iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000162402.13	ENST00000294383.6	ENSP00000294383.5
ENSG00000162402.13	ENST00000484447.5	ENSP00000489026.1
ENSG00000162402.13	ENST00000634589.1	ENSP00000489531.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
iRefIndex	Mentha
Disease-associated Information
GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	12401499
UBD/Alpha-Helix/UBA	UBA	23159851

Classification

Family	E-value	Score	Start	End
DUB/USP	1.50e-78	266.0	1689	2041
UBD/Alpha-Helix/UBA	4.00e-05	25.2	4	41

Active Site

Position(s)	Description	Evidence
1698	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
1970	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           +Gl+N g+tCYmN+v Q+L++ p l e ll+     ++++  ++p+ ++  ++q+lf +l++sk +++ p++++k++k++++e+   eqq
   Q: 1689 VGLRNGGATCYMNAVFQQLYMQPGLPESLLS-----VDDD-TDNPDDSVFYQVQSLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQ 1772
           6******************************.....5444.468999******************************************* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgke 180
           Da Ef++ l+dq++e+l                          kk+  +++ +++Fqg +++q +c++c ++++ree f+ l+l v + +
   Q: 1773 DAYEFFTSLIDQMDEYL--------------------------KKMGRDQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQ 1836
           *****************..........................78999****************************************** PP
   S: 181  etkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts... 267
                sl+ +L++f++ e leg+n+yycekck+k+ ++k++ +k+lP vL++hL+Rf f+ e ++++k ++++ fp +L+++p+++s   
   Q: 1837 -----SLEISLDQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNMEPYTVSgma 1921
           .....9*********************************************************************************666 PP
   S: 268  ..peekqke.........................kkkYeLiavvvHsGslssGHYvayvkn....ekgkWllfdDskVtevk.eeevlee 325
             +     +                         +++YeL++v+vHsG+++ GHY++++k+     kgkW++f+D+ ++e +  +e le 
   Q: 1922 rqD-----SssevgengrsvdqggggsprkkvalTENYELVGVIVHSGQAHAGHYYSFIKDrrgcGKGKWYKFNDTVIEEFDlNDETLEY 2006
           550.....34445555566666666666666666***************************55555666************844666664 PP
   S: 326  tg.......................staYvlfYkr 337
           +                        ++aY+lfY+r
   Q: 2007 ECfggeyrpkvydqtnpytdvrrryWNAYMLFYQR 2041
           449******************************98 PP

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlveMGF.dreealqaLraannnleaAveyL 38
           e+e+ +  l  MGF d+ ++++aLr a n++++Av++L
   Q: 4    EEEQHMTTLLCMGFsDPATIRKALRLAKNDINEAVALL 41
           6788889999**************************98 PP

Organism

Homo sapiens

Functional Description
(View)

Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Deubiquitinates DDB2, preventing its proteasomal degradation.

Protein Sequence
(Fasta)

MESEEEQHMT TLLCMGFSDP ATIRKALRLA KNDINEAVAL LTNERPGLDY GGYEPMDSGG 60
GPSPGPGGGP RGDGGGDGGG GGPSRGGSTG GGGGFDPPPA YHEVVDAEKN DENGNCSGEG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAATCGG AGGAGGAGCA GCACATGACC ACGCTGCTGT GCATGGGCTT CTCAGACCCC 60
GCCACCATCC GCAAGGCCCT GCGCCTGGCC AAGAACGACA TTAACGAGGC CGTGGCACTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR016024--ARM-type_fold
IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR029071--Ubiquitin-rel_dom
IPR033382--USP24
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:23358

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002266	Ailuropoda melanoleuca	99.05	0.00e+00	4841.00
IUUC-Apl-003203	Anas platyrhynchos	74.72	0.00e+00	3504.00
IUUC-Aca-004396	Anolis carolinensis	90.02	0.00e+00	4512.00
IUUC-Ame-011886	Astyanax mexicanus	84.62	0.00e+00	1770.00
IUUC-Bta-013381	Bos taurus	98.09	0.00e+00	4912.00
IUUC-Cel-018352	Caenorhabditis elegans	29.80	2.00e-61	233.00
IUUC-Cja-018955	Callithrix jacchus	99.24	0.00e+00	4455.00
IUUC-Cfa-020720	Canis familiaris	98.85	0.00e+00	4826.00
IUUC-Cpo-022430	Cavia porcellus	96.06	0.00e+00	3447.00
IUUC-Csa-024180	Chlorocebus sabaeus	99.67	0.00e+00	4675.00
IUUC-Cho-025074	Choloepus hoffmanni	92.64	0.00e+00	1842.00
IUUC-Dre-027696	Danio rerio	80.68	0.00e+00	4088.00
IUUC-Dno-029307	Dasypus novemcinctus	95.78	0.00e+00	4776.00
IUUC-Dor-030889	Dipodomys ordii	95.26	0.00e+00	4621.00
IUUC-Ete-032294	Echinops telfairi	92.94	0.00e+00	2324.00
IUUC-Eca-033823	Equus caballus	93.07	0.00e+00	4524.00
IUUC-Eeu-035178	Erinaceus europaeus	89.22	0.00e+00	2129.00
IUUC-Fca-035444	Felis catus	98.85	0.00e+00	4774.00
IUUC-Fal-037555	Ficedula albicollis	92.79	0.00e+00	4528.00
IUUC-Gmo-038587	Gadus morhua	80.19	0.00e+00	2494.00
IUUC-Gga-041231	Gallus gallus	92.29	0.00e+00	4638.00
IUUC-Gac-041584	Gasterosteus aculeatus	80.19	0.00e+00	2463.00
IUUC-Ggo-044502	Gorilla gorilla	99.27	0.00e+00	4920.00
IUUC-Itr-048746	Ictidomys tridecemlineatus	98.32	0.00e+00	1582.00
IUUC-Lch-049999	Latimeria chalumnae	79.69	0.00e+00	3927.00
IUUC-Loc-051767	Lepisosteus oculatus	82.40	0.00e+00	4118.00
IUUC-Laf-054139	Loxodonta africana	98.02	0.00e+00	4885.00
IUUC-Mcc-055217	Macaca mulatta	99.20	0.00e+00	4926.00
IUUC-Meu-056659	Macropus eugenii	81.68	0.00e+00	2258.00
IUUC-Mga-059267	Meleagris gallopavo	93.04	0.00e+00	4565.00
IUUC-Mmr-060971	Microcebus murinus	96.89	0.00e+00	4845.00
IUUC-Mdo-061925	Monodelphis domestica	94.24	0.00e+00	4648.00
IUUC-Mmu-064019	Mus musculus	96.76	0.00e+00	4952.00
IUUC-Mpu-066652	Mustela putorius furo	98.44	0.00e+00	4945.00
IUUC-Mlu-067518	Myotis lucifugus	98.53	0.00e+00	4768.00
IUUC-Nle-069763	Nomascus leucogenys	99.52	0.00e+00	4800.00
IUUC-Opr-071031	Ochotona princeps	91.76	0.00e+00	4418.00
IUUC-Ont-072136	Oreochromis niloticus	78.41	0.00e+00	3997.00
IUUC-Oan-072908	Ornithorhynchus anatinus	84.97	0.00e+00	966.00
IUUC-Ocu-073880	Oryctolagus cuniculus	97.18	0.00e+00	4897.00
IUUC-Ola-086544	Oryzias latipes	77.33	0.00e+00	3848.00
IUUC-Oga-088695	Otolemur garnettii	98.28	0.00e+00	4947.00
IUUC-Oar-089401	Ovis aries	98.33	0.00e+00	4759.00
IUUC-Ptr-091657	Pan troglodytes	99.92	0.00e+00	4832.00
IUUC-Pan-092394	Papio anubis	99.24	0.00e+00	4928.00
IUUC-Psi-093813	Pelodiscus sinensis	93.16	0.00e+00	4543.00
IUUC-Pma-094698	Petromyzon marinus	53.63	4.00e-137	481.00
IUUC-Pfo-096811	Poecilia formosa	78.99	0.00e+00	3984.00
IUUC-Pab-097814	Pongo abelii	99.24	0.00e+00	4927.00
IUUC-Pca-101135	Procavia capensis	93.26	0.00e+00	2228.00
IUUC-Pva-102334	Pteropus vampyrus	93.54	0.00e+00	4646.00
IUUC-Rno-105040	Rattus norvegicus	96.56	0.00e+00	4900.00
IUUC-Sha-106658	Sarcophilus harrisii	94.72	0.00e+00	4663.00
IUUC-Sar-113153	Sorex araneus	87.04	0.00e+00	2755.00
IUUC-Ssc-115641	Sus scrofa	97.21	0.00e+00	4620.00
IUUC-Tgu-117467	Taeniopygia guttata	93.49	0.00e+00	3317.00
IUUC-Tru-118074	Takifugu rubripes	72.44	0.00e+00	3456.00
IUUC-Tsy-119165	Tarsius syrichta	94.43	0.00e+00	4531.00
IUUC-Tni-119923	Tetraodon nigroviridis	68.86	0.00e+00	3222.00
IUUC-Tbe-127910	Tupaia belangeri	91.24	0.00e+00	1821.00
IUUC-Ttr-128218	Tursiops truncatus	97.33	0.00e+00	4759.00
IUUC-Vpa-130090	Vicugna pacos	99.08	0.00e+00	1741.00
IUUC-Xtr-131911	Xenopus tropicalis	86.30	0.00e+00	1713.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence