.10
IUUC-Tvi-122477	Trichoderma virens	29.22	3.00e-33	135.00
IUUC-Tae-124781	Triticum aestivum	28.53	3.00e-27	115.00
IUUC-Tme-127099	Tuber melanosporum	28.82	1.00e-26	113.00
IUUC-Ttr-129156	Tursiops truncatus	72.30	6.00e-125	440.00
IUUC-Uma-129328	Ustilago maydis	28.09	2.00e-16	80.50
IUUC-Vvi-131549	Vitis vinifera	30.79	2.00e-38	153.00
IUUC-Xtr-131788	Xenopus tropicalis	54.46	1.00e-101	362.00
IUUC-Xma-133828	Xiphophorus maculatus	52.58	2.00e-80	292.00
IUUC-Yli-134363	Yarrowia lipolytica	27.20	6.00e-31	128.00
IUUC-Zma-135178	Zea mays	28.07	5.00e-34	138.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence