iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-012542

Ensembl Protein ID

ENSBTAP00000014915.2

UniProt Accession

Q3ZBI9; TMUB1_BOVIN

Genbank Protein ID

AAI03271.1

Protein Name

Transmembrane and ubiquitin-like domain-containing protein 1; iHOPS

Genbank Nucleotide ID

BC103270

Gene Name

TMUB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000011229.2	ENSBTAT00000014915.2	ENSBTAP00000014915.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UBQ/UBQ_Other	1.50e-10	40.9	110	175

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_Other

   S: 8    ldgs.eltlkvnpsdtVaeLKekiekklgip.pe.qqrLiykGkiL.eddktLadyglkdgstihllekksg 75
           l++s    +  +p+dt++ LK+     + +p +e  +rLiy+G++L +d +tL++++l++++++h+ +++++
   Q: 110  LNDSeQVAR-AWPHDTIGSLKR-----TQFPgREqHVRLIYQGQLLgDDTQTLGSLHLPPNCVLHCHVSTRV 175
           555533343.49**********.....9999877678******************************99986 PP

Organism

Bos taurus

Functional Description
(View)

iHOPS: May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation. May be involved in centrosome assembly. Modulates stabilization and nucleolar localization of tumor suppressor CDKN2A and enhances association between CDKN2A and NPM1 (By similarity).

Protein Sequence
(Fasta)

MALIEGVGDE VTILFSALAC LLVLALAWVS THTAEGADPL PQPSGTPTPT QPSEAMAVTD 60
SIRGEAPGAE TPGLRHRGQA APPEPSVGLA ATPPPPDSPQ EPLVLRLKFL NDSEQVARAW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGGGTCCGC TATGGAGCTG GCGGAGCCGG GCGGTGAGTC CCTGCGCCTT GGCCGCACCA 60
CCCCGCTGCC CCAGCAGCTG GCCCTACTGG CCCCGCCCCT GGATCTCCCG CGCCCGCCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0967--Endosome
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0628--Postsynaptic cell membrane
KW-1185--Reference proteome
KW-0770--Synapse
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF00240--ubiquitin

Gene Ontology

GO:0030054--C:cell junction
GO:0005829--C:cytosol
GO:0016021--C:integral component of membrane
GO:0005815--C:microtubule organizing center
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0045211--C:postsynaptic membrane
GO:0055037--C:recycling endosome
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

bta:539388

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001821	Ailuropoda melanoleuca	93.09	7.00e-81	293.00
IUUC-Aca-004375	Anolis carolinensis	47.78	6.00e-34	137.00
IUUC-Cel-018429	Caenorhabditis elegans	43.06	6.00e-12	65.90
IUUC-Cja-019142	Callithrix jacchus	88.31	1.00e-71	262.00
IUUC-Cfa-020517	Canis familiaris	94.31	3.00e-85	307.00
IUUC-Cpo-021653	Cavia porcellus	86.23	3.00e-69	254.00
IUUC-Csa-023914	Chlorocebus sabaeus	91.46	4.00e-71	260.00
IUUC-Cin-025480	Ciona intestinalis	28.97	8.00e-13	67.40
IUUC-Dno-029028	Dasypus novemcinctus	91.46	8.00e-75	273.00
IUUC-Dor-030758	Dipodomys ordii	89.47	9.00e-74	269.00
IUUC-Ete-032267	Echinops telfairi	86.11	2.00e-50	191.00
IUUC-Eca-034010	Equus caballus	92.68	5.00e-78	283.00
IUUC-Fca-035402	Felis catus	94.31	1.00e-85	309.00
IUUC-Fal-037183	Ficedula albicollis	69.77	3.00e-12	63.50
IUUC-Gac-041487	Gasterosteus aculeatus	45.96	4.00e-39	154.00
IUUC-Ggo-045556	Gorilla gorilla	89.84	8.00e-67	246.00
IUUC-Hsa-046639	Homo sapiens	93.09	4.00e-73	267.00
IUUC-Itr-048729	Ictidomys tridecemlineatus	90.24	2.00e-79	288.00
IUUC-Laf-054495	Loxodonta africana	58.13	2.00e-32	131.00
IUUC-Mcc-055870	Macaca mulatta	91.87	7.00e-72	263.00
IUUC-Meu-056759	Macropus eugenii	72.65	6.00e-59	220.00
IUUC-Mdo-062740	Monodelphis domestica	72.65	5.00e-61	227.00
IUUC-Mmu-063171	Mus musculus	84.55	1.00e-66	246.00
IUUC-Mpu-066100	Mustela putorius furo	92.28	2.00e-82	298.00
IUUC-Mlu-067839	Myotis lucifugus	89.80	4.00e-74	271.00
IUUC-Nle-069603	Nomascus leucogenys	92.28	2.00e-71	261.00
IUUC-Opr-070539	Ochotona princeps	94.44	1.00e-41	161.00
IUUC-Ont-072413	Oreochromis niloticus	43.27	7.00e-39	153.00
IUUC-Ocu-074589	Oryctolagus cuniculus	89.92	4.00e-73	267.00
IUUC-Ola-087411	Oryzias latipes	45.20	7.00e-41	160.00
IUUC-Oga-088156	Otolemur garnettii	90.65	5.00e-77	280.00
IUUC-Oar-089302	Ovis aries	98.37	3.00e-74	271.00
IUUC-Ptr-091176	Pan troglodytes	93.09	4.00e-73	267.00
IUUC-Pab-098432	Pongo abelii	91.46	2.00e-68	252.00
IUUC-Pca-100595	Procavia capensis	68.78	2.00e-48	185.00
IUUC-Pva-102157	Pteropus vampyrus	49.55	3.00e-30	124.00
IUUC-Rno-105447	Rattus norvegicus	85.77	7.00e-76	276.00
IUUC-Sha-106499	Sarcophilus harrisii	73.47	1.00e-62	232.00
IUUC-Ssc-116410	Sus scrofa	94.31	7.00e-77	280.00
IUUC-Tgu-117495	Taeniopygia guttata	70.00	8.00e-24	102.00
IUUC-Tru-118609	Takifugu rubripes	45.77	2.00e-39	155.00
IUUC-Tni-120885	Tetraodon nigroviridis	46.67	1.00e-40	159.00
IUUC-Tbe-127898	Tupaia belangeri	93.02	2.00e-48	183.00
IUUC-Ttr-129209	Tursiops truncatus	96.34	2.00e-82	298.00
IUUC-Uma-129636	Ustilago maydis	44.90	3.80e-01	29.60

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence