iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074911

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

AAGW02053040

Gene Name

NAE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000000573.3	ENSOCUT00000000575.3	ENSOCUP00000000498.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.40e-131	439.6	13	525

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvn 89
           YDRQ+rlwG+++qe+l+sa+v+l++a+++G+E+lKnLvl G+gs+t++D+++v+ ++ +++F+++++++gk++A++a+++l+eln dv+
   Q: 13   YDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDAGNNFFLQRSSIGKNRAQAAMAFLQELNNDVS 101
           ***************************************************************************************** PP
   S: 90   veaheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfc 174
           + ++ees++ l ++++ Ff++f+vVv+++ ++++ ++++++++n ++pl++++t+Gl+G++r++ik++++++s++d   +++++++Pf+
   Q: 102  GNFVEESPEHLLDNDPsFFCRFTVVVATQLPESTLLRLADVLWNSQIPLLICRTYGLVGYMRIVIKEHPVIESHPDnalEDLRLDKPFP 190
           ***************************************************************************************** PP
   S: 175  tlketpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks......edeenfeeaieiavkafakt 248
           +l+e+++         +++++++w+v+++k+l+++++e++++ +++++eke+++d++++++ +      edeenfeeai+++++a+++t
   Q: 191  ELREHFQsydldhmdkKDHSHTPWIVIVAKYLAQWYSETNGRIPKTYKEKEDFRDLIRQGILKnesgtpEDEENFEEAIKNVNTALNTT 279
           *****999999**999***********************************************9************************* PP
   S: 249  tins.ikqllksfecdivtkskspfwv.............................................................. 274
           +i+s i++++++++c ++tk++++fw+                                                              
   Q: 280  QIPSsIEDIFNDDRCINITKQTPSFWIlaralkefvakegqgnlpvrgtipdmiadsgkyiklqnvyrekakkdaaavgnhvakllqsi 368
           ***************************************************************************************** PP
   S: 275  .............sfcsnaealqvp...........ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..a 332
                         +csn++ l+v            ++v+kde+++++++p     lyl+lra++rf+k++gr+pg++++++++d   +
   Q: 369  gqapesiserelkLLCSNSAFLRVVrcrslaeeyglDTVNKDEIISSMDSPdneivLYLMLRAVDRFHKQHGRYPGVSNYQVEEDVgkL 457
           *************9*********7777777888888*************************************************9999 PP
   S: 333  vdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
            +++t ++    +++g++ +++dd+i+e++++++++ +t++a++gG+aaqEviK+++++f+ ++n++++ ++
   Q: 458  KSCLTGFL----QEYGLSVMVKDDYIHEFCRYGATEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGM 525
           99999999....********************************************************9776 PP

Organism

Oryctolagus cuniculus

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

Protein Sequence
(Fasta)

MAEPGKLLKE QKYDRQLRLW GDHGQEALES AHVCLINATA TGTEILKNLV LPGIGSFTII 60
DGNQVSGEDA GNNFFLQRSS IGKNRAQAAM AFLQELNNDV SGNFVEESPE HLLDNDPSFF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAGAGCTGG CCTGGAAGAG GGGCAACCGG GACAGAATCC GGCGCCCCGA CCGGGACTAG 60
AACCCGGTGT GCCGGCGCCG CTAGGTGGAG GATTAGCCTA GTGAGCCGCG GTGCCGGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0033314--P:mitotic DNA replication checkpoint
GO:0051402--P:neuron apoptotic process
GO:0045116--P:protein neddylation
GO:0043523--P:regulation of neuron apoptotic process

KEGG

ocu:100350243

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	43.10	5.00e-127	447.00
IUUC-Aml-002333	Ailuropoda melanoleuca	95.34	0.00e+00	1076.00
IUUC-Atr-002644	Amborella trichopoda	41.70	4.00e-116	411.00
IUUC-Apl-003446	Anas platyrhynchos	84.01	0.00e+00	920.00
IUUC-Aca-004450	Anolis carolinensis	79.55	0.00e+00	914.00
IUUC-Aly-006187	Arabidopsis lyrata	40.00	1.00e-125	443.00
IUUC-Ath-007600	Arabidopsis thaliana	40.56	4.00e-127	448.00
IUUC-Ago-007900	Ashbya gossypii	26.42	4.00e-39	155.00
IUUC-Acl-008333	Aspergillus clavatus	34.17	9.00e-81	294.00
IUUC-Afl-008529	Aspergillus flavus	36.19	2.00e-87	316.00
IUUC-Afu-009071	Aspergillus fumigatus	33.75	1.00e-81	296.00
IUUC-Ani-009443	Aspergillus nidulans	33.33	1.00e-77	283.00
IUUC-Ang-009669	Aspergillus niger	33.27	3.00e-82	299.00
IUUC-Aor-009914	Aspergillus oryzae	35.51	7.00e-84	304.00
IUUC-Ate-010450	Aspergillus terreus	34.35	9.00e-84	304.00
IUUC-Ame-011183	Astyanax mexicanus	71.64	0.00e+00	827.00
IUUC-Bgr-012111	Blumeria graminis	33.15	1.00e-66	247.00
IUUC-Bta-012583	Bos taurus	96.63	0.00e+00	1088.00
IUUC-Bci-013892	Botrytis cinerea	33.15	4.00e-65	242.00
IUUC-Bdi-014592	Brachypodium distachyon	43.51	2.00e-129	455.00
IUUC-Bol-016399	Brassica oleracea	40.65	3.00e-125	441.00
IUUC-Bra-017506	Brassica rapa	39.37	6.00e-122	431.00
IUUC-Cel-018456	Caenorhabditis elegans	35.42	6.00e-92	331.00
IUUC-Cja-020007	Callithrix jacchus	95.72	0.00e+00	1081.00
IUUC-Cfa-020324	Canis familiaris	96.25	0.00e+00	1085.00
IUUC-Cpo-022248	Cavia porcellus	66.17	0.00e+00	643.00
IUUC-Csa-023149	Chlorocebus sabaeus	96.68	0.00e+00	924.00
IUUC-Cho-024537	Choloepus hoffmanni	84.38	0.00e+00	804.00
IUUC-Cin-025763	Ciona intestinalis	49.53	3.00e-155	541.00
IUUC-Csv-026113	Ciona savignyi	46.11	7.00e-146	510.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	32.27	1.00e-65	244.00
IUUC-Cne-026884	Cryptococcus neoformans	30.94	2.00e-72	266.00
IUUC-Cme-027210	Cyanidioschyzon merolae	27.80	1.00e-18	88.20
IUUC-Dre-028140	Danio rerio	72.85	0.00e+00	848.00
IUUC-Dno-030033	Dasypus novemcinctus	96.41	0.00e+00	956.00
IUUC-Dor-030513	Dipodomys ordii	67.73	6.00e-115	407.00
IUUC-Dse-031536	Dothistroma septosporum	34.94	2.00e-85	310.00
IUUC-Dme-031683	Drosophila melanogaster	44.47	1.00e-127	449.00
IUUC-Ete-032420	Echinops telfairi	82.17	0.00e+00	883.00
IUUC-Eca-033992	Equus caballus	96.40	0.00e+00	908.00
IUUC-Eeu-034713	Erinaceus europaeus	79.13	4.00e-117	414.00
IUUC-Fca-036548	Felis catus	95.51	0.00e+00	1074.00
IUUC-Fal-037600	Ficedula albicollis	81.03	0.00e+00	890.00
IUUC-Fox-038037	Fusarium oxysporum	33.94	4.00e-78	285.00
IUUC-Fso-038387	Fusarium solani	34.95	7.00e-79	287.00
IUUC-Gmo-038562	Gadus morhua	71.40	0.00e+00	823.00
IUUC-Ggr-040005	Gaeumannomyces graminis	33.93	1.00e-72	266.00
IUUC-Gga-041129	Gallus gallus	84.30	0.00e+00	944.00
IUUC-Gac-042558	Gasterosteus aculeatus	72.69	0.00e+00	833.00
IUUC-Gma-043610	Glycine max	41.34	9.00e-122	430.00
IUUC-Ggo-045611	Gorilla gorilla	95.72	0.00e+00	1077.00
IUUC-Hsa-046563	Homo sapiens	96.25	0.00e+00	1082.00
IUUC-Hvu-047790	Hordeum vulgare	38.62	4.00e-77	281.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	96.44	0.00e+00	1083.00
IUUC-Kpa-049309	Komagataella pastoris	35.04	4.00e-82	298.00
IUUC-Lch-050038	Latimeria chalumnae	75.66	0.00e+00	852.00
IUUC-Lpe-051535	Leersia perrieri	42.05	1.00e-112	400.00
IUUC-Loc-051917	Lepisosteus oculatus	69.34	0.00e+00	791.00
IUUC-Lma-053112	Leptosphaeria maculans	35.22	2.00e-87	316.00
IUUC-Laf-053690	Loxodonta africana	95.13	0.00e+00	1077.00
IUUC-Mcc-055117	Macaca mulatta	94.42	0.00e+00	1065.00
IUUC-Meu-056761	Macropus eugenii	76.07	0.00e+00	823.00
IUUC-Mor-057230	Magnaporthe oryzae	33.63	8.00e-78	284.00
IUUC-Mpo-057514	Magnaporthe poae	33.45	2.00e-71	263.00
IUUC-Mtr-058551	Medicago truncatula	40.47	5.00e-119	421.00
IUUC-Mla-059183	Melampsora laricipopulina	36.89	9.00e-98	350.00
IUUC-Mga-060144	Meleagris gallopavo	82.58	0.00e+00	914.00
IUUC-Mvi-060221	Microbotryum violaceum	35.99	5.00e-83	301.00
IUUC-Mmr-061325	Microcebus murinus	94.23	0.00e+00	1060.00
IUUC-Mdo-062532	Monodelphis domestica	90.24	0.00e+00	1020.00
IUUC-Mmu-063956	Mus musculus	95.13	0.00e+00	1074.00
IUUC-Mac-064521	Musa acuminata	40.56	4.00e-123	434.00
IUUC-Mpu-066716	Mustela putorius furo	95.22	0.00e+00	1015.00
IUUC-Mlu-067459	Myotis lucifugus	94.96	0.00e+00	1065.00
IUUC-Nfi-068245	Neosartorya fischeri	34.11	1.00e-81	297.00
IUUC-Ncr-068910	Neurospora crassa	34.18	2.00e-77	283.00
IUUC-Nle-070034	Nomascus leucogenys	93.71	0.00e+00	1034.00
IUUC-Opr-070552	Ochotona princeps	87.82	0.00e+00	891.00
IUUC-Ont-071426	Oreochromis niloticus	73.35	0.00e+00	850.00
IUUC-Oan-073389	Ornithorhynchus anatinus	83.60	0.00e+00	776.00
IUUC-Oba-075437	Oryza barthii	43.51	6.00e-120	424.00
IUUC-Obr-076684	Oryza brachyantha	43.70	7.00e-115	407.00
IUUC-Ogl-077170	Oryza glaberrima	43.51	6.00e-120	424.00
IUUC-Ogu-078844	Oryza glumaepatula	44.31	6.00e-113	400.00
IUUC-Oin-079105	Oryza indica	43.51	3.00e-119	422.00
IUUC-Olo-080943	Oryza longistaminata	41.05	1.00e-107	383.00
IUUC-Oni-082891	Oryza nivara	40.65	3.00e-113	401.00
IUUC-Opu-083457	Oryza punctata	43.51	2.00e-119	422.00
IUUC-Oru-084960	Oryza rufipogon	40.75	9.00e-108	384.00
IUUC-Osa-085358	Oryza sativa	43.70	5.00e-120	424.00
IUUC-Ola-086420	Oryzias latipes	71.58	3.00e-168	583.00
IUUC-Olu-087625	Ostreococcus lucimarinus	31.06	3.00e-61	229.00
IUUC-Oga-088810	Otolemur garnettii	94.94	0.00e+00	1070.00
IUUC-Oar-089196	Ovis aries	96.09	0.00e+00	1081.00
IUUC-Ptr-090617	Pan troglodytes	96.44	0.00e+00	1084.00
IUUC-Pan-092761	Papio anubis	96.44	0.00e+00	1088.00
IUUC-Psi-093191	Pelodiscus sinensis	86.27	0.00e+00	962.00
IUUC-Pma-094380	Petromyzon marinus	62.68	0.00e+00	667.00
IUUC-Pno-095084	Phaeosphaeria nodorum	32.67	1.00e-74	275.00
IUUC-Ppa-095875	Physcomitrella patens	40.99	7.00e-122	430.00
IUUC-Pfo-096467	Poecilia formosa	72.97	0.00e+00	833.00
IUUC-Pab-098255	Pongo abelii	96.17	0.00e+00	904.00
IUUC-Pop-099722	Populus trichocarpa	41.31	7.00e-127	447.00
IUUC-Pca-100807	Procavia capensis	78.87	6.00e-119	420.00
IUUC-Ppe-101280	Prunus persica	40.78	1.00e-124	440.00
IUUC-Pva-102333	Pteropus vampyrus	91.99	0.00e+00	1025.00
IUUC-Pgr-103401	Puccinia graminis	32.30	4.00e-81	295.00
IUUC-Ptt-103889	Puccinia triticina	27.67	2.00e-58	220.00
IUUC-Pte-104355	Pyrenophora teres	36.19	9.00e-90	324.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	36.36	8.00e-91	327.00
IUUC-Rno-105810	Rattus norvegicus	94.38	0.00e+00	1066.00
IUUC-Sce-106397	Saccharomyces cerevisiae	26.82	8.00e-38	151.00
IUUC-Sha-106770	Sarcophilus harrisii	89.05	2.00e-153	534.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	32.51	2.00e-76	280.00
IUUC-Spo-108276	Schizosaccharomyces pombe	35.65	5.00e-85	308.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	32.25	2.00e-67	249.00
IUUC-Smo-109296	Selaginella moellendorffii	43.18	2.00e-125	442.00
IUUC-Sit-110157	Setaria italica	44.86	3.00e-136	478.00
IUUC-Sly-111105	Solanum lycopersicum	40.29	7.00e-124	437.00
IUUC-Stu-112469	Solanum tuberosum	40.80	6.00e-126	444.00
IUUC-Sar-113083	Sorex araneus	72.29	0.00e+00	746.00
IUUC-Sbi-113813	Sorghum bicolor	45.05	2.00e-136	479.00
IUUC-Sre-115058	Sporisorium reilianum	39.11	3.00e-85	309.00
IUUC-Tgu-116772	Taeniopygia guttata	80.83	0.00e+00	890.00
IUUC-Tru-118686	Takifugu rubripes	71.83	0.00e+00	834.00
IUUC-Tsy-119111	Tarsius syrichta	87.99	2.00e-148	519.00
IUUC-Tni-120231	Tetraodon nigroviridis	66.42	0.00e+00	752.00
IUUC-Tca-121491	Theobroma cacao	40.78	6.00e-118	417.00
IUUC-Tre-122103	Trichoderma reesei	36.72	3.00e-82	299.00
IUUC-Tvi-122672	Trichoderma virens	36.46	2.00e-75	276.00
IUUC-Tae-125679	Triticum aestivum	43.70	3.00e-129	455.00
IUUC-Tur-126487	Triticum urartu	41.98	2.00e-122	432.00
IUUC-Tme-127097	Tuber melanosporum	39.27	5.00e-95	341.00
IUUC-Ttr-128465	Tursiops truncatus	89.20	0.00e+00	994.00
IUUC-Uma-129645	Ustilago maydis	34.17	1.00e-90	327.00
IUUC-Vda-129989	Verticillium dahliae	31.39	2.00e-57	216.00
IUUC-Vpa-130529	Vicugna pacos	91.62	0.00e+00	1025.00
IUUC-Vvi-131059	Vitis vinifera	41.71	3.00e-124	438.00
IUUC-Xtr-132002	Xenopus tropicalis	78.94	0.00e+00	906.00
IUUC-Xma-133930	Xiphophorus maculatus	73.38	0.00e+00	838.00
IUUC-Yli-134505	Yarrowia lipolytica	35.11	6.00e-86	311.00
IUUC-Zma-135895	Zea mays	44.85	5.00e-135	474.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence