iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000164663.14	ENST00000394253.7	ENSP00000377797.2
ENSG00000164663.14	ENST00000373010.5	ENSP00000362101.1
ENSG00000164663.14	ENST00000448078.1	ENSP00000389842.1
ENSG00000164663.14	ENST00000373006.5	ENSP00000362097.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	miRecords
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	14715245

Classification

Family	E-value	Score	Start	End
DUB/USP	1.70e-97	328.3	253	656

Active Site

Position(s)	Description	Evidence
262	Nucleophile	ECO:0000305}
615	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp.................................................. 42
           tGl+NlgNtCYmNS+LQ+Ls+++++re++l+ +++k+++  p                                                  
   Q: 253  TGLRNLGNTCYMNSILQVLSHLQKFRECFLNLDPSKTEHLFPkatngktqlsgkptnssatelslrndraeaceregfcwngrasisrslel 344
           7******************************7777777777777777888999999999999999999999999999999999999999999 PP
   S: 43   ......kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsd 128
                 ++++ +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ ll+++++el         e+e+++++ l  
   Q: 345  iqnkepSSKHISLCRELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQEL---------ESEGTTRRILIP 427
           99999989999************************************************************.........668888899999 PP
   S: 129  eaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke..........slqdcLesftkeeelegenkyycek 210
            +++k +k+  ++++++F+gql sq++c +c+ +s++ epf+dlsl++p++ ++ ++           l+++L++ft++e leg+  y c++
   Q: 428  FSQRKLTKQVLKVVNTIFHGQLLSQVTCISCNYKSNTIEPFWDLSLEFPERYHCIEKgfvplnqtecLLTEMLAKFTETEALEGRI-YACDQ 518
           9***************************************************998879*************************965.***** PP
   S: 211  ckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke..kkkYeLiavvvHsG. 288
           c++k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c+++  ++ +  +  Y+L+avv+H+G 
   Q: 519  CNSKRRksnpkplvlseARKQLMIYRLPQVLRLHLKRFRWSGR-NHREKIGVHVVFDQVLTMEPYCCRDMLSSLDkeTFAYDLSAVVMHHGk 609
           **9999999*******************************997.8889********************876654433999************ PP
   S: 289  slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           +++sGHY+ay++n++g+ W++++Dsk ++++ eev++   ++aY+lfY++
   Q: 610  GFGSGHYTAYCYNTEGGfWVHCNDSKLNVCSVEEVCK---TQAYILFYTQ 656
           *************9999********************...********98 PP

Organism

Homo sapiens

Functional Description
(View)

Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons.

Protein Sequence
(Fasta)

MDRCKHVGRL RLAQDHSILN PQKWCCLECA TTESVWACLK CSHVACGRYI EDHALKHFEE 60
TGHPLAMEVR DLYVFCYLCK DYVLNDNPEG DLKLLRSSLL AVRGQKQDTP VRRGRTLRSM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCGCCCTGG TGACAGCTCG CGCGTGCTGA TGATGGCGGT AAATAGAGGG GGCCGGGGGA 60
GGGGACGGAG GAGGTGGGGA GGCAGCAAAG TGGGTAGCTC CAGGGGGTAG GGGGAACGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0004197--F:cysteine-type endopeptidase activity
GO:0042393--F:histone binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0035616--P:histone H2B conserved C-terminal lysine deubiquitination
GO:0000398--P:mRNA splicing, via spliceosome
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:25862

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002395	Ailuropoda melanoleuca	95.07	0.00e+00	846.00
IUUC-Apl-003658	Anas platyrhynchos	79.31	0.00e+00	1059.00
IUUC-Aca-005278	Anolis carolinensis	80.46	0.00e+00	1086.00
IUUC-Bta-012911	Bos taurus	90.55	0.00e+00	1144.00
IUUC-Cja-019171	Callithrix jacchus	96.95	0.00e+00	1284.00
IUUC-Cfa-020408	Canis familiaris	91.27	0.00e+00	1189.00
IUUC-Cpo-022233	Cavia porcellus	83.98	0.00e+00	1080.00
IUUC-Csa-024272	Chlorocebus sabaeus	97.92	0.00e+00	1065.00
IUUC-Cho-025051	Choloepus hoffmanni	90.00	0.00e+00	650.00
IUUC-Cin-025587	Ciona intestinalis	47.94	1.00e-105	377.00
IUUC-Dno-029856	Dasypus novemcinctus	91.27	0.00e+00	1197.00
IUUC-Ete-032761	Echinops telfairi	75.72	0.00e+00	863.00
IUUC-Eca-033851	Equus caballus	84.35	0.00e+00	1017.00
IUUC-Fca-035919	Felis catus	94.50	0.00e+00	791.00
IUUC-Fal-037290	Ficedula albicollis	77.15	0.00e+00	951.00
IUUC-Gmo-039249	Gadus morhua	77.36	2.00e-145	509.00
IUUC-Gac-042595	Gasterosteus aculeatus	59.94	0.00e+00	756.00
IUUC-Ggo-044979	Gorilla gorilla	99.56	0.00e+00	1322.00
IUUC-Itr-048251	Ictidomys tridecemlineatus	92.58	0.00e+00	1236.00
IUUC-Lch-050294	Latimeria chalumnae	75.79	0.00e+00	962.00
IUUC-Loc-051961	Lepisosteus oculatus	68.62	0.00e+00	815.00
IUUC-Laf-053819	Loxodonta africana	94.38	0.00e+00	847.00
IUUC-Mcc-055048	Macaca mulatta	98.40	0.00e+00	1305.00
IUUC-Meu-055971	Macropus eugenii	67.76	7.00e-150	524.00
IUUC-Mmr-061253	Microcebus murinus	79.11	3.00e-157	548.00
IUUC-Mdo-062073	Monodelphis domestica	82.90	0.00e+00	1103.00
IUUC-Mmu-064095	Mus musculus	90.54	0.00e+00	1202.00
IUUC-Mpu-066318	Mustela putorius furo	94.50	0.00e+00	862.00
IUUC-Mlu-067090	Myotis lucifugus	88.36	0.00e+00	1155.00
IUUC-Nle-069486	Nomascus leucogenys	99.27	0.00e+00	1320.00
IUUC-Opr-070563	Ochotona princeps	91.45	0.00e+00	1219.00
IUUC-Oan-073245	Ornithorhynchus anatinus	89.97	0.00e+00	627.00
IUUC-Ocu-074851	Oryctolagus cuniculus	90.43	0.00e+00	959.00
IUUC-Ola-086413	Oryzias latipes	58.10	0.00e+00	707.00
IUUC-Oga-088862	Otolemur garnettii	93.30	0.00e+00	1224.00
IUUC-Oar-089462	Ovis aries	89.93	0.00e+00	802.00
IUUC-Ptr-091525	Pan troglodytes	99.84	0.00e+00	1195.00
IUUC-Pan-092363	Papio anubis	98.34	0.00e+00	1249.00
IUUC-Psi-093353	Pelodiscus sinensis	81.64	0.00e+00	1082.00
IUUC-Pma-094155	Petromyzon marinus	59.39	7.00e-84	303.00
IUUC-Pfo-096413	Poecilia formosa	61.16	0.00e+00	782.00
IUUC-Pab-098592	Pongo abelii	98.27	0.00e+00	1069.00
IUUC-Pca-100449	Procavia capensis	90.72	0.00e+00	1209.00
IUUC-Pva-102868	Pteropus vampyrus	91.12	0.00e+00	1179.00
IUUC-Rno-105190	Rattus norvegicus	89.67	0.00e+00	1214.00
IUUC-Sha-107337	Sarcophilus harrisii	83.16	0.00e+00	1090.00
IUUC-Sar-113561	Sorex araneus	95.18	4.00e-94	338.00
IUUC-Ssc-115735	Sus scrofa	90.98	0.00e+00	1163.00
IUUC-Tgu-117025	Taeniopygia guttata	72.13	0.00e+00	877.00
IUUC-Tru-117585	Takifugu rubripes	60.59	0.00e+00	760.00
IUUC-Tsy-118814	Tarsius syrichta	94.18	0.00e+00	1241.00
IUUC-Xtr-132090	Xenopus tropicalis	71.47	0.00e+00	939.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence