iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-046921

Ensembl Protein ID

ENSP00000366482.3

UniProt Accession

Q16595; A8MXJ6; C9JJ89; O15545; O95656; Q15294; Q5VZ01; FRDA_HUMAN

Genbank Protein ID

AAA98510.1; AAA98508.1; AAA98508.1; AAA98508.1; AAA98508.1; AAA98508.1; AAA98509.1; AAA98509.1; AAA98509.1; AAA98509.1; AAA98509.1; CAH71829.1; AAH23633.1; AAH48097.1; CAA74077.1; AAB84047.1; AAD00734.1

Protein Name

Frataxin, mitochondrial; Friedreich ataxia protein; Frataxin intermediate form; Frataxin(56-210); m56-FXN; Frataxin(78-210); d-FXN; m78-FXN; Frataxin mature form; Frataxin(81-210); m81-FXN

Genbank Nucleotide ID

U43747; U43752; U43748; U43749; U43750; U43751; U43753; U43748; U43749; U43750; U43751; AL162730; BC023633; BC048097; Y13751; AF028240; U93173

Gene Name

FXN; FRDA; X25

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000165060.11	ENST00000377270.7	ENSP00000366482.3
ENSG00000165060.11	ENST00000396366.6	ENSP00000379652.2
ENSG00000165060.11	ENST00000484259.1	ENSP00000419243.1
ENSG00000165060.11	ENST00000396364.7	ENSP00000379650.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Other/Other	UBD/Other/Other	23506486

Organism

Homo sapiens

Functional Description
(View)

Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems. Modulates the RNA-binding activity of ACO1.

Protein Sequence
(Fasta)

MWTLGRRAVA GLLASPSPAQ AQTLTRVPRP AELAPLCGRR GLRTDIDATC TPRRASSNQR 60
GLNQIWNVKK QSVYLMNLRK SGTLGHPGSL DETTYERLAE ETLDSLAEFF EDLADKPYTF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTACAGGGC TTAACTCATT TTATCCTTAC CACAATCCTA TGAAGTAGGA ACTTTTATAA 60
AACGCATTTT ATAAACAAGG CACAGAGAGG TTAATTAACT TGCCCTCTGG TCACACAGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0350--Heme biosynthesis
KW-0406--Ion transport
KW-0408--Iron
KW-0409--Iron storage
KW-0410--Iron transport
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-0560--Oxidoreductase
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0809--Transit peptide
KW-0813--Transport
KW-0818--Triplet repeat expansion

Interpro

IPR017789--Frataxin
IPR002908--Frataxin/CyaY
IPR020895--Frataxin_CS

PROSITE

PS01344--FRATAXIN_1
PS50810--FRATAXIN_2

Pfam

PF01491--Frataxin_Cyay

PRINTS

PR00904--FRATAXIN

SMART

SM01219--Frataxin_Cyay

Gene Ontology

GO:0005829--C:cytosol
GO:0005759--C:mitochondrial matrix
GO:0005739--C:mitochondrion
GO:0051537--F:2 iron, 2 sulfur cluster binding
GO:0008199--F:ferric iron binding
GO:0008198--F:ferrous iron binding
GO:0004322--F:ferroxidase activity
GO:0034986--F:iron chaperone activity
GO:0051536--F:iron-sulfur cluster binding
GO:0007628--P:adult walking behavior
GO:0009060--P:aerobic respiration
GO:0006879--P:cellular iron ion homeostasis
GO:0070301--P:cellular response to hydrogen peroxide
GO:0009792--P:embryo development ending in birth or egg hatching
GO:0006783--P:heme biosynthetic process
GO:0006811--P:ion transport
GO:0018283--P:iron incorporation into metallo-sulfur cluster
GO:0007005--P:mitochondrion organization
GO:0043066--P:negative regulation of apoptotic process
GO:0040015--P:negative regulation of multicellular organism growth
GO:0046621--P:negative regulation of organ growth
GO:0090201--P:negative regulation of release of cytochrome c from mitochondria
GO:0006119--P:oxidative phosphorylation
GO:1904234--P:positive regulation of aconitate hydratase activity
GO:0043085--P:positive regulation of catalytic activity
GO:0030307--P:positive regulation of cell growth
GO:0008284--P:positive regulation of cell proliferation
GO:0051349--P:positive regulation of lyase activity
GO:1904231--P:positive regulation of succinate dehydrogenase activity
GO:0019230--P:proprioception
GO:0016540--P:protein autoprocessing
GO:0010722--P:regulation of ferrochelatase activity
GO:0010039--P:response to iron ion
GO:0044281--P:small molecule metabolic process

KEGG

hsa:2395

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002122	Ailuropoda melanoleuca	76.47	3.00e-81	294.00
IUUC-Apl-003853	Anas platyrhynchos	84.30	2.00e-57	214.00
IUUC-Aca-005026	Anolis carolinensis	72.48	8.00e-61	225.00
IUUC-Aly-006200	Arabidopsis lyrata	44.79	3.00e-19	87.80
IUUC-Ath-007033	Arabidopsis thaliana	44.79	3.00e-19	88.20
IUUC-Ago-007707	Ashbya gossypii	46.30	1.00e-18	85.10
IUUC-Acl-008146	Aspergillus clavatus	39.39	3.00e-18	85.10
IUUC-Afl-008501	Aspergillus flavus	45.78	2.00e-14	72.40
IUUC-Afu-008851	Aspergillus fumigatus	32.16	2.00e-18	85.50
IUUC-Ani-009129	Aspergillus nidulans	40.00	1.00e-11	63.20
IUUC-Ang-009557	Aspergillus niger	37.90	5.00e-17	81.30
IUUC-Ate-010486	Aspergillus terreus	33.50	1.00e-19	89.40
IUUC-Bgr-012108	Blumeria graminis	41.88	1.00e-15	76.60
IUUC-Bta-013437	Bos taurus	74.76	3.00e-76	278.00
IUUC-Bci-013810	Botrytis cinerea	53.25	2.00e-15	75.50
IUUC-Bdi-014226	Brachypodium distachyon	44.92	3.00e-24	105.00
IUUC-Bol-015092	Brassica oleracea	48.86	1.00e-19	89.40
IUUC-Bra-017945	Brassica rapa	48.86	4.00e-19	87.00
IUUC-Cel-018466	Caenorhabditis elegans	51.38	1.00e-25	108.00
IUUC-Cja-019306	Callithrix jacchus	85.92	2.00e-93	335.00
IUUC-Cfa-020063	Canis familiaris	75.12	1.00e-81	295.00
IUUC-Cpo-021325	Cavia porcellus	74.88	5.00e-82	296.00
IUUC-Cre-022889	Chlamydomonas reinhardtii	53.19	3.00e-21	95.10
IUUC-Csa-023739	Chlorocebus sabaeus	94.29	2.00e-114	404.00
IUUC-Cho-024324	Choloepus hoffmanni	79.34	5.00e-79	286.00
IUUC-Cgl-026402	Colletotrichum gloeosporioides	44.74	9.00e-19	86.70
IUUC-Cne-027094	Cryptococcus neoformans	39.51	3.00e-13	68.20
IUUC-Cme-027112	Cyanidioschyzon merolae	43.56	3.00e-13	67.80
IUUC-Dre-028813	Danio rerio	66.12	5.00e-45	173.00
IUUC-Dno-029949	Dasypus novemcinctus	90.37	3.00e-58	216.00
IUUC-Dse-031482	Dothistroma septosporum	40.17	2.00e-18	85.50
IUUC-Dme-031608	Drosophila melanogaster	53.28	2.00e-33	135.00
IUUC-Ete-032937	Echinops telfairi	96.88	3.00e-13	67.80
IUUC-Eca-033899	Equus caballus	90.85	9.00e-65	238.00
IUUC-Fca-036579	Felis catus	79.66	3.00e-67	247.00
IUUC-Fox-037940	Fusarium oxysporum	48.25	1.00e-22	99.80
IUUC-Fso-038465	Fusarium solani	50.88	3.00e-23	101.00
IUUC-Ggr-040089	Gaeumannomyces graminis	45.61	9.00e-21	93.20
IUUC-Gga-040910	Gallus gallus	78.87	1.00e-63	235.00
IUUC-Gma-044349	Glycine max	44.63	2.00e-24	105.00
IUUC-Ggo-044854	Gorilla gorilla	98.57	9.00e-107	379.00
IUUC-Hvu-047142	Hordeum vulgare	45.76	4.00e-24	104.00
IUUC-Kpa-049187	Komagataella pastoris	41.23	1.00e-15	76.30
IUUC-Lch-050614	Latimeria chalumnae	67.83	6.00e-56	210.00
IUUC-Lpe-051184	Leersia perrieri	42.98	3.00e-23	101.00
IUUC-Loc-052083	Lepisosteus oculatus	69.42	3.00e-48	183.00
IUUC-Lma-053209	Leptosphaeria maculans	41.96	2.00e-15	75.10
IUUC-Laf-054090	Loxodonta africana	76.78	2.00e-86	311.00
IUUC-Meu-056814	Macropus eugenii	80.27	1.00e-67	248.00
IUUC-Mor-057169	Magnaporthe oryzae	48.72	2.00e-22	98.60
IUUC-Mpo-057483	Magnaporthe poae	47.37	5.00e-22	97.40
IUUC-Mtr-058166	Medicago truncatula	49.52	2.00e-19	88.20
IUUC-Mla-059015	Melampsora laricipopulina	41.46	6.00e-19	86.70
IUUC-Mvi-060356	Microbotryum violaceum	51.06	2.00e-20	92.00
IUUC-Mdo-062658	Monodelphis domestica	64.98	5.00e-72	263.00
IUUC-Mmu-063470	Mus musculus	73.08	2.00e-79	288.00
IUUC-Mac-065327	Musa acuminata	47.11	4.00e-25	107.00
IUUC-Mpu-065761	Mustela putorius furo	86.58	3.00e-67	246.00
IUUC-Mlu-067175	Myotis lucifugus	75.23	4.00e-84	303.00
IUUC-Nfi-068535	Neosartorya fischeri	32.16	5.00e-18	84.30
IUUC-Ncr-068966	Neurospora crassa	44.00	5.00e-22	97.40
IUUC-Opr-070533	Ochotona princeps	54.30	3.00e-31	127.00
IUUC-Oan-073024	Ornithorhynchus anatinus	81.21	1.00e-58	218.00
IUUC-Ocu-074451	Oryctolagus cuniculus	78.69	4.00e-72	265.00
IUUC-Oba-075540	Oryza barthii	44.92	7.00e-24	103.00
IUUC-Obr-076285	Oryza brachyantha	42.15	1.00e-23	103.00
IUUC-Ogl-077827	Oryza glaberrima	44.92	7.00e-24	103.00
IUUC-Ogu-078491	Oryza glumaepatula	44.92	6.00e-24	103.00
IUUC-Oin-080149	Oryza indica	45.61	2.00e-23	102.00
IUUC-Olo-080318	Oryza longistaminata	43.33	2.00e-21	94.70
IUUC-Oni-083037	Oryza nivara	44.92	8.00e-24	103.00
IUUC-Opu-083448	Oryza punctata	43.90	2.00e-24	105.00
IUUC-Oru-084793	Oryza rufipogon	44.92	1.00e-23	103.00
IUUC-Osa-086032	Oryza sativa	44.92	8.00e-24	103.00
IUUC-Ola-086956	Oryzias latipes	64.06	1.00e-43	169.00
IUUC-Olu-087806	Ostreococcus lucimarinus	40.00	1.00e-16	79.30
IUUC-Oga-089029	Otolemur garnettii	84.83	2.00e-88	317.00
IUUC-Oar-089471	Ovis aries	73.33	4.00e-75	274.00
IUUC-Pan-092091	Papio anubis	94.29	5.00e-114	403.00
IUUC-Psi-093193	Pelodiscus sinensis	77.55	3.00e-66	243.00
IUUC-Pma-094540	Petromyzon marinus	62.18	9.00e-42	161.00
IUUC-Pno-094873	Phaeosphaeria nodorum	40.80	2.00e-17	82.40
IUUC-Ppa-095343	Physcomitrella patens	46.59	6.00e-18	84.30
IUUC-Pfo-097093	Poecilia formosa	61.72	7.00e-44	170.00
IUUC-Pab-098781	Pongo abelii	100.00	1.00e-30	125.00
IUUC-Pop-098983	Populus trichocarpa	40.74	3.00e-22	98.20
IUUC-Pca-100872	Procavia capensis	71.56	6.00e-63	233.00
IUUC-Ppe-101711	Prunus persica	51.14	8.00e-20	90.10
IUUC-Pva-102256	Pteropus vampyrus	74.76	2.00e-82	298.00
IUUC-Pgr-103607	Puccinia graminis	42.28	5.00e-21	94.00
IUUC-Pte-104220	Pyrenophora teres	36.80	2.00e-15	74.70
IUUC-Pyt-104562	Pyrenophora triticirepentis	36.80	5.00e-16	77.40
IUUC-Rno-105021	Rattus norvegicus	69.23	1.00e-76	279.00
IUUC-Sce-106182	Saccharomyces cerevisiae	49.30	2.00e-15	75.10
IUUC-Sha-107279	Sarcophilus harrisii	73.48	4.00e-71	260.00
IUUC-Sja-107819	Schizosaccharomyces japonicus	42.02	7.00e-20	89.70
IUUC-Spo-108197	Schizosaccharomyces pombe	42.28	9.00e-22	95.90
IUUC-Smo-108810	Selaginella moellendorffii	54.76	2.00e-21	93.60
IUUC-Sit-110256	Setaria italica	43.86	6.00e-23	100.00
IUUC-Sly-111448	Solanum lycopersicum	45.61	2.00e-22	99.00
IUUC-Stu-112702	Solanum tuberosum	45.61	1.00e-22	99.40
IUUC-Sbi-113956	Sorghum bicolor	46.61	3.00e-25	108.00
IUUC-Sre-115024	Sporisorium reilianum	37.98	2.00e-16	79.30
IUUC-Ssc-116034	Sus scrofa	76.56	2.00e-82	298.00
IUUC-Tgu-117503	Taeniopygia guttata	75.52	2.00e-57	214.00
IUUC-Tsy-119166	Tarsius syrichta	67.32	1.00e-43	168.00
IUUC-Tni-120703	Tetraodon nigroviridis	40.14	4.00e-24	104.00
IUUC-Tca-121473	Theobroma cacao	51.14	2.00e-19	89.00
IUUC-Tre-122241	Trichoderma reesei	46.49	7.00e-20	89.40
IUUC-Tvi-122347	Trichoderma virens	41.94	2.00e-18	85.10
IUUC-Tae-124560	Triticum aestivum	44.95	7.00e-23	100.00
IUUC-Tur-126452	Triticum urartu	46.43	5.00e-24	103.00
IUUC-Tme-127205	Tuber melanosporum	47.66	6.00e-19	85.50
IUUC-Ttr-128186	Tursiops truncatus	78.02	4.00e-75	273.00
IUUC-Uma-129523	Ustilago maydis	34.33	6.00e-15	74.30
IUUC-Vda-129793	Verticillium dahliae	45.61	3.00e-20	91.70
IUUC-Vpa-130040	Vicugna pacos	90.67	3.00e-75	273.00
IUUC-Vvi-131588	Vitis vinifera	45.83	7.00e-20	90.10
IUUC-Yli-134631	Yarrowia lipolytica	49.41	1.00e-17	82.40
IUUC-Zma-135478	Zea mays	47.01	1.00e-25	109.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence