iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
FBgn0261854	FBtr0303434	FBpp0292491
FBgn0261854	FBtr0303429	FBpp0292486
FBgn0261854	FBtr0303435	FBpp0292492
FBgn0261854	FBtr0329889	FBpp0302923
FBgn0261854	FBtr0303437	FBpp0292494
FBgn0261854	FBtr0329888	FBpp0302922
FBgn0261854	FBtr0329890	FBpp0302924
FBgn0261854	FBtr0329887	FBpp0302921
FBgn0261854	FBtr0303432	FBpp0292489
FBgn0261854	FBtr0303431	FBpp0292488

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UDP/UFD/PB1	66.45	0.00e+00	802.00	IUUC-Hsa-046991

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Drosophila melanogaster

Functional Description
(View)

Serine/threonine protein kinase which is required for apico-basal cell polarity in the germ line as well as in epithelial and neural precursor cells, for epithelial planar cell polarity and for cell proliferation. During oocyte development, required for the posterior translocation of oocyte specification factors and for the posterior establishment of the microtubule organizing center within the presumptive oocyte. Phosphorylates l(2)gl which restricts l(2)gl activity to the oocyte posterior and regulates posterior enrichment of par-1, leading to establishment of correct oocyte polarity. Essential for apical localization of l(2)gl and par-6 in neuroblasts and for exclusion of mira from the apical cortex. Phosphorylates baz which is required for targeting of baz to the postsynaptic region where it is involved in actin organization, and for apical exclusion of baz which is necessary for establishment of the apical/lateral border in epithelial cells. Phosphorylates yrt which prevents its premature apical localization and is necessary for correct epithelial cell polarization. Required for the establishment of mitotic spindle orientation during symmetric division of epithelial cells and for apical exclusion of raps/Pins. Involved in symmetric adherens junction positioning during embryogenesis. Required for polarization of the spermatid cyst which is necessary for sperm differentiation. Required for stimulation of the Toll signaling pathway which activates Dif and dl and plays a role in innate immunity. Plays a role in memory enhancement.

Protein Sequence
(Fasta)

MQKMPSQILN DGSSVSLNSA SMNMANTPNS ITVKTAYNGQ IIITTINKNI SYEELCYEIR 60
NICRFPLDQP FTIKWVDEEN DPCTISTKME LDEAIRLYEM NFDSQLVIHV FPNVPQAPGL 120

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Nucleotide Sequence
(Fasta)

TTGTCGGTAT TTTCTGTGCT GTCACTTCGC GTTCTCCGCT TTGTGCTCTC CTTCCACAAC 60
GAAATAAACG GAGAAATAGC AATGTTAGTT TTAATTCGTT TTAGCCATAA CAATTAATTA 120

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Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0418--Kinase
KW-0472--Membrane
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000961--AGC-kinase_C
IPR034659--Atypical_PKC
IPR020454--DAG/PE-bd
IPR011009--Kinase-like_dom
IPR000270--PB1_dom
IPR002219--PE/DAG-bd
IPR012233--PKC
IPR017892--Pkinase_C
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS51285--AGC_KINASE_CTER
PS51745--PB1
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF00564--PB1
PF00069--Pkinase
PF00433--Pkinase_C

PRINTS

PR00008--DAGPEDOMAIN

SMART

SM00109--C1
SM00666--PB1
SM00133--S_TK_X
SM00220--S_TKc

Gene Ontology

GO:0045179--C:apical cortex
GO:0016324--C:apical plasma membrane
GO:0016327--C:apicolateral plasma membrane
GO:0005938--C:cell cortex
GO:0035003--C:subapical complex
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0017022--F:myosin binding
GO:0004697--F:protein kinase C activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0034332--P:adherens junction organization
GO:0045176--P:apical protein localization
GO:0055059--P:asymmetric neuroblast division
GO:0045167--P:asymmetric protein localization involved in cell fate determination
GO:0060446--P:branching involved in open tracheal system development
GO:0007043--P:cell-cell junction assembly
GO:0046667--P:compound eye retinal cell programmed cell death
GO:0042335--P:cuticle development
GO:0003382--P:epithelial cell morphogenesis
GO:0045198--P:establishment of epithelial cell apical/basal polarity
GO:0090163--P:establishment of epithelial cell planar polarity
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007163--P:establishment or maintenance of cell polarity
GO:0045197--P:establishment or maintenance of epithelial cell apical/basal polarity
GO:0045196--P:establishment or maintenance of neuroblast polarity
GO:0016332--P:establishment or maintenance of polarity of embryonic epithelium
GO:0016334--P:establishment or maintenance of polarity of follicular epithelium
GO:0051601--P:exocyst localization
GO:0007294--P:germarium-derived oocyte fate determination
GO:0035556--P:intracellular signal transduction
GO:0030011--P:maintenance of cell polarity
GO:0035011--P:melanotic encapsulation of foreign target
GO:0007613--P:memory
GO:0001738--P:morphogenesis of a polarized epithelium
GO:0007314--P:oocyte anterior/posterior axis specification
GO:0007309--P:oocyte axis specification
GO:0018105--P:peptidyl-serine phosphorylation
GO:0051491--P:positive regulation of filopodium assembly
GO:0010592--P:positive regulation of lamellipodium assembly
GO:0002052--P:positive regulation of neuroblast proliferation
GO:0072659--P:protein localization to plasma membrane
GO:0006468--P:protein phosphorylation
GO:0030860--P:regulation of polarized epithelial cell differentiation
GO:0007423--P:sensory organ development
GO:0007283--P:spermatogenesis
GO:0007416--P:synapse assembly
GO:0007430--P:terminal branching, open tracheal system
GO:0045186--P:zonula adherens assembly

KEGG

dme:Dmel_CG42783

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001764	Ailuropoda melanoleuca	70.04	0.00e+00	739.00
IUUC-Apl-003711	Anas platyrhynchos	69.59	0.00e+00	784.00
IUUC-Aca-005142	Anolis carolinensis	68.86	0.00e+00	788.00
IUUC-Ame-010977	Astyanax mexicanus	66.95	0.00e+00	762.00
IUUC-Bta-013414	Bos taurus	66.39	0.00e+00	797.00
IUUC-Bol-015169	Brassica oleracea	33.03	5.00e-49	189.00
IUUC-Cel-018340	Caenorhabditis elegans	56.48	0.00e+00	673.00
IUUC-Cja-019802	Callithrix jacchus	69.40	0.00e+00	780.00
IUUC-Cfa-021236	Canis familiaris	66.01	0.00e+00	784.00
IUUC-Cpo-022127	Cavia porcellus	67.85	0.00e+00	757.00
IUUC-Csa-023332	Chlorocebus sabaeus	70.73	0.00e+00	689.00
IUUC-Cho-025054	Choloepus hoffmanni	71.53	8.00e-50	191.00
IUUC-Cin-025740	Ciona intestinalis	55.28	0.00e+00	650.00
IUUC-Csv-026145	Ciona savignyi	75.57	3.00e-165	574.00
IUUC-Dre-028444	Danio rerio	67.17	0.00e+00	768.00
IUUC-Dno-029228	Dasypus novemcinctus	80.32	4.00e-156	543.00
IUUC-Ete-032633	Echinops telfairi	61.67	9.00e-122	429.00
IUUC-Eca-033572	Equus caballus	69.52	0.00e+00	785.00
IUUC-Eeu-035110	Erinaceus europaeus	67.23	0.00e+00	786.00
IUUC-Fca-035559	Felis catus	66.45	0.00e+00	794.00
IUUC-Fal-036953	Ficedula albicollis	70.13	0.00e+00	788.00
IUUC-Gmo-039334	Gadus morhua	66.50	0.00e+00	786.00
IUUC-Gga-040223	Gallus gallus	68.49	0.00e+00	795.00
IUUC-Gac-042113	Gasterosteus aculeatus	66.22	0.00e+00	786.00
IUUC-Ggo-044520	Gorilla gorilla	63.85	0.00e+00	733.00
IUUC-Hsa-046991	Homo sapiens	66.45	0.00e+00	793.00
IUUC-Lch-050263	Latimeria chalumnae	65.66	0.00e+00	770.00
IUUC-Loc-052221	Lepisosteus oculatus	68.13	0.00e+00	769.00
IUUC-Laf-053591	Loxodonta africana	66.61	0.00e+00	798.00
IUUC-Mcc-055118	Macaca mulatta	66.50	0.00e+00	792.00
IUUC-Mga-059886	Meleagris gallopavo	69.77	0.00e+00	787.00
IUUC-Mmr-060926	Microcebus murinus	66.61	0.00e+00	796.00
IUUC-Mdo-062698	Monodelphis domestica	67.64	0.00e+00	773.00
IUUC-Mmu-063689	Mus musculus	66.28	0.00e+00	796.00
IUUC-Mpu-066630	Mustela putorius furo	66.67	0.00e+00	790.00
IUUC-Mlu-067416	Myotis lucifugus	63.49	0.00e+00	747.00
IUUC-Nle-069811	Nomascus leucogenys	66.28	0.00e+00	791.00
IUUC-Opr-070466	Ochotona princeps	64.10	7.00e-159	553.00
IUUC-Ont-072278	Oreochromis niloticus	69.16	0.00e+00	756.00
IUUC-Oan-073651	Ornithorhynchus anatinus	79.83	8.00e-175	605.00
IUUC-Ocu-074383	Oryctolagus cuniculus	66.78	0.00e+00	796.00
IUUC-Ola-087283	Oryzias latipes	84.50	3.00e-143	501.00
IUUC-Oga-088337	Otolemur garnettii	60.10	0.00e+00	689.00
IUUC-Oar-089954	Ovis aries	69.70	0.00e+00	787.00
IUUC-Ptr-091673	Pan troglodytes	66.45	0.00e+00	793.00
IUUC-Pan-092494	Papio anubis	66.39	0.00e+00	797.00
IUUC-Psi-094044	Pelodiscus sinensis	68.66	0.00e+00	788.00
IUUC-Pfo-096661	Poecilia formosa	66.61	0.00e+00	757.00
IUUC-Pab-097659	Pongo abelii	66.07	0.00e+00	793.00
IUUC-Pca-101107	Procavia capensis	79.88	3.00e-172	597.00
IUUC-Rno-105790	Rattus norvegicus	66.78	0.00e+00	798.00
IUUC-Sha-106895	Sarcophilus harrisii	69.59	0.00e+00	771.00
IUUC-Sar-113513	Sorex araneus	63.12	6.00e-105	374.00
IUUC-Ssc-115835	Sus scrofa	69.92	0.00e+00	741.00
IUUC-Tgu-116874	Taeniopygia guttata	66.61	0.00e+00	793.00
IUUC-Tru-117823	Takifugu rubripes	67.92	0.00e+00	765.00
IUUC-Tsy-119154	Tarsius syrichta	69.70	0.00e+00	786.00
IUUC-Tni-119968	Tetraodon nigroviridis	66.11	0.00e+00	753.00
IUUC-Tbe-127238	Tupaia belangeri	55.78	1.00e-143	502.00
IUUC-Ttr-129208	Tursiops truncatus	66.50	0.00e+00	791.00
IUUC-Vpa-130363	Vicugna pacos	79.47	1.00e-147	515.00
IUUC-Xtr-132652	Xenopus tropicalis	60.77	0.00e+00	741.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence