iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000163162.8	ENST00000424632.5	ENSP00000399090.1
ENSG00000163162.8	ENST00000295317.3	ENSP00000295317.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	miRecords	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Variation
GWASdb	GWAS Central
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	9.60e-06	27.7	269	310

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           Ca+C e f  kd  ++lpC+H+fh+ C+  w         + +CP C+
   Q: 269  CAVCIENFkvKDIIRILPCKHIFHRICIDPW------LLDHRTCPMCK 310
           ********8866699****************......9999******6 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation.

Protein Sequence
(Fasta)

MAWRRREASV GARGVLALAL LALALCVPGA RGRALEWFSA VVNIEYVDPQ TNLTVWSVSE 60
SGRFGDSSPK EGAHGLVGVP WAPGGDLEGC APDTRFFVPE PGGRGAAPWV ALVARGGCTF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACCCCGCCT CAGTCTTCCA GGGCGGCGGT GGGTGTCCGC TTCTCTCTGC TCTTCGACTG 60
CACCGCACTC GCGCGTGACC CTGACTCCCC CTAGTCAGCT CAGCGGTGCT GCCATGGCGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0732--Signal
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003137--PA_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF02225--PA
PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0016021--C:integral component of membrane
GO:0016020--C:membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0035690--P:cellular response to drug
GO:0043409--P:negative regulation of MAPK cascade
GO:0031647--P:regulation of protein stability

KEGG

hsa:284996

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001968	Ailuropoda melanoleuca	83.87	4.00e-175	607.00
IUUC-Apl-004109	Anas platyrhynchos	71.16	1.00e-100	359.00
IUUC-Bta-012340	Bos taurus	81.54	7.00e-165	573.00
IUUC-Cja-019566	Callithrix jacchus	91.25	0.00e+00	674.00
IUUC-Cfa-020289	Canis familiaris	84.94	3.00e-109	387.00
IUUC-Cpo-021916	Cavia porcellus	66.67	5.00e-73	267.00
IUUC-Csa-024084	Chlorocebus sabaeus	96.00	0.00e+00	685.00
IUUC-Cho-024305	Choloepus hoffmanni	81.94	7.00e-134	469.00
IUUC-Cgl-026578	Colletotrichum gloeosporioides	48.08	3.00e-12	66.20
IUUC-Cne-026985	Cryptococcus neoformans	29.91	4.00e-11	63.90
IUUC-Dno-030098	Dasypus novemcinctus	82.00	1.00e-178	619.00
IUUC-Dor-030620	Dipodomys ordii	74.42	4.00e-141	494.00
IUUC-Ete-032306	Echinops telfairi	82.62	6.00e-166	577.00
IUUC-Fca-035950	Felis catus	82.11	1.00e-114	405.00
IUUC-Fal-037429	Ficedula albicollis	67.47	1.00e-133	469.00
IUUC-Fso-038141	Fusarium solani	41.25	1.00e-15	77.80
IUUC-Gga-041201	Gallus gallus	65.97	6.00e-131	460.00
IUUC-Ggo-045429	Gorilla gorilla	98.89	0.00e+00	687.00
IUUC-Itr-048018	Ictidomys tridecemlineatus	80.11	6.00e-158	550.00
IUUC-Lch-049498	Latimeria chalumnae	62.16	5.00e-128	451.00
IUUC-Laf-054239	Loxodonta africana	69.17	7.00e-129	453.00
IUUC-Meu-056382	Macropus eugenii	73.61	1.00e-149	523.00
IUUC-Mor-056917	Magnaporthe oryzae	43.94	9.00e-13	68.60
IUUC-Mga-059435	Meleagris gallopavo	68.25	7.00e-66	243.00
IUUC-Mmr-061513	Microcebus murinus	85.48	1.00e-172	598.00
IUUC-Mdo-063028	Monodelphis domestica	74.04	2.00e-151	528.00
IUUC-Mmu-063545	Mus musculus	77.01	8.00e-153	533.00
IUUC-Mpu-066370	Mustela putorius furo	82.70	1.00e-170	592.00
IUUC-Mlu-067271	Myotis lucifugus	68.94	3.00e-131	461.00
IUUC-Nle-069207	Nomascus leucogenys	98.00	0.00e+00	717.00
IUUC-Opr-070704	Ochotona princeps	68.42	6.00e-92	330.00
IUUC-Oan-072837	Ornithorhynchus anatinus	69.31	1.00e-136	479.00
IUUC-Ocu-074671	Oryctolagus cuniculus	78.67	2.00e-121	427.00
IUUC-Oga-089083	Otolemur garnettii	83.25	1.00e-175	608.00
IUUC-Oar-089254	Ovis aries	81.22	1.00e-108	385.00
IUUC-Ptr-090940	Pan troglodytes	99.19	0.00e+00	710.00
IUUC-Pan-092636	Papio anubis	95.89	0.00e+00	678.00
IUUC-Psi-093435	Pelodiscus sinensis	74.48	1.00e-93	335.00
IUUC-Pab-098525	Pongo abelii	98.45	0.00e+00	697.00
IUUC-Pva-102395	Pteropus vampyrus	80.82	4.00e-169	587.00
IUUC-Pgr-103263	Puccinia graminis	36.56	1.00e-11	65.50
IUUC-Rno-105789	Rattus norvegicus	77.47	7.00e-151	526.00
IUUC-Sha-107305	Sarcophilus harrisii	71.01	6.00e-91	326.00
IUUC-Ssc-115598	Sus scrofa	81.87	3.00e-167	581.00
IUUC-Tgu-116463	Taeniopygia guttata	68.06	1.00e-129	456.00
IUUC-Tsy-118915	Tarsius syrichta	87.40	4.00e-109	387.00
IUUC-Tre-121978	Trichoderma reesei	48.98	3.00e-12	67.00
IUUC-Tme-126970	Tuber melanosporum	49.06	1.00e-12	68.20
IUUC-Tbe-127906	Tupaia belangeri	64.90	5.00e-77	280.00
IUUC-Xtr-131821	Xenopus tropicalis	61.66	3.00e-127	447.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence