iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000160796.16	ENST00000450053.7	ENSP00000415034.2
ENSG00000160796.16	ENST00000416683.5	ENSP00000410405.1
ENSG00000160796.16	ENST00000443829.5	ENSP00000414560.1
ENSG00000160796.16	ENST00000441027.5	ENSP00000409601.1
ENSG00000160796.16	ENST00000423436.1	ENSP00000415063.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Variation
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.70e-09	39.2	2501	2531

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDl 30
           H d vtcla+ ++  +l+sGs+D t++vW+l
   Q: 2501 HLDVVTCLALdTCgIYLISGSRDTTCMVWRL 2531
           99********6443449************97 PP

Organism

Homo sapiens

Functional Description
(View)

Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis.

Protein Sequence
(Fasta)

MAASERLYEL WLLYYAQKDL GYLQQWLKAF VGAFKKSISL SSLEPRRPEE AGAEVPLLPL 60
DELHVLAEQL HQADLEQALL LLKLFIILCR NLENIEAGRG QVLVPRVLAL LTKLVAELKG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCAGACTTG GGTGGCTCTG CGCCGCGGAG GCCACAGCCG CAGACTTCCC CAGTAGTACC 60
GCGCCGCTCC GCCCCGGAGT GACGCCCTCC GCCCATGGGC CTGGCCGAGG GCAACCGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0256--Endoplasmic reticulum
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000409--BEACH_dom
IPR013320--ConA-like_dom
IPR031570--DUF4704
IPR023362--PH-BEACH_dom
IPR011993--PH_dom-like
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50197--BEACH
PS51783--PH_BEACH
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF02138--Beach
PF15787--DUF4704
PF14844--PH_BEACH
PF00400--WD40

SMART

SM01026--Beach
SM00320--WD40

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0101003--C:ficolin-1-rich granule membrane
GO:0016020--C:membrane
GO:0005886--C:plasma membrane
GO:0070821--C:tertiary granule membrane
GO:0043312--P:neutrophil degranulation
GO:0030220--P:platelet formation

KEGG

hsa:23218

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001282	Ailuropoda melanoleuca	89.13	0.00e+00	4452.00
IUUC-Atr-002854	Amborella trichopoda	34.40	5.00e-131	462.00
IUUC-Apl-004183	Anas platyrhynchos	63.89	0.00e+00	2568.00
IUUC-Aly-006298	Arabidopsis lyrata	33.58	1.00e-125	446.00
IUUC-Ame-010605	Astyanax mexicanus	65.71	0.00e+00	1368.00
IUUC-Cfa-020738	Canis familiaris	89.91	0.00e+00	3485.00
IUUC-Cpo-022242	Cavia porcellus	90.60	0.00e+00	2362.00
IUUC-Csa-023466	Chlorocebus sabaeus	96.33	0.00e+00	4818.00
IUUC-Dno-029597	Dasypus novemcinctus	84.88	0.00e+00	3801.00
IUUC-Ete-032532	Echinops telfairi	85.65	0.00e+00	1464.00
IUUC-Eca-033286	Equus caballus	91.98	0.00e+00	4474.00
IUUC-Eeu-035290	Erinaceus europaeus	82.73	0.00e+00	629.00
IUUC-Fca-035638	Felis catus	90.91	0.00e+00	4514.00
IUUC-Gmo-039339	Gadus morhua	53.85	0.00e+00	2580.00
IUUC-Gac-041466	Gasterosteus aculeatus	54.47	0.00e+00	2641.00
IUUC-Ggo-045191	Gorilla gorilla	92.28	0.00e+00	1682.00
IUUC-Itr-048531	Ictidomys tridecemlineatus	90.30	0.00e+00	4249.00
IUUC-Lch-050380	Latimeria chalumnae	58.47	0.00e+00	2867.00
IUUC-Loc-052386	Lepisosteus oculatus	63.63	0.00e+00	1704.00
IUUC-Laf-053913	Loxodonta africana	86.18	0.00e+00	4212.00
IUUC-Mcc-055769	Macaca mulatta	97.21	0.00e+00	4888.00
IUUC-Meu-056286	Macropus eugenii	77.75	0.00e+00	2044.00
IUUC-Mtr-057650	Medicago truncatula	34.28	2.00e-129	458.00
IUUC-Mmr-061713	Microcebus murinus	89.86	0.00e+00	4403.00
IUUC-Mdo-062048	Monodelphis domestica	70.15	0.00e+00	3588.00
IUUC-Mmu-063585	Mus musculus	87.44	0.00e+00	4392.00
IUUC-Mac-065578	Musa acuminata	33.65	9.00e-137	483.00
IUUC-Mpu-066234	Mustela putorius furo	89.04	0.00e+00	4487.00
IUUC-Mlu-067920	Myotis lucifugus	82.26	0.00e+00	1857.00
IUUC-Nle-069979	Nomascus leucogenys	94.78	0.00e+00	4672.00
IUUC-Opr-070275	Ochotona princeps	86.46	0.00e+00	2050.00
IUUC-Ont-072584	Oreochromis niloticus	54.97	0.00e+00	2659.00
IUUC-Ocu-074927	Oryctolagus cuniculus	91.48	0.00e+00	4483.00
IUUC-Ogl-077738	Oryza glaberrima	30.55	2.00e-101	365.00
IUUC-Opu-083624	Oryza punctata	31.88	2.00e-124	442.00
IUUC-Ola-086673	Oryzias latipes	54.27	0.00e+00	2642.00
IUUC-Olu-087890	Ostreococcus lucimarinus	36.20	5.00e-117	415.00
IUUC-Oga-089117	Otolemur garnettii	91.33	0.00e+00	4486.00
IUUC-Oar-089873	Ovis aries	85.54	0.00e+00	3991.00
IUUC-Ptr-091015	Pan troglodytes	99.24	0.00e+00	4952.00
IUUC-Pfo-096854	Poecilia formosa	54.80	0.00e+00	2584.00
IUUC-Pab-098213	Pongo abelii	97.81	0.00e+00	2532.00
IUUC-Pop-099812	Populus trichocarpa	33.90	1.00e-124	441.00
IUUC-Pca-100386	Procavia capensis	89.89	0.00e+00	2348.00
IUUC-Pva-102854	Pteropus vampyrus	89.76	0.00e+00	2029.00
IUUC-Rno-105792	Rattus norvegicus	88.24	0.00e+00	4429.00
IUUC-Sha-107194	Sarcophilus harrisii	70.01	0.00e+00	3507.00
IUUC-Sit-110476	Setaria italica	34.74	9.00e-124	439.00
IUUC-Sly-111319	Solanum lycopersicum	37.00	8.00e-132	465.00
IUUC-Ssc-115876	Sus scrofa	90.68	0.00e+00	632.00
IUUC-Tru-118404	Takifugu rubripes	55.10	0.00e+00	2613.00
IUUC-Tni-120641	Tetraodon nigroviridis	54.20	0.00e+00	2612.00
IUUC-Tca-121575	Theobroma cacao	34.84	3.00e-125	445.00
IUUC-Tae-124085	Triticum aestivum	34.13	3.00e-121	430.00
IUUC-Ttr-128451	Tursiops truncatus	92.48	0.00e+00	2362.00
IUUC-Vvi-131542	Vitis vinifera	34.02	2.00e-134	475.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence