iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000049502.16	ENSMUST00000081933.13	ENSMUSP00000080601.7
ENSMUSG00000049502.16	ENSMUST00000114885.1	ENSMUSP00000110535.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	circBase	miRTarBase	microRNA
TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	57.48	0.00e+00	808.00	IUUC-Hsa-045921

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation (By similarity). In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.

Protein Sequence
(Fasta)

MASSPDPPSP LLVRLRESIP KAHRKLEIYF QSRASGGGEC SVQPVGPSAP DTYEVKFLKK 60
ADKEKVLKKS EHEMLVHNKP VTIVLETTKK PVEDLRPRLP SLTQPVETPS SRPPSLTGSL 120

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Nucleotide Sequence
(Fasta)

AAACTTCCGA TCCTGCAAGA ATAGAAGGGC GACCTGCCAC CGTAGGGAAA CTTCCTCTGA 60
GCGCCCACCG CCGAGCGTGC GAACTACTCA CCGGGTGATG GCTCTGAGAG ATGGCAGAGC 120

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Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0042393--F:histone binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006302--P:double-strand break repair
GO:0010390--P:histone monoubiquitination

KEGG

mmu:209200

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001770	Ailuropoda melanoleuca	49.39	0.00e+00	669.00
IUUC-Aca-004465	Anolis carolinensis	36.33	5.00e-108	385.00
IUUC-Ame-011794	Astyanax mexicanus	32.68	1.00e-62	234.00
IUUC-Bta-012460	Bos taurus	51.11	0.00e+00	719.00
IUUC-Cja-019340	Callithrix jacchus	56.50	0.00e+00	819.00
IUUC-Cfa-020691	Canis familiaris	52.02	0.00e+00	741.00
IUUC-Cpo-021781	Cavia porcellus	51.58	0.00e+00	710.00
IUUC-Csa-024106	Chlorocebus sabaeus	58.01	0.00e+00	832.00
IUUC-Cho-024817	Choloepus hoffmanni	53.49	0.00e+00	721.00
IUUC-Csv-025973	Ciona savignyi	50.00	3.00e-47	181.00
IUUC-Dre-028024	Danio rerio	30.39	7.00e-63	235.00
IUUC-Dno-028880	Dasypus novemcinctus	55.02	0.00e+00	763.00
IUUC-Dor-030737	Dipodomys ordii	52.55	0.00e+00	716.00
IUUC-Ete-033015	Echinops telfairi	46.52	2.00e-76	280.00
IUUC-Eca-034086	Equus caballus	54.30	0.00e+00	736.00
IUUC-Eeu-034446	Erinaceus europaeus	52.02	5.00e-174	604.00
IUUC-Fca-036218	Felis catus	53.27	0.00e+00	769.00
IUUC-Fal-036797	Ficedula albicollis	36.68	3.00e-117	416.00
IUUC-Gmo-039104	Gadus morhua	59.14	3.00e-60	224.00
IUUC-Gga-041219	Gallus gallus	35.84	5.00e-109	389.00
IUUC-Ggo-044786	Gorilla gorilla	57.35	0.00e+00	823.00
IUUC-Hsa-045921	Homo sapiens	57.48	0.00e+00	830.00
IUUC-Itr-047911	Ictidomys tridecemlineatus	56.03	0.00e+00	818.00
IUUC-Loc-052602	Lepisosteus oculatus	32.71	1.00e-68	254.00
IUUC-Laf-054092	Loxodonta africana	53.01	0.00e+00	759.00
IUUC-Meu-056309	Macropus eugenii	43.76	7.00e-128	451.00
IUUC-Mga-059221	Meleagris gallopavo	34.89	4.00e-105	375.00
IUUC-Mmr-061722	Microcebus murinus	55.20	0.00e+00	779.00
IUUC-Mdo-062897	Monodelphis domestica	41.88	9.00e-150	524.00
IUUC-Mpu-065715	Mustela putorius furo	50.59	0.00e+00	702.00
IUUC-Mlu-068125	Myotis lucifugus	60.91	1.00e-76	278.00
IUUC-Opr-070573	Ochotona princeps	51.65	0.00e+00	701.00
IUUC-Ont-071501	Oreochromis niloticus	58.20	1.00e-60	225.00
IUUC-Ocu-074404	Oryctolagus cuniculus	52.32	0.00e+00	741.00
IUUC-Ola-087174	Oryzias latipes	54.60	2.00e-51	194.00
IUUC-Oga-088174	Otolemur garnettii	51.58	0.00e+00	656.00
IUUC-Oar-089488	Ovis aries	50.14	0.00e+00	651.00
IUUC-Ptr-091454	Pan troglodytes	57.35	0.00e+00	824.00
IUUC-Pan-092016	Papio anubis	57.87	0.00e+00	826.00
IUUC-Psi-093616	Pelodiscus sinensis	42.97	4.00e-108	385.00
IUUC-Pma-094722	Petromyzon marinus	60.87	1.00e-65	242.00
IUUC-Pfo-097512	Poecilia formosa	50.00	5.00e-60	223.00
IUUC-Pab-098106	Pongo abelii	56.05	0.00e+00	801.00
IUUC-Pva-103155	Pteropus vampyrus	50.57	0.00e+00	635.00
IUUC-Pgr-103282	Puccinia graminis	45.10	4.00e-07	48.10
IUUC-Rno-105277	Rattus norvegicus	76.21	0.00e+00	1119.00
IUUC-Sha-107310	Sarcophilus harrisii	41.54	5.00e-151	528.00
IUUC-Sar-113237	Sorex araneus	50.93	2.00e-118	419.00
IUUC-Ssc-115952	Sus scrofa	53.14	3.00e-150	525.00
IUUC-Tgu-117018	Taeniopygia guttata	37.64	5.00e-110	392.00
IUUC-Tsy-119396	Tarsius syrichta	51.23	6.00e-143	500.00
IUUC-Tbe-127250	Tupaia belangeri	50.73	7.00e-163	567.00
IUUC-Ttr-128283	Tursiops truncatus	49.81	0.00e+00	696.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence