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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045701
UUCD1 version UUC-HoS-00284
Ensembl Protein ID ENSP00000313034.3
UniProt Accession Q969U6; B2RDZ6; Q59ET5; Q5SPZ8; Q5SPZ9; Q5SQ00; Q5SQ02; Q5SQ03; Q5SQ04; Q8WY79; Q96GJ6; Q9BSU8; Q9H6A8; Q9HBQ6; Q9NSZ3; FBXW5_HUMAN
Genbank Protein ID BAB15354.1; BAG38093.1; EAW88307.1; AAH00850.1; AAH04541.2; AAH09429.1; AAH14297.1; CAI12741.1; CAI12743.1; CAI12744.1; CAI12746.1; AAH14130.1; BAD92963.1; CAB70851.1; AAG17240.1; AAG23772.1
Protein Name F-box/WD repeat-containing protein 5; F-box and WD-40 domain-containing protein 5
Genbank Nucleotide ID AK026081; AK315738; CH471090; BC000850; BC004541; BC009429; BC014297; AL807752; AL807752; AL807752; AL807752; BC014130; AB209726; AL137631; AF217998; AF258569
Gene Name FBXW5; FBW5; PP3971
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000159069.13 ENST00000487794.5 ENSP00000485109.1
ENSG00000159069.13 ENST00000325285.7 ENSP00000313034.3
ENSG00000159069.13 ENST00000428398.5 ENSP00000404829.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBaseCircNetmicroRNA
TRANSFACTargetScanRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 21725316; 18381890; 24082123
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 21725316; 18381890; 17588513; 24082123
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/SCF/F-box 0.013 17.3 7 48
E3 adaptor/Cullin RING/DCX/DWD 3.70e-11 44.5 91 120
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/F-box
   S: 104  drlpeeilveilklldkeellraarvcrrwqelasqkalwkt 145
             lp+ ++ +i+  l + ++l+a +vcr+wq +++++ lw++
   Q: 7    PLLPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWRE 48
           5699*******************************9999986 PP
   

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWD 29
           Htd v  l+f  s+  ++s+s D+t+k+W+
   Q: 91   HTDQVLHLSFshSGYQFASCSKDCTVKIWS 120
           9*********955588*************8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway.
 Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway.
Protein Sequence
(Fasta)
MDEGGTPLLP DSLVYQIFLS LGPADVLAAG LVCRQWQAVS RDEFLWREQF YRYYQVARDV 60
PRHPAAMSWY EEFQRLYDTV PCVEVQTLRE HTDQVLHLSF SHSGYQFASC SKDCTVKIWS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045701|E3,F-box;E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGCTCCCCG TTGGGCGGGG GCGGCGGTCC GAGCGGCTGC GGCAGCGGAA GCGGGTCCGG 60
GTCGCGCAGG GCGGGGGCGG CGCAGCGGGC GGAGGCGGCC GTGGTGAGTG CGCCTGCGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045701|E3,F-box;E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR001810--F-box_dom
IPR027295--Quinoprotein_ADH-like_fam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50181--FBOX
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12937--F-box-like
PF00400--WD40
SMART

SM00256--FBOX
SM00320--WD40
Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0019005--C:SCF ubiquitin ligase complex
GO:0019901--F:protein kinase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0010824--P:regulation of centrosome duplication
GO:0007088--P:regulation of mitotic nuclear division
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
KEGG hsa:54461
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001942 Ailuropoda melanoleuca 90.00 0.00e+00 1008.00
IUUC-Apl-003274 Anas platyrhynchos 77.27 0.00e+00 780.00
IUUC-Aca-004626 Anolis carolinensis 59.35 5.00e-98 350.00
IUUC-Ame-011823 Astyanax mexicanus 60.91 1.00e-176 613.00
IUUC-Bta-012523 Bos taurus 90.27 0.00e+00 1027.00
IUUC-Cja-018729 Callithrix jacchus 94.72 0.00e+00 1106.00
IUUC-Cfa-020303 Canis familiaris 90.53 0.00e+00 1045.00
IUUC-Cpo-022134 Cavia porcellus 91.56 0.00e+00 1065.00
IUUC-Csa-023253 Chlorocebus sabaeus 97.35 0.00e+00 1151.00
IUUC-Cin-025742 Ciona intestinalis 34.68 9.00e-83 301.00
IUUC-Dre-027511 Danio rerio 68.11 0.00e+00 734.00
IUUC-Dno-029044 Dasypus novemcinctus 89.42 0.00e+00 1023.00
IUUC-Dor-030565 Dipodomys ordii 89.63 0.00e+00 1041.00
IUUC-Dme-031713 Drosophila melanogaster 40.79 2.00e-126 446.00
IUUC-Eca-033709 Equus caballus 91.20 0.00e+00 1035.00
IUUC-Eeu-035093 Erinaceus europaeus 95.58 2.00e-102 366.00
IUUC-Fca-035674 Felis catus 89.81 0.00e+00 1033.00
IUUC-Fal-037104 Ficedula albicollis 71.45 0.00e+00 826.00
IUUC-Gmo-039041 Gadus morhua 62.34 0.00e+00 648.00
IUUC-Gga-041230 Gallus gallus 75.04 0.00e+00 881.00
IUUC-Gac-042594 Gasterosteus aculeatus 61.34 0.00e+00 653.00
IUUC-Ggo-044486 Gorilla gorilla 99.29 0.00e+00 1139.00
IUUC-Itr-048811 Ictidomys tridecemlineatus 90.37 0.00e+00 1065.00
IUUC-Kpa-049204 Komagataella pastoris 38.00 5.00e-06 46.60
IUUC-Lch-050058 Latimeria chalumnae 70.02 0.00e+00 828.00
IUUC-Loc-052525 Lepisosteus oculatus 71.35 0.00e+00 740.00
IUUC-Laf-054120 Loxodonta africana 87.68 0.00e+00 1023.00
IUUC-Mcc-054915 Macaca mulatta 97.35 0.00e+00 1122.00
IUUC-Meu-056715 Macropus eugenii 78.95 0.00e+00 925.00
IUUC-Mga-059831 Meleagris gallopavo 74.86 0.00e+00 785.00
IUUC-Mvi-060236 Microbotryum violaceum 34.62 2.00e-06 48.90
IUUC-Mmr-060655 Microcebus murinus 92.24 0.00e+00 1083.00
IUUC-Mdo-062641 Monodelphis domestica 83.22 0.00e+00 962.00
IUUC-Mmu-063471 Mus musculus 88.52 0.00e+00 1032.00
IUUC-Mpu-066586 Mustela putorius furo 90.18 0.00e+00 1026.00
IUUC-Nle-069429 Nomascus leucogenys 97.17 0.00e+00 1150.00
IUUC-Ont-071780 Oreochromis niloticus 66.90 0.00e+00 716.00
IUUC-Ola-086458 Oryzias latipes 66.00 0.00e+00 729.00
IUUC-Oga-088739 Otolemur garnettii 91.37 0.00e+00 1090.00
IUUC-Oar-089275 Ovis aries 93.02 1.00e-46 177.00
IUUC-Ptr-090716 Pan troglodytes 98.32 0.00e+00 944.00
IUUC-Pan-092182 Papio anubis 88.87 0.00e+00 994.00
IUUC-Psi-093449 Pelodiscus sinensis 75.51 0.00e+00 883.00
IUUC-Pma-094289 Petromyzon marinus 53.86 5.00e-175 607.00
IUUC-Pfo-096062 Poecilia formosa 66.44 0.00e+00 724.00
IUUC-Pab-098726 Pongo abelii 95.95 0.00e+00 1105.00
IUUC-Pca-100163 Procavia capensis 81.25 7.00e-91 327.00
IUUC-Pva-103051 Pteropus vampyrus 89.86 2.00e-147 516.00
IUUC-Rno-105707 Rattus norvegicus 89.32 0.00e+00 1037.00
IUUC-Sha-107074 Sarcophilus harrisii 83.64 0.00e+00 911.00
IUUC-Ssc-116020 Sus scrofa 88.73 0.00e+00 853.00
IUUC-Tgu-116683 Taeniopygia guttata 69.53 3.00e-100 357.00
IUUC-Tru-118143 Takifugu rubripes 65.86 0.00e+00 704.00
IUUC-Tni-120777 Tetraodon nigroviridis 65.81 0.00e+00 714.00
IUUC-Ttr-128439 Tursiops truncatus 89.93 0.00e+00 1026.00
IUUC-Xtr-132774 Xenopus tropicalis 56.76 2.00e-150 526.00
Created Date 25-Jun-2017

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