iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000158717.10	ENST00000312838.8	ENSP00000326095.4
ENSG00000158717.10	ENST00000567408.1	ENSP00000455617.1
ENSG00000158717.10	ENST00000562544.1	ENSP00000455539.1
ENSG00000158717.10	ENST00000568683.5	ENSP00000457374.1
ENSG00000158717.10	ENST00000567844.1	ENSP00000457336.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UIM	UIM	17990982

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	2.00e-05	26.2	30	90
E3 activity/RING/RING	5.60e-06	28.4	33	73

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 5    eflCpIslelMrdPvvlp.sGitydrssIekwlasggktcPvtrqplteedl.vPnltlrr 63
           ++ CpI le+ + Pv +  +G+t+  ++++ +l+     cP++r p++++++ +  ++ ++
   Q: 30   QYTCPICLEVYHRPVAIGsCGHTFCGECLQPCLQVPSPLCPLCRLPFDPKKVdKATHVEKQ 90
           689************9877****************************99988666665555 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCle + +++ +++CgH+f+ +Clq       ++ ++ +CPlCr
   Q: 33   CPICLEVYHRPVAIGSCGHTFCGECLQPC-----LQVPSPLCPLCR 73
           **********999************9444.....799********8 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MAMFRSLVAS AQQRQPPAGP AGGDSGLEAQ YTCPICLEVY HRPVAIGSCG HTFCGECLQP 60
CLQVPSPLCP LCRLPFDPKK VDKATHVEKQ LSSYKAPCRG CNKKVTLAKM RVHISSCLKV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTACGATGAC GTCAGCGCGG CGCAGTAGCG GCTGTGACTA GCGGGCCGGC CCGGGCCAGG 60
ACAGCGGGCG GCGGGCGGCG CGGGCCTGGC CCCGGGATGG CTATGTTCCG CAGCCTGGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008598--Di19_Zn_binding_dom
IPR034734--ZF_C2HC_RNF
IPR027370--Znf-RING_LisH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51803--ZF_C2HC_RNF
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF05605--zf-Di19
PF13445--zf-RING_UBOX

SMART

SM00184--RING

Gene Ontology

GO:0005622--C:intracellular
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination

KEGG

hsa:115992

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002042	Ailuropoda melanoleuca	67.33	1.00e-66	246.00
IUUC-Apl-003816	Anas platyrhynchos	70.98	8.00e-75	273.00
IUUC-Aca-005379	Anolis carolinensis	87.69	8.00e-104	369.00
IUUC-Ame-011339	Astyanax mexicanus	89.35	9.00e-91	325.00
IUUC-Bta-012575	Bos taurus	94.12	9.00e-116	409.00
IUUC-Cja-019772	Callithrix jacchus	82.84	1.00e-77	281.00
IUUC-Cfa-021271	Canis familiaris	94.57	2.00e-116	411.00
IUUC-Cpo-022471	Cavia porcellus	98.64	8.00e-130	456.00
IUUC-Csa-023435	Chlorocebus sabaeus	100.00	5.00e-131	459.00
IUUC-Dre-027458	Danio rerio	81.78	1.00e-108	385.00
IUUC-Dor-030798	Dipodomys ordii	98.29	9.00e-67	244.00
IUUC-Eca-033686	Equus caballus	96.45	3.00e-96	343.00
IUUC-Eeu-035051	Erinaceus europaeus	94.12	2.00e-125	441.00
IUUC-Fca-035399	Felis catus	88.95	5.00e-100	356.00
IUUC-Fal-036707	Ficedula albicollis	89.60	1.00e-92	332.00
IUUC-Gga-040346	Gallus gallus	88.72	2.00e-105	375.00
IUUC-Gac-042409	Gasterosteus aculeatus	57.95	1.00e-48	186.00
IUUC-Ggo-045264	Gorilla gorilla	100.00	5.00e-131	459.00
IUUC-Itr-048243	Ictidomys tridecemlineatus	98.22	6.00e-97	345.00
IUUC-Loc-052767	Lepisosteus oculatus	72.62	1.00e-102	365.00
IUUC-Laf-053402	Loxodonta africana	96.83	4.00e-128	450.00
IUUC-Mcc-055236	Macaca mulatta	87.39	1.00e-106	378.00
IUUC-Mga-059430	Meleagris gallopavo	89.71	3.00e-94	337.00
IUUC-Mmr-061214	Microcebus murinus	97.29	3.00e-128	450.00
IUUC-Mdo-062112	Monodelphis domestica	86.38	6.00e-116	409.00
IUUC-Mmu-063307	Mus musculus	98.64	8.00e-130	455.00
IUUC-Mpu-066881	Mustela putorius furo	94.08	9.00e-95	339.00
IUUC-Mlu-067382	Myotis lucifugus	95.27	1.00e-95	342.00
IUUC-Nle-069388	Nomascus leucogenys	94.12	2.00e-120	424.00
IUUC-Oan-072786	Ornithorhynchus anatinus	91.81	1.00e-79	288.00
IUUC-Ola-087498	Oryzias latipes	79.61	6.00e-100	356.00
IUUC-Oga-088354	Otolemur garnettii	88.94	3.00e-123	434.00
IUUC-Oar-090300	Ovis aries	93.98	2.00e-112	397.00
IUUC-Ptr-090594	Pan troglodytes	100.00	5.00e-131	459.00
IUUC-Pan-091714	Papio anubis	100.00	5.00e-131	459.00
IUUC-Psi-093536	Pelodiscus sinensis	91.12	1.00e-92	331.00
IUUC-Pma-094178	Petromyzon marinus	45.92	5.00e-51	193.00
IUUC-Pfo-096266	Poecilia formosa	76.75	5.00e-104	370.00
IUUC-Pab-098752	Pongo abelii	100.00	1.00e-98	352.00
IUUC-Pca-101015	Procavia capensis	96.58	5.00e-66	242.00
IUUC-Pva-102695	Pteropus vampyrus	95.48	2.00e-116	411.00
IUUC-Rno-104836	Rattus norvegicus	98.64	8.00e-130	455.00
IUUC-Sha-106920	Sarcophilus harrisii	81.05	5.00e-115	407.00
IUUC-Tgu-117434	Taeniopygia guttata	90.53	6.00e-92	329.00
IUUC-Tru-118479	Takifugu rubripes	75.42	9.00e-104	369.00
IUUC-Tni-119994	Tetraodon nigroviridis	54.20	4.00e-66	244.00
IUUC-Ttr-129306	Tursiops truncatus	79.19	3.00e-90	324.00
IUUC-Xtr-132746	Xenopus tropicalis	86.73	6.00e-112	396.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence