iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046307

UUCD1 version

UUC-HoS-00061

Ensembl Protein ID

ENSP00000349543.4

UniProt Accession

P28328; Q567S6; Q9BW41; PEX2_HUMAN

Genbank Protein ID

AAC12785.1; AAF97687.1; AAA60141.1; AAH05375.1; AAH93043.1

Protein Name

Peroxisome biogenesis factor 2; 35 kDa peroxisomal membrane protein; Peroxin-2; Peroxisomal membrane protein 3; Peroxisome assembly factor 1; RING finger protein 72

Genbank Nucleotide ID

M86852; AF133826; M85038; AC090810; BC093043

Gene Name

PEX2; PAF1; PMP3; PMP35; PXMP3; RNF72

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000164751.14	ENST00000357039.8	ENSP00000349543.4

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
ClinVar	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19687296

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.38	13.0	244	283

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           Ca+C e +   p++ +C H+f+  C      ++ +    f+CP C
   Q: 244  CALCGEWPTM-PHTIGCEHIFCYFCA----KSSFLFDVYFTCPKC 283
           ****998877.**************5....444677777899988 PP

Organism

Homo sapiens

Functional Description
(View)

Belongs to the pex2/pex10/pex12 family.

Protein Sequence
(Fasta)

MASRKENAKS ANRVLRISQL DALELNKALE QLVWSQFTQC FHGFKPGLLA RFEPEVKACL 60
WVFLWRFTIY SKNATVGQSV LNIKYKNDFS PNLRYQPPSK NQKIWYAVCT IGGRWLEERC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGGTAAGA ACTAAGACGT TCTTAAACCC TACTACGTGC TGGAATCCTG AAGTGCCTGC 60
CATCATTCAA ACTTAAGCAC TAACTCTCTA GAGAGACACT GCCATTCATA CCACAGAACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0472--Membrane
KW-0479--Metal-binding
KW-0576--Peroxisome
KW-0962--Peroxisome biogenesis
KW-0958--Peroxisome biogenesis disorder
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0861--Zellweger syndrome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006845--Pex_N
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF04757--Pex2_Pex12
PF00097--zf-C3HC4

SMART

SM00184--RING

Gene Ontology

GO:0016593--C:Cdc73/Paf1 complex
GO:0005779--C:integral component of peroxisomal membrane
GO:0016020--C:membrane
GO:0005778--C:peroxisomal membrane
GO:0008270--F:zinc ion binding
GO:0006635--P:fatty acid beta-oxidation
GO:0050680--P:negative regulation of epithelial cell proliferation
GO:0048147--P:negative regulation of fibroblast proliferation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0007031--P:peroxisome organization
GO:0031648--P:protein destabilization
GO:0016558--P:protein import into peroxisome matrix
GO:0000038--P:very long-chain fatty acid metabolic process

KEGG

hsa:5828

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000106	Aegilops tauschii	28.78	2.00e-20	92.80
IUUC-Aml-001595	Ailuropoda melanoleuca	89.84	3.00e-161	560.00
IUUC-Atr-002766	Amborella trichopoda	28.23	5.00e-32	131.00
IUUC-Apl-004019	Anas platyrhynchos	73.36	1.00e-135	475.00
IUUC-Aca-004791	Anolis carolinensis	70.39	5.00e-119	420.00
IUUC-Aly-005607	Arabidopsis lyrata	29.22	4.00e-33	135.00
IUUC-Ath-006880	Arabidopsis thaliana	28.90	4.00e-33	135.00
IUUC-Ago-007841	Ashbya gossypii	23.92	1.00e-08	53.90
IUUC-Acl-008272	Aspergillus clavatus	29.11	2.00e-23	103.00
IUUC-Afl-008698	Aspergillus flavus	31.46	3.00e-24	106.00
IUUC-Afu-008859	Aspergillus fumigatus	31.05	2.00e-24	106.00
IUUC-Ani-009210	Aspergillus nidulans	30.00	5.00e-23	102.00
IUUC-Ang-009515	Aspergillus niger	29.76	6.00e-23	102.00
IUUC-Aor-009913	Aspergillus oryzae	31.46	3.00e-24	106.00
IUUC-Ate-010581	Aspergillus terreus	29.61	1.00e-23	104.00
IUUC-Ame-010951	Astyanax mexicanus	54.08	2.00e-88	318.00
IUUC-Bgr-012274	Blumeria graminis	27.27	1.00e-20	94.40
IUUC-Bta-012949	Bos taurus	86.51	8.00e-155	539.00
IUUC-Bci-013654	Botrytis cinerea	28.16	9.00e-17	81.60
IUUC-Bdi-014062	Brachypodium distachyon	30.23	5.00e-34	138.00
IUUC-Bra-016860	Brassica rapa	30.27	2.00e-33	135.00
IUUC-Cel-018250	Caenorhabditis elegans	23.31	1.00e-18	87.00
IUUC-Cja-019623	Callithrix jacchus	95.41	1.00e-175	608.00
IUUC-Cfa-020899	Canis familiaris	89.84	4.00e-167	580.00
IUUC-Cpo-021971	Cavia porcellus	89.18	7.00e-164	569.00
IUUC-Cre-022853	Chlamydomonas reinhardtii	34.43	2.00e-04	39.70
IUUC-Csa-023552	Chlorocebus sabaeus	97.38	8.00e-179	619.00
IUUC-Cho-024309	Choloepus hoffmanni	91.15	1.00e-169	588.00
IUUC-Csv-025909	Ciona savignyi	28.52	2.00e-23	103.00
IUUC-Cgl-026469	Colletotrichum gloeosporioides	27.84	5.00e-21	95.90
IUUC-Cne-027011	Cryptococcus neoformans	24.43	7.00e-14	71.60
IUUC-Cme-027206	Cyanidioschyzon merolae	26.18	3.00e-15	75.90
IUUC-Dre-027627	Danio rerio	57.05	1.00e-97	349.00
IUUC-Dno-029220	Dasypus novemcinctus	91.15	2.00e-168	584.00
IUUC-Dor-030828	Dipodomys ordii	87.87	5.00e-166	576.00
IUUC-Dse-031469	Dothistroma septosporum	30.34	1.00e-15	78.60
IUUC-Dme-031865	Drosophila melanogaster	28.87	5.00e-33	134.00
IUUC-Ete-033020	Echinops telfairi	68.52	3.00e-105	374.00
IUUC-Eca-034078	Equus caballus	89.84	8.00e-167	579.00
IUUC-Fca-036406	Felis catus	88.52	3.00e-164	570.00
IUUC-Fal-037365	Ficedula albicollis	72.70	2.00e-124	438.00
IUUC-Fox-037825	Fusarium oxysporum	31.33	4.00e-21	95.90
IUUC-Fso-038458	Fusarium solani	31.33	4.00e-20	92.80
IUUC-Gmo-038729	Gadus morhua	55.36	1.00e-25	110.00
IUUC-Ggr-039992	Gaeumannomyces graminis	31.98	9.00e-15	75.10
IUUC-Gga-040364	Gallus gallus	74.01	6.00e-137	479.00
IUUC-Gac-041501	Gasterosteus aculeatus	50.00	3.00e-67	248.00
IUUC-Gma-044174	Glycine max	30.00	2.00e-31	129.00
IUUC-Ggo-045248	Gorilla gorilla	98.69	5.00e-180	623.00
IUUC-Hvu-047618	Hordeum vulgare	30.56	9.00e-34	137.00
IUUC-Itr-048006	Ictidomys tridecemlineatus	90.13	1.00e-167	582.00
IUUC-Kpa-049382	Komagataella pastoris	23.68	1.00e-14	74.30
IUUC-Lch-049694	Latimeria chalumnae	68.90	3.00e-120	424.00
IUUC-Lpe-050779	Leersia perrieri	29.67	1.00e-26	114.00
IUUC-Loc-052253	Lepisosteus oculatus	56.48	6.00e-100	357.00
IUUC-Lma-053100	Leptosphaeria maculans	32.00	5.00e-14	72.40
IUUC-Laf-053543	Loxodonta africana	91.15	2.00e-168	584.00
IUUC-Mcc-055435	Macaca mulatta	97.70	4.00e-179	620.00
IUUC-Meu-056096	Macropus eugenii	83.55	7.00e-157	546.00
IUUC-Mor-057285	Magnaporthe oryzae	27.43	3.00e-22	99.80
IUUC-Mtr-058501	Medicago truncatula	28.52	1.00e-27	117.00
IUUC-Mla-059178	Melampsora laricipopulina	24.05	4.00e-12	65.50
IUUC-Mga-060125	Meleagris gallopavo	72.04	2.00e-134	471.00
IUUC-Mvi-060252	Microbotryum violaceum	40.79	3.00e-13	70.10
IUUC-Mmr-061696	Microcebus murinus	92.13	5.00e-170	589.00
IUUC-Mdo-062789	Monodelphis domestica	82.57	1.00e-154	539.00
IUUC-Mmu-063391	Mus musculus	87.87	2.00e-162	565.00
IUUC-Mac-064555	Musa acuminata	30.82	1.00e-34	140.00
IUUC-Mpu-065832	Mustela putorius furo	89.84	2.00e-167	580.00
IUUC-Mlu-067811	Myotis lucifugus	85.57	7.00e-162	562.00
IUUC-Nfi-068362	Neosartorya fischeri	30.43	3.00e-19	89.70
IUUC-Ncr-068621	Neurospora crassa	32.60	9.00e-19	89.00
IUUC-Nle-069980	Nomascus leucogenys	97.70	7.00e-179	619.00
IUUC-Opr-070196	Ochotona princeps	89.51	1.00e-166	578.00
IUUC-Ont-071826	Oreochromis niloticus	52.03	2.00e-77	282.00
IUUC-Oan-072999	Ornithorhynchus anatinus	56.98	3.00e-26	110.00
IUUC-Ocu-074466	Oryctolagus cuniculus	90.82	8.00e-168	582.00
IUUC-Oba-075893	Oryza barthii	29.45	1.00e-27	117.00
IUUC-Obr-076621	Oryza brachyantha	30.23	1.00e-33	137.00
IUUC-Ogl-077881	Oryza glaberrima	29.24	1.00e-32	133.00
IUUC-Ogu-078407	Oryza glumaepatula	29.53	7.00e-33	134.00
IUUC-Oin-080063	Oryza indica	29.24	1.00e-32	133.00
IUUC-Olo-080529	Oryza longistaminata	29.33	1.00e-23	103.00
IUUC-Ome-081350	Oryza meridionalis	29.09	1.00e-27	117.00
IUUC-Oni-082647	Oryza nivara	29.33	1.00e-23	103.00
IUUC-Opu-083358	Oryza punctata	28.78	5.00e-27	115.00
IUUC-Oru-084263	Oryza rufipogon	29.08	7.00e-25	107.00
IUUC-Osa-085561	Oryza sativa	29.24	1.00e-32	133.00
IUUC-Ola-087048	Oryzias latipes	48.98	2.00e-66	246.00
IUUC-Olu-087782	Ostreococcus lucimarinus	27.15	4.00e-15	75.10
IUUC-Oga-088107	Otolemur garnettii	91.48	2.00e-169	587.00
IUUC-Oar-089967	Ovis aries	87.17	9.00e-155	539.00
IUUC-Ptr-091627	Pan troglodytes	98.69	8.00e-180	622.00
IUUC-Pan-091754	Papio anubis	97.38	2.00e-179	620.00
IUUC-Psi-093286	Pelodiscus sinensis	73.11	4.00e-127	447.00
IUUC-Pma-094543	Petromyzon marinus	45.30	4.00e-66	244.00
IUUC-Pno-094850	Phaeosphaeria nodorum	28.91	7.00e-18	85.50
IUUC-Ppa-095816	Physcomitrella patens	30.87	5.00e-29	121.00
IUUC-Pfo-097377	Poecilia formosa	48.68	1.00e-75	276.00
IUUC-Pab-097671	Pongo abelii	98.03	5.00e-179	619.00
IUUC-Pop-099692	Populus trichocarpa	30.54	1.00e-33	137.00
IUUC-Ppe-101194	Prunus persica	29.21	4.00e-28	118.00
IUUC-Pva-102697	Pteropus vampyrus	83.61	3.00e-156	543.00
IUUC-Pgr-103472	Puccinia graminis	44.90	5.00e-05	42.40
IUUC-Pte-104058	Pyrenophora teres	28.30	2.00e-23	103.00
IUUC-Pyt-104435	Pyrenophora triticirepentis	29.49	1.00e-20	94.70
IUUC-Rno-105925	Rattus norvegicus	87.87	2.00e-163	567.00
IUUC-Sce-106321	Saccharomyces cerevisiae	21.53	2.00e-07	49.30
IUUC-Sha-106928	Sarcophilus harrisii	82.57	1.00e-154	539.00
IUUC-Ssl-108434	Sclerotinia sclerotiorum	27.85	6.00e-17	82.00
IUUC-Smo-108998	Selaginella moellendorffii	28.57	5.00e-27	115.00
IUUC-Sit-110018	Setaria italica	29.57	2.00e-32	133.00
IUUC-Sly-111670	Solanum lycopersicum	31.62	2.00e-36	146.00
IUUC-Stu-112190	Solanum tuberosum	31.06	5.00e-36	145.00
IUUC-Sar-112920	Sorex araneus	82.62	1.00e-153	535.00
IUUC-Sbi-114300	Sorghum bicolor	29.34	2.00e-33	136.00
IUUC-Sre-115019	Sporisorium reilianum	29.27	1.00e-11	64.70
IUUC-Ssc-116289	Sus scrofa	85.25	8.00e-154	536.00
IUUC-Tgu-116936	Taeniopygia guttata	73.36	5.00e-135	473.00
IUUC-Tru-118611	Takifugu rubripes	46.69	8.00e-81	293.00
IUUC-Tsy-119073	Tarsius syrichta	92.13	2.00e-169	587.00
IUUC-Tni-119824	Tetraodon nigroviridis	45.28	4.00e-70	258.00
IUUC-Tca-121117	Theobroma cacao	28.85	2.00e-33	136.00
IUUC-Tre-122081	Trichoderma reesei	28.64	1.00e-21	97.40
IUUC-Tvi-122454	Trichoderma virens	24.85	8.00e-22	98.20
IUUC-Tae-123108	Triticum aestivum	30.56	9.00e-34	137.00
IUUC-Tur-125989	Triticum urartu	28.70	1.00e-18	87.00
IUUC-Tme-127082	Tuber melanosporum	29.66	2.00e-21	97.40
IUUC-Tbe-127229	Tupaia belangeri	90.49	2.00e-166	577.00
IUUC-Ttr-129251	Tursiops truncatus	87.21	9.00e-163	565.00
IUUC-Vda-130008	Verticillium dahliae	32.16	6.00e-15	75.50
IUUC-Vpa-130084	Vicugna pacos	89.18	1.00e-154	538.00
IUUC-Vvi-130953	Vitis vinifera	31.06	9.00e-36	144.00
IUUC-Xtr-132429	Xenopus tropicalis	65.69	1.00e-121	429.00
IUUC-Xma-133897	Xiphophorus maculatus	49.17	1.00e-72	266.00
IUUC-Yli-134504	Yarrowia lipolytica	25.95	2.00e-14	73.60
IUUC-Zma-135123	Zea mays	27.76	2.00e-30	126.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence