iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Fca-035401

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AANG02199495

Gene Name

CUL5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000012427.3	ENSFCAT00000012430.3	ENSFCAP00000011528.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	1.50e-225	750.6	16	663

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 2    lreavkkilrqesv.kkeyeelytavynlclsk..vgaklYkklkevleefikqvkkkveesedeq.lLktynreWekfreqlkvlrki 86
           +r +v k+lrqesv k+++ +l+++v+++cl++  + ak++++lke++ efikq++++v +++d++ lLk+y++eW+kf++q+++l+k+
   Q: 16   MRPIVLKLLRQESVtKQQWFDLFSDVHAVCLWDdkGPAKIHQALKEDILEFIKQAQARVLSHQDDTaLLKAYIVEWRKFFTQCDILPKP 104
           7899****************************9999***************************************************** PP
   S: 87   fayldrtyvkk....skkv....sevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvveslveLslnk...laiy 164
           f++l+ t ++k    +       s vrkL+ld+w+++i+++ik+rl+++++kl++aeR gea+d++l+ gv+es+v+L++n    l+iy
   Q: 105  FCQLEITLMGKqgsnK--StvedSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQLVIGVRESYVNLCSNPedkLQIY 191
           ***********76543..1458899*******************************************************99999**** PP
   S: 165  kesFEakfleatqefykaesaeflqenevdeYlkkvearlneeeeraaryleestetk....Llevvekeliakhlesllaelvallrd 249
           +++FE+++l++t++fy++++ ++lq+n+v++Y+k+++a+l+eee+ra ryle+++e++    L+e+++++l++++ e++lae++ ++++
   Q: 192  RDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKEEEKRALRYLETRRECNsveaLMECCVNALVTSFKETILAECQGMIKR 280
           ********************************************************999999*************************** PP
   S: 250  kktedlsrmykLlsrvlngleellkeleshikeqgkaalt..aeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetf 336
           ++te+l++m++L+++v+ng+e++lk+le+hi ++g+a+++  ae++++d++kyVe+ll+l+n+++klv+eaF++d++Fl+a+dka++++
   Q: 281  NETEKLHLMFSLMDKVPNGIEPMLKDLEEHIISAGLADMVaaAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTARDKAYKAV 369
           ***************************************99999********************************************* PP
   S: 337  vnknsvlka................akspEllAryiDqlLrks..skglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsg 407
           vn+++++k+                +k+pEllA+y+D+lLrk+  sk+lt+ee+ea+l++vllv+ky+++kdvF +y+k hL++RL+++
   Q: 370  VNDATIFKLelplkqkgvglktqpeSKCPELLANYCDMLLRKTplSKKLTSEEIEAKLKEVLLVLKYVQNKDVF-RYHKAHLTRRLILD 457
           **************************************************************************.7************* PP
   S: 408  ksasseaEesviekLkeec.gaeftskLerMfqdlkvSedlnrqFk.eekenteesesvelsvlvLsagaWptasetekvsLPaelekt 494
           +sa+se Ee+++e+L+e++ +a++++kL+rMfqd+kvSedln++Fk ++k+n+ + +++++++++L+agaW+++se++ vsLP+ele++
   Q: 458  ISADSE-EENMVEWLREVGmPADYVNKLARMFQDIKVSEDLNQAFKeMHKNNKLALPADSVNIKILNAGAWSRSSEKVFVSLPTELEDL 545
           ***998.779************************************5688888899********************************* PP
   S: 495  iekfeefYlekhsgRkLqWqhtlgraelkaelkkgkyelqVstfQmavLLafnns..ekvsveelkkatelpeeeLrrtlqsLvs.sk. 579
           i+++eefY+++hsgRkL+W+h ++++ +++++++g+y+l+V+tfQ+avL+a+n++  ek+s+e+lk atelp++eLrrtl+sLv+ +k 
   Q: 546  IPEVEEFYKKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRprEKISFENLKLATELPDAELRRTLWSLVAfPKl 634
           ******************************************************999****************************9999 PP
   S: 580  .kqvlkkepeske...ieeedlfsvNqef 604
            +qvl +ep+ ++   ++e++lfsvNqef
   Q: 635  kRQVLLYEPQVNSpkdFTEGTLFSVNQEF 663
           99********977778************9 PP

Organism

Felis catus

Protein Sequence
(Fasta)

LKNKGSLQFE DKWDFMRPIV LKLLRQESVT KQQWFDLFSD VHAVCLWDDK GPAKIHQALK 60
EDILEFIKQA QARVLSHQDD TALLKAYIVE WRKFFTQCDI LPKPFCQLEI TLMGKQGSNK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTAAAGAATA AAGGTTCACT TCAGTTTGAA GACAAATGGG ATTTCATGCG TCCAATTGTT 60
TTGAAGCTTT TACGCCAGGA ATCTGTTACA AAACAGCAGT GGTTTGATCT GTTTTCGTAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0031466--C:Cul5-RING ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002082	Ailuropoda melanoleuca	98.97	0.00e+00	1526.00
IUUC-Apl-003564	Anas platyrhynchos	98.97	0.00e+00	1528.00
IUUC-Aca-004319	Anolis carolinensis	98.71	0.00e+00	1527.00
IUUC-Ame-011742	Astyanax mexicanus	96.39	0.00e+00	1494.00
IUUC-Bta-012515	Bos taurus	99.34	0.00e+00	1501.00
IUUC-Cel-018522	Caenorhabditis elegans	51.61	0.00e+00	744.00
IUUC-Cja-018785	Callithrix jacchus	99.23	0.00e+00	1532.00
IUUC-Cfa-020932	Canis familiaris	99.47	0.00e+00	1504.00
IUUC-Cpo-022317	Cavia porcellus	99.23	0.00e+00	1532.00
IUUC-Csa-023949	Chlorocebus sabaeus	99.35	0.00e+00	1534.00
IUUC-Cho-024570	Choloepus hoffmanni	98.60	4.00e-125	441.00
IUUC-Cin-025540	Ciona intestinalis	72.55	1.00e-147	515.00
IUUC-Csv-025978	Ciona savignyi	64.93	0.00e+00	995.00
IUUC-Dre-027958	Danio rerio	96.26	0.00e+00	1508.00
IUUC-Dno-029195	Dasypus novemcinctus	99.35	0.00e+00	1534.00
IUUC-Dor-030573	Dipodomys ordii	86.42	7.00e-168	583.00
IUUC-Dme-032083	Drosophila melanogaster	67.98	0.00e+00	906.00
IUUC-Ete-032428	Echinops telfairi	87.73	0.00e+00	1078.00
IUUC-Eca-033232	Equus caballus	99.23	0.00e+00	1531.00
IUUC-Eeu-035348	Erinaceus europaeus	99.23	0.00e+00	739.00
IUUC-Fal-037514	Ficedula albicollis	98.84	0.00e+00	1523.00
IUUC-Gmo-038577	Gadus morhua	93.57	0.00e+00	1458.00
IUUC-Gga-041096	Gallus gallus	98.84	0.00e+00	1526.00
IUUC-Gac-042108	Gasterosteus aculeatus	94.34	0.00e+00	1469.00
IUUC-Ggo-045313	Gorilla gorilla	99.23	0.00e+00	1529.00
IUUC-Hsa-045974	Homo sapiens	99.35	0.00e+00	1534.00
IUUC-Itr-049009	Ictidomys tridecemlineatus	99.35	0.00e+00	1531.00
IUUC-Lch-050615	Latimeria chalumnae	98.42	0.00e+00	1488.00
IUUC-Loc-051807	Lepisosteus oculatus	97.68	0.00e+00	1511.00
IUUC-Laf-053601	Loxodonta africana	99.35	0.00e+00	1533.00
IUUC-Mcc-055260	Macaca mulatta	99.35	0.00e+00	1533.00
IUUC-Meu-056632	Macropus eugenii	98.74	0.00e+00	925.00
IUUC-Mga-059658	Meleagris gallopavo	98.84	0.00e+00	1526.00
IUUC-Mmr-061424	Microcebus murinus	89.39	0.00e+00	1330.00
IUUC-Mdo-061836	Monodelphis domestica	98.97	0.00e+00	1528.00
IUUC-Mmu-063757	Mus musculus	97.81	0.00e+00	1514.00
IUUC-Mpu-065823	Mustela putorius furo	99.35	0.00e+00	1535.00
IUUC-Mlu-066969	Myotis lucifugus	98.97	0.00e+00	1526.00
IUUC-Nle-069943	Nomascus leucogenys	99.35	0.00e+00	1534.00
IUUC-Opr-070820	Ochotona princeps	99.08	0.00e+00	845.00
IUUC-Ont-071599	Oreochromis niloticus	95.74	0.00e+00	1492.00
IUUC-Oan-072743	Ornithorhynchus anatinus	98.95	0.00e+00	1499.00
IUUC-Ocu-074586	Oryctolagus cuniculus	99.35	0.00e+00	1534.00
IUUC-Ola-087526	Oryzias latipes	95.48	0.00e+00	1489.00
IUUC-Oga-088425	Otolemur garnettii	94.85	0.00e+00	1492.00
IUUC-Oar-089785	Ovis aries	99.35	0.00e+00	1534.00
IUUC-Ptr-091242	Pan troglodytes	99.35	0.00e+00	1534.00
IUUC-Pan-092246	Papio anubis	99.35	0.00e+00	1534.00
IUUC-Psi-094081	Pelodiscus sinensis	98.97	0.00e+00	1531.00
IUUC-Pma-094735	Petromyzon marinus	82.26	0.00e+00	744.00
IUUC-Pfo-096357	Poecilia formosa	94.97	0.00e+00	1484.00
IUUC-Pab-098248	Pongo abelii	93.16	0.00e+00	1412.00
IUUC-Pca-100756	Procavia capensis	87.72	0.00e+00	858.00
IUUC-Pva-102990	Pteropus vampyrus	85.36	0.00e+00	894.00
IUUC-Rno-105887	Rattus norvegicus	98.06	0.00e+00	1516.00
IUUC-Sha-107016	Sarcophilus harrisii	98.97	0.00e+00	1528.00
IUUC-Sar-113558	Sorex araneus	93.53	0.00e+00	1459.00
IUUC-Ssc-115414	Sus scrofa	99.35	0.00e+00	1534.00
IUUC-Tgu-116801	Taeniopygia guttata	98.32	0.00e+00	1514.00
IUUC-Tru-117565	Takifugu rubripes	95.74	0.00e+00	1493.00
IUUC-Tsy-119292	Tarsius syrichta	93.34	0.00e+00	1347.00
IUUC-Tni-120471	Tetraodon nigroviridis	95.62	0.00e+00	1488.00
IUUC-Tbe-127838	Tupaia belangeri	93.55	0.00e+00	1464.00
IUUC-Ttr-128345	Tursiops truncatus	98.84	0.00e+00	1526.00
IUUC-Vpa-130191	Vicugna pacos	89.89	0.00e+00	821.00
IUUC-Xtr-132810	Xenopus tropicalis	98.19	0.00e+00	1519.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence