iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	UniProt
PHOSIDA	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Other/Other	UBD/Other/Other	11733065; 15732117

Reviewed

Classification

Family	Identity	E-value	Score	Source Orthology
UBD/Other/Other	69.97	0.00e+00	1049.00	IUUC-Hsa-046162

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Involved in spindle disassembly, degradation of ubiquitinated proteins and protein export from the endoplasmic reticulum to the cytoplasm. Acts as a chaperone that collects ubiquitinated substrates. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway. Required for the proteasome-dependent processing/activation of MGA2 and SPT23 transcription factors leading to the subsequent expression of OLE1. Has an additional role in the turnover of OLE1 where it targets ubiquitinated OLE1 and other proteins to the ERAD (PubMed:11733065, PubMed:11740563, PubMed:11813000, PubMed:11847109, PubMed:21070972, PubMed:21148305). Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. CDC48 may provide the mechanical force that dislodges the polyubiquitinated nascent peptides from the exit channel (PubMed:23178123, PubMed:24261871).

Protein Sequence
(Fasta)

MGEEHKPLLD ASGVDPREED KTATAILRRK KKDNMLLVDD AINDDNSVIA INSNTMDKLE 60
LFRGDTVLVK GKKRKDTVLI VLIDDELEDG ACRINRVVRN NLRIRLGDLV TIHPCPDIKY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGTGAAG AACATAAACC ACTTTTGGAC GCCTCGGGTG TCGACCCTCG TGAGGAGGAT 60
AAAACCGCCA CCGCCATTTT AAGAAGAAAG AAGAAGGACA ACATGCTTTT GGTGGACGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-1017--Isopeptide bond
KW-0492--Microsome
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0832--Ubl conjugation

Interpro

IPR003593--AAA+_ATPase
IPR005938--AAA_ATPase_CDC48
IPR009010--Asp_de-COase-like_dom
IPR003959--ATPase_AAA_core
IPR003960--ATPase_AAA_CS
IPR004201--Cdc48_dom2
IPR029067--CDC48_domain_2-like
IPR003338--CDC4_N-term_subdom
IPR027417--P-loop_NTPase
IPR015415--Vps4_C

PROSITE

PS00674--AAA

Pfam

PF00004--AAA
PF02933--CDC48_2
PF02359--CDC48_N
PF09336--Vps4_C

SMART

SM00382--AAA
SM01072--CDC48_2
SM01073--CDC48_N

Gene Ontology

GO:0036266--C:Cdc48p-Npl4p-Vms1p AAA ATPase complex
GO:0005829--C:cytosol
GO:0000837--C:Doa10p ubiquitin ligase complex
GO:0005789--C:endoplasmic reticulum membrane
GO:0000839--C:Hrd1p ubiquitin ligase ERAD-L complex
GO:0005634--C:nucleus
GO:1990112--C:RQC complex
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:0005524--F:ATP binding
GO:0016887--F:ATPase activity
GO:0042802--F:identical protein binding
GO:0019888--F:protein phosphatase regulator activity
GO:0043130--F:ubiquitin binding
GO:0046034--P:ATP metabolic process
GO:0016320--P:endoplasmic reticulum membrane fusion
GO:0071712--P:ER-associated misfolded protein catabolic process
GO:0016236--P:macroautophagy
GO:0072671--P:mitochondria-associated ubiquitin-dependent protein catabolic process
GO:0051228--P:mitotic spindle disassembly
GO:0051974--P:negative regulation of telomerase activity
GO:0070651--P:nonfunctional rRNA decay
GO:0034727--P:piecemeal microautophagy of nucleus
GO:2001168--P:positive regulation of histone H2B ubiquitination
GO:1900182--P:positive regulation of protein localization to nucleus
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0030970--P:retrograde protein transport, ER to cytosol
GO:0034517--P:ribophagy
GO:1990116--P:ribosome-associated ubiquitin-dependent protein catabolic process
GO:1990171--P:SCF complex disassembly in response to cadmium stress
GO:0031134--P:sister chromatid biorientation
GO:0071629--P:ubiquitin-dependent catabolism of misfolded proteins by cytoplasm-associated proteasome
GO:0071630--P:ubiquitin-dependent catabolism of misfolded proteins by nucleus-associated proteasome
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

sce:YDL126C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000524	Aegilops tauschii	67.47	0.00e+00	1066.00
IUUC-Aml-001849	Ailuropoda melanoleuca	70.53	0.00e+00	1097.00
IUUC-Atr-002619	Amborella trichopoda	66.95	0.00e+00	1119.00
IUUC-Apl-004070	Anas platyrhynchos	70.47	0.00e+00	1092.00
IUUC-Aca-004847	Anolis carolinensis	70.23	0.00e+00	1097.00
IUUC-Aly-005470	Arabidopsis lyrata	68.37	0.00e+00	1093.00
IUUC-Ath-006796	Arabidopsis thaliana	68.56	0.00e+00	1112.00
IUUC-Ago-008001	Ashbya gossypii	88.54	0.00e+00	1332.00
IUUC-Acl-008066	Aspergillus clavatus	77.02	0.00e+00	1178.00
IUUC-Afl-008505	Aspergillus flavus	77.18	0.00e+00	1198.00
IUUC-Afu-008840	Aspergillus fumigatus	78.31	0.00e+00	1211.00
IUUC-Ani-009368	Aspergillus nidulans	73.74	0.00e+00	1196.00
IUUC-Ang-009724	Aspergillus niger	77.06	0.00e+00	1201.00
IUUC-Aor-010204	Aspergillus oryzae	77.18	0.00e+00	1198.00
IUUC-Ate-010370	Aspergillus terreus	74.64	0.00e+00	1186.00
IUUC-Ame-011388	Astyanax mexicanus	70.71	0.00e+00	1084.00
IUUC-Bgr-012223	Blumeria graminis	75.54	0.00e+00	1238.00
IUUC-Bta-013188	Bos taurus	70.23	0.00e+00	1101.00
IUUC-Bci-013831	Botrytis cinerea	77.39	0.00e+00	1189.00
IUUC-Bdi-014967	Brachypodium distachyon	68.85	0.00e+00	1103.00
IUUC-Bol-016113	Brassica oleracea	67.73	0.00e+00	1123.00
IUUC-Bra-017796	Brassica rapa	67.86	0.00e+00	1124.00
IUUC-Cel-018243	Caenorhabditis elegans	67.11	0.00e+00	1075.00
IUUC-Cja-019904	Callithrix jacchus	69.72	0.00e+00	1081.00
IUUC-Cfa-020304	Canis familiaris	70.23	0.00e+00	1100.00
IUUC-Cpo-021518	Cavia porcellus	70.66	0.00e+00	1094.00
IUUC-Cre-022719	Chlamydomonas reinhardtii	68.69	0.00e+00	1105.00
IUUC-Csa-023444	Chlorocebus sabaeus	70.36	0.00e+00	1098.00
IUUC-Cho-024482	Choloepus hoffmanni	69.63	0.00e+00	1069.00
IUUC-Cin-025517	Ciona intestinalis	69.37	0.00e+00	1080.00
IUUC-Csv-026060	Ciona savignyi	68.40	0.00e+00	1125.00
IUUC-Cgl-026690	Colletotrichum gloeosporioides	77.83	0.00e+00	1219.00
IUUC-Cne-026910	Cryptococcus neoformans	70.54	0.00e+00	1150.00
IUUC-Cme-027145	Cyanidioschyzon merolae	66.50	0.00e+00	1060.00
IUUC-Dre-028487	Danio rerio	70.58	0.00e+00	1083.00
IUUC-Dno-029257	Dasypus novemcinctus	70.36	0.00e+00	1098.00
IUUC-Dor-030473	Dipodomys ordii	68.87	0.00e+00	1058.00
IUUC-Dse-031319	Dothistroma septosporum	76.40	0.00e+00	1174.00
IUUC-Dme-032203	Drosophila melanogaster	67.36	0.00e+00	1071.00
IUUC-Eca-033311	Equus caballus	70.40	0.00e+00	1094.00
IUUC-Eeu-035293	Erinaceus europaeus	75.82	3.00e-177	613.00
IUUC-Fca-036097	Felis catus	71.72	0.00e+00	1060.00
IUUC-Fal-037292	Ficedula albicollis	70.66	0.00e+00	1096.00
IUUC-Fox-037827	Fusarium oxysporum	77.69	0.00e+00	1233.00
IUUC-Fso-038226	Fusarium solani	78.33	0.00e+00	1238.00
IUUC-Gmo-039157	Gadus morhua	65.67	0.00e+00	991.00
IUUC-Ggr-039951	Gaeumannomyces graminis	78.58	0.00e+00	1212.00
IUUC-Gga-041183	Gallus gallus	70.36	0.00e+00	1099.00
IUUC-Gac-042039	Gasterosteus aculeatus	70.36	0.00e+00	1070.00
IUUC-Gma-044090	Glycine max	66.06	0.00e+00	1107.00
IUUC-Ggo-045568	Gorilla gorilla	70.36	0.00e+00	1098.00
IUUC-Hsa-046162	Homo sapiens	70.36	0.00e+00	1098.00
IUUC-Hvu-047107	Hordeum vulgare	72.15	0.00e+00	912.00
IUUC-Itr-047885	Ictidomys tridecemlineatus	70.18	0.00e+00	1094.00
IUUC-Kpa-049220	Komagataella pastoris	83.75	0.00e+00	1399.00
IUUC-Lch-050657	Latimeria chalumnae	71.64	0.00e+00	984.00
IUUC-Lpe-051083	Leersia perrieri	68.41	0.00e+00	1098.00
IUUC-Loc-052064	Lepisosteus oculatus	70.45	0.00e+00	1083.00
IUUC-Lma-053323	Leptosphaeria maculans	77.38	0.00e+00	1203.00
IUUC-Laf-054574	Loxodonta africana	70.66	0.00e+00	1095.00
IUUC-Mcc-055448	Macaca mulatta	70.36	0.00e+00	1098.00
IUUC-Meu-056316	Macropus eugenii	65.64	0.00e+00	991.00
IUUC-Mor-057057	Magnaporthe oryzae	78.58	0.00e+00	1210.00
IUUC-Mpo-057406	Magnaporthe poae	77.82	0.00e+00	1201.00
IUUC-Mtr-057648	Medicago truncatula	68.78	0.00e+00	1114.00
IUUC-Mla-059156	Melampsora laricipopulina	74.97	0.00e+00	1195.00
IUUC-Mga-060004	Meleagris gallopavo	67.62	0.00e+00	948.00
IUUC-Mvi-060488	Microbotryum violaceum	71.46	0.00e+00	1170.00
IUUC-Mmr-061027	Microcebus murinus	70.66	0.00e+00	1094.00
IUUC-Mdo-062159	Monodelphis domestica	70.36	0.00e+00	1099.00
IUUC-Mmu-063633	Mus musculus	70.36	0.00e+00	1098.00
IUUC-Mac-064919	Musa acuminata	68.81	0.00e+00	1109.00
IUUC-Mpu-066078	Mustela putorius furo	70.23	0.00e+00	1101.00
IUUC-Mlu-067757	Myotis lucifugus	70.23	0.00e+00	1098.00
IUUC-Nfi-068533	Neosartorya fischeri	77.41	0.00e+00	1191.00
IUUC-Ncr-068775	Neurospora crassa	78.20	0.00e+00	1177.00
IUUC-Nle-069424	Nomascus leucogenys	70.66	0.00e+00	1095.00
IUUC-Opr-071147	Ochotona princeps	70.06	0.00e+00	1078.00
IUUC-Ont-071351	Oreochromis niloticus	70.71	0.00e+00	1061.00
IUUC-Oan-073335	Ornithorhynchus anatinus	67.97	0.00e+00	1095.00
IUUC-Ocu-074072	Oryctolagus cuniculus	70.36	0.00e+00	1098.00
IUUC-Oba-075914	Oryza barthii	69.62	0.00e+00	1116.00
IUUC-Obr-076224	Oryza brachyantha	70.17	0.00e+00	1107.00
IUUC-Ogl-077282	Oryza glaberrima	69.21	0.00e+00	1124.00
IUUC-Ogu-078174	Oryza glumaepatula	69.62	0.00e+00	1116.00
IUUC-Oin-079103	Oryza indica	69.62	0.00e+00	1116.00
IUUC-Olo-080675	Oryza longistaminata	69.49	0.00e+00	1115.00
IUUC-Ome-081959	Oryza meridionalis	69.21	0.00e+00	1124.00
IUUC-Oni-082078	Oryza nivara	69.62	0.00e+00	1116.00
IUUC-Opu-083806	Oryza punctata	69.57	0.00e+00	1120.00
IUUC-Oru-084634	Oryza rufipogon	69.62	0.00e+00	1118.00
IUUC-Osa-085960	Oryza sativa	69.62	0.00e+00	1116.00
IUUC-Ola-086382	Oryzias latipes	70.40	0.00e+00	1059.00
IUUC-Olu-087839	Ostreococcus lucimarinus	69.37	0.00e+00	1089.00
IUUC-Oga-088037	Otolemur garnettii	70.23	0.00e+00	1095.00
IUUC-Oar-089684	Ovis aries	70.53	0.00e+00	1097.00
IUUC-Ptr-091378	Pan troglodytes	70.36	0.00e+00	1098.00
IUUC-Pan-092849	Papio anubis	70.36	0.00e+00	1098.00
IUUC-Psi-093725	Pelodiscus sinensis	69.61	0.00e+00	1052.00
IUUC-Pma-094537	Petromyzon marinus	65.30	2.00e-158	549.00
IUUC-Pno-094915	Phaeosphaeria nodorum	81.42	0.00e+00	1142.00
IUUC-Ppa-095632	Physcomitrella patens	66.91	0.00e+00	1078.00
IUUC-Pfo-097440	Poecilia formosa	70.58	0.00e+00	1060.00
IUUC-Pab-098469	Pongo abelii	70.36	0.00e+00	1098.00
IUUC-Pop-100047	Populus trichocarpa	69.28	0.00e+00	1113.00
IUUC-Pca-100399	Procavia capensis	66.16	0.00e+00	1004.00
IUUC-Ppe-101767	Prunus persica	65.94	0.00e+00	1115.00
IUUC-Pva-102426	Pteropus vampyrus	69.59	0.00e+00	1068.00
IUUC-Pgr-103599	Puccinia graminis	75.06	0.00e+00	1171.00
IUUC-Ptt-103740	Puccinia triticina	73.97	0.00e+00	1173.00
IUUC-Pte-104030	Pyrenophora teres	73.51	0.00e+00	1183.00
IUUC-Pyt-104541	Pyrenophora triticirepentis	73.60	0.00e+00	1183.00
IUUC-Rno-105144	Rattus norvegicus	70.36	0.00e+00	1099.00
IUUC-Sha-106589	Sarcophilus harrisii	70.66	0.00e+00	1096.00
IUUC-Sja-107673	Schizosaccharomyces japonicus	74.88	0.00e+00	1218.00
IUUC-Spo-108247	Schizosaccharomyces pombe	75.76	0.00e+00	1177.00
IUUC-Ssl-108642	Sclerotinia sclerotiorum	77.51	0.00e+00	1184.00
IUUC-Smo-108877	Selaginella moellendorffii	69.67	0.00e+00	1108.00
IUUC-Sit-110368	Setaria italica	69.16	0.00e+00	1113.00
IUUC-Sly-111011	Solanum lycopersicum	67.00	0.00e+00	1122.00
IUUC-Stu-112133	Solanum tuberosum	67.04	0.00e+00	1125.00
IUUC-Sar-113021	Sorex araneus	70.66	0.00e+00	1095.00
IUUC-Sbi-114462	Sorghum bicolor	68.78	0.00e+00	1113.00
IUUC-Sre-115052	Sporisorium reilianum	73.56	0.00e+00	1179.00
IUUC-Ssc-116293	Sus scrofa	70.05	0.00e+00	1095.00
IUUC-Tgu-116544	Taeniopygia guttata	67.87	0.00e+00	1018.00
IUUC-Tru-117991	Takifugu rubripes	72.04	0.00e+00	780.00
IUUC-Tsy-119131	Tarsius syrichta	75.85	9.00e-171	591.00
IUUC-Tni-120192	Tetraodon nigroviridis	70.06	0.00e+00	1053.00
IUUC-Tca-121502	Theobroma cacao	68.48	0.00e+00	1082.00
IUUC-Tre-122189	Trichoderma reesei	74.16	0.00e+00	1214.00
IUUC-Tvi-122310	Trichoderma virens	74.16	0.00e+00	1202.00
IUUC-Tae-123524	Triticum aestivum	68.43	0.00e+00	1062.00
IUUC-Tur-126733	Triticum urartu	68.39	0.00e+00	1063.00
IUUC-Tme-127147	Tuber melanosporum	77.59	0.00e+00	1170.00
IUUC-Tbe-127255	Tupaia belangeri	65.31	0.00e+00	1023.00
IUUC-Ttr-128876	Tursiops truncatus	70.27	0.00e+00	1090.00
IUUC-Uma-129448	Ustilago maydis	72.86	0.00e+00	1156.00
IUUC-Vda-129800	Verticillium dahliae	75.00	0.00e+00	1201.00
IUUC-Vpa-130573	Vicugna pacos	76.72	0.00e+00	674.00
IUUC-Vvi-131622	Vitis vinifera	69.54	0.00e+00	1119.00
IUUC-Xtr-132458	Xenopus tropicalis	71.52	0.00e+00	1057.00
IUUC-Xma-134045	Xiphophorus maculatus	70.58	0.00e+00	1060.00
IUUC-Yli-134382	Yarrowia lipolytica	83.29	0.00e+00	1322.00
IUUC-Zma-135400	Zea mays	68.96	0.00e+00	1111.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence