iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
Mentha
Post-translational Modifications (PTMs)
dbPTM
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19000158; 18005227

Reviewed

Classification

Family	Identity	E-value	Score	Source Orthology
E3 activity/RING/RING	28.60	3.00e-48	192.00	IUUC-Hsa-046786

Organism

Arabidopsis thaliana

Functional Description
(View)

E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of KRP1 and KRP2.

Protein Sequence
(Fasta)

MAEDSLRVGM ISSGLAVLLN GEDAKENSSK ARIVPHFDYS GHRPLERTIE FIFGLAEKSV 60
GPLDGQVDSS LIRAVIKNQF SKLHGDLDVS VSQREGISVV HHGVGPPIVG LEEFSICGDI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATACGTCAT CAGCCACGTC ATCGACACCG ACACGTGTCG GTAAAAAACC CACACGCCAC 60
ATGATCCATT GGCTCGTTCG GTGTTAGCCA CCGGTCTTCT GATTCCTCTC TCTCTCTTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR003877--SPRY_dom
IPR019474--Ub_conjug_fac_E4_core
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50188--B302_SPRY
PS50089--ZF_RING_2

Pfam

PF00622--SPRY
PF10408--Ufd2P_core

SMART

SM00449--SPRY

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0000151--C:ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0008270--F:zinc ion binding
GO:0060154--P:cellular process regulating host cell cycle in response to virus
GO:0030163--P:protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT2G22010

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002334	Ailuropoda melanoleuca	33.05	8.00e-46	179.00
IUUC-Atr-002731	Amborella trichopoda	58.80	0.00e+00	1481.00
IUUC-Apl-003337	Anas platyrhynchos	25.75	3.00e-85	310.00
IUUC-Aca-005266	Anolis carolinensis	50.30	8.00e-47	181.00
IUUC-Aly-005720	Arabidopsis lyrata	96.80	0.00e+00	2415.00
IUUC-Ame-011173	Astyanax mexicanus	54.67	3.00e-48	186.00
IUUC-Bta-012466	Bos taurus	33.71	5.00e-48	186.00
IUUC-Bol-016281	Brassica oleracea	91.04	0.00e+00	2308.00
IUUC-Bra-016892	Brassica rapa	90.51	0.00e+00	2320.00
IUUC-Cel-018326	Caenorhabditis elegans	35.92	7.00e-17	82.00
IUUC-Cja-019535	Callithrix jacchus	34.17	5.00e-47	182.00
IUUC-Cfa-020260	Canis familiaris	33.71	2.00e-47	184.00
IUUC-Cpo-021921	Cavia porcellus	33.99	1.00e-48	187.00
IUUC-Cre-022617	Chlamydomonas reinhardtii	57.58	2.00e-54	207.00
IUUC-Csa-024158	Chlorocebus sabaeus	33.70	1.00e-46	181.00
IUUC-Cho-025093	Choloepus hoffmanni	47.14	9.00e-19	89.00
IUUC-Cin-025392	Ciona intestinalis	25.18	3.00e-29	122.00
IUUC-Csv-026376	Ciona savignyi	37.58	3.00e-15	75.90
IUUC-Dre-027457	Danio rerio	27.38	1.00e-42	167.00
IUUC-Dno-028922	Dasypus novemcinctus	39.44	2.00e-22	99.80
IUUC-Dor-030129	Dipodomys ordii	33.24	2.00e-46	181.00
IUUC-Dme-032022	Drosophila melanogaster	29.41	6.00e-44	172.00
IUUC-Ete-032681	Echinops telfairi	47.65	6.00e-41	162.00
IUUC-Eca-033488	Equus caballus	25.50	2.00e-87	317.00
IUUC-Eeu-035141	Erinaceus europaeus	26.48	1.00e-30	128.00
IUUC-Fca-036540	Felis catus	33.05	2.00e-45	177.00
IUUC-Fal-036716	Ficedula albicollis	52.00	2.00e-46	181.00
IUUC-Gmo-038827	Gadus morhua	24.34	7.00e-35	141.00
IUUC-Gga-040227	Gallus gallus	52.00	3.00e-46	180.00
IUUC-Gac-041611	Gasterosteus aculeatus	26.23	3.00e-41	162.00
IUUC-Gma-043507	Glycine max	67.55	0.00e+00	1722.00
IUUC-Ggo-045274	Gorilla gorilla	33.70	1.00e-46	181.00
IUUC-Hsa-046786	Homo sapiens	33.89	3.00e-48	186.00
IUUC-Itr-047988	Ictidomys tridecemlineatus	26.32	1.00e-91	330.00
IUUC-Lch-050613	Latimeria chalumnae	27.32	5.00e-41	161.00
IUUC-Lpe-050692	Leersia perrieri	55.95	0.00e+00	1369.00
IUUC-Loc-052484	Lepisosteus oculatus	54.67	3.00e-47	183.00
IUUC-Laf-053359	Loxodonta africana	32.69	1.00e-44	175.00
IUUC-Mcc-054643	Macaca mulatta	33.89	4.00e-48	186.00
IUUC-Meu-056856	Macropus eugenii	22.87	2.00e-27	117.00
IUUC-Mtr-058494	Medicago truncatula	65.41	0.00e+00	1690.00
IUUC-Mga-060198	Meleagris gallopavo	26.73	6.00e-28	119.00
IUUC-Mmr-061762	Microcebus murinus	25.48	4.00e-83	302.00
IUUC-Mdo-062049	Monodelphis domestica	25.43	4.00e-87	316.00
IUUC-Mmu-064274	Mus musculus	33.43	2.00e-47	184.00
IUUC-Mac-064561	Musa acuminata	55.43	0.00e+00	925.00
IUUC-Mpu-066413	Mustela putorius furo	33.05	6.00e-45	176.00
IUUC-Mlu-067411	Myotis lucifugus	33.33	4.00e-47	183.00
IUUC-Nle-069644	Nomascus leucogenys	33.89	4.00e-48	186.00
IUUC-Opr-070465	Ochotona princeps	28.38	7.00e-49	189.00
IUUC-Ont-072552	Oreochromis niloticus	26.23	3.00e-62	233.00
IUUC-Oan-073066	Ornithorhynchus anatinus	36.76	6.00e-15	74.70
IUUC-Ocu-074740	Oryctolagus cuniculus	33.43	9.00e-48	185.00
IUUC-Oba-075088	Oryza barthii	51.71	0.00e+00	722.00
IUUC-Obr-076657	Oryza brachyantha	55.16	0.00e+00	1298.00
IUUC-Ogl-077313	Oryza glaberrima	57.86	4.00e-110	390.00
IUUC-Ogu-078672	Oryza glumaepatula	51.99	0.00e+00	726.00
IUUC-Oin-079756	Oryza indica	54.00	0.00e+00	1232.00
IUUC-Olo-080369	Oryza longistaminata	52.20	0.00e+00	723.00
IUUC-Oni-082996	Oryza nivara	51.85	0.00e+00	725.00
IUUC-Opu-083892	Oryza punctata	53.51	2.00e-67	247.00
IUUC-Oru-084434	Oryza rufipogon	51.71	0.00e+00	742.00
IUUC-Osa-085595	Oryza sativa	56.60	6.00e-84	303.00
IUUC-Ola-086405	Oryzias latipes	25.66	9.00e-38	151.00
IUUC-Oga-088794	Otolemur garnettii	32.14	9.00e-45	175.00
IUUC-Oar-089775	Ovis aries	44.89	1.00e-42	168.00
IUUC-Ptr-090721	Pan troglodytes	39.44	2.00e-22	99.80
IUUC-Pan-092845	Papio anubis	33.70	3.00e-46	180.00
IUUC-Psi-093521	Pelodiscus sinensis	52.00	4.00e-43	167.00
IUUC-Pma-094157	Petromyzon marinus	39.22	5.00e-16	77.80
IUUC-Ppa-095770	Physcomitrella patens	47.51	0.00e+00	1067.00
IUUC-Pfo-097083	Poecilia formosa	53.64	8.00e-46	179.00
IUUC-Pab-098302	Pongo abelii	33.89	5.00e-48	186.00
IUUC-Pop-099033	Populus trichocarpa	67.39	0.00e+00	1722.00
IUUC-Pca-100742	Procavia capensis	46.71	1.00e-44	174.00
IUUC-Ppe-101476	Prunus persica	66.80	0.00e+00	1652.00
IUUC-Pva-103045	Pteropus vampyrus	29.35	4.00e-40	159.00
IUUC-Rno-105433	Rattus norvegicus	33.43	1.00e-47	184.00
IUUC-Sha-107441	Sarcophilus harrisii	53.33	6.00e-47	182.00
IUUC-Smo-109606	Selaginella moellendorffii	47.23	0.00e+00	1038.00
IUUC-Sit-110792	Setaria italica	56.56	0.00e+00	1404.00
IUUC-Sly-110982	Solanum lycopersicum	63.54	0.00e+00	1588.00
IUUC-Stu-112003	Solanum tuberosum	63.73	0.00e+00	1305.00
IUUC-Sar-113146	Sorex araneus	33.06	2.00e-46	181.00
IUUC-Sbi-113941	Sorghum bicolor	54.35	1.00e-180	626.00
IUUC-Ssc-115635	Sus scrofa	33.14	3.00e-46	180.00
IUUC-Tgu-116688	Taeniopygia guttata	51.66	5.00e-45	176.00
IUUC-Tru-118707	Takifugu rubripes	36.62	2.00e-18	87.00
IUUC-Tsy-119023	Tarsius syrichta	27.71	3.00e-26	114.00
IUUC-Tni-120291	Tetraodon nigroviridis	35.19	1.00e-18	87.40
IUUC-Tca-121219	Theobroma cacao	69.85	0.00e+00	1785.00
IUUC-Tbe-127542	Tupaia belangeri	47.06	2.00e-17	84.00
IUUC-Ttr-128241	Tursiops truncatus	33.43	4.00e-47	182.00
IUUC-Vpa-130102	Vicugna pacos	39.44	3.00e-22	99.80
IUUC-Vvi-131629	Vitis vinifera	67.76	0.00e+00	1727.00
IUUC-Xtr-132790	Xenopus tropicalis	25.90	4.00e-92	332.00
IUUC-Xma-133302	Xiphophorus maculatus	54.00	6.00e-47	182.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence