iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000163820.14	ENST00000433878.5	ENSP00000388136.1
ENSG00000163820.14	ENST00000296137.6	ENSP00000296137.2
ENSG00000163820.14	ENST00000535325.5	ENSP00000441178.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	miRecords	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
Phospho.ELM	UniProt	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	60.47	3.00e-11	66.60	IUUC-Sce-106309

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Homo sapiens

Functional Description
(View)

May mediate microtubule plus end-directed vesicle transport.

Protein Sequence
(Fasta)

MASTNAESQL QRIIRDLQDA VTELSKEFQE AGEPITDDST SLHKFSYKLE YLLQFDQKEK 60
ATLLGNKKDY WDYFCACLAK VKGANDGIRF VKSISELRTS LGKGRAFIRY SLVHQRLADT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCCTCTTGG TGTGCGCGTC ATGGCCGTCA GCACCGCGTT CCCGTCCTCT TCCGCTTGGC 60
CCCAGAAAGT TTCGGTTCTG CCCGGCGGTG GACCCACGAG CGCGTAAGTG CCGCGGAAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0898--Cataract
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0225--Disease mutation
KW-0967--Endosome
KW-0458--Lysosome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR009038--GOLD_dom
IPR004012--Run_dom
IPR000306--Znf_FYVE
IPR017455--Znf_FYVE-rel
IPR011011--Znf_FYVE_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50866--GOLD
PS50826--RUN
PS50178--ZF_FYVE

Pfam

PF01363--FYVE
PF02759--RUN

SMART

SM00064--FYVE

Gene Ontology

GO:0005776--C:autophagosome
GO:0005794--C:Golgi apparatus
GO:0016021--C:integral component of membrane
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005770--C:late endosome
GO:0005764--C:lysosome
GO:0016020--C:membrane
GO:0046872--F:metal ion binding
GO:0044183--F:protein binding involved in protein folding
GO:0051082--F:unfolded protein binding
GO:0006458--P:'de novo' protein folding
GO:0061077--P:chaperone-mediated protein folding
GO:0072383--P:plus-end-directed vesicle transport along microtubule
GO:1901098--P:positive regulation of autophagosome maturation

KEGG

hsa:79443

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001622	Ailuropoda melanoleuca	77.80	0.00e+00	1967.00
IUUC-Apl-004173	Anas platyrhynchos	40.70	3.00e-170	592.00
IUUC-Ame-010798	Astyanax mexicanus	50.83	5.00e-115	407.00
IUUC-Bta-012394	Bos taurus	78.52	0.00e+00	1961.00
IUUC-Cja-019711	Callithrix jacchus	93.10	0.00e+00	2404.00
IUUC-Cfa-020392	Canis familiaris	79.04	0.00e+00	2008.00
IUUC-Cpo-021456	Cavia porcellus	74.92	0.00e+00	1891.00
IUUC-Csa-023192	Chlorocebus sabaeus	95.47	0.00e+00	2443.00
IUUC-Dre-027779	Danio rerio	40.31	4.00e-161	563.00
IUUC-Dno-029277	Dasypus novemcinctus	75.80	0.00e+00	1435.00
IUUC-Eca-033806	Equus caballus	85.04	0.00e+00	2217.00
IUUC-Fca-035563	Felis catus	74.76	0.00e+00	1149.00
IUUC-Fal-036657	Ficedula albicollis	50.91	0.00e+00	1373.00
IUUC-Gmo-038911	Gadus morhua	38.12	0.00e+00	634.00
IUUC-Gga-041069	Gallus gallus	52.15	0.00e+00	1429.00
IUUC-Gac-042183	Gasterosteus aculeatus	40.31	0.00e+00	897.00
IUUC-Ggo-045276	Gorilla gorilla	98.51	0.00e+00	2498.00
IUUC-Itr-048929	Ictidomys tridecemlineatus	82.18	0.00e+00	2056.00
IUUC-Lch-049451	Latimeria chalumnae	43.63	0.00e+00	978.00
IUUC-Loc-052441	Lepisosteus oculatus	43.48	0.00e+00	1080.00
IUUC-Lma-053072	Leptosphaeria maculans	48.65	6.00e-09	56.20
IUUC-Laf-053370	Loxodonta africana	80.05	0.00e+00	1719.00
IUUC-Mcc-054975	Macaca mulatta	95.81	0.00e+00	2518.00
IUUC-Meu-056668	Macropus eugenii	58.52	0.00e+00	681.00
IUUC-Mor-056945	Magnaporthe oryzae	32.43	4.00e-09	57.00
IUUC-Mmr-061339	Microcebus murinus	87.42	0.00e+00	2259.00
IUUC-Mdo-063054	Monodelphis domestica	60.00	0.00e+00	1529.00
IUUC-Mlu-067157	Myotis lucifugus	79.32	0.00e+00	1982.00
IUUC-Nle-069695	Nomascus leucogenys	96.21	0.00e+00	2400.00
IUUC-Ont-072336	Oreochromis niloticus	38.15	1.00e-163	571.00
IUUC-Oan-073536	Ornithorhynchus anatinus	61.93	0.00e+00	1751.00
IUUC-Ola-086470	Oryzias latipes	38.43	0.00e+00	802.00
IUUC-Oga-088658	Otolemur garnettii	85.13	0.00e+00	2287.00
IUUC-Oar-089316	Ovis aries	82.99	0.00e+00	958.00
IUUC-Ptr-091653	Pan troglodytes	99.26	0.00e+00	2504.00
IUUC-Pan-092033	Papio anubis	94.39	0.00e+00	2396.00
IUUC-Psi-093520	Pelodiscus sinensis	62.86	0.00e+00	669.00
IUUC-Pfo-096903	Poecilia formosa	39.36	0.00e+00	866.00
IUUC-Pab-098777	Pongo abelii	97.23	0.00e+00	2485.00
IUUC-Pva-102241	Pteropus vampyrus	81.86	0.00e+00	2041.00
IUUC-Pte-104063	Pyrenophora teres	48.65	2.00e-08	54.70
IUUC-Rno-104949	Rattus norvegicus	77.12	0.00e+00	1973.00
IUUC-Sce-106309	Saccharomyces cerevisiae	44.00	2.00e-12	66.20
IUUC-Sha-106591	Sarcophilus harrisii	62.42	0.00e+00	1575.00
IUUC-Spo-108288	Schizosaccharomyces pombe	51.22	5.00e-11	61.60
IUUC-Ssc-115324	Sus scrofa	80.15	0.00e+00	1765.00
IUUC-Tgu-116887	Taeniopygia guttata	67.15	2.00e-144	508.00
IUUC-Tru-118394	Takifugu rubripes	33.66	7.00e-89	322.00
IUUC-Tsy-119577	Tarsius syrichta	83.42	0.00e+00	2098.00
IUUC-Tni-119998	Tetraodon nigroviridis	40.31	2.00e-163	570.00
IUUC-Tvi-122664	Trichoderma virens	42.55	2.00e-09	57.40
IUUC-Tbe-127875	Tupaia belangeri	34.65	1.00e-14	76.60
IUUC-Ttr-128386	Tursiops truncatus	83.08	0.00e+00	927.00
IUUC-Vpa-130696	Vicugna pacos	34.65	1.00e-14	76.30

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence