iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000160584.15	ENST00000445177.5	ENSP00000391295.1
ENSG00000160584.15	ENST00000375300.5	ENSP00000364449.1
ENSG00000160584.15	ENST00000454905.5	ENSP00000392849.1
ENSG00000160584.15	ENST00000415541.5	ENSP00000392761.1
ENSG00000160584.15	ENST00000446921.6	ENSP00000390442.2
ENSG00000160584.15	ENST00000413553.1	ENSP00000414347.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Disease-associated Information
GWASdb	OMIM
Drug and target
TTD	GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	24061540

Organism

Homo sapiens

Protein Sequence
(Fasta)

MAAAAASGAG GAAGAGTGGA GPAGRLLPPP APGSPAAPAA VSPAAGQPRP PAPASRGPMP 60
ARIGYYEIDR TIGKGNFAVV KRATHLVTKA KVAIKIIDKT QLDEENLKKI FREVQIMKML 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGGTTTCA CTGCACAACA AGATGGCGGC GGCGGCGGCG AGCGGAGCTG GCGGGGCTGC 60
CGGGGCCGGG ACTGGGGGAG CCGGGCCCGC GGGCCGCCTG CTGCCTCCGC CCGCGCCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0488--Methylation
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase

Interpro

IPR011992--EF-hand-dom_pair
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
IPR034672--SIK
IPR015940--UBA

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50030--UBA

Pfam

PF00069--Pkinase

SMART

SM00220--S_TKc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0006468--P:protein phosphorylation

KEGG

hsa:23387

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-011685	Astyanax mexicanus	90.34	5.00e-135	473.00
IUUC-Cja-019739	Callithrix jacchus	91.27	0.00e+00	1843.00
IUUC-Cho-024317	Choloepus hoffmanni	90.92	0.00e+00	1745.00
IUUC-Csv-026013	Ciona savignyi	67.26	2.00e-142	498.00
IUUC-Dre-027537	Danio rerio	70.09	1.00e-174	605.00
IUUC-Dor-030146	Dipodomys ordii	92.03	0.00e+00	1787.00
IUUC-Ete-032889	Echinops telfairi	81.09	0.00e+00	1731.00
IUUC-Eca-033614	Equus caballus	95.06	0.00e+00	2144.00
IUUC-Eeu-035150	Erinaceus europaeus	87.08	0.00e+00	1054.00
IUUC-Gmo-039322	Gadus morhua	67.36	0.00e+00	973.00
IUUC-Gga-041104	Gallus gallus	83.45	0.00e+00	1957.00
IUUC-Gac-042453	Gasterosteus aculeatus	58.23	0.00e+00	1136.00
IUUC-Ggo-044865	Gorilla gorilla	96.97	0.00e+00	1031.00
IUUC-Mcc-054691	Macaca mulatta	98.41	0.00e+00	2303.00
IUUC-Meu-056201	Macropus eugenii	80.19	0.00e+00	1771.00
IUUC-Mmu-064117	Mus musculus	91.64	0.00e+00	2149.00
IUUC-Opr-071103	Ochotona princeps	92.78	0.00e+00	1420.00
IUUC-Oan-072865	Ornithorhynchus anatinus	74.41	0.00e+00	1471.00
IUUC-Ptr-091679	Pan troglodytes	99.84	0.00e+00	2308.00
IUUC-Pab-098094	Pongo abelii	99.60	0.00e+00	2336.00
IUUC-Pca-100633	Procavia capensis	85.78	0.00e+00	1534.00
IUUC-Pva-102747	Pteropus vampyrus	93.59	0.00e+00	2157.00
IUUC-Ssc-115276	Sus scrofa	92.86	0.00e+00	2103.00
IUUC-Tru-117598	Takifugu rubripes	58.05	0.00e+00	1115.00
IUUC-Tsy-118859	Tarsius syrichta	90.57	5.00e-152	532.00
IUUC-Tni-120589	Tetraodon nigroviridis	58.06	0.00e+00	1128.00
IUUC-Tbe-127501	Tupaia belangeri	90.30	0.00e+00	1956.00
IUUC-Ttr-128329	Tursiops truncatus	87.14	0.00e+00	1948.00
IUUC-Vpa-130601	Vicugna pacos	81.61	2.00e-179	623.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence