iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045962

UUCD1 version

UUC-HoS-00457

Ensembl Protein ID

ENSP00000359206.3

UniProt Accession

Q9Y297; B5MD49; Q5W141; Q5W142; Q9Y213; FBW1A_HUMAN

Genbank Protein ID

AAD08702.1; CAA74572.1; AAF04464.1; ADU87633.1; BAG36155.1; CAH70019.1; CAH70019.1; CAH70019.1; CAH70020.1; CAH70020.1; CAH70020.1; CAI12963.1; CAI12963.1; CAI12963.1; CAI12964.1; CAI12964.1; CAI12964.1; CAI41042.1; CAI41042.1; CAI41042.1; CAI41043.1; CAI41043.1; CAI41043.1; EAW49772.1; EAW49774.1; AAH27994.1

Protein Name

F-box/WD repeat-containing protein 1A; E3RSIkappaB; Epididymis tissue protein Li 2a; F-box and WD repeats protein beta-TrCP; pIkappaBalpha-E3 receptor subunit

Genbank Nucleotide ID

AF101784; Y14153; AF129530; GU727631; AK313353; AL133387; AL445463; AL627424; AL133387; AL445463; AL627424; AL445463; AL133387; AL627424; AL445463; AL133387; AL627424; AL627424; AL133387; AL445463; AL627424; AL133387; AL445463; CH471066; CH471066; BC027994

Gene Name

BTRC; BTRCP; FBW1A; FBXW1A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000166167.17	ENST00000370187.7	ENSP00000359206.3
ENSG00000166167.17	ENST00000408038.6	ENSP00000385339.2
ENSG00000166167.17	ENST00000393441.8	ENSP00000377088.5

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	miRecords	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	18166147; 18378670; 18460583; 18500245; 10074433; 18650423; 18354483; 19004823; 19631635; 19478868; 19297328; 15082796; 19276348; 19270156; 19244340; 17965458; 10437795; 19211746; 19196987; 17217622; 14525958; 14988407; 20068069; 19929170; 16303288; 21173164; 18575781; 19797085; 16219772; 21402774; 21068446; 17445772
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	18166147; 18460583; 18500245; 10074433; 18650423; 19004823; 19631635; 19557001; 19478868; 19297328; 19276348; 17965458; 10437795; 19196987; 17217622; 19929170; 16303288; 21173164; 19797085; 16219772

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	0.00097	20.9	191	228
E3 adaptor/Cullin RING/DCX/DWD	1.60e-58	193.6	504	539
UBD/Beta-Prp	2.20e-68	232.3	418	582

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 109  eilveilklldkeellraarvcrrwqelasqkalwktv 146
           +i  +il++ld+++l++a++vc++w++++s+  lwk++
   Q: 191  HIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 228
           7899**************************9****987 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvll 36
           gH++ v+c++f d +++vsG++Dg+ikvWDl    ++
   Q: 504  GHEELVRCIRF-DnKRIVSGAYDGKIKVWDLVAALDP 539
           8**********.44****************9876665 PP

UBD/Beta-Prp

   S: 44   llrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsg 135
           l r l gh a+v+ v+f+++  ++v++s Drtikvw+ st++ v+tl+gh++ + +l++      +vsGs+d+tir+wd+e g cl+ +l+g
   Q: 418  LRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLR-VLEG 504
           445569*************9..8**************************************..************************.**** PP
   S: 136  hdgvvncvvvhpdgnllvsGslDrtvrlWdl.........ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdl 209
           h+++v+c++++   + +vsG++D+++++Wdl         +   +lrtl + h ++v  l+fd+  +++vs s+d t+ +wd+
   Q: 505  HEELVRCIRFDN--KRIVSGAYDGKIKVWDLvaaldprapAGTLCLRTLVE-HSGRVFRLQFDE--FQIVSSSHDDTILIWDF 582
           ***********9..*************************877889****98.************..99**************7 PP

Organism

Homo sapiens

Functional Description
(View)

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25704143, PubMed:25503564). SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3.

Protein Sequence
(Fasta)

MDPAEAVLQE KALKFMCSMP RSLWLGCSSL ADSMPSLRCL YNPGTGALTA FQNSSEREDC 60
NNGEPPRKII PEKNSLRQTY NSCARLCLNQ ETVCLASTAM KTENCVAKTK LANGTSSMIV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATTCTCCTT GGCCCCTCAG CCTGCGCCTG AGAGGTAAGA GAGGGCGGGG GGAAGGAAGA 60
GGAGGCGGGA TCCGGGCGCT GCGTTGGCTG CGGCCTGGCA CCAAAGGGGC GGCCCCGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0945--Host-virus interaction
KW-0436--Ligase
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
KW-0879--Wnt signaling pathway

Interpro

IPR021977--Beta-TrCP_D
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12125--Beta-TrCP_D
PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM01028--Beta-TrCP_D
SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0008013--F:beta-catenin binding
GO:0016874--F:ligase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0060444--P:branching involved in mammary gland duct morphogenesis
GO:0071407--P:cellular response to organic cyclic compound
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0033598--P:mammary gland epithelial cell proliferation
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045879--P:negative regulation of smoothened signaling pathway
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0038061--P:NIK/NF-kappaB signaling
GO:0042753--P:positive regulation of circadian rhythm
GO:0045862--P:positive regulation of proteolysis
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006470--P:protein dephosphorylation
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0060828--P:regulation of canonical Wnt signaling pathway
GO:0042752--P:regulation of circadian rhythm
GO:0043122--P:regulation of I-kappaB kinase/NF-kappaB signaling
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0048511--P:rhythmic process
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0007165--P:signal transduction
GO:0002223--P:stimulatory C-type lectin receptor signaling pathway
GO:0051403--P:stress-activated MAPK cascade
GO:0050852--P:T cell receptor signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0016032--P:viral process
GO:0016055--P:Wnt signaling pathway

KEGG

hsa:8945

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001961	Ailuropoda melanoleuca	99.67	0.00e+00	1260.00
IUUC-Apl-003437	Anas platyrhynchos	98.60	0.00e+00	1024.00
IUUC-Aca-004410	Anolis carolinensis	92.83	0.00e+00	1209.00
IUUC-Acl-008355	Aspergillus clavatus	29.69	3.00e-51	196.00
IUUC-Afl-008580	Aspergillus flavus	27.46	2.00e-44	174.00
IUUC-Afu-008790	Aspergillus fumigatus	30.02	6.00e-49	189.00
IUUC-Ani-009324	Aspergillus nidulans	29.40	1.00e-48	187.00
IUUC-Aor-010185	Aspergillus oryzae	29.58	2.00e-51	197.00
IUUC-Ate-010492	Aspergillus terreus	30.18	2.00e-50	193.00
IUUC-Bgr-012194	Blumeria graminis	32.52	3.00e-54	206.00
IUUC-Bta-013453	Bos taurus	93.72	0.00e+00	1166.00
IUUC-Bci-013685	Botrytis cinerea	31.58	5.00e-55	209.00
IUUC-Cel-018392	Caenorhabditis elegans	63.71	0.00e+00	635.00
IUUC-Cja-019121	Callithrix jacchus	95.37	0.00e+00	1190.00
IUUC-Cfa-020553	Canis familiaris	99.83	0.00e+00	1261.00
IUUC-Cpo-022126	Cavia porcellus	97.14	0.00e+00	1169.00
IUUC-Csa-023688	Chlorocebus sabaeus	100.00	0.00e+00	1263.00
IUUC-Cin-025188	Ciona intestinalis	80.50	0.00e+00	827.00
IUUC-Csv-026020	Ciona savignyi	76.54	0.00e+00	790.00
IUUC-Cgl-026429	Colletotrichum gloeosporioides	33.55	3.00e-61	229.00
IUUC-Dno-029484	Dasypus novemcinctus	93.55	0.00e+00	1167.00
IUUC-Dor-031010	Dipodomys ordii	92.70	0.00e+00	1099.00
IUUC-Dse-031287	Dothistroma septosporum	29.34	5.00e-53	202.00
IUUC-Dme-031885	Drosophila melanogaster	80.41	0.00e+00	819.00
IUUC-Ete-032978	Echinops telfairi	86.72	0.00e+00	1055.00
IUUC-Eca-033374	Equus caballus	98.82	0.00e+00	1224.00
IUUC-Eeu-034760	Erinaceus europaeus	78.35	0.00e+00	946.00
IUUC-Fca-035427	Felis catus	95.54	0.00e+00	1192.00
IUUC-Fal-037530	Ficedula albicollis	98.64	0.00e+00	1212.00
IUUC-Fox-037978	Fusarium oxysporum	33.55	2.00e-62	234.00
IUUC-Fso-038077	Fusarium solani	32.75	3.00e-57	216.00
IUUC-Ggr-039974	Gaeumannomyces graminis	32.08	4.00e-56	213.00
IUUC-Gga-041087	Gallus gallus	95.06	0.00e+00	1232.00
IUUC-Ggo-045369	Gorilla gorilla	99.64	0.00e+00	1152.00
IUUC-Itr-047872	Ictidomys tridecemlineatus	99.56	0.00e+00	941.00
IUUC-Lch-050285	Latimeria chalumnae	90.18	0.00e+00	945.00
IUUC-Loc-052686	Lepisosteus oculatus	92.56	0.00e+00	1171.00
IUUC-Lma-053289	Leptosphaeria maculans	38.43	8.00e-48	185.00
IUUC-Laf-054022	Loxodonta africana	98.82	0.00e+00	1224.00
IUUC-Mcc-055782	Macaca mulatta	100.00	0.00e+00	1226.00
IUUC-Meu-056078	Macropus eugenii	84.60	0.00e+00	900.00
IUUC-Mor-057283	Magnaporthe oryzae	33.26	6.00e-59	222.00
IUUC-Mpo-057540	Magnaporthe poae	32.30	9.00e-57	215.00
IUUC-Mla-058989	Melampsora laricipopulina	40.88	4.00e-61	228.00
IUUC-Mga-059388	Meleagris gallopavo	97.33	0.00e+00	1217.00
IUUC-Mmr-060969	Microcebus murinus	99.83	0.00e+00	1261.00
IUUC-Mdo-063041	Monodelphis domestica	99.34	0.00e+00	1224.00
IUUC-Mmu-064096	Mus musculus	98.68	0.00e+00	1249.00
IUUC-Mpu-066875	Mustela putorius furo	99.64	0.00e+00	1149.00
IUUC-Mlu-067621	Myotis lucifugus	99.01	0.00e+00	1036.00
IUUC-Nfi-068263	Neosartorya fischeri	29.50	2.00e-50	193.00
IUUC-Ncr-068639	Neurospora crassa	34.82	3.00e-45	177.00
IUUC-Nle-069548	Nomascus leucogenys	99.83	0.00e+00	1261.00
IUUC-Opr-071194	Ochotona princeps	93.72	0.00e+00	1166.00
IUUC-Oan-072867	Ornithorhynchus anatinus	95.67	0.00e+00	1233.00
IUUC-Ocu-074246	Oryctolagus cuniculus	99.83	0.00e+00	1261.00
IUUC-Oga-088244	Otolemur garnettii	99.60	0.00e+00	1037.00
IUUC-Oar-089199	Ovis aries	99.02	0.00e+00	1047.00
IUUC-Ptr-090475	Pan troglodytes	79.70	0.00e+00	939.00
IUUC-Pan-092826	Papio anubis	100.00	0.00e+00	1263.00
IUUC-Psi-093485	Pelodiscus sinensis	95.96	0.00e+00	1182.00
IUUC-Pma-094315	Petromyzon marinus	80.79	0.00e+00	894.00
IUUC-Pab-097680	Pongo abelii	99.50	0.00e+00	1257.00
IUUC-Pca-100843	Procavia capensis	92.73	0.00e+00	1136.00
IUUC-Pva-102793	Pteropus vampyrus	89.42	0.00e+00	1096.00
IUUC-Pgr-103331	Puccinia graminis	37.69	3.00e-52	199.00
IUUC-Ptt-103853	Puccinia triticina	32.08	6.00e-61	228.00
IUUC-Pte-104392	Pyrenophora teres	37.37	9.00e-48	185.00
IUUC-Pyt-104678	Pyrenophora triticirepentis	37.72	5.00e-48	186.00
IUUC-Rno-105304	Rattus norvegicus	98.47	0.00e+00	1211.00
IUUC-Sha-107454	Sarcophilus harrisii	94.79	0.00e+00	1207.00
IUUC-Spo-108200	Schizosaccharomyces pombe	32.08	1.00e-66	247.00
IUUC-Sar-113471	Sorex araneus	78.18	0.00e+00	926.00
IUUC-Sre-114916	Sporisorium reilianum	33.71	8.00e-46	179.00
IUUC-Ssc-115490	Sus scrofa	99.60	0.00e+00	1054.00
IUUC-Tgu-117445	Taeniopygia guttata	98.51	0.00e+00	1244.00
IUUC-Tsy-118983	Tarsius syrichta	95.25	0.00e+00	1164.00
IUUC-Tre-122207	Trichoderma reesei	33.63	8.00e-56	211.00
IUUC-Tvi-122344	Trichoderma virens	34.00	7.00e-56	212.00
IUUC-Tme-127141	Tuber melanosporum	35.86	2.00e-64	240.00
IUUC-Tbe-128146	Tupaia belangeri	89.92	0.00e+00	1070.00
IUUC-Ttr-128946	Tursiops truncatus	99.67	0.00e+00	1260.00
IUUC-Uma-129491	Ustilago maydis	33.42	7.00e-47	182.00
IUUC-Vda-129941	Verticillium dahliae	32.23	2.00e-57	217.00
IUUC-Vpa-130709	Vicugna pacos	97.85	0.00e+00	1228.00
IUUC-Xtr-132861	Xenopus tropicalis	92.54	0.00e+00	1167.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence