iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
PINA
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	19182904

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	6.40e-09	36.1	4	42
ULD/UDP/UFD/UBX	8.80e-21	74.6	210	291

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraa.nnnleaAveyLldg 41
             +le l+eMGF+r +a +aL+ + n  +eaA+++L+++
   Q: 4    LTALESLIEMGFPRGRAEKALALTgNQGIEAAMDWLMEH 42
           5689********************************987 PP

ULD/UDP/UFD/UBX

   S: 2    tteqatlqiRlpdGkrlvrkFpssttleqiyqfve....yllvessdpFeLvspfPrrtlkpeehmstlqeagLvpsgsllv 79
           +++q+++q+RlpdG  l+++F+++++l +++ +ve    ++ ++++dp +L+s+fPrr +++ ++++ lqe+gLvps++l+v
   Q: 210  EYDQCRIQVRLPDGTSLTQTFRAREQLAAVRLYVElhrgEEPGQDQDPVQLLSGFPRRAFSEADMERPLQELGLVPSAVLIV 291
           578*****************************************************************************98 PP

Organism

Rattus norvegicus

Functional Description
(View)

Ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol (By similarity).

Protein Sequence
(Fasta)

MAELTALESL IEMGFPRGRA EKALALTGNQ GIEAAMDWLM EHEDDPDVDE PLETPLSHIL 60
GREPTPSEQV GPEGSGSAAG ESKPVLTEEE RQEQTKRMLE LVAQKQRERE EREEREALER 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CACTCTCCTC ACTCAGTGTC TACACCCCCC GTCCCCGGGT CCCCCGCCCG GTGAGTTAGC 60
GAGCGCCGGG AGGGCGGCGT CGCGGGCGGA GTCGCCCCGG GCTGACCCTT GCCGCCTTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-1185--Reference proteome

Interpro

IPR015940--UBA
IPR009060--UBA-like
IPR029071--Ubiquitin-rel_dom
IPR001012--UBX_dom

PROSITE

PS50030--UBA
PS50033--UBX

Pfam

PF00627--UBA
PF00789--UBX

SMART

SM00165--UBA
SM00166--UBX

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0043025--C:neuronal cell body
GO:0005634--C:nucleus
GO:0000502--C:proteasome complex
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:0071796--F:K6-linked polyubiquitin binding
GO:1904293--P:negative regulation of ERAD pathway
GO:0032435--P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:1903094--P:negative regulation of protein K48-linked deubiquitination
GO:0031397--P:negative regulation of protein ubiquitination
GO:2000157--P:negative regulation of ubiquitin-specific protease activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001103	Aegilops tauschii	38.37	2.00e-09	57.00
IUUC-Aml-002325	Ailuropoda melanoleuca	92.18	1.00e-111	395.00
IUUC-Atr-002907	Amborella trichopoda	42.19	1.00e-09	57.40
IUUC-Aca-004329	Anolis carolinensis	70.18	3.00e-49	187.00
IUUC-Aly-005639	Arabidopsis lyrata	41.67	5.00e-12	65.50
IUUC-Ath-006887	Arabidopsis thaliana	42.86	3.00e-12	66.20
IUUC-Ago-007989	Ashbya gossypii	35.90	6.00e-06	44.70
IUUC-Ame-011399	Astyanax mexicanus	54.40	1.00e-64	239.00
IUUC-Bta-013151	Bos taurus	91.58	3.00e-123	434.00
IUUC-Bdi-014311	Brachypodium distachyon	54.55	1.00e-09	57.80
IUUC-Bol-016537	Brassica oleracea	50.91	9.00e-12	64.70
IUUC-Bra-017906	Brassica rapa	59.09	2.00e-11	63.90
IUUC-Cel-018300	Caenorhabditis elegans	34.85	6.00e-13	67.80
IUUC-Cja-019084	Callithrix jacchus	91.90	6.00e-100	357.00
IUUC-Cfa-020997	Canis familiaris	89.79	1.00e-89	322.00
IUUC-Cpo-021736	Cavia porcellus	79.80	3.00e-83	301.00
IUUC-Csa-024040	Chlorocebus sabaeus	93.27	3.00e-101	360.00
IUUC-Cho-024543	Choloepus hoffmanni	92.12	9.00e-70	256.00
IUUC-Cin-025719	Ciona intestinalis	40.34	4.00e-41	161.00
IUUC-Csv-025854	Ciona savignyi	38.33	3.00e-39	155.00
IUUC-Cme-027235	Cyanidioschyzon merolae	47.73	4.00e-08	52.80
IUUC-Dre-027745	Danio rerio	53.18	7.00e-61	227.00
IUUC-Dno-029598	Dasypus novemcinctus	89.23	1.00e-101	362.00
IUUC-Dor-030917	Dipodomys ordii	80.63	6.00e-90	323.00
IUUC-Dme-032055	Drosophila melanogaster	41.38	7.00e-24	104.00
IUUC-Ete-032960	Echinops telfairi	75.53	1.00e-77	283.00
IUUC-Eca-034294	Equus caballus	92.59	3.00e-111	394.00
IUUC-Eeu-034906	Erinaceus europaeus	87.37	6.00e-104	370.00
IUUC-Fca-035653	Felis catus	90.49	4.00e-95	340.00
IUUC-Gmo-038755	Gadus morhua	50.96	7.00e-58	217.00
IUUC-Gac-042481	Gasterosteus aculeatus	53.87	3.00e-57	214.00
IUUC-Ggo-044821	Gorilla gorilla	92.25	2.00e-94	338.00
IUUC-Hsa-046797	Homo sapiens	92.59	1.00e-102	365.00
IUUC-Itr-048850	Ictidomys tridecemlineatus	95.29	3.00e-116	411.00
IUUC-Lch-049508	Latimeria chalumnae	53.07	6.00e-57	214.00
IUUC-Laf-053932	Loxodonta africana	91.58	1.00e-126	445.00
IUUC-Mcc-055300	Macaca mulatta	92.93	5.00e-101	360.00
IUUC-Mtr-058774	Medicago truncatula	50.00	8.00e-10	57.80
IUUC-Mla-059083	Melampsora laricipopulina	26.98	1.00e-14	73.90
IUUC-Mvi-060245	Microbotryum violaceum	40.48	6.00e-12	64.70
IUUC-Mmr-060979	Microcebus murinus	90.57	2.00e-106	379.00
IUUC-Mdo-062299	Monodelphis domestica	82.75	4.00e-94	337.00
IUUC-Mmu-063212	Mus musculus	97.31	8.00e-125	439.00
IUUC-Mac-065072	Musa acuminata	60.53	1.00e-10	60.50
IUUC-Mpu-066540	Mustela putorius furo	91.58	9.00e-112	396.00
IUUC-Mlu-067589	Myotis lucifugus	90.91	3.00e-105	374.00
IUUC-Nle-069045	Nomascus leucogenys	93.15	4.00e-76	277.00
IUUC-Opr-070772	Ochotona princeps	88.34	2.00e-90	325.00
IUUC-Ont-072006	Oreochromis niloticus	53.82	1.00e-57	216.00
IUUC-Oan-073244	Ornithorhynchus anatinus	61.07	3.00e-46	178.00
IUUC-Ocu-074333	Oryctolagus cuniculus	90.57	1.00e-102	365.00
IUUC-Ogl-077259	Oryza glaberrima	41.10	3.00e-10	59.70
IUUC-Ome-081253	Oryza meridionalis	50.94	3.00e-11	62.80
IUUC-Oni-082110	Oryza nivara	39.08	9.00e-11	60.80
IUUC-Ola-086781	Oryzias latipes	54.19	2.00e-54	205.00
IUUC-Oga-088429	Otolemur garnettii	91.92	1.00e-102	365.00
IUUC-Oar-089885	Ovis aries	90.91	1.00e-122	432.00
IUUC-Ptr-091315	Pan troglodytes	91.90	3.00e-94	338.00
IUUC-Pan-092885	Papio anubis	93.27	3.00e-101	360.00
IUUC-Psi-093299	Pelodiscus sinensis	69.55	2.00e-64	238.00
IUUC-Pma-094221	Petromyzon marinus	64.37	2.00e-28	117.00
IUUC-Ppa-095484	Physcomitrella patens	51.11	2.00e-10	60.10
IUUC-Pfo-096188	Poecilia formosa	54.40	1.00e-55	209.00
IUUC-Pab-097881	Pongo abelii	87.21	1.00e-99	355.00
IUUC-Pop-098863	Populus trichocarpa	40.91	6.00e-12	65.10
IUUC-Pca-100977	Procavia capensis	88.85	5.00e-102	363.00
IUUC-Ppe-101243	Prunus persica	47.06	6.00e-10	58.20
IUUC-Pva-102169	Pteropus vampyrus	91.55	2.00e-98	352.00
IUUC-Sha-107526	Sarcophilus harrisii	85.19	1.00e-94	339.00
IUUC-Ssl-108389	Sclerotinia sclerotiorum	28.26	4.00e-06	46.20
IUUC-Sit-110434	Setaria italica	30.81	3.00e-10	59.30
IUUC-Stu-112122	Solanum tuberosum	47.54	5.00e-11	62.40
IUUC-Sar-112945	Sorex araneus	89.18	8.00e-68	249.00
IUUC-Sbi-114159	Sorghum bicolor	31.35	8.00e-12	64.30
IUUC-Ssc-116114	Sus scrofa	91.58	2.00e-98	352.00
IUUC-Tru-117839	Takifugu rubripes	53.67	3.00e-59	221.00
IUUC-Tsy-118813	Tarsius syrichta	69.37	8.00e-96	343.00
IUUC-Tni-120504	Tetraodon nigroviridis	56.52	2.00e-60	225.00
IUUC-Tur-126615	Triticum urartu	38.37	3.00e-09	56.60
IUUC-Tbe-128034	Tupaia belangeri	91.55	3.00e-104	371.00
IUUC-Ttr-128468	Tursiops truncatus	87.50	3.00e-103	368.00
IUUC-Uma-129569	Ustilago maydis	33.33	3.00e-04	39.30
IUUC-Vpa-130179	Vicugna pacos	86.58	1.00e-75	275.00
IUUC-Xtr-132119	Xenopus tropicalis	63.09	7.00e-67	247.00
IUUC-Xma-134067	Xiphophorus maculatus	53.90	7.00e-56	210.00
IUUC-Zma-134709	Zea mays	32.07	1.00e-10	60.10

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence