iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000162585.16	ENST00000428120.5	ENSP00000405430.1
ENSG00000162585.16	ENST00000414253.5	ENSP00000410450.1
ENSG00000162585.16	ENST00000400918.7	ENSP00000383709.3
ENSG00000162585.16	ENST00000378546.8	ENSP00000367808.4
ENSG00000162585.16	ENST00000440825.6	ENSP00000410740.2
ENSG00000162585.16	ENST00000420515.1	ENSP00000409721.1
ENSG00000162585.16	ENST00000400919.7	ENSP00000383710.4

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
AREsite	CircNet	miRTarBase	microRNA
TRANSFAC	TargetScan	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	UniProt
BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/ZnF/UBZ	UBZ	22396592

Classification

Family	E-value	Score	Start	End
UBD/ZnF/UBZ	3.30e-07	32.1	145	171

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/UBZ

   S: 2    lvCPvCqkm....vdqtdfeeHlDeCl 24
            +CP+Cqk+    ++q d+++Hl++Cl
   Q: 145  RSCPMCQKEfaprLTQLDVDSHLAQCL 171
           69************************8 PP

Organism

Homo sapiens

Functional Description
(View)

Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1.

Protein Sequence
(Fasta)

MEAARRPRLG LSRRRPRPAG GPSGGRPWFL LGGDERERLW AELLRTVSPE LILDHEVPSL 60
PAFPGQEPRC GPEPTEVFTV GPKTFSWTPF PPDLWGPGRS YRLLHGAGGH LESPARSLPQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAACATGGAT GCCTCGCTTT TCAGAGACTC GCGTTCTTGG AACTTACACC CTTTTGGGTT 60
TGCTATTTTT ACCCACCCTG AGCCTTCCGG TCTCCATGGC GACGCCTCCA AACAGCAGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR031491--FANCA_interact
IPR031490--UBZ_FAAP20

Pfam

PF15751--FANCA_interact
PF15750--UBZ_FAAP20

Gene Ontology

GO:0030054--C:cell junction
GO:0005694--C:chromosome
GO:0043240--C:Fanconi anaemia nuclear complex
GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0070530--F:K63-linked polyubiquitin binding
GO:0046872--F:metal ion binding
GO:0031593--F:polyubiquitin binding
GO:0043130--F:ubiquitin binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0036297--P:interstrand cross-link repair
GO:0019985--P:translesion synthesis

KEGG

hsa:199990

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002409	Ailuropoda melanoleuca	56.45	9.00e-13	64.70
IUUC-Aly-005778	Arabidopsis lyrata	34.29	1.60e-01	27.30
IUUC-Ani-009438	Aspergillus nidulans	34.78	1.90e-01	28.90
IUUC-Bta-013416	Bos taurus	46.95	4.00e-23	101.00
IUUC-Cja-019117	Callithrix jacchus	80.95	4.00e-64	238.00
IUUC-Cpo-021546	Cavia porcellus	69.64	4.00e-17	79.00
IUUC-Csa-024066	Chlorocebus sabaeus	92.16	1.00e-76	278.00
IUUC-Dno-029273	Dasypus novemcinctus	76.92	7.00e-18	82.00
IUUC-Ete-033066	Echinops telfairi	50.00	4.00e-33	134.00
IUUC-Eca-033947	Equus caballus	57.23	6.00e-30	123.00
IUUC-Eeu-034567	Erinaceus europaeus	58.04	1.00e-31	128.00
IUUC-Gac-041654	Gasterosteus aculeatus	52.94	4.00e-09	53.90
IUUC-Ggo-045315	Gorilla gorilla	99.34	4.00e-83	300.00
IUUC-Itr-048140	Ictidomys tridecemlineatus	56.96	2.00e-30	125.00
IUUC-Laf-054078	Loxodonta africana	58.48	6.00e-32	130.00
IUUC-Mmr-060675	Microcebus murinus	66.88	2.00e-47	181.00
IUUC-Mmu-063902	Mus musculus	53.70	2.00e-32	131.00
IUUC-Nle-069135	Nomascus leucogenys	97.39	1.00e-82	298.00
IUUC-Oga-088370	Otolemur garnettii	67.28	5.00e-51	193.00
IUUC-Oar-090037	Ovis aries	66.67	2.00e-15	76.30
IUUC-Ptr-091600	Pan troglodytes	95.86	4.00e-79	286.00
IUUC-Pan-091731	Papio anubis	94.34	6.00e-82	296.00
IUUC-Pfo-096538	Poecilia formosa	51.28	3.00e-07	47.80
IUUC-Pab-098384	Pongo abelii	96.69	3.00e-80	291.00
IUUC-Pca-100684	Procavia capensis	51.48	1.00e-34	139.00
IUUC-Rno-105623	Rattus norvegicus	52.12	8.00e-33	133.00
IUUC-Sha-107222	Sarcophilus harrisii	65.79	1.00e-12	65.50

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence