iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046639

Ensembl Protein ID

ENSP00000297533.4

UniProt Accession

Q9BVT8; D3DX06; Q53AQ2; TMUB1_HUMAN

Genbank Protein ID

AAU00156.1; AAK67645.1; AAQ88845.1; BAG36745.1; EAW54030.1; EAW54032.1; AAH00936.1; AAH33182.1

Protein Name

Transmembrane and ubiquitin-like domain-containing protein 1; Dendritic cell-derived ubiquitin-like protein; Hepatocyte odd protein shuttling protein; Ubiquitin-like protein SB144; iHOPS

Genbank Nucleotide ID

AY603380; AY037155; AY358481; AK314035; AC010973; CH471173; BC000936; BC033182

Gene Name

TMUB1; C7orf21; DULP; HOPS; SB144; UNQ763/PRO1555

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000164897.12	ENST00000297533.8	ENSP00000297533.4

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UBQ/UBQ_Other	4.10e-11	44.2	110	175

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_Other

   S: 8    ldgs.eltlkvnpsdtVaeLKekiekklgip.pe.qqrLiykGkiL.eddktLadyglkdgstihllekksg 75
           l++s    +  +p+dt++ LK+     + +p +e q+rLiy+G++L +d +tL++++l++++++h+ +++++
   Q: 110  LNDSeQVAR-AWPHDTIGSLKR-----TQFPgREqQVRLIYQGQLLgDDTQTLGSLHLPPNCVLHCHVSTRV 175
           555533343.49**********.....9999988799******************************99986 PP

Organism

Homo sapiens

Functional Description
(View)

iHOPS: May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation (By similarity). May be involved in centrosome assembly. Modulates stabilization and nucleolar localization of tumor suppressor CDKN2A and enhances association between CDKN2A and NPM1 (By similarity).

Protein Sequence
(Fasta)

MTLIEGVGDE VTVLFSVLAC LLVLALAWVS THTAEGGDPL PQPSGTPTPS QPSAAMAATD 60
SMRGEAPGAE TPSLRHRGQA AQPEPSTGFT ATPPAPDSPQ EPLVLRLKFL NDSEQVARAW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATGCCCCGG GCCGCGGCGG CGGGGAAGGA GGGGTGCTTC AGGTGCCTGC GACCTCCGCG 60
CCTCCCGCCC GGAAGTGCCC GAGGGGCCGC GATGGAGCTG GGGGAGCCGG GCGGTGAGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0967--Endosome
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0628--Postsynaptic cell membrane
KW-1185--Reference proteome
KW-0770--Synapse
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF00240--ubiquitin

Gene Ontology

GO:0030054--C:cell junction
GO:0005829--C:cytosol
GO:0016021--C:integral component of membrane
GO:0005815--C:microtubule organizing center
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0045211--C:postsynaptic membrane
GO:0055037--C:recycling endosome
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

hsa:83590

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001821	Ailuropoda melanoleuca	92.28	2.00e-85	308.00
IUUC-Aca-004375	Anolis carolinensis	46.49	3.00e-33	135.00
IUUC-Bta-012542	Bos taurus	93.09	5.00e-77	280.00
IUUC-Cel-018429	Caenorhabditis elegans	39.81	3.00e-13	70.50
IUUC-Cja-019142	Callithrix jacchus	96.37	3.00e-82	298.00
IUUC-Cfa-020517	Canis familiaris	93.90	1.00e-91	328.00
IUUC-Cpo-021653	Cavia porcellus	88.26	3.00e-69	254.00
IUUC-Csa-023914	Chlorocebus sabaeus	97.97	2.00e-84	305.00
IUUC-Cin-025480	Ciona intestinalis	28.90	7.00e-13	67.80
IUUC-Csv-025923	Ciona savignyi	28.89	2.00e-14	72.80
IUUC-Dno-029028	Dasypus novemcinctus	92.68	1.00e-75	276.00
IUUC-Dor-030758	Dipodomys ordii	91.50	3.00e-81	294.00
IUUC-Ete-032267	Echinops telfairi	87.67	2.00e-52	197.00
IUUC-Eca-034010	Equus caballus	92.28	1.00e-77	282.00
IUUC-Fca-035402	Felis catus	93.50	1.00e-90	325.00
IUUC-Fal-037183	Ficedula albicollis	72.09	5.00e-13	66.20
IUUC-Gac-041487	Gasterosteus aculeatus	44.85	6.00e-39	154.00
IUUC-Ggo-045556	Gorilla gorilla	96.34	1.00e-80	292.00
IUUC-Itr-048729	Ictidomys tridecemlineatus	91.06	2.00e-86	311.00
IUUC-Laf-054495	Loxodonta africana	58.54	6.00e-36	143.00
IUUC-Mcc-055870	Macaca mulatta	98.37	3.00e-85	308.00
IUUC-Meu-056759	Macropus eugenii	71.43	7.00e-59	220.00
IUUC-Mdo-062740	Monodelphis domestica	71.43	4.00e-61	227.00
IUUC-Mmu-063171	Mus musculus	89.43	2.00e-74	271.00
IUUC-Mpu-066100	Mustela putorius furo	91.87	3.00e-86	311.00
IUUC-Mlu-067839	Myotis lucifugus	90.61	2.00e-79	288.00
IUUC-Nle-069603	Nomascus leucogenys	99.19	1.00e-85	309.00
IUUC-Opr-070539	Ochotona princeps	94.04	2.00e-44	171.00
IUUC-Ont-072413	Oreochromis niloticus	42.91	8.00e-39	153.00
IUUC-Ocu-074589	Oryctolagus cuniculus	91.53	2.00e-78	285.00
IUUC-Ola-087411	Oryzias latipes	44.57	1.00e-40	159.00
IUUC-Oga-088156	Otolemur garnettii	91.46	7.00e-84	303.00
IUUC-Oar-089302	Ovis aries	92.28	5.00e-75	274.00
IUUC-Ptr-091176	Pan troglodytes	100.00	3.00e-87	314.00
IUUC-Pab-098432	Pongo abelii	98.37	1.00e-81	296.00
IUUC-Pca-100595	Procavia capensis	68.33	1.00e-48	186.00
IUUC-Pva-102157	Pteropus vampyrus	49.10	7.00e-29	120.00
IUUC-Rno-105447	Rattus norvegicus	90.24	1.00e-82	299.00
IUUC-Sha-106499	Sarcophilus harrisii	73.47	3.00e-63	234.00
IUUC-Ssc-116410	Sus scrofa	91.46	3.00e-80	291.00
IUUC-Tgu-117495	Taeniopygia guttata	70.67	3.00e-25	107.00
IUUC-Tru-118609	Takifugu rubripes	43.75	1.00e-39	156.00
IUUC-Tni-120885	Tetraodon nigroviridis	45.88	5.00e-43	167.00
IUUC-Tbe-127898	Tupaia belangeri	89.92	3.00e-54	203.00
IUUC-Ttr-129209	Tursiops truncatus	92.68	4.00e-84	304.00
IUUC-Uma-129636	Ustilago maydis	44.90	3.00e-01	30.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence