iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-072743

UUCD1 version

UUC-OrA-00128

Ensembl Protein ID

ENSOANP00000016570.2

UniProt Accession

F6SG39; F6SG39_ORNAN

Protein Name

Uncharacterized protein

Gene Name

CUL5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000010459.2	ENSOANT00000016573.2	ENSOANP00000016570.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	5.40e-230	765.5	1	651

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 2    lreavkkilrqesv.kkeyeelytavynlclsk..vgaklYkklkevleefikqvkkkveesedeq.lLktynreWekfreqlkvlrki 86
           +r +v k+lrqesv k+++ +l+++v+++cl++  + ak++++lke++ +fikq++++v +++d++ lLk+y++eW+kf++q+++l+k+
   Q: 1    MRPIVLKLLRQESVtKQQWFDLFSDVHAVCLWDdkGPAKIHQALKEDILDFIKQAQARVLSHQDDTaLLKAYIVEWRKFFTQCDILPKP 89
           5789****************************9999***************************************************** PP
   S: 87   fayldrtyvkk.....skkv..sevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvveslveLslnk...laiyk 165
           f++l+ t ++k     +++v  s vrkL+ld+w+++i+++ik+rl+++++kl++aeR gea+d++l+ gv+es+v+L++n    l+iy+
   Q: 90   FCQLEITLMGKqgsnkKSNVedSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQLVIGVRESYVNLCSNPedkLQIYR 178
           ***********8765544448899*******************************************************99999***** PP
   S: 166  esFEakfleatqefykaesaeflqenevdeYlkkvearlneeeeraaryleestetk....Llevvekeliakhlesllaelvallrdk 250
           ++FE+++l++t++fy++++ ++lq+n+v++Y+k+++a+l+eee+ra ryle+++e++    L+e+++++l++++ e++lae++ +++++
   Q: 179  DNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKEEEKRALRYLETRRECNsveaLMECCVNALVTSFKETILAECQGMIKRN 267
           *******************************************************999999**************************** PP
   S: 251  ktedlsrmykLlsrvlngleellkeleshikeqgkaalt..aeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfv 337
           +te+l++m++L+++v+ng+e++lk+le+hi ++g+a+++  ae++++d++kyVe+ll+l+n+++klv+eaF++d++Fl+a+dka++++v
   Q: 268  ETEKLHLMFSLMDKVPNGIEPMLKDLEEHIVSAGLADMVaaAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTARDKAYKAVV 356
           **************************************99999********************************************** PP
   S: 338  nknsvlka................akspEllAryiDqlLrks..skglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgk 408
           n+++++k+                +k+pEllA+y+D+lLrk+  sk+lt+ee+ea+l++vllv+ky+++kdvF++y+k hL++RL++++
   Q: 357  NDATIFKLelplkqkgvglktqpeSKCPELLANYCDMLLRKTplSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDI 445
           ***************************************************************************************** PP
   S: 409  sasseaEesviekLkeec.gaeftskLerMfqdlkvSedlnrqFk.eekenteesesvelsvlvLsagaWptasetekvsLPaelekti 495
           sa+se+Ee+++e+L+e++ +a++++kL+rMfqd+kvSedln++Fk ++k+n+ + +++++++++L+agaW+++se++ vsLP+ele++i
   Q: 446  SADSEIEENMVEWLREVGmPADYVNKLARMFQDIKVSEDLNQAFKeMHKNNKLALPADSVNIKILNAGAWSRSSEKVFVSLPTELEDLI 534
           *********************************************5688888899********************************** PP
   S: 496  ekfeefYlekhsgRkLqWqhtlgraelkaelkkgkyelqVstfQmavLLafnns..ekvsveelkkatelpeeeLrrtlqsLvs.sk.. 579
           +++eefY+++hsgRkL+W+h ++++ +++++++g+y+l+V+tfQ+avL+a+n++  ek+s+e+lk atelp++eLrrtl+sLv+ +k  
   Q: 535  PEVEEFYKKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRprEKISFENLKLATELPDAELRRTLWSLVAfPKlk 623
           *****************************************************999****************************99999 PP
   S: 580  kqvlkkepeske...ieeedlfsvNqef 604
           +qvl +ep+ ++   ++e++lfsvNqef
   Q: 624  RQVLLYEPQVNSpkdFTEGTLFSVNQEF 651
           9********977778************9 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

MRPIVLKLLR QESVTKQQWF DLFSDVHAVC LWDDKGPAKI HQALKEDILD FIKQAQARVL 60
SHQDDTALLK AYIVEWRKFF TQCDILPKPF CQLEITLMGK QGSNKKSNVE DSIVRKLMLD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCTGCATGT AAATTAAGCT GCTCTTTCTT GCTGTTTTTT GTCAAGAATA AAGGTTCACT 60
TCAGTTTGAA GACAAATGGG ATTTCATGCG CCCCATAGTT CTGAAGCTTT TACGCCAGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0031466--C:Cul5-RING ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

oaa:100077442

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002082	Ailuropoda melanoleuca	99.08	0.00e+00	1515.00
IUUC-Apl-003564	Anas platyrhynchos	100.00	0.00e+00	1528.00
IUUC-Aca-004319	Anolis carolinensis	99.74	0.00e+00	1524.00
IUUC-Ame-011742	Astyanax mexicanus	97.24	0.00e+00	1495.00
IUUC-Bta-012515	Bos taurus	99.60	0.00e+00	1526.00
IUUC-Cel-018522	Caenorhabditis elegans	51.96	0.00e+00	752.00
IUUC-Cja-018785	Callithrix jacchus	99.47	0.00e+00	1524.00
IUUC-Cfa-020932	Canis familiaris	99.47	0.00e+00	1524.00
IUUC-Cpo-022317	Cavia porcellus	99.34	0.00e+00	1522.00
IUUC-Csa-023949	Chlorocebus sabaeus	99.60	0.00e+00	1525.00
IUUC-Cho-024570	Choloepus hoffmanni	99.07	2.00e-127	449.00
IUUC-Cin-025540	Ciona intestinalis	73.02	5.00e-152	529.00
IUUC-Csv-025978	Ciona savignyi	65.39	0.00e+00	999.00
IUUC-Dre-027958	Danio rerio	97.10	0.00e+00	1507.00
IUUC-Dno-029195	Dasypus novemcinctus	99.60	0.00e+00	1523.00
IUUC-Dor-030573	Dipodomys ordii	87.25	1.00e-173	602.00
IUUC-Dme-032083	Drosophila melanogaster	68.13	0.00e+00	920.00
IUUC-Ete-032428	Echinops telfairi	81.82	0.00e+00	1190.00
IUUC-Eca-033232	Equus caballus	99.47	0.00e+00	1522.00
IUUC-Eeu-035348	Erinaceus europaeus	99.74	0.00e+00	756.00
IUUC-Fca-035401	Felis catus	98.95	0.00e+00	1499.00
IUUC-Fal-037514	Ficedula albicollis	100.00	0.00e+00	1527.00
IUUC-Gmo-038577	Gadus morhua	94.36	0.00e+00	1457.00
IUUC-Gga-041096	Gallus gallus	100.00	0.00e+00	1527.00
IUUC-Gac-042108	Gasterosteus aculeatus	95.28	0.00e+00	1470.00
IUUC-Ggo-045313	Gorilla gorilla	99.60	0.00e+00	1524.00
IUUC-Hsa-045974	Homo sapiens	99.60	0.00e+00	1525.00
IUUC-Itr-049009	Ictidomys tridecemlineatus	99.60	0.00e+00	1524.00
IUUC-Lch-050615	Latimeria chalumnae	99.21	0.00e+00	1519.00
IUUC-Loc-051807	Lepisosteus oculatus	98.55	0.00e+00	1510.00
IUUC-Laf-053601	Loxodonta africana	99.60	0.00e+00	1524.00
IUUC-Mcc-055260	Macaca mulatta	99.60	0.00e+00	1524.00
IUUC-Meu-056632	Macropus eugenii	100.00	0.00e+00	916.00
IUUC-Mga-059658	Meleagris gallopavo	99.87	0.00e+00	1524.00
IUUC-Mmr-061424	Microcebus murinus	89.72	0.00e+00	1325.00
IUUC-Mdo-061836	Monodelphis domestica	99.74	0.00e+00	1524.00
IUUC-Mmu-063757	Mus musculus	98.02	0.00e+00	1505.00
IUUC-Mpu-065823	Mustela putorius furo	99.60	0.00e+00	1523.00
IUUC-Mlu-066969	Myotis lucifugus	99.21	0.00e+00	1518.00
IUUC-Nle-069943	Nomascus leucogenys	99.60	0.00e+00	1525.00
IUUC-Opr-070820	Ochotona princeps	99.54	0.00e+00	866.00
IUUC-Ont-072527	Oreochromis niloticus	96.18	0.00e+00	1488.00
IUUC-Ocu-074586	Oryctolagus cuniculus	99.60	0.00e+00	1525.00
IUUC-Ola-087526	Oryzias latipes	96.18	0.00e+00	1487.00
IUUC-Oga-088425	Otolemur garnettii	95.13	0.00e+00	1485.00
IUUC-Oar-089785	Ovis aries	99.60	0.00e+00	1525.00
IUUC-Ptr-091242	Pan troglodytes	99.60	0.00e+00	1525.00
IUUC-Pan-092246	Papio anubis	99.60	0.00e+00	1525.00
IUUC-Psi-094081	Pelodiscus sinensis	100.00	0.00e+00	1529.00
IUUC-Pma-094735	Petromyzon marinus	82.38	0.00e+00	724.00
IUUC-Pfo-096357	Poecilia formosa	95.78	0.00e+00	1481.00
IUUC-Pab-098248	Pongo abelii	93.28	0.00e+00	1404.00
IUUC-Pca-100756	Procavia capensis	88.08	0.00e+00	875.00
IUUC-Pva-102990	Pteropus vampyrus	84.93	0.00e+00	872.00
IUUC-Rno-105887	Rattus norvegicus	98.29	0.00e+00	1508.00
IUUC-Sha-107016	Sarcophilus harrisii	99.74	0.00e+00	1524.00
IUUC-Sar-113558	Sorex araneus	93.68	0.00e+00	1455.00
IUUC-Ssc-115414	Sus scrofa	99.60	0.00e+00	1525.00
IUUC-Tgu-116801	Taeniopygia guttata	99.47	0.00e+00	1516.00
IUUC-Tru-117565	Takifugu rubripes	96.57	0.00e+00	1493.00
IUUC-Tsy-119292	Tarsius syrichta	93.61	0.00e+00	1373.00
IUUC-Tni-120471	Tetraodon nigroviridis	96.45	0.00e+00	1486.00
IUUC-Tbe-127838	Tupaia belangeri	93.68	0.00e+00	1455.00
IUUC-Ttr-128345	Tursiops truncatus	99.21	0.00e+00	1519.00
IUUC-Vpa-130191	Vicugna pacos	90.22	0.00e+00	809.00
IUUC-Xtr-132810	Xenopus tropicalis	99.21	0.00e+00	1518.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence