iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Post-translational Modifications (PTMs)
dbPAF	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.50e-16	60.5	161	214

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            +++ dye  ++ e+t   Gdvv+v+  e+ + gW+ +  + ++krG +P+ + e l+
   Q: 161  YRAIADYEKGSKTEMTVATGDVVDVV--EKSESGWWFC--QMKTKRGWVPASYLEPLD 214
           678889********************..9999******..7************99886 PP

Organism

Rattus norvegicus

Functional Description
(View)

NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).

Protein Sequence
(Fasta)

MGDTFIRHIA LLGFEKRFVP SQHYVYMFLV KWQDLSEKVV YRKFTEIYEF HKMLKEMFPI 60
EAGEIHTENR VIPHLPAPRW YDGQRAAESR QGTLTEYFNS LMGLPMKISR CPHLLNFFKV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCACTGCCC AGCCATGGGG GACACCTTCA TTCGCCACAT CGCCCTCCTG GGCTTCGAGA 60
AACGCTTCGT CCCCAGCCAA CACTATGTAA GTAGTCCAAG AGTGCCCTGC AGGAGTGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR015039--NADPH_oxidase_p47Phox_C
IPR032136--NECFESHC
IPR001655--P47PHOX
IPR001683--Phox
IPR001452--SH3_domain

PROSITE

PS50195--PX
PS50002--SH3

Pfam

PF16621--NECFESHC
PF08944--p47_phox_C
PF00787--PX
PF00018--SH3_1

PRINTS

PR00498--P47PHOX
PR00452--SH3DOMAIN

SMART

SM00312--PX
SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0019898--C:extrinsic component of membrane
GO:0005794--C:Golgi apparatus
GO:0016020--C:membrane
GO:0043020--C:NADPH oxidase complex
GO:0043025--C:neuronal cell body
GO:0005886--C:plasma membrane
GO:0002102--C:podosome
GO:0005791--C:rough endoplasmic reticulum
GO:0035091--F:phosphatidylinositol binding
GO:0043325--F:phosphatidylinositol-3,4-bisphosphate binding
GO:0016176--F:superoxide-generating NADPH oxidase activator activity
GO:0016175--F:superoxide-generating NADPH oxidase activity
GO:0006915--P:apoptotic process
GO:0071800--P:podosome assembly
GO:0006612--P:protein targeting to membrane
GO:0045730--P:respiratory burst
GO:0042554--P:superoxide anion generation
GO:0006801--P:superoxide metabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001307	Ailuropoda melanoleuca	81.84	0.00e+00	629.00
IUUC-Apl-003633	Anas platyrhynchos	66.75	2.00e-154	538.00
IUUC-Ame-011567	Astyanax mexicanus	59.09	2.00e-132	465.00
IUUC-Bta-013024	Bos taurus	83.42	0.00e+00	656.00
IUUC-Cja-019026	Callithrix jacchus	82.95	0.00e+00	651.00
IUUC-Cfa-020704	Canis familiaris	82.10	0.00e+00	638.00
IUUC-Cpo-021794	Cavia porcellus	81.07	0.00e+00	666.00
IUUC-Csa-023617	Chlorocebus sabaeus	82.86	0.00e+00	654.00
IUUC-Dre-027789	Danio rerio	56.05	2.00e-127	449.00
IUUC-Dno-029091	Dasypus novemcinctus	64.85	3.00e-96	344.00
IUUC-Dor-030695	Dipodomys ordii	74.27	2.00e-86	312.00
IUUC-Eeu-035337	Erinaceus europaeus	74.78	1.00e-142	498.00
IUUC-Fca-035712	Felis catus	71.81	1.00e-154	539.00
IUUC-Fal-036697	Ficedula albicollis	65.82	6.00e-163	566.00
IUUC-Gmo-039060	Gadus morhua	49.11	5.00e-91	327.00
IUUC-Gga-040325	Gallus gallus	66.75	6.00e-161	560.00
IUUC-Gac-042580	Gasterosteus aculeatus	56.02	4.00e-118	417.00
IUUC-Hsa-046017	Homo sapiens	82.10	0.00e+00	648.00
IUUC-Itr-048254	Ictidomys tridecemlineatus	84.91	0.00e+00	704.00
IUUC-Lch-050575	Latimeria chalumnae	58.46	3.00e-135	474.00
IUUC-Loc-052607	Lepisosteus oculatus	61.42	2.00e-122	432.00
IUUC-Mcc-054644	Macaca mulatta	83.12	0.00e+00	656.00
IUUC-Mga-059367	Meleagris gallopavo	65.82	2.00e-161	561.00
IUUC-Mmr-061698	Microcebus murinus	82.86	0.00e+00	640.00
IUUC-Mdo-061949	Monodelphis domestica	74.29	5.00e-174	603.00
IUUC-Mmu-063793	Mus musculus	90.12	0.00e+00	747.00
IUUC-Mpu-066081	Mustela putorius furo	76.79	2.00e-171	594.00
IUUC-Ont-072602	Oreochromis niloticus	54.93	2.00e-130	459.00
IUUC-Ocu-073838	Oryctolagus cuniculus	61.11	1.00e-117	416.00
IUUC-Ola-086427	Oryzias latipes	53.22	1.00e-116	413.00
IUUC-Oga-088639	Otolemur garnettii	85.42	0.00e+00	674.00
IUUC-Oar-089376	Ovis aries	80.49	8.00e-171	592.00
IUUC-Ptr-090689	Pan troglodytes	82.35	0.00e+00	650.00
IUUC-Pan-092800	Papio anubis	83.12	0.00e+00	656.00
IUUC-Psi-093746	Pelodiscus sinensis	69.23	3.00e-169	587.00
IUUC-Pfo-096204	Poecilia formosa	53.37	3.00e-116	411.00
IUUC-Pab-098062	Pongo abelii	80.27	5.00e-179	620.00
IUUC-Pca-100793	Procavia capensis	84.44	0.00e+00	664.00
IUUC-Pva-102363	Pteropus vampyrus	80.31	7.00e-175	606.00
IUUC-Sha-107450	Sarcophilus harrisii	71.32	2.00e-179	621.00
IUUC-Ssc-115354	Sus scrofa	82.14	0.00e+00	639.00
IUUC-Tgu-117439	Taeniopygia guttata	69.93	3.00e-134	470.00
IUUC-Tru-118215	Takifugu rubripes	53.33	9.00e-127	446.00
IUUC-Tni-120011	Tetraodon nigroviridis	55.31	1.00e-131	462.00
IUUC-Ttr-128852	Tursiops truncatus	69.50	2.00e-130	458.00
IUUC-Xtr-132894	Xenopus tropicalis	62.95	3.00e-150	524.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence