iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000161036.11	ENST00000292616.9	ENSP00000292616.5
ENSG00000161036.11	ENST00000464107.5	ENSP00000418204.1
ENSG00000161036.11	ENST00000476270.1	ENSP00000417913.1
ENSG00000161036.11	ENST00000485808.5	ENSP00000420729.1
ENSG00000161036.11	ENST00000468175.1	ENSP00000420373.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
ArrayExpress	TCGA	ICGC	COSMIC
THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
TRANSFAC	TargetScan	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.30e-07	30.8	391	421

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf...sdtllvsGsdDgtikvWD 29
           H+  +  l+f   ++t+l ++s+D+ i +WD
   Q: 391  HKKAIATLCFspaHETHLFTASYDKRIILWD 421
           888899999*98666**************** PP

Organism

Homo sapiens

Functional Description
(View)

Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.

Protein Sequence
(Fasta)

MGPLSARLLM QRGRPKSDRL GKIRSLDLSG LELLSEHLDP KLLCRLTQLQ ELDLSNNHLE 60
TLPDNLGLSH LRVLRCANNQ LGDVTALCQF PKLEELSLEG NPFLTVNDNL KVSFLLPTLR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTTCCTTCC GGTCGTTAAC GCCCACGGGC TCGCGCGGCG CCGCCTCCTG GGCTCAGTTA 60
CCGCGGACGC CAGTGCCGGG CTCCAGGAGA CGCAGGGCGA CGCCACACGC CGGGGTGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0137--Centromere
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0235--DNA replication
KW-0995--Kinetochore
KW-0433--Leucine-rich repeat
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0779--Telomere
KW-0832--Ubl conjugation
KW-0853--WD repeat

Interpro

IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR025875--Leu-rich_rpt_4
IPR003591--Leu-rich_rpt_typical-subtyp
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS51450--LRR
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12799--LRR_4

SMART

SM00369--LRR_TYP
SM00320--WD40

Gene Ontology

GO:0000777--C:condensed chromosome kinetochore
GO:0005829--C:cytosol
GO:0000776--C:kinetochore
GO:0005815--C:microtubule organizing center
GO:0005664--C:nuclear origin of replication recognition complex
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005721--C:pericentric heterochromatin
GO:0031933--C:telomeric heterochromatin
GO:0003682--F:chromatin binding
GO:0008327--F:methyl-CpG binding
GO:0035064--F:methylated histone binding
GO:0006325--P:chromatin organization
GO:0016569--P:covalent chromatin modification
GO:0006270--P:DNA replication initiation
GO:0071169--P:establishment of protein localization to chromatin

KEGG

hsa:222229

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001948	Ailuropoda melanoleuca	84.76	0.00e+00	680.00
IUUC-Bta-012858	Bos taurus	79.51	0.00e+00	1000.00
IUUC-Cja-019702	Callithrix jacchus	95.21	0.00e+00	1165.00
IUUC-Cfa-020910	Canis familiaris	87.38	0.00e+00	1078.00
IUUC-Cpo-022523	Cavia porcellus	82.52	0.00e+00	1082.00
IUUC-Csa-023359	Chlorocebus sabaeus	96.91	0.00e+00	1224.00
IUUC-Dno-029426	Dasypus novemcinctus	87.06	0.00e+00	1063.00
IUUC-Dor-030654	Dipodomys ordii	81.15	0.00e+00	823.00
IUUC-Eca-034035	Equus caballus	88.54	0.00e+00	1090.00
IUUC-Eeu-034711	Erinaceus europaeus	76.43	8.00e-171	593.00
IUUC-Gmo-039096	Gadus morhua	39.13	5.00e-79	288.00
IUUC-Ggo-044714	Gorilla gorilla	99.69	0.00e+00	1214.00
IUUC-Laf-054449	Loxodonta africana	85.67	0.00e+00	1071.00
IUUC-Mcc-055193	Macaca mulatta	97.53	0.00e+00	1191.00
IUUC-Mmr-061572	Microcebus murinus	88.54	0.00e+00	1118.00
IUUC-Mmu-063240	Mus musculus	77.66	0.00e+00	952.00
IUUC-Mpu-066295	Mustela putorius furo	87.37	0.00e+00	1079.00
IUUC-Mlu-067766	Myotis lucifugus	86.15	0.00e+00	1084.00
IUUC-Nle-069200	Nomascus leucogenys	94.75	0.00e+00	1112.00
IUUC-Ola-086965	Oryzias latipes	39.35	2.00e-87	317.00
IUUC-Oga-088411	Otolemur garnettii	82.03	0.00e+00	1091.00
IUUC-Oar-089415	Ovis aries	80.59	0.00e+00	949.00
IUUC-Ptr-090663	Pan troglodytes	99.69	0.00e+00	1214.00
IUUC-Pan-092467	Papio anubis	95.53	0.00e+00	1159.00
IUUC-Pab-098479	Pongo abelii	97.53	0.00e+00	1198.00
IUUC-Pca-101023	Procavia capensis	75.39	0.00e+00	884.00
IUUC-Pva-102812	Pteropus vampyrus	83.59	0.00e+00	1050.00
IUUC-Rno-105469	Rattus norvegicus	78.21	0.00e+00	971.00
IUUC-Ssc-115884	Sus scrofa	87.06	0.00e+00	1107.00
IUUC-Tbe-127247	Tupaia belangeri	89.27	4.00e-139	488.00
IUUC-Ttr-128723	Tursiops truncatus	86.07	0.00e+00	1074.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence