iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000163874.9	ENST00000373087.6	ENSP00000362179.5
ENSG00000163874.9	ENST00000471012.1	ENSP00000473447.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2	LncRNADisease
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/Other	DUB/Other	21115689
UBD/Other/Other	UBD/Other/Other	22771441

Organism

Homo sapiens

Functional Description
(View)

(Microbial infection) Exhibits broad antiviral activity by cleaving viral RNAs (PubMed:23355615). Binds to Japanese encephalitis virus (JEV) and dengue virus (DEN) RNAs (PubMed:23355615). Exhibits antiviral activity against HIV-1 in lymphocytes by decreasing the abundance of HIV-1 viral RNA species (PubMed:24191027).

Protein Sequence
(Fasta)

MSGPCGEKPV LEASPTMSLW EFEDSHSRQG TPRPGQELAA EEASALELQM KVDFFRKLGY 60
SSTEIHSVLQ KLGVQADTNT VLGELVKHGT ATERERQTSP DPCPQLPLVP RGGGTPKAPN 120

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Nucleotide Sequence
(Fasta)

ATATAAAGGC GCCGCCGTCC TTACCCCCAG GACTCGGCCC CATGGAGACG CCGCCGGCCG 60
CCGCTGGCGC ATGGCGGGGT GAGGCGCGGC GGGGAGGGTG CGGGCCTCGG CGGGGAAGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0037--Angiogenesis
KW-0051--Antiviral defense
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0227--DNA damage
KW-0238--DNA-binding
KW-0255--Endonuclease
KW-0256--Endoplasmic reticulum
KW-0378--Hydrolase
KW-0391--Immunity
KW-0395--Inflammatory response
KW-0460--Magnesium
KW-0472--Membrane
KW-0479--Metal-binding
KW-0524--Neurogenesis
KW-0540--Nuclease
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0678--Repressor
KW-0694--RNA-binding
KW-0346--Stress response
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR021869--RNase_Zc3h12_NYN

Pfam

PF11977--RNase_Zc3h12a

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0042406--C:extrinsic component of endoplasmic reticulum membrane
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0043234--C:protein complex
GO:0005791--C:rough endoplasmic reticulum
GO:0030867--C:rough endoplasmic reticulum membrane
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0004521--F:endoribonuclease activity
GO:0004532--F:exoribonuclease activity
GO:0046872--F:metal ion binding
GO:0035198--F:miRNA binding
GO:0035925--F:mRNA 3'-UTR AU-rich region binding
GO:0003730--F:mRNA 3'-UTR binding
GO:0003729--F:mRNA binding
GO:0004540--F:ribonuclease activity
GO:0043022--F:ribosome binding
GO:0003723--F:RNA binding
GO:0035613--F:RNA stem-loop binding
GO:0061158--P:3'-UTR-mediated mRNA destabilization
GO:0001525--P:angiogenesis
GO:0006915--P:apoptotic process
GO:0030154--P:cell differentiation
GO:1990869--P:cellular response to chemokine
GO:0006974--P:cellular response to DNA damage stimulus
GO:0042149--P:cellular response to glucose starvation
GO:0071347--P:cellular response to interleukin-1
GO:1904637--P:cellular response to ionomycin
GO:0071222--P:cellular response to lipopolysaccharide
GO:0034599--P:cellular response to oxidative stress
GO:1904628--P:cellular response to phorbol 13-acetate 12-myristate
GO:1903936--P:cellular response to sodium arsenite
GO:0071356--P:cellular response to tumor necrosis factor
GO:0098586--P:cellular response to virus
GO:0051607--P:defense response to virus
GO:0006954--P:inflammatory response
GO:0044828--P:negative regulation by host of viral genome replication
GO:0055118--P:negative regulation of cardiac muscle contraction
GO:1900016--P:negative regulation of cytokine production involved in inflammatory response
GO:0010629--P:negative regulation of gene expression
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:1902714--P:negative regulation of interferon-gamma secretion
GO:0050713--P:negative regulation of interleukin-1 beta secretion
GO:0032715--P:negative regulation of interleukin-6 production
GO:1900165--P:negative regulation of interleukin-6 secretion
GO:0043031--P:negative regulation of macrophage activation
GO:0010656--P:negative regulation of muscle cell apoptotic process
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045019--P:negative regulation of nitric oxide biosynthetic process
GO:1903799--P:negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:0001933--P:negative regulation of protein phosphorylation
GO:0032720--P:negative regulation of tumor necrosis factor production
GO:1904468--P:negative regulation of tumor necrosis factor secretion
GO:0007399--P:nervous system development
GO:0000294--P:nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay
GO:0045766--P:positive regulation of angiogenesis
GO:0010508--P:positive regulation of autophagy
GO:0010942--P:positive regulation of cell death
GO:0002230--P:positive regulation of defense response to virus by host
GO:0010595--P:positive regulation of endothelial cell migration
GO:1900119--P:positive regulation of execution phase of apoptosis
GO:0045600--P:positive regulation of fat cell differentiation
GO:0010628--P:positive regulation of gene expression
GO:0010884--P:positive regulation of lipid storage
GO:2000627--P:positive regulation of miRNA catabolic process
GO:0061014--P:positive regulation of mRNA catabolic process
GO:1900745--P:positive regulation of p38MAPK cascade
GO:1903003--P:positive regulation of protein deubiquitination
GO:0042307--P:positive regulation of protein import into nucleus
GO:2000379--P:positive regulation of reactive oxygen species metabolic process
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0016579--P:protein deubiquitination
GO:0051259--P:protein oligomerization
GO:0010468--P:regulation of gene expression
GO:0090501--P:RNA phosphodiester bond hydrolysis
GO:0090502--P:RNA phosphodiester bond hydrolysis, endonucleolytic
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:80149

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002223	Ailuropoda melanoleuca	86.36	0.00e+00	823.00
IUUC-Apl-003631	Anas platyrhynchos	66.51	4.00e-150	524.00
IUUC-Aca-005301	Anolis carolinensis	55.59	7.00e-149	520.00
IUUC-Aly-005403	Arabidopsis lyrata	31.82	1.20e-01	32.30
IUUC-Ate-010342	Aspergillus terreus	31.25	2.40e-01	29.60
IUUC-Ame-010867	Astyanax mexicanus	69.48	1.00e-121	430.00
IUUC-Bta-012505	Bos taurus	86.79	0.00e+00	873.00
IUUC-Bol-016598	Brassica oleracea	30.99	1.40e-01	32.00
IUUC-Bra-016919	Brassica rapa	30.99	1.40e-01	32.30
IUUC-Cja-019490	Callithrix jacchus	92.32	0.00e+00	911.00
IUUC-Cfa-021149	Canis familiaris	80.68	0.00e+00	785.00
IUUC-Cpo-021301	Cavia porcellus	86.41	0.00e+00	831.00
IUUC-Csa-023367	Chlorocebus sabaeus	96.34	0.00e+00	961.00
IUUC-Cin-025756	Ciona intestinalis	65.33	6.00e-17	80.50
IUUC-Dre-027579	Danio rerio	68.40	1.00e-120	426.00
IUUC-Dno-030064	Dasypus novemcinctus	84.62	0.00e+00	791.00
IUUC-Dor-031093	Dipodomys ordii	75.93	0.00e+00	737.00
IUUC-Ete-032302	Echinops telfairi	72.06	1.00e-173	602.00
IUUC-Eca-033237	Equus caballus	88.34	0.00e+00	899.00
IUUC-Eeu-035130	Erinaceus europaeus	81.77	0.00e+00	687.00
IUUC-Fca-035416	Felis catus	87.14	0.00e+00	815.00
IUUC-Fal-037281	Ficedula albicollis	56.05	4.00e-166	578.00
IUUC-Fso-038424	Fusarium solani	29.79	2.50e-02	32.70
IUUC-Gmo-039204	Gadus morhua	64.78	4.00e-107	382.00
IUUC-Gac-041980	Gasterosteus aculeatus	55.08	1.00e-117	417.00
IUUC-Ggo-044933	Gorilla gorilla	99.33	0.00e+00	1002.00
IUUC-Itr-048614	Ictidomys tridecemlineatus	86.48	0.00e+00	856.00
IUUC-Lch-050063	Latimeria chalumnae	54.96	4.00e-166	578.00
IUUC-Loc-051993	Lepisosteus oculatus	52.07	7.00e-147	514.00
IUUC-Laf-053400	Loxodonta africana	87.25	0.00e+00	865.00
IUUC-Mcc-054768	Macaca mulatta	97.00	0.00e+00	959.00
IUUC-Meu-056059	Macropus eugenii	56.01	5.00e-128	451.00
IUUC-Mga-059707	Meleagris gallopavo	59.22	6.00e-171	594.00
IUUC-Mvi-060339	Microbotryum violaceum	38.30	7.80e-02	30.00
IUUC-Mmr-061391	Microcebus murinus	88.65	0.00e+00	882.00
IUUC-Mdo-062040	Monodelphis domestica	63.54	0.00e+00	658.00
IUUC-Mmu-064420	Mus musculus	82.14	0.00e+00	815.00
IUUC-Mpu-066099	Mustela putorius furo	85.25	0.00e+00	809.00
IUUC-Mlu-067979	Myotis lucifugus	84.76	0.00e+00	861.00
IUUC-Nle-069830	Nomascus leucogenys	94.49	0.00e+00	927.00
IUUC-Opr-071005	Ochotona princeps	84.48	0.00e+00	629.00
IUUC-Ont-072306	Oreochromis niloticus	47.03	3.00e-128	452.00
IUUC-Oan-073138	Ornithorhynchus anatinus	64.50	5.00e-169	587.00
IUUC-Ocu-073908	Oryctolagus cuniculus	88.68	0.00e+00	637.00
IUUC-Ola-087280	Oryzias latipes	45.61	5.00e-122	431.00
IUUC-Oga-088418	Otolemur garnettii	88.31	0.00e+00	882.00
IUUC-Oar-090414	Ovis aries	86.01	0.00e+00	679.00
IUUC-Ptr-091275	Pan troglodytes	99.33	0.00e+00	1006.00
IUUC-Pan-092541	Papio anubis	97.17	0.00e+00	939.00
IUUC-Psi-094002	Pelodiscus sinensis	60.14	2.00e-177	615.00
IUUC-Pab-098538	Pongo abelii	98.16	0.00e+00	964.00
IUUC-Pca-100137	Procavia capensis	84.27	0.00e+00	688.00
IUUC-Pva-102367	Pteropus vampyrus	86.03	0.00e+00	701.00
IUUC-Rno-105133	Rattus norvegicus	82.47	0.00e+00	872.00
IUUC-Sha-106603	Sarcophilus harrisii	66.05	9.00e-156	543.00
IUUC-Tgu-117358	Taeniopygia guttata	60.30	8.00e-148	516.00
IUUC-Tru-118112	Takifugu rubripes	48.36	4.00e-122	431.00
IUUC-Tsy-119005	Tarsius syrichta	78.43	1.00e-153	535.00
IUUC-Ttr-129314	Tursiops truncatus	87.65	0.00e+00	912.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence